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ABSTRACT BACKGROUND: Treating patients with multi-morbidities have always been more difficult when compared to patients with no co-morbid conditions. Hence data from this study will empower us in exhibiting effective plans in the management of multi-morbidities with sepsis in our region. Objective: To determine the association of multi-morbidities with sepsis in adult patients admitted in a tertiary care hospital. Materials and Method: This is a case-control study conducted in the Medicine Wards and Intensive Care Unit of a tertiary care hospital in Karachi during the period of May 2018 to October 2018. Results: In this study, 52 patients were enrolled. The mean age of patients was 59.35 ± 6.17. Socioeconomic Status showed significant association (p-value 0.034). The Mean SOFA Score was 2.13 ± 1.86. The Odds of having cancer [OR: 3.10 (0.10 - 80.1), p-value 0.50] and other multimorbidities like rheumatoid arthritis [OR: 3.30 (0.30 - 33.6), p-value 0.32] in cases of sepsis respectively were more than in controls but the data was not statistically significant. The Mean Length of Hospital Stay was 4.71 ± 2.08. Conclusion: An association of multimorbidities in patients with sepsis could not be determined and requires to be researched further.