Search

Quiescent mature oligodendrocytes (OL) expressing myelin basic protein (MBP) in OL cultures were treated for 3 days with cytosine arabinoside (ARA-C) to kill O-2A precursors which separate in chemically established medium. An examination of the treated OL reveals the influence of the basic fibroblast growth factor (bFGF) and the platelet-derived growth factor (PDGF). The O-2A progenitors regulate the proliferation of a subpopulation of mature OL through the bFGF. Stimulated OL proliferation after treatment with ARA-C was lowered by half by conditioned medium from O-2A precursors.

PURPOSE: The purpose of the study was to compare urinary retention rates following orthopaedic surgery in patients who received low-dose intravenous naloxone while receiving morphine patient-controlled analgesia with patients who did not receive naloxone. DESIGN: Randomized controlled trial without blinding. SAMPLE: There were 97 participants consenting to the study, 45 were randomly assigned to a control group and 52 assigned to an experimental group. Forty-three patients in the control group and 47 in the experimental group (90 total) completed the study protocol. FINDINGS: Postoperative urinary residuals were lower, patients voided more frequently, and fewer catheterizations were needed when given low-dose naloxone while receiving morphine patient-controlled analgesia. At the same time, naloxone in small doses was found to have negligible effect on overall patient pain control. [ABSTRACT FROM AUTHOR]