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Urban landscape and tourism, a complementary binomial or a dual antithesis? The question is becoming more and more interesting, and it is a cause of concern among local administrators. To this end, we aim to investigate the dynamics of a specific case, the city of Naples (Italy), where the fast, increasing touristification of the historic city center - a phenomenon for which the expression "overtourism" is increasingly used – is now showing the other side of the coin. Through an interpretivist-constructivist epistemological approach based on the analysis of the context, the critical issues relating to an uncontrolled management of urban space are first brought to light and then some strategies and public policies that could prove effective in containing the phenomenon are proposed. Finally, the results found for the specific case of Naples are described in inductive terms to be replicable in similar contexts. [ABSTRACT FROM AUTHOR]

Small and Medium Enterprises (SMEs) in urban areas are increasingly relevant, with a consistent impact on various territories. This research explores the re-territorialization processes, contextualized by the post-Fordism era, in urban areas. The objective of this work is to verify a hypothesis assumed at the base of the research relating to the presence of a uniformity of orientation regarding the settlement determinants of companies that are co-located in specific areas of the cities. This hypothesis is tested in relation to various industrial sectors. The availability of these survey elements constitutes a useful driver of awareness to be then translated into specific actions in urban planning in terms of policies, services and infrastructures to be dedicated to these urban spaces characterized by clusters of firms. From a methodological point of view, the followed approach is based on two aspects relating both to a cartographic comparison and both to a statistical comparison between the answers provided by the service companies of different sectors of some European cities selected for the sample survey. [ABSTRACT FROM AUTHOR]

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Ex-situ machine perfusion (MP) techniques are increasingly used in clinical settings, especially on grafts from donors after cardiac death (DCD). However, the biological effects elicited by machine perfusion are largely unknown, and a substantial number of animal studies are presently focused on this topic. The aim of the present study was to describe a model of DCD based on ex-situ perfusion of liver grafts derived from animals used for food production. Procurement took place within a slaughterhouse facility. After cold storage, the liver grafts were perfused with autologous blood-enriched perfusion fluid in a clinically fashioned closed circuit normothermic MP (NMP). During the rewarming phase, temperature and flows were progressively increased to reach target values. Perfusate and tissue samples were collected to assess NMP functionality. Grafts were classified as transplantable (LT-G) or not (nLT-G) according to clinical criteria, and viability was confirmed by histopathological analysis. Four grafts were classified as LT-G and three as nLT-G at the end of NMP. Histology confirmed the absence of major damage in LT-G, while nLT-G presented diffuse necrosis. Interestingly, an early impairment of the hepatocyte respiratory chain, leading to cell necrosis and graft non-viability, was documented in nLT-G for the first time. These parameters, together with indocyanine-green dye and citrate clearance could contribute to graft evaluation in clinical settings. The model provides a promising and reproducible method to replace dedicated experimental animals in research on machine perfusion of DCD grafts in line with the 3Rs principles. [ABSTRACT FROM AUTHOR]