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Your search keyword '"Farré, Magí"' showing total 590 results
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590 results on '"Farré, Magí"'

4. Oral linezolid compared with benzathine penicillin G for treatment of early syphilis in adults (Trep-AB Study) in Spain: a prospective, open-label, non-inferiority, randomised controlled trial

Author

Ubals, Maria, Nadal-Baron, Patricia, Arando, Maider, Rivero, Ángel, Mendoza, Adrià, Descalzo Jorro, Vicent, Ouchi, Dan, Pérez-Mañá, Clara, Álvarez, Marlene, Alemany, Andrea, Hoyos-Mallecot, Yannick, Nunley, Ethan, Lieberman, Nicole A P, Greninger, Alexander L, Galván-Casas, Cristina, Suñer, Clara, G-Beiras, Camila, Paredes, Roger, Rodríguez-Gascón, Alicia, Canut, Andrés, García-Patos, Vicente, Farré, Magí, Marks, Michael, Giacani, Lorenzo, Vall-Mayans, Martí, and Mitjà, Oriol

Published
2024
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5. Development of enantioselective high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its phase-1 metabolites in human biological fluids

Author

Lo Faro, Alfredo Fabrizio, Sprega, Giorgia, Beradinelli, Diletta, Tini, Anstasio, Poyatos, Lourdes, Papaseit, Esther, Berretta, Paolo, Di Giorgi, Alessandro, Farre, Magì, Takaishvili, Nino, Farkas, Tivadar, Busardò, Francesco Paolo, and Chankvetadze, Bezhan

Published
2024
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8. Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder

Author

Study, CohRTA, Center, Coordinating, Sanvisens, Arantza, Zuluaga, Paola, Fuster, Daniel, Hernández-Rubio, Anna, Farré, Magí, Papasseit, Esther, Pérez-Mañá, Clara, Poyatos, Lourdes, García-Marchena, Nuria, Abellí, Enric, Muga, Robert, Short, Antonio, Moranta, Catalina, Blanes, Rafael, Rubio, Gabriel, Sion, Ana, Miquel, Laia, Ortega, Lluisa, Bruguera, Pol, Caballeria, Elsa, Messeguer, Ana, Torrens, Marta, Fonseca, Francina, Ignacio Mestre-Pinto, Juan, Alías, María, Dinamarca, Fernando, Bolao, Ferran, Rodríguez de Fonseca, Fernando, Javier Pavón-Morón, Francisco, Araos, Pedro, Flores-López, María, Serrano, Antonia, Marcos, Miguel, Martín, Candelaria, Pérez-Hernández, Onán, Manzanares, Jorge, Illescas, Lucía, and Barbier-Torres, Lucía

Published
2023
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10. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author

Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, Grau, Eulàlia, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara, Clotet, Bonaventura, and Mitjà, Oriol

Published
2022
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19. TRABAJOS DE FIN DE GRADO SOBRE HUMANIDADES EN TRES ESTUDIOS DE CIENCIAS DE LA SALUD.

Author

CAMBRA-BADII, Irene, FARRÉ, Magí, and PÉREZ, Jorge

Abstract

Copyright of Revista de Medicina y Cine / Journal of Medicine & Movies is the property of Ediciones Universidad de Salamanca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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38. GC–MS/MS Determination of Synthetic Cathinones: 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study.

Author

Nuñez-Montero, Melani, Lombroni, Claudia, Maida, Nunzia La, Rotolo, Maria Concetta, Pichini, Simona, Papaseit, Esther, Hladun, Olga, Ventura, Mireia, Poyatos, Lourdes, Pérez-Mañá, Clara, Farré, Magí, and Marchei, Emilia

Subjects
SYNTHETIC cathinone, SALIVA, PERSPIRATION, AMMONIUM bicarbonate, CONSUMERS, PILOT projects
Abstract

This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. A total of 48 oral fluid and 12 sweat samples were collected from six consumers. After the addition of 5 μL of methylone-d3 and 200 μL of 0.5 M ammonium hydrogen carbonate, an L/L extraction was carried out using ethyl acetate. The samples, dried under a nitrogen flow, were then derivatized with pentafluoropropionic anhydride and dried again. One microliter of the sample reconstituted in 50 μL of ethyl acetate was injected into GC-MS/MS. The method was fully validated according to international guidelines. Our results showed how, in oral fluid, the two cathinones taken intranasally were absorbed very rapidly, within the first hour, when compared with the 4-CMC which reached its maximum concentration peak in the first three hours. We observed that these cathinones were excreted in sweat in an amount equivalent to approximately 0.3% of the administered dose for 4-CMC and NEP. The total NEH excreted in sweat 4 h after administration was approximately 0.2% of the administered dose. Our results provide, for the first time, preliminary information about the disposition of these synthetic cathinones in the consumers' oral fluid and sweat after controlled administration. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans.

Author

Di Giorgi, Alessandro, Sprega, Giorgia, Poyatos, Lourdes, Papaseit, Esther, Pérez-Mañá, Clara, Di Trana, Annagiulia, Varì, Maria Rosaria, Busardò, Francesco Paolo, Pichini, Simona, Zaami, Simona, Lo Faro, Alfredo Fabrizio, and Farré, Magí

Subjects
PERSPIRATION, LIQUID chromatography-mass spectrometry, TANDEM mass spectrometry, DRUG utilization
Abstract

The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. Methylone and its metabolites 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone (MDC) were analyzed in sweat patches by liquid chromatography–tandem mass spectrometry. Methylone and MDC were detected in sweat at 2 h and reached their highest accumulation (Cmax) at 24 h after the administration of 50, 100, 150 and 200 mg doses. In contrast, HMMC was not detectable at any time interval after each dose. Sweat proved to be a suitable matrix for methylone and its metabolites' determination in clinical and toxicological studies, providing a concentration that reveals recent drug consumption. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Usefulness of Oral Fluid for Measurement of Methylone and Its Metabolites: Correlation with Plasma Drug Concentrations and the Effect of Oral Fluid pH.

Author

Sprega, Giorgia, Di Giorgi, Alessandro, Poyatos, Lourdes, Papaseit, Esther, Pérez-Mañá, Clara, Tini, Anastasio, Pichini, Simona, Busardò, Francesco Paolo, Lo Faro, Alfredo Fabrizio, and Farré, Magí

Subjects
SALIVA, LIQUID chromatography-mass spectrometry, PHARMACODYNAMICS, METABOLITES
Abstract

The aim of this study was to investigate methylone and its metabolites concentration in oral fluid following controlled increasing doses, focusing on the effect of oral fluid pH. Samples were obtained from a clinical trial where twelve healthy volunteers participated after ingestion of 50, 100, 150 and 200 mg of methylone. Concentration of methylone and its metabolites 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone in oral fluid were measured using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Pharmacokinetic parameters were estimated, and the oral fluid-to-plasma ratio (OF/P) at each time interval was calculated and correlated with the oral fluid pH using data from our previous study in plasma. Methylone was detected at all time intervals after each dose; MDC and HMMC were not detectable after the lowest dose. Oral fluid concentrations of methylone ranged between 88.3–503.8, 85.5–5002.3, 182.8–13,201.8 and 214.6–22,684.6 ng/mL following 50, 100, 150 and 200 mg doses, respectively, peaked between 1.5 and 2.0 h, and were followed by a progressive decrease. Oral fluid pH was demonstrated to be affected by methylone administration. Oral fluid is a valid alternative to plasma for methylone determination for clinical and toxicological studies, allowing for a simple, easy and non-invasive sample collection. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Is There a Recreational Misuse Potential for Pregabalin? Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data

Author

Schifano, Fabrizio, D’Offizi, Stefano, Piccione, Michele, Corazza, Ornella, Deluca, Paolo, Davey, Zoe, Di Melchiorre, Giuditta, Di Furia, Lucia, Farré, Magí, Flesland, Liv, Mannonen, Miia, Majava, Aino, Pagani, Stefania, Peltoniemi, Teuvo, Siemann, Holger, Skutle, Arvid, Torrens, Marta, Pezzolesi, Cinzia, van der Kreeft, Peer, and Scherbaum, Norbert

Published
2011

49. Pharmacological effects of methylone and MDMA in humans.

Author

Poyatos, Lourdes, Pérez-Mañá, Clara, Hladun, Olga, Núñez-Montero, Melani, de la Rosa, Georgina, Martín, Soraya, Maria Barriocanal, Ana, Carabias, Lydia, Kelmendi, Benjamin, Taoussi, Omayema, Paolo Busardò, Francesco, Fonseca, Francina, Torrens, Marta, Pichini, Simona, Farré, Magí, and Papaseit, Esther

Subjects
ECSTASY (Drug), SYNTHETIC cathinone, ORAL drug administration, PUPILLOMETRY, BLOOD pressure, PSYCHOLOGY of movement, HEART beat
Abstract

Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Both psychostimulants exhibit similar chemistry (i.e., methylone is a β-keto analog of MDMA) and mechanisms of action. Currently, the pharmacology of methylone remains scarcely explored in humans. Herein, we aimed to evaluate the acute pharmacological effects of methylone and its abuse potential in humans when compared with that of MDMA following oral administration under controlled conditions. Seventeen participants of both sexes (14 males, 3 females) with a previous history of psychostimulant use completed a randomized, double-blind, placebo-controlled, crossover clinical trial. Participants received a single oral dose of 200 mg of methylone, 100 mg of MDMA, and a placebo. The variables included physiological effects (blood pressure, heart rate, oral temperature, pupil diameter), subjective effects using visual analog scales (VAS), the short form of the Addiction Research Center Inventory (ARCI), the Evaluation of Subjective Effects of Substances with Abuse Potential questionnaire (VESSPA-SSE), and the Sensitivity to Drug Reinforcement Questionnaire (SDRQ), and psychomotor performance (Maddox wing, psychomotor vigilance task). We observed that methylone could significantly increase blood pressure and heart rate and induce pleasurable effects, such as stimulation, euphoria, wellbeing, enhanced empathy, and altered perception. Methylone exhibited an effect profile similar to MDMA, with a faster overall onset and earlier disappearance of subjective effects. These results suggest that abuse potential of methylone is comparable to that of MDMA in humans. [ABSTRACT FROM AUTHOR]

Published
2023
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