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719 results on '"Engstrøm, Thomas"'

3. Time From Distress Call to Percutaneous Coronary Intervention and Outcomes in Myocardial Infarction

Author

Mills, Elisabeth Helen Anna, Møller, Amalie Lykkemark, Engstrøm, Thomas, Folke, Fredrik, Pedersen, Frants, Køber, Lars, Gnesin, Filip, Zylyftari, Nertila, Blomberg, Stig Nikolaj Fasmer, Kragholm, Kristian, Gislason, Gunnar, Jensen, Britta, Lippert, Freddy, Kragelund, Charlotte, Christensen, Helle Collatz, Andersen, Mikkel Porsborg, and Torp-Pedersen, Christian

Published
2024
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4. A Systematic Approach to the Evaluation of the Coronary Microcirculation Using Bolus Thermodilution: CATH CMD

Author

Collet, Carlos, Yong, Andy, Munhoz, Daniel, Akasaka, Takashi, Berry, Colin, Blair, John E.A., Collison, Damien, Engstrøm, Thomas, Escaned, Javier, Fearon, William F., Ford, Tom, Gori, Tommaso, Koo, Bon-Kwon, Low, Adrian F, Miner, Steve, Ng, Martin K.C., Mizukami, Takuya, Shimokawa, Hiroki, Smilowitz, Nathaniel R., Sutton, Nadia R., Svanerud, Johan, Tremmel, Jennifer A., Warisawa, Takayuki, West, Nick E.J., and Ali, Ziad A.

Published
2024
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5. Effects of alirocumab on endothelial function and coronary atherosclerosis in myocardial infarction: A PACMAN-AMI randomized clinical trial substudy

Author

Rexhaj, Emrush, Bär, Sarah, Soria, Rodrigo, Ueki, Yasushi, Häner, Jonas D., Otsuka, Tatsuhiko, Kavaliauskaite, Raminta, Siontis, George CM., Stortecky, Stefan, Shibutani, Hiroki, Spirk, David, Engstrøm, Thomas, Lang, Irene, Morf, Laura, Ambühl, Maria, Windecker, Stephan, Losdat, Sylvain, Koskinas, Konstantinos C., and Räber, Lorenz

Published
2024
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7. The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease

Author

Kofoed, Klaus F., Nordestgaard, Børge, Køber, Lars V., Kühl, J. Tobias, Fuchs, Andreas, Sigvardsen, Per E., Sørgaard, Mathias, de Knegt, Martina C., Norsk, Jakob, Frestad, Daria, Mejdahl, Mads, Elming, Marie, Sørensen, Samuel Kiil, Hindsøe, Louise, Thomsen, Anna Foged, Udholm, Patricia Martens, Pihl, Christian, Nilsson, Julia, Byrne, Christina, Knudsen, Andreas Dehlbæk, Haugen, Morten, Windfeld-Mathiasen, Josefine, Laura Wiegandt, Yaffah Tamar, Pham, Michael H.C., Ballegaard, Christian, Arnaa, Kirsten, Møller, Christina, Thrysøe, Kirsten, Linde, Jesper J., Hove, Jens D., Jensen, Gorm B., Kelbæk, Henning, Nielsen, Walter, Trysøe, Kirsten, Bock-Pedersen, Tina, Hansen, Bettina, Kløvgaard, Lene, Holmvang, Lene, Engstrøm, Thomas, Helquist, Steffen, Jørgensen, Erik, Petersen, Frans, Saunamaki, Kari, Clemmensen, Peter, Høfsten, Dan E., Sadjadieh, Golnaz, Laursen, Peter Nørkjær, Petersen, Christian Torp, Hansen, Peter Riis, Gislason, Gunnar, Abildgaard, Ulrik, Jensen, Jan Skov, Galatius, Søren, Fritz-Hansen, Thomas, Bech, Jan, Wachtell, Christian, Madsen, Jan Kyst, Smedegaard, Lærke, Özcan, Cengiz, Heitmann, Merete, Svendsen, Ida Hastrup, Nielsen, Olav Wendelboe, Kristiansen, Ole, Bjerre, Andreas Fabricius, Dixen, Ulrik, Madsen, Johnny Koertz, Fornitz, Gitte Gleerup, Raymond, Ilan, Abdulla, Jawdat, Lyngbæk, Stig, Steffensen, Rolf, Jurlander, Birgit, Kragelund, Charlotte, Dominguez, Helena, Schou, Morten, Elming, Hanne, Therkelsen, Susette, Jensen, Andreas K., Hansen, Peter R., and Nordestgaard, Børge G.

Published
2024
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9. Rationale and design of the pullback pressure gradient (PPG) global registry

Author

Munhoz, Daniel, Collet, Carlos, Mizukami, Takuya, Yong, Andy, Leone, Antonio Maria, Eftekhari, Ashkan, Ko, Brian, da Costa, Bruno R., Berry, Colin, Collison, Damien, Perera, Divaka, Christiansen, Evald Høj, Rivero, Fernando, Zimmermann, Frederik M., Ando, Hirohiko, Matsuo, Hitoshi, Nakayama, Masafumi, Escaned, Javier, Sonck, Jeroen, Sakai, Koshiro, Adjedj, Julien, Desta, Liyew, van Nunen, Lokien X., West, Nick E.J., Fournier, Stephane, Storozhenko, Tatyana, Amano, Tetsuya, Engstrøm, Thomas, Johnson, Thomas, Shinke, Toshiro, Biscaglia, Simone, Fearon, William F., Ali, Ziad, De Bruyne, Bernard, and Johnson, Nils P.

Published
2023
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10. Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy

Author

Biccirè, Flavio G., Häner, Jonas, Losdat, Sylvain, Ueki, Yasushi, Shibutani, Hiroki, Otsuka, Tatsuhiko, Kakizaki, Ryota, Hofbauer, Thomas M., van Geuns, Robert-Jan, Stortecky, Stefan, Siontis, George C.M., Bär, Sarah, Lønborg, Jacob, Heg, Dik, Kaiser, Christoph, Spirk, David, Daemen, Joost, Iglesias, Juan F., Windecker, Stephan, Engstrøm, Thomas, Lang, Irene, Koskinas, Konstantinos C., and Räber, Lorenz

Published
2023
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11. Impact of Post-PCI FFR Stratified by Coronary Artery

Author

Collet, Carlos, Johnson, Nils P., Mizukami, Takuya, Fearon, William F., Berry, Colin, Sonck, Jeroen, Collison, Damien, Koo, Bon-Kwon, Meneveau, Nicolas, Agarwal, Shiv Kumar, Uretsky, Barry, Hakeem, Abdul, Doh, Joon-Hyung, Da Costa, Bruno R., Oldroyd, Keith G., Leipsic, Jonathon A., Morbiducci, Umberto, Taylor, Charles, Ko, Brian, Tonino, Pim A.L., Perera, Divaka, Shinke, Toshiro, Chiastra, Claudio, Sposito, Andrei C., Leone, Antonio Maria, Muller, Olivier, Fournier, Stephane, Matsuo, Hitoshi, Adjedj, Julien, Amabile, Nicolas, Piróth, Zsolt, Alfonso, Fernando, Rivero, Fernando, Ahn, Jung-Min, Toth, Gabor G., Ihdayhid, Abdul, West, Nick E.J., Amano, Tetsuya, Wyffels, Eric, Munhoz, Daniel, Belmonte, Marta, Ohashi, Hirofumi, Sakai, Koshiro, Gallinoro, Emanuele, Barbato, Emanuele, Engstrøm, Thomas, Escaned, Javier, Ali, Ziad A., Kern, Morton J., Pijls, Nico H.J., Jüni, Peter, and De Bruyne, Bernard

Published
2023
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12. Optimal timing of influenza vaccination among patients with acute myocardial infarction – Findings from the IAMI trial

Author

Akhtar, Zubair, Götberg, Matthias, Erlinge, David, Christiansen, Evald H., Oldroyd, Keith G., Motovska, Zuzana, Erglis, Andrejs, Hlinomaz, Ota, Jakobsen, Lars, Engstrøm, Thomas, Jensen, Lisette O., Fallesen, Christian O., Jensen, Svend E., Angerås, Oskar, Calais, Fredrik, Kåregren, Amra, Lauermann, Jörg, Mokhtari, Arash, Nilsson, Johan, Persson, Jonas, Islam, Abu K.M.M., Rahman, Afzalur, Malik, Fazila, Choudhury, Sohel, Collier, Timothy, Pocock, Stuart J., Pernow, John, MacIntyre, Chandini R., and Fröbert, Ole

Published
2023
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13. Routine revascularization with percutaneous coronary intervention in patients with coronary artery disease undergoing transcatheter aortic valve implantation – the third nordic aortic valve intervention trial – NOTION-3

Author

Sabbah, Muhammad, Veien, Karsten, Niemela, Matti, Freeman, Phillip, Linder, Rickard, Ioanes, Dan, Terkelsen, Christian Juhl, Kajander, Olli A., Koul, Sasha, Savontaus, Mikko, Karjalainen, Pasi, Erglis, Andrejs, Minkkinen, Mikko, Jørgensen, Troels, Sondergaard, Lars, De Backer, Ole, Engstrøm, Thomas, and Lønborg, Jacob

Published
2023
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14. Clinical impact of influenza vaccination after ST- and non-ST-segment elevation myocardial infarction - insights from the IAMI trial

Author

Fröbert, Ole, Götberg, Matthias, Erlinge, David, Akhtar, Zubair, Christiansen, Evald H., MacIntyre, Chandini R., Oldroyd, Keith G., Motovska, Zuzana, Erglis, Andrejs, Moer, Rasmus, Hlinomaz, Ota, Jakobsen, Lars, Engstrøm, Thomas, Jensen, Lisette O., Fallesen, Christian O., Jensen, Svend E, Angerås, Oskar, Calais, Fredrik, Kåregren, Amra, Lauermann, Jörg, Mokhtari, Arash, Nilsson, Johan, Persson, Jonas, Stalby, Per, Islam, Abu K.M.M., Rahman, Afzalur, Malik, Fazila, Choudhury, Sohel, Collier, Timothy, Pocock, Stuart J., and Pernow, John

Published
2023
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15. A comprehensive evaluation of the genetic architecture of sudden cardiac arrest

Author

Ashar, Foram N, Mitchell, Rebecca N, Albert, Christine M, Newton-Cheh, Christopher, Brody, Jennifer A, Müller-Nurasyid, Martina, Moes, Anna, Meitinger, Thomas, Mak, Angel, Huikuri, Heikki, Junttila, M Juhani, Goyette, Philippe, Pulit, Sara L, Pazoki, Raha, Tanck, Michael W, Blom, Marieke T, Zhao, XiaoQing, Havulinna, Aki S, Jabbari, Reza, Glinge, Charlotte, Tragante, Vinicius, Escher, Stefan A, Chakravarti, Aravinda, Ehret, Georg, Coresh, Josef, Li, Man, Prineas, Ronald J, Franco, Oscar H, Kwok, Pui-Yan, Lumley, Thomas, Dumas, Florence, McKnight, Barbara, Rotter, Jerome I, Lemaitre, Rozenn N, Heckbert, Susan R, O’Donnell, Christopher J, Hwang, Shih-Jen, Tardif, Jean-Claude, VanDenburgh, Martin, Uitterlinden, André G, Hofman, Albert, Stricker, Bruno HC, de Bakker, Paul IW, Franks, Paul W, Jansson, Jan-Hakan, Asselbergs, Folkert W, Halushka, Marc K, Maleszewski, Joseph J, Tfelt-Hansen, Jacob, Engstrøm, Thomas, Salomaa, Veikko, Virmani, Renu, Kolodgie, Frank, Wilde, Arthur AM, Tan, Hanno L, Bezzina, Connie R, Eijgelsheim, Mark, Rioux, John D, Jouven, Xavier, Kääb, Stefan, Psaty, Bruce M, Siscovick, David S, Arking, Dan E, and Sotoodehnia, Nona

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Prevention, Heart Disease, Human Genome, Genetics, Clinical Research, Heart Disease - Coronary Heart Disease, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Arrhythmias, Cardiac, Body Mass Index, Coronary Artery Disease, Death, Sudden, Cardiac, Female, Genome-Wide Association Study, Heart Conduction System, Humans, Male, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Risk Assessment, Risk Factors, Sex Factors, Sudden cardiac arrest, Genome-wide association study, Mendelian randomization, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

AimsSudden cardiac arrest (SCA) accounts for 10% of adult mortality in Western populations. We aim to identify potential loci associated with SCA and to identify risk factors causally associated with SCA.Methods and resultsWe carried out a large genome-wide association study (GWAS) for SCA (n = 3939 cases, 25 989 non-cases) to examine common variation genome-wide and in candidate arrhythmia genes. We also exploited Mendelian randomization (MR) methods using cross-trait multi-variant genetic risk score associations (GRSA) to assess causal relationships of 18 risk factors with SCA. No variants were associated with SCA at genome-wide significance, nor were common variants in candidate arrhythmia genes associated with SCA at nominal significance. Using cross-trait GRSA, we established genetic correlation between SCA and (i) coronary artery disease (CAD) and traditional CAD risk factors (blood pressure, lipids, and diabetes), (ii) height and BMI, and (iii) electrical instability traits (QT and atrial fibrillation), suggesting aetiologic roles for these traits in SCA risk.ConclusionsOur findings show that a comprehensive approach to the genetic architecture of SCA can shed light on the determinants of a complex life-threatening condition with multiple influencing factors in the general population. The results of this genetic analysis, both positive and negative findings, have implications for evaluating the genetic architecture of patients with a family history of SCA, and for efforts to prevent SCA in high-risk populations and the general community.

Published
2018

19. Effects of the PCSK9 antibody alirocumab on coronary atherosclerosis in patients with acute myocardial infarction: a serial, multivessel, intravascular ultrasound, near-infrared spectroscopy and optical coherence tomography imaging study–Rationale and design of the PACMAN-AMI trial

Author

Zanchin, Christian, Koskinas, Konstantinos C., Ueki, Yasushi, Losdat, Sylvain, Häner, Jonas D., Bär, Sarah, Otsuka, Tatsuhiko, Inderkum, Andrea, Jensen, Maria Radu Juul, Lonborg, Jacob, Fahrni, Gregor, Ondracek, Anna S., Daemen, Joost, van Geuns, Robert-Jan, Iglesias, Juan F., Matter, Christian M., Spirk, David, Juni, Peter, Mach, Francois, Heg, Dik, Engstrom, Thomas, Lang, Irene, Windecker, Stephan, and Räber, Lorenz

Published
2021
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21. Prognostic Value of Coronary CT Angiography in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes

Author

Kofoed, Klaus F., Engstrøm, Thomas, Sigvardsen, Per E., Linde, Jesper J., Torp-Pedersen, Christian, de Knegt, Martina, Hansen, Peter R., Fritz-Hansen, Thomas, Bech, Jan, Heitmann, Merete, Nielsen, Olav W., Høfsten, Dan, Kühl, Jørgen T., Raymond, Ilan E., Kristiansen, Ole P., Svendsen, Ida H., Domínguez Vall-Lamora, M.H., Kragelund, Charlotte, Hove, Jens D., Jørgensen, Tem, Fornitz, Gitte G., Steffensen, Rolf, Jurlander, Birgit, Abdulla, Jawdat, Lyngbæk, Stig, Elming, Hanne, Therkelsen, Susette K., Jørgensen, Erik, Kløvgaard, Lene, Bang, Lia E., Helqvist, Steffen, Galatius, Søren, Pedersen, Frants, Abildgaard, Ulrik, Clemmensen, Peter, Saunamäki, Kari, Holmvang, Lene, Gislason, Gunnar, Kelbæk, Henning, and Køber, Lars V.

Published
2021
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23. Immediate vs Delayed Stenting in ST-Elevation Myocardial Infarction: Rationale and Design of the International PRIMACY Bayesian Randomized Controlled Trial

Author

Jolicoeur, E. Marc, Dendukuri, Nandini, Belisle, Patrick, Range, Grégoire, Souteyrand, Geraud, Bouisset, Frédéric, Zemour, Gilles, Delarche, Nicolas, Harbaoui, Brahim, Schampaert, Erick, Kouz, Simon, Cayla, Guillaume, Roubille, François, Boueri, Ziad, Mansour, Samer, Marcaggi, Xavier, Tardif, Jean-Claude, McGillion, Michael, Tanguay, Jean-François, Brophy, James, Yu, Cheol Woong, Berry, Colin, Carrick, David, Høfsten, Dan Eik, Engstrøm, Thomas, Kober, Lars, Kelbæk, Henning, and Belle, Loic

Published
2020
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24. Usefulness of High Sensitivity Troponin T to Predict Long-Term Left Ventricular Dysfunction After ST-Elevation Myocardial Infarction

Author

Mohammad, Moman A., Koul, Sasha, Lønborg, Jacob Thomsen, Nepper-Christensen, Lars, Høfsten, Dan E., Ahtarovski, Kiril A., Bang, Lia E., Helqvist, Steffen, Kyhl, Kasper, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Holmvang, Lene, Schoos, Mikkel Malby, Göransson, Christoffer, Engstrøm, Thomas, and Erlinge, David

Published
2020
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27. Evaluation and Management of Nonculprit Lesions in STEMI

Author

Thim, Troels, van der Hoeven, Nina W., Musto, Carmine, Nijveldt, Robin, Götberg, Matthias, Engstrøm, Thomas, Smits, Pieter C., Oldroyd, Keith G., Gershlick, Anthony H., Escaned, Javier, Baptista, Sergio Bravo, Raposo, Luis, van Royen, Niels, and Maeng, Michael

Published
2020
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32. Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy

Author

Francis, Rohin, Chong, Jun, Ramlall, Manish, Bucciarelli-Ducci, Chiara, Clayton, Tim, Dodd, Matthew, Engstrøm, Thomas, Evans, Richard, Ferreira, Vanessa M., Fontana, Marianna, Greenwood, John P., Kharbanda, Rajesh K., Kim, Won Yong, Kotecha, Tushar, Lønborg, Jacob T., Mathur, Anthony, Møller, Ulla Kristine, Moon, James, Perkins, Alexander, Rakhit, Roby D., Yellon, Derek M., Bøtker, Hans Erik, Bulluck, Heerajnarain, and Hausenloy, Derek J.

Published
2021
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36. Complete Revascularization Versus Culprit Lesion Only in Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A DANAMI-3–PRIMULTI Cardiac Magnetic Resonance Substudy

Author

Kyhl, Kasper, Ahtarovski, Kiril Aleksov, Nepper-Christensen, Lars, Ekström, Kathrine, Ghotbi, Adam Ali, Schoos, Mikkel, Göransson, Christoffer, Bertelsen, Litten, Helqvist, Steffen, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Høfsten, Dan Eik, Køber, Lars, Kelbæk, Henning, Vejlstrup, Niels, Lønborg, Jacob, and Engstrøm, Thomas

Published
2019
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38. Influenza Vaccination After Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

Author

Fröbert, Ole, Götberg, Matthias, Erlinge, David, Akhtar, Zubair, Christiansen, Evald H., MacIntyre, Chandini R., Oldroyd, Keith G., Motovska, Zuzana, Erglis, Andrejs, Moer, Rasmus, Hlinomaz, Ota, Jakobsen, Lars, Engstrøm, Thomas, Jensen, Lisette O., Fallesen, Christian O., Jensen, Svend E, Angerås, Oskar, Calais, Fredrik, Kåregren, Amra, Lauermann, Jörg, Mokhtari, Arash, Nilsson, Johan, Persson, Jonas, Stalby, Per, Islam, Abu K.M.M., Rahman, Afzalur, Malik, Fazila, Choudhury, Sohel, Collier, Timothy, Pocock, Stuart J., and Pernow, John

Published
2021
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39. Bleeding Events After ST-segment Elevation Myocardial Infarction in Patients Randomized to an All-comer Clinical Trial Compared With Unselected Patients

Author

Sadjadieh, Golnaz, Engstrøm, Thomas, Høfsten, Dan Eik, Helqvist, Steffen, Køber, Lars, Pedersen, Frants, Laursen, Peter Nørkjær, Andersson, Hedvig Bille, Nepper-Christensen, Lars, Clemmensen, Peter, Sørensen, Rikke, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Kelbæk, Henning, and Holmvang, Lene

Published
2018
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40. The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease.

Author

de Knegt, Martina C., Linde, Jesper J., Sigvardsen, Per E., Engstrøm, Thomas, Fuchs, Andreas, Jensen, Andreas K., Elming, Hanne, Kühl, J. Tobias, Hansen, Peter R., Høfsten, Dan E., Kelbæk, Henning, Nordestgaard, Børge G., Hove, Jens D., Køber, Lars V., and Kofoed, Klaus F.

Abstract

We examined obstructive and nonobstructive plaque volumes in populations with subclinical and clinically manifested coronary artery disease (CAD) using quantitative computed tomography (QCT). 855 participants with CAD (274 asymptomatic individuals, 254 acute chest pain patients without acute coronary syndrome (ACS), and 327 patients with ACS) underwent QCT of proximal coronary segments to assess participant-level plaque volumes of dense calcium, fibrous, fibrofatty, and necrotic core tissue. Nonobstructive (<50% stenosis) plaque volumes were greater than obstructive plaque volumes, irrespective of population (all p <0.0001): Asymptomatic individuals (mean (95% CI)): 218 [190-250] vs. 16 [12-22] mm3; acute chest pain patients without ACS: 300 [263-341] vs. 51 [41-62] mm3; patients with ACS: 370 [332-412] vs. 159 [139-182] mm3. After multivariable adjustment, nonobstructive fibrous and fibrofatty tissue volumes were greater in acute chest pain patients without ACS compared to asymptomatic individuals (fibrous tissue: 122 [107-139] vs. 175 [155-197] mm3, p <0.01; fibrofatty tissue: 44 [38-50] vs. 71 [63-80] mm3, p <0.01. Necrotic core tissue was greater in ACS patients (29 [26-33] mm3) compared to both asymptomatic individuals (15 [13-18] mm3, p <0.0001) and acute chest pain patients without ACS (21 [18-24] mm3, p <0.05). Nonobstructive dense calcium volumes did not differ between the three populations: 29 [24-36], 29 [23-35], and 41 [34-48] mm3, p >0.3 respectively. Nonobstructive CAD was the predominant contributor to total atherosclerotic plaque volume in both subclinical and clinically manifested CAD. Nonobstructive fibrous, fibrofatty and necrotic core tissue volumes increased with worsening clinical presentation, while nonobstructive dense calcium tissue volumes did not. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Prevalence and Impact of Frailty in Patients ≥70 Years Old with Acute Coronary Syndrome Referred for Coronary Angiography.

Author

Ratcovich, Hanna, Joshi, Francis R., Palm, Pernille, Færch, Jane, Bang, Lia E., Tilsted, Hans-Henrik, Sadjadieh, Golnaz, Engstrøm, Thomas, and Holmvang, Lene

Subjects
ACUTE coronary syndrome, CORONARY angiography, DISEASE risk factors, FRAILTY, OLDER patients
Abstract

Introduction: Elderly patients with acute coronary syndrome (ACS) have a higher risk of adverse cardiovascular events and may be frail but are underrepresented in clinical trials. Previous studies have proposed that frailty assessment is a better tool than chronological age, in assessing older patients' biological age, and may exceed conventional risk scores in predicting the prognosis. Therefore, we wanted to investigate the prevalence and impact on 12-month outcomes of frailty in patients ≥70 years with ACS referred for coronary angiography (CAG). Methods: Patients ≥70 years with ACS referred for CAG underwent frailty scoring with the clinical frailty scale (CFS). Patients were divided into three groups depending on their CFS: robust (1–3), vulnerable (4), and frail (5–9) and followed for 12 months. Results: Of 455 patients, 69 (15%) patients were frail, 79 (17%) were vulnerable, and 307 (68%) were robust. Frail patients were older (frail: 80.9 ± 5.7 years, vulnerable: 78.5 ± 5.5 years, and robust: 76.6 ± 4.9 years, p < 0.001) and less often treated with percutaneous coronary intervention (frail: 56.5%, vulnerable: 53.2%, and robust: 68.6%, p = 0.014). 12-month mortality was higher among frail patients (frail: 24.6%, vulnerable: 21.8%, and robust: 6.2%, p < 0.001). Frailty was associated with a higher mortality after adjustment for age, sex, comorbidities, the Global Registry of Acute Coronary Events (GRACE) score, and revascularisation (HR 2.67, 95% CI 1.30–5.50, p = 0.008). There was no difference between GRACE and CFS in predicting 12-month mortality (p = 0.893). Conclusions: Fifteen percent of patients ≥70 years old with ACS referred for CAG are frail. Frail patients have significantly higher 12-month mortality. GRACE and CFS are similar in predicting 12-month mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Relation of Bleeding Events to Mortality in Patients With ST-Segment Elevation Myocardial Infarction Treated by Percutaneous Coronary Intervention (a DANAMI-3 Substudy)

Author

Sadjadieh, Golnaz, Engstrøm, Thomas, Helqvist, Steffen, Høfsten, Dan Eik, Køber, Lars, Pedersen, Frants, Laursen, Peter Nørkjær, Nepper-Christensen, Lars, Clemmensen, Peter, Møller-Helgestad, Ole Kristian, Sørensen, Rikke, Ravkilde, Jan, Terkelsen, Christian Juhl, Jørgensen, Erik, Saunamäki, Kari, Tilsted, Hans-Henrik, Kelbæk, Henning, and Holmvang, Lene

Published
2018
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49. Clinical benefit of drugs targeting mitochondrial function as an adjunct to reperfusion in ST-segment elevation myocardial infarction: A meta-analysis of randomized clinical trials

Author

Campo, Gianluca, Pavasini, Rita, Morciano, Giampaolo, Lincoff, A. Michael, Gibson, C. Michael, Kitakaze, Masafumi, Lonborg, Jacob, Ahluwalia, Amrita, Ishii, Hideki, Frenneaux, Michael, Ovize, Michel, Galvani, Marcello, Atar, Dan, Ibanez, Borja, Cerisano, Giampaolo, Biscaglia, Simone, Neil, Brandon J., Asakura, Masanori, Engstrom, Thomas, Jones, Daniel A., Dawson, Dana, Ferrari, Roberto, Pinton, Paolo, and Ottani, Filippo

Published
2017
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