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Your search keyword '"Elizaveta S. Leshchiner"' showing total 2 results
Start Over Author "Elizaveta S. Leshchiner" Publication Type Academic Journals
2 results on '"Elizaveta S. Leshchiner"'

1. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

Author

Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen-Yi Tseng, Rebecca Deasy, Maria Kost-Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons, and Stuart L. Schreiber

Subjects
Science
Abstract

Clear-cell carcinomas are aggressive tumours characterised by high accumulation of lipids and glycogen. Here, the authors report that these cancers have a common vulnerability to GPX4 inhibition-induced ferroptosis and using CRISPR screen and lipodomic profiling, they identify HIF-2α- HILPDA axis promotes ferroptosis via enrichment of PUFA lipids.

Published
2019
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