1. Cortisol awakening response and developmental outcomes at 6–7 years in children born extremely preterm
- Author
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Jobe, Alan H, Caplan, Michael S, Polin, Richard A, Laptook, Abbot R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Johnson, Katharine, Alksninis, Barbara, Keszler, Mary Lenore, Knoll, Andrea M, Leach, Theresa M, McGowan, Elisabeth C, Watson, Victoria E, Walsh, Michele C, Fanaroff, Avroy A, Payne, Allison, Wilson-Costello, Deanne E, Newman, Nancy S, Siner, Bonnie S, Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G, Yalcinkaya, Gulgun, Goldberg, Ronald N, Cotten, C Michael, Gustafson, Kathryn E, Goldstein, Ricki F, Ashley, Patricia, Auten, Kathy J, Fisher, Kimberley A, Foy, Katherine A, Freedman, Sharon F, Lohmeyer, Melody B, Malcolm, William F, Wallace, David K, Carlton, David P, Stoll, Barbara J, Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J, Carter, Sheena, Fritz, Sobha, Hale, Ellen C, Hutchinson, Amy K, LaRossa, Maureen Mulligan, Loggins, Yvonne, Bottcher, Diane, Higgins, Rosemary D, Archer, Stephanie Wilson, Poindexter, Brenda B, Sokol, Gregory M, Harmon, Heidi M, Papile, Lu-Ann, Hines, Abbey C, Wilson, Leslie D, Herron, Dianne E, Smiley, Lucy, Granger, Douglas A, Kennedy, Kathleen A, Tyson, Jon E, Duncan, Andrea F, Dempsey, Allison G, John, Janice, Jones, Patrick M, Lillie, M Layne, Siddiki, Saba, Sperry, Daniel K, Blaisdell, Carol J, Das, Abhik, Wallace, Dennis, Gantz, Marie G, O’Donnell Auman, Jeanette, Hammond, Jane A, Newman, Jamie E, Poole, W Kenneth, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, DeAnda, Maria Elena, Goodlin, Gabrielle T, Frantz, Ivan D, Fiascone, John M, Kurfiss, Anne, MacKinnon, Brenda L, Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Phillips, Vivien A, Domanovich, Kristy, Whitley, Sally, Smith, Leigh Ann, Kiser, Carin R, and Finer, Neil N
- Subjects
Paediatrics ,Biomedical and Clinical Sciences ,Basic Behavioral and Social Science ,Behavioral and Social Science ,Mind and Body ,Mental Health ,Neurosciences ,Clinical Research ,Pediatric ,2.3 Psychological ,social and economic factors ,Aetiology ,Mental health ,Child ,Female ,Humans ,Infant ,Newborn ,Executive Function ,Hydrocortisone ,Hypothalamo-Hypophyseal System ,Infant ,Extremely Premature ,Pituitary-Adrenal System ,SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network ,Paediatrics and Reproductive Medicine ,Public Health and Health Services ,Pediatrics - Abstract
BackgroundExtremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children.MethodsThis secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed.ResultsCortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were significantly worse among EPT children only. Conners Parent Rating Scale behavior scores were significantly worse among EPT children. After adjusting for covariates, blunted cortisol awakening responses were found to be associated with poorer scores on memory tests and greater problems with inattention for the EPT group (p
- Published
- 2023