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1,343 results on '"Drosten, Christian"'

2. Biphasic MERS-CoV Incidence in Nomadic Dromedaries with Putative Transmission to Humans, Kenya, 2022-2023

Author

Ogoti, Brian Maina, Riitho, Victor, Wildemann, Johanna, Mutono, Nyamai, Tesch, Julia, Rodon, Jordi, Harichandran, Kaneemozhe, Emanuel, Jackson, Moncke-Buchner, Elisabeth, Kiambi, Stella, Oyugi, Julius, Mureithi, Marianne, Corman, Victor M., Drosten, Christian, Thumbi, Samuel M., and Muller, Marcel A.

Subjects
Zoonoses -- Risk factors -- Diagnosis, Disease transmission -- Risk factors, Health
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is endemic in dromedary camels from the Arabian Peninsula and Africa; seroprevalence is >75% (1-3). Zoonotic transmission to humans has occurred sporadically, mainly on [...]

Published
2024
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3. Bat species assemblage predicts coronavirus prevalence

Author

Meyer, Magdalena, Melville, Dominik W., Baldwin, Heather J., Wilhelm, Kerstin, Nkrumah, Evans Ewald, Badu, Ebenezer K., Oppong, Samuel Kingsley, Schwensow, Nina, Stow, Adam, Vallo, Peter, Corman, Victor M., Tschapka, Marco, Drosten, Christian, and Sommer, Simone

Published
2024
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5. Four principles to establish a universal virus taxonomy

Author

Simmonds, Peter, Adriaenssens, Evelien M, Zerbini, F Murilo, Abrescia, Nicola GA, Aiewsakun, Pakorn, Alfenas-Zerbini, Poliane, Bao, Yiming, Barylski, Jakub, Drosten, Christian, Duffy, Siobain, Duprex, W Paul, Dutilh, Bas E, Elena, Santiago F, García, Maria Laura, Junglen, Sandra, Katzourakis, Aris, Koonin, Eugene V, Krupovic, Mart, Kuhn, Jens H, Lambert, Amy J, Lefkowitz, Elliot J, Łobocka, Małgorzata, Lood, Cédric, Mahony, Jennifer, Meier-Kolthoff, Jan P, Mushegian, Arcady R, Oksanen, Hanna M, Poranen, Minna M, Reyes-Muñoz, Alejandro, Robertson, David L, Roux, Simon, Rubino, Luisa, Sabanadzovic, Sead, Siddell, Stuart, Skern, Tim, Smith, Donald B, Sullivan, Matthew B, Suzuki, Nobuhiro, Turner, Dann, Van Doorslaer, Koenraad, Vandamme, Anne-Mieke, Varsani, Arvind, and Vasilakis, Nikos

Subjects
Infectious Diseases, Infection, Humans, Bacteriophages, Metagenomics, Phylogeny, Viruses, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Developmental Biology
Abstract

A universal taxonomy of viruses is essential for a comprehensive view of the virus world and for communicating the complicated evolutionary relationships among viruses. However, there are major differences in the conceptualisation and approaches to virus classification and nomenclature among virologists, clinicians, agronomists, and other interested parties. Here, we provide recommendations to guide the construction of a coherent and comprehensive virus taxonomy, based on expert scientific consensus. Firstly, assignments of viruses should be congruent with the best attainable reconstruction of their evolutionary histories, i.e., taxa should be monophyletic. This fundamental principle for classification of viruses is currently included in the International Committee on Taxonomy of Viruses (ICTV) code only for the rank of species. Secondly, phenotypic and ecological properties of viruses may inform, but not override, evolutionary relatedness in the placement of ranks. Thirdly, alternative classifications that consider phenotypic attributes, such as being vector-borne (e.g., "arboviruses"), infecting a certain type of host (e.g., "mycoviruses," "bacteriophages") or displaying specific pathogenicity (e.g., "human immunodeficiency viruses"), may serve important clinical and regulatory purposes but often create polyphyletic categories that do not reflect evolutionary relationships. Nevertheless, such classifications ought to be maintained if they serve the needs of specific communities or play a practical clinical or regulatory role. However, they should not be considered or called taxonomies. Finally, while an evolution-based framework enables viruses discovered by metagenomics to be incorporated into the ICTV taxonomy, there are essential requirements for quality control of the sequence data used for these assignments. Combined, these four principles will enable future development and expansion of virus taxonomy as the true evolutionary diversity of viruses becomes apparent.

Published
2023

6. Divergent Genotype of Hepatitis A Virus in Alpacas, Bolivia, 2019

Author

Veith, Talitha, Beltran-Saavedra, L. Fabian, Bleicker, Tobias, Schmidt, Marie Luisa, Mollericona, Jose L., Grutzmacher, Kim, Wallace, Rob, Drexler, Jan Felix, Walzer, Christian, Jones, Terry C., Drosten, Christian, and Corman, Victor Max

Subjects
Hepatitis A -- Risk factors -- Causes of, Alpaca -- Health aspects, Genotype -- Research, Hepatitis A virus -- Identification and classification -- Genetic aspects -- Distribution, Virus research, Company distribution practices, Health
Abstract

Hepatitis A virus (HAV) causes acute hepatitis in humans worldwide; [approximately equal to] 159 million infections and [approximately equal to] 39,000 deaths were associated with HAV in 2019 (1), despite [...]

Published
2023
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7. 90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection

Author

Bosquillon de Jarcy, Laure, Akbil, Bengisu, Mhlekude, Baxolele, Leyens, Johanna, Postmus, Dylan, Harnisch, Greta, Jansen, Jenny, Schmidt, Marie L., Aigner, Annette, Pott, Fabian, Chua, Robert Lorenz, Krist, Lilian, Gentile, Roberta, Mühlemann, Barbara, Jones, Terence C., Niemeyer, Daniela, Fricke, Julia, Keil, Thomas, Pischon, Tobias, Janke, Jürgen, Conrad, Christian, Iacobelli, Stefano, Drosten, Christian, Corman, Victor M., Ralser, Markus, Eils, Roland, Kurth, Florian, Sander, Leif, and Goffinet, Christine

Published
2023
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8. Defining the risk of SARS-CoV-2 variants on immune protection

Author

DeGrace, Marciela M, Ghedin, Elodie, Frieman, Matthew B, Krammer, Florian, Grifoni, Alba, Alisoltani, Arghavan, Alter, Galit, Amara, Rama R, Baric, Ralph S, Barouch, Dan H, Bloom, Jesse D, Bloyet, Louis-Marie, Bonenfant, Gaston, Boon, Adrianus CM, Boritz, Eli A, Bratt, Debbie L, Bricker, Traci L, Brown, Liliana, Buchser, William J, Carreño, Juan Manuel, Cohen-Lavi, Liel, Darling, Tamarand L, Davis-Gardner, Meredith E, Dearlove, Bethany L, Di, Han, Dittmann, Meike, Doria-Rose, Nicole A, Douek, Daniel C, Drosten, Christian, Edara, Venkata-Viswanadh, Ellebedy, Ali, Fabrizio, Thomas P, Ferrari, Guido, Fischer, Will M, Florence, William C, Fouchier, Ron AM, Franks, John, García-Sastre, Adolfo, Godzik, Adam, Gonzalez-Reiche, Ana Silvia, Gordon, Aubree, Haagmans, Bart L, Halfmann, Peter J, Ho, David D, Holbrook, Michael R, Huang, Yaoxing, James, Sarah L, Jaroszewski, Lukasz, Jeevan, Trushar, Johnson, Robert M, Jones, Terry C, Joshi, Astha, Kawaoka, Yoshihiro, Kercher, Lisa, Koopmans, Marion PG, Korber, Bette, Koren, Eilay, Koup, Richard A, LeGresley, Eric B, Lemieux, Jacob E, Liebeskind, Mariel J, Liu, Zhuoming, Livingston, Brandi, Logue, James P, Luo, Yang, McDermott, Adrian B, McElrath, Margaret J, Meliopoulos, Victoria A, Menachery, Vineet D, Montefiori, David C, Mühlemann, Barbara, Munster, Vincent J, Munt, Jenny E, Nair, Manoj S, Netzl, Antonia, Niewiadomska, Anna M, O’Dell, Sijy, Pekosz, Andrew, Perlman, Stanley, Pontelli, Marjorie C, Rockx, Barry, Rolland, Morgane, Rothlauf, Paul W, Sacharen, Sinai, Scheuermann, Richard H, Schmidt, Stephen D, Schotsaert, Michael, Schultz-Cherry, Stacey, Seder, Robert A, Sedova, Mayya, Sette, Alessandro, Shabman, Reed S, Shen, Xiaoying, Shi, Pei-Yong, Shukla, Maulik, Simon, Viviana, Stumpf, Spencer, Sullivan, Nancy J, Thackray, Larissa B, and Theiler, James

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Emerging Infectious Diseases, Pneumonia, Vaccine Related, Pneumonia & Influenza, Infectious Diseases, Biodefense, Immunization, Biotechnology, Prevention, Lung, Prevention of disease and conditions, and promotion of well-being, 2.1 Biological and endogenous factors, 3.4 Vaccines, Aetiology, Infection, Good Health and Well Being, Animals, Biological Evolution, COVID-19, COVID-19 Vaccines, Humans, National Institute of Allergy and Infectious Diseases (U.S.), Pandemics, Pharmacogenomic Variants, SARS-CoV-2, United States, Virulence, General Science & Technology
Abstract

The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or vaccination. To address the public health threat caused by the increasing SARS-CoV-2 genomic diversity, the National Institute of Allergy and Infectious Diseases within the National Institutes of Health established the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme. This effort was designed to provide a real-time risk assessment of SARS-CoV-2 variants that could potentially affect the transmission, virulence, and resistance to infection- and vaccine-induced immunity. The SAVE programme is a critical data-generating component of the US Government SARS-CoV-2 Interagency Group to assess implications of SARS-CoV-2 variants on diagnostics, vaccines and therapeutics, and for communicating public health risk. Here we describe the coordinated approach used to identify and curate data about emerging variants, their impact on immunity and effects on vaccine protection using animal models. We report the development of reagents, methodologies, models and notable findings facilitated by this collaborative approach and identify future challenges. This programme is a template for the response to rapidly evolving pathogens with pandemic potential by monitoring viral evolution in the human population to identify variants that could reduce the effectiveness of countermeasures.

Published
2022

11. A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity

Author

Stern, Daniel, Meyer, Tanja C., Treindl, Fridolin, Mages, Hans Werner, Krüger, Maren, Skiba, Martin, Krüger, Jan Philipp, Zobel, Christian M., Schreiner, Maximilian, Grossegesse, Marica, Rinner, Thomas, Peine, Caroline, Stoliaroff-Pépin, Anna, Harder, Thomas, Hofmann, Natalie, Michel, Janine, Nitsche, Andreas, Stahlberg, Silke, Kneuer, Antje, Sandoni, Anna, Kubisch, Ulrike, Schlaud, Martin, Mankertz, Annette, Schwarz, Tatjana, Corman, Victor M., Müller, Marcel A., Drosten, Christian, de la Rosa, Kathrin, Schaade, Lars, Dorner, Martin B., and Dorner, Brigitte G.

Published
2023
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12. Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Author

Schröder, Simon, Richter, Anja, Veith, Talitha, Emanuel, Jackson, Gudermann, Luca, Friedmann, Kirstin, Jeworowski, Lara M., Mühlemann, Barbara, Jones, Terry C., Müller, Marcel A., Corman, Victor M., and Drosten, Christian

Published
2023
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13. Results of German external quality assessment schemes for SARS-CoV-2 antigen detection

Author

Vierbaum, Laura, Wojtalewicz, Nathalie, Grunert, Hans-Peter, Zimmermann, Anika, Scholz, Annemarie, Goseberg, Sabine, Kaiser, Patricia, Duehring, Ulf, Drosten, Christian, Corman, Victor, Niemeyer, Daniela, Rabenau, Holger F., Obermeier, Martin, Nitsche, Andreas, Michel, Janine, Puyskens, Andreas, Huggett, Jim F., O’Sullivan, Denise M., Busby, Eloise, Cowen, Simon, Vallone, Peter M., Cleveland, Megan H., Falak, Samreen, Kummrow, Andreas, Schellenberg, Ingo, Zeichhardt, Heinz, and Kammel, Martin

Published
2023
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14. Omicron subvariant BA.5 efficiently infects lung cells

Author

Hoffmann, Markus, Wong, Lok-Yin Roy, Arora, Prerna, Zhang, Lu, Rocha, Cheila, Odle, Abby, Nehlmeier, Inga, Kempf, Amy, Richter, Anja, Halwe, Nico Joel, Schön, Jacob, Ulrich, Lorenz, Hoffmann, Donata, Beer, Martin, Drosten, Christian, Perlman, Stanley, and Pöhlmann, Stefan

Published
2023
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16. US National Institutes of Health Prioritization of SARS-CoV-2 Variants

Author

Turner, Sam, Alisoltani, Arghavan, Bratt, Debbie, Cohen-Lavi, Liel, Dearlove, Bethany L., Drosten, Christian, Fischer, Will M., Fouchier, Ron A.M., Gonzalez-Reiche, Ana Silvia, Jaroszewski, Lukasz, Khalil, Zain, LeGresley, Eric, Johnson, Marc, Jones, Terry C., Muhlemann, Barbara, O'Connor, David, Sedova, Mayya, Shukla, Maulik, Theiler, James, Wallace, Zachary S., Yoon, Hyejin, Zhang, Yun, van Bakel, Harm, Degrace, Marciela M., Ghedin, Elodie, Godzik, Adam, Hertz, Tomer, Korber, Bette, Lemieux, Jacob, Niewiadomska, Anna M., Post, Diane J., Rolland, Morgane, Scheuermann, Richard, and Smith, Derek J.

Subjects
Values -- Analysis, Microbial mutation -- Health aspects, Epidemiology -- Methods, Health
Abstract

As part of the US National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) SARS-CoV-2 Assessment of Viral Evolution (SAVE) effort to combat the SARS-CoV-2 pandemic, [...]

Published
2023
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17. Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

Author

Nouailles, Geraldine, Adler, Julia M., Pennitz, Peter, Peidli, Stefan, Teixeira Alves, Luiz Gustavo, Baumgardt, Morris, Bushe, Judith, Voss, Anne, Langenhagen, Alina, Langner, Christine, Martin Vidal, Ricardo, Pott, Fabian, Kazmierski, Julia, Ebenig, Aileen, Lange, Mona V., Mühlebach, Michael D., Goekeri, Cengiz, Simmons, Szandor, Xing, Na, Abdelgawad, Azza, Herwig, Susanne, Cichon, Günter, Niemeyer, Daniela, Drosten, Christian, Goffinet, Christine, Landthaler, Markus, Blüthgen, Nils, Wu, Haibo, Witzenrath, Martin, Gruber, Achim D., Praktiknjo, Samantha D., Osterrieder, Nikolaus, Wyler, Emanuel, Kunec, Dusan, and Trimpert, Jakob

Published
2023
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20. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Author

Weiner, January, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H, Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arkal, Rao Arjun, Fragiadakis, Gabriela K, Mick, Eran, COMET, Consortium, Calfee, Carolyn S, Erle, David J, Hendrickson, Carolyn M, Kangelaris, Kirsten N, Krummel, Matthew F, Woodruff, Prescott G, Langelier, Charles R, Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Coronaviruses, Emerging Infectious Diseases, Human Genome, Clinical Research, Infectious Diseases, Genetics, 2.1 Biological and endogenous factors, 2.5 Research design and methodologies (aetiology), Good Health and Well Being, SARS-CoV-2, COVID-19, Human Leukocyte Antigen&nbsp, intubation, Human Leukocyte Antigen, Clinical sciences, Health services and systems, Public health
Abstract

BackgroundSince the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors that affect individual immune response to SARS-CoV-2. We sought to evaluate this hypothesis by conducting a multicenter study using HLA sequencing.MethodsWe analyzed the association between COVID-19 severity and HLAs in 435 individuals from Germany (n = 135), Spain (n = 133), Switzerland (n = 20) and the United States (n = 147), who had been enrolled from March 2020 to August 2020. This study included patients older than 18 years, diagnosed with COVID-19 and representing the full spectrum of the disease. Finally, we tested our results by meta-analysing data from prior genome-wide association studies (GWAS).FindingsWe describe a potential association of HLA-C*04:01 with severe clinical course of COVID-19. Carriers of HLA-C*04:01 had twice the risk of intubation when infected with SARS-CoV-2 (risk ratio 1.5 [95% CI 1.1-2.1], odds ratio 3.5 [95% CI 1.9-6.6], adjusted p-value = 0.0074). These findings are based on data from four countries and corroborated by independent results from GWAS. Our findings are biologically plausible, as HLA-C*04:01 has fewer predicted bindings sites for relevant SARS-CoV-2 peptides compared to other HLA alleles.InterpretationHLA-C*04:01 carrier state is associated with severe clinical course in SARS-CoV-2. Our findings suggest that HLA class I alleles have a relevant role in immune defense against SARS-CoV-2.FundingFunded by Roche Sequencing Solutions, Inc.

Published
2021

23. Primary series COVID-19 vaccine effectiveness among healthcare workers in Albania, February–December 2021

Author

Rubin-Smith, Julia E., Castro, Madelyn Yiseth Rojas, Preza, Iria, Hasibra, Iris, Sulo, Jonilda, Fico, Albana, Daja, Rovena, Vasili, Adela, Kota, Majlinda, Schmid, Alexis, Sridhar, Shela, Guseinova, Alina, Boshevska, Golubinka, Bejtja, Gazmend, Mühlemann, Barbara, Drosten, Christian, Jorgensen, Pernille, Pebody, Richard, Kissling, Esther, Lafond, Kathryn E., Katz, Mark A., and Bino, Silvia

Published
2023
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25. Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19

Author

Calisher, Charles, Carroll, Dennis, Colwell, Rita, Corley, Ronald B, Daszak, Peter, Drosten, Christian, Enjuanes, Luis, Farrar, Jeremy, Field, Hume, Golding, Josie, Gorbalenya, Alexander, Haagmans, Bart, Hughes, James M, Karesh, William B, Keusch, Gerald T, Lam, Sai Kit, Lubroth, Juan, Mackenzie, John S, Madoff, Larry, Mazet, Jonna, Palese, Peter, Perlman, Stanley, Poon, Leo, Roizman, Bernard, Saif, Linda, Subbarao, Kanta, and Turner, Mike

Subjects
Biomedical and Clinical Sciences, Health Sciences, Good Health and Well Being, Betacoronavirus, Biomedical Research, COVID-19, China, Coronavirus Infections, Health Personnel, Humans, Information Dissemination, Interprofessional Relations, Pneumonia, Viral, Public Health, SARS-CoV-2, Science, Truth Disclosure, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Published
2020

26. Effectiveness of Naturally Acquired and Vaccine-Induced Immune Responses to SARS-CoV-2 Mu Variant

Author

de Oliveira-Filho, Edmilson F., Rincon-Orozco, Bladimiro, Jones-Cifuentes, Natalia, Pena-Lopez, Brigitte, Muhlemann, Barbara, Drosten, Christian, Moreira-Soto, Andres, and Drexler, Jan Felix

Subjects
Immune response -- Evaluation, Company distribution practices, Health
Abstract

Diverse SARS-CoV-2 variants have arisen during the pandemic. As of May 4, 2022, there had been 2 recognized variants of concern (VOC), Delta and Omicron, in addition to earlier emerging [...]

Published
2022
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27. Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies

Author

Akbil, Bengisu, Meyer, Tim, Stubbemann, Paula, Thibeault, Charlotte, Staudacher, Olga, Niemeyer, Daniela, Jansen, Jenny, Mühlemann, Barbara, Doehn, Jan, Tabeling, Christoph, Nusshag, Christian, Hirzel, Cédric, Sanchez, David Sökler, Nieters, Alexandra, Lother, Achim, Duerschmied, Daniel, Schallner, Nils, Lieberum, Jan Nikolaus, August, Dietrich, Rieg, Siegbert, Falcone, Valeria, Hengel, Hartmut, Kölsch, Uwe, Unterwalder, Nadine, Hübner, Ralf-Harto, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Warnatz, Klaus, Spinetti, Thibaud, Schefold, Joerg C., Dörner, Thomas, Sander, Leif Erik, Corman, Victor M., Merle, Uta, Kurth, Florian, von Bernuth, Horst, Meisel, Christian, and Goffinet, Christine

Published
2022
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28. An early warning system for emerging SARS-CoV-2 variants

Author

Subissi, Lorenzo, von Gottberg, Anne, Thukral, Lipi, Worp, Nathalie, Oude Munnink, Bas B., Rathore, Surabhi, Abu-Raddad, Laith J., Aguilera, Ximena, Alm, Erik, Archer, Brett N., Attar Cohen, Homa, Barakat, Amal, Barclay, Wendy S., Bhiman, Jinal N., Caly, Leon, Chand, Meera, Chen, Mark, Cullinane, Ann, de Oliveira, Tulio, Drosten, Christian, Druce, Julian, Effler, Paul, El Masry, Ihab, Faye, Adama, Gaseitsiwe, Simani, Ghedin, Elodie, Grant, Rebecca, Haagmans, Bart L., Herring, Belinda L., Iyer, Shilpa S., Kassamali, Zyleen, Kakkar, Manish, Kondor, Rebecca J., Leite, Juliana A., Leo, Yee-Sin, Leung, Gabriel M., Marklewitz, Marco, Moyo, Sikhulile, Mendez-Rico, Jairo, Melhem, Nada M., Munster, Vincent, Nahapetyan, Karen, Oh, Djin-Ye, Pavlin, Boris I., Peacock, Thomas P., Peiris, Malik, Peng, Zhibin, Poon, Leo L. M., Rambaut, Andrew, Sacks, Jilian, Shen, Yinzhong, Siqueira, Marilda M., Tessema, Sofonias K., Volz, Erik M., Thiel, Volker, van der Werf, Sylvie, Briand, Sylvie, Perkins, Mark D., Van Kerkhove, Maria D., Koopmans, Marion P. G., and Agrawal, Anurag

Published
2022
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30. Emergence of SARS-CoV-2 Delta Variant, Benin, May--July 2021

Author

Yadouleton, Anges, Sander, Anna-Lena, Adewumi, Praise, de Oliveira Filho, Edmilson F., Tchibozo, Carine, Hounkanrin, Gildas, Rene, Keke K., Ange, Dossou, Kohoun, Rodrigue K., Nari, Ramalia Chabi, Salifou, Sourakatou, Saizonou, Raoul, Kakai, Clement G., Bedie, Sonia V., Onifade, Fattah Al, Nagel, Michael, Aissi, Melchior A. Joel, Akogbeto, Petas, Drosten, Christian, Wulf, Ben, Moreira-Soto, Andres, Djingarey, Mamoudou Harouna, Hounkpatin, Benjamin, and Drexler, Jan Felix

Subjects
Epidemics -- Statistics -- Causes of -- Benin, Health
Abstract

Numerous genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged globally since the start of the coronavirus disease (COVID-19) pandemic (https://cov-lineages.org). By September 2021, the World Health [...]

Published
2022
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31. Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

Author

Ulrich, Lorenz, Halwe, Nico Joel, Taddeo, Adriano, Ebert, Nadine, Schön, Jacob, Devisme, Christelle, Trüeb, Bettina Salome, Hoffmann, Bernd, Wider, Manon, Fan, Xiaoyu, Bekliz, Meriem, Essaidi-Laziosi, Manel, Schmidt, Marie Luisa, Niemeyer, Daniela, Corman, Victor Max, Kraft, Anna, Godel, Aurélie, Laloli, Laura, Kelly, Jenna N., Calderon, Brenda M., Breithaupt, Angele, Wylezich, Claudia, Berenguer Veiga, Inês, Gultom, Mitra, Osman, Sarah, Zhou, Bin, Adea, Kenneth, Meyer, Benjamin, Eberhardt, Christiane S., Thomann, Lisa, Gsell, Monika, Labroussaa, Fabien, Jores, Jörg, Summerfield, Artur, Drosten, Christian, Eckerle, Isabella Anne, Wentworth, David E., Dijkman, Ronald, Hoffmann, Donata, Thiel, Volker, Beer, Martin, and Benarafa, Charaf

Published
2022
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32. Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021

Author

Sorg, Anna-Lisa, Bergfeld, Leon, Jank, Marietta, Corman, Victor, Semmler, Ilia, Goertz, Anna, Beyerlein, Andreas, Verjans, Eva, Wagner, Norbert, Von Bernuth, Horst, Lander, Fabian, Weil, Katharina, Hufnagel, Markus, Spiekerkoetter, Ute, Chao, Cho-Ming, Naehrlich, Lutz, Muntau, Ania Carolina, Schulze-Sturm, Ulf, Hansen, Gesine, Wetzke, Martin, Jung, Anna-Maria, Niehues, Tim, Fricke-Otto, Susanne, Von Both, Ulrich, Huebner, Johannes, Behrends, Uta, Liese, Johannes G., Schwerk, Christian, Drosten, Christian, Von Kries, Ruediger, and Schroten, Horst

Published
2022
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34. Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome

Author

Fathi, Anahita, Dahlke, Christine, Krähling, Verena, Kupke, Alexandra, Okba, Nisreen M. A., Raadsen, Matthijs P., Heidepriem, Jasmin, Müller, Marcel A., Paris, Grigori, Lassen, Susan, Klüver, Michael, Volz, Asisa, Koch, Till, Ly, My L., Friedrich, Monika, Fux, Robert, Tscherne, Alina, Kalodimou, Georgia, Schmiedel, Stefan, Corman, Victor M., Hesterkamp, Thomas, Drosten, Christian, Loeffler, Felix F., Haagmans, Bart L., Sutter, Gerd, Becker, Stephan, and Addo, Marylyn M.

Published
2022
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35. Genetic characterization of varicella-zoster and HIV-1 viruses from the cerebrospinal fluid of a co-infected encephalitic patient, Ghana

Author

El-Duah, Philip, Sylverken, Augustina Angelina, Owusu, Michael, Amoako, Yaw Ampem, Yeboah, Richmond, Gorman, Richmond, Nyarko-Afriyie, Emmanuella, Schneider, Julia, Jones, Terry C., Bonney, Joseph, Adade, Titus, Yeboah, Eric Smart, Binger, Tabea, Corman, Victor Max, Drosten, Christian, and Phillips, Richard Odame

Published
2022
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37. Oxysterole-binding protein targeted by SARS-CoV-2 viral proteins regulates coronavirus replication.

Author

Yue Ma-Lauer, Pengyuan Li, Niemeyer, Daniela, Richter, Anja, Pusl, Konstantin, von Brunn, Brigitte, Yi Ru, Chengyu Xiang, Schwinghammer, Sebastian, Jia Liu, Baral, Priya, Berthold, Emilia J., Haibo Qiu, Roy, Avishek, Kremmer, Elisabeth, Flaswinkel, Heinrich, Drosten, Christian, Zhendong Jin, and von Brunn, Albrecht

Subjects
CORONAVIRUS diseases, COVID-19, CORONAVIRUSES, VIRAL proteins, GOLGI apparatus
Abstract

Introduction: Oxysterol-binding protein (OSBP) is known for its crucial role in lipid transport, facilitating cholesterol exchange between the Golgi apparatus and endoplasmic reticulum membranes. Despite its established function in cellular processes, its involvement in coronavirus replication remains unclear. Methods: In this study, we investigated the role of OSBP in coronavirus replication and explored the potential of a novel OSBP-binding compound, ZJ-1, as an antiviral agent against coronaviruses, including SARS-CoV-2. We utilized a combination of biochemical and cellular assays to elucidate the interactions between OSBP and SARS-CoV-2 non-structural proteins (Nsps) and other viral proteins. Results: Our findings demonstrate that OSBP positively regulates coronavirus replication. Moreover, treatment with ZJ-1 resulted in reduced OSBP levels and exhibited potent antiviral effects against multiple coronaviruses. Through our investigation, we identified specific interactions between OSBP and SARS-CoV-2 Nsps, particularly Nsp3, Nsp4, and Nsp6, which are involved in doublemembrane vesicle formation--a crucial step in viral replication. Additionally, we observed that Nsp3 a.a.1-1363, Nsp4, and Nsp6 target vesicle-associated membrane protein (VAMP)-associated protein B (VAP-B), which anchors OSBP to the ER membrane. Interestingly, the interaction between OSBP and VAP-B is disrupted by Nsp3 a.a.1-1363 and partially impaired by Nsp6. Furthermore, we identified SARS-CoV-2 orf7a, orf7b, and orf3a as additional OSBP targets, with OSBP contributing to their stabilization. Conclusion: Our study highlights the significance of OSBP in coronavirus replication and identifies it as a promising target for the development of antiviral therapies against SARS-CoV-2 and other coronaviruses. These findings underscore the potential of OSBP-targeted interventions in combating coronavirus infections. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Detection of Bombali Virus in a Mops condylurus Bat in Kyela, Tanzania.

Author

Düx, Ariane, Lwitiho, Sudi E., Ayouba, Ahidjo, Röthemeier, Caroline, Merkel, Kevin, Weiss, Sabrina, Thaurignac, Guillaume, Lander, Angelika, Kouadio, Leonce, Nowak, Kathrin, Corman, Victor, Drosten, Christian, Couacy-Hymann, Emmanuel, Krüger, Detlev H., Kurth, Andreas, Calvignac-Spencer, Sébastien, Peeters, Martine, Ntinginya, Nyanda E., Leendertz, Fabian H., and Mangu, Chacha

Abstract

Bombali virus (BOMV) is a novel Orthoebolavirus that has been detected in free-tailed bats in Sierra Leone, Guinea, Kenya, and Mozambique. We screened our collection of 349 free-tailed bat lungs collected in Côte d'Ivoire and Tanzania for BOMV RNA and tested 228 bat blood samples for BOMV antibodies. We did not detect BOMV-specific antibodies but found BOMV RNA in a Mops condylurus bat from Tanzania, marking the first detection of an ebolavirus in this country. Our findings further expand the geographic range of BOMV and support M. condylurus' role as a natural BOMV host. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Mutations Associated with SARS-CoV-2 Variants of Concern, Benin, Early 2021

Author

Sander, Anna-Lena, Yadouleton, Anges, de Oliveira Filho, Edmilson F., Tchibozo, Carine, Hounkanrin, Gildas, Badou, Yvette, Adewumi, Praise, Rene, Keke K., Ange, Dossou, Sourakatou, Salifou, Sedjro, Eclou, Aissi, Melchior A. Joel, Fidelia, Hinson, Djingarey, Mamoudou Harouna, Nagel, Michael, Jo, Wendy Karen, Moreira-Soto, Andres, Drosten, Christian, Landt, Olfert, Corman, Victor Max, Hounkpatin, Benjamin, and Drexler, Jan Felix

Subjects
Gene mutations -- Research, Epidemics -- Causes of -- Benin, Virus research, Health
Abstract

Genomic surveillance is key to elucidate coronavirus disease (COVID-19) transmission chains and to monitor emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants associated with partial or complete immune escape [...]

Published
2021
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40. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

Author

Witkowski, Mario, Tizian, Caroline, Ferreira-Gomes, Marta, Niemeyer, Daniela, Jones, Terry C., Heinrich, Frederik, Frischbutter, Stefan, Angermair, Stefan, Hohnstein, Thordis, Mattiola, Irene, Nawrath, Philipp, McEwen, Sophie, Zocche, Silvia, Viviano, Edoardo, Heinz, Gitta Anne, Maurer, Marcus, Kölsch, Uwe, Chua, Robert Lorenz, Aschman, Tom, Meisel, Christian, Radke, Josefine, Sawitzki, Birgit, Roehmel, Jobst, Allers, Kristina, Moos, Verena, Schneider, Thomas, Hanitsch, Leif, Mall, Marcus A., Conrad, Christian, Radbruch, Helena, Duerr, Claudia U., Trapani, Joseph A., Marcenaro, Emanuela, Kallinich, Tilmann, Corman, Victor M., Kurth, Florian, Sander, Leif Erik, Drosten, Christian, Treskatsch, Sascha, Durek, Pawel, Kruglov, Andrey, Radbruch, Andreas, Mashreghi, Mir-Farzin, and Diefenbach, Andreas

Published
2021
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41. Virus-induced senescence is a driver and therapeutic target in COVID-19

Author

Lee, Soyoung, Yu, Yong, Trimpert, Jakob, Benthani, Fahad, Mairhofer, Mario, Richter-Pechanska, Paulina, Wyler, Emanuel, Belenki, Dimitri, Kaltenbrunner, Sabine, Pammer, Maria, Kausche, Lea, Firsching, Theresa C., Dietert, Kristina, Schotsaert, Michael, Martínez-Romero, Carles, Singh, Gagandeep, Kunz, Séverine, Niemeyer, Daniela, Ghanem, Riad, Salzer, Helmut J. F., Paar, Christian, Mülleder, Michael, Uccellini, Melissa, Michaelis, Edward G., Khan, Amjad, Lau, Andrea, Schönlein, Martin, Habringer, Anna, Tomasits, Josef, Adler, Julia M., Kimeswenger, Susanne, Gruber, Achim D., Hoetzenecker, Wolfram, Steinkellner, Herta, Purfürst, Bettina, Motz, Reinhard, Di Pierro, Francesco, Lamprecht, Bernd, Osterrieder, Nikolaus, Landthaler, Markus, Drosten, Christian, García-Sastre, Adolfo, Langer, Rupert, Ralser, Markus, Eils, Roland, Reimann, Maurice, Fan, Dorothy N. Y., and Schmitt, Clemens A.

Published
2021
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42. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study

Author

Al-Rim, Ben, Bardtke, Lara, Beheim-Schwarzbach, Jörn Ilmo, Behn, Kerstin, Bergfeld, Leon, Bethke, Norma, Bleicker, Tobias, Briesemeister, Dana, Brumhard, Sophia, Conrad, Claudia, Dieckmann, Sebastian, Frey, Doris, Gabelich, Julie-Anne, Georg, Philipp, Gläser, Ute, Hasler, Lisbeth, Hetey, Andreas, Hiller, Anna Luisa, Horn, Alexandra, Hülso, Claudia, Kegel, Luisa, Koch, Willi, Krannich, Alexander, Kroneberg, Paolo, Lisy, Michelle, Mackeldanz, Petra, Maeß, Birgit, Münn, Friederike, Olk, Nadine, Peiser, Christian, Pohl, Kai, Hermel, Annelie, Rönnefarth, Maria, Rubisch, Carolin, Sanchez Rezza, Angela, Schellenberger, Isabelle, Schenkel, Viktoria, Schlesinger, Jenny, Schmidt, Sein, Schwanitz, Georg, Sinnigen, Anne-Sophie, Stubbemann, Paula, Tesch, Julia, Treue, Denise, Wendisch, Daniel, Zvorc, Saskia, Hillus, David, Schwarz, Tatjana, Tober-Lau, Pinkus, Vanshylla, Kanika, Hastor, Hana, Thibeault, Charlotte, Jentzsch, Stefanie, Helbig, Elisa T, Lippert, Lena J, Tscheak, Patricia, Schmidt, Marie Luisa, Riege, Johanna, Solarek, André, von Kalle, Christof, Dang-Heine, Chantip, Gruell, Henning, Kopankiewicz, Piotr, Suttorp, Norbert, Drosten, Christian, Bias, Harald, Seybold, Joachim, Klein, Florian, Kurth, Florian, Corman, Victor Max, and Sander, Leif Erik

Published
2021
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43. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Author

Weiner, January, 3rd, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H., Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arjun Arkal, Rao, Fragiadakis, Gabriela K., Mick, Eran, COMET, Consortium, Calfee, Carolyn S., Erle, David J., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Langelier, Charles R., Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina

Published
2021
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44. Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany

Author

Schwarz, Tatjana, Tober-Lau, Pinkus, Hillus, David, Helbig, Elisa T., Lippert, Lena J., Thibeault, Charlotte, Koch, Willi, Landgraf, Irmgard, Michel, Janine, Bergfeld, Leon, Niemeyer, Daniela, Muhlemann, Barbara, Conrad, Claudia, Dang-Heine, Chantip, Kasper, Stefanie, Munn, Friederike, Kappert, Kai, Nitsche, Andreas, Tauber, Rudolf, Schmidt, Sein, Kopankiewicz, Piotr, Bias, Harald, Seybold, Joachim, von Kalle, Christof, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Sander, Leif Erik, Corman, Victor M., and Kurth, Florian

Subjects
Antigen-antibody reactions -- Health aspects, Aged patients -- Care and treatment, T cells -- Health aspects, Immune response -- Health aspects, Health
Abstract

We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in [...]

Published
2021
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45. Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021

Author

Tober-Lau, Pinkus, Schwarz, Tatjana, Hillus, David, Spieckermann, Jana, Helbig, Elisa T., Lippert, Lena J., Thibeault, Charlotte, Koch, Willi, Bergfeld, Leon, Niemeyer, Daniela, Muhlemann, Barbara, Conrad, Claudia, Kasper, Stefanie, Munn, Friederike, Kunitz, Frank, Jones, Terry C., Suttorp, Norbert, Drosten, Christian, Sander, Leif Erik, Kurth, Florian, and Corman, Victor M.

Subjects
Vaccination -- Patient outcomes, Epidemics -- Risk factors -- Demographic aspects -- Control -- Germany, Long-term care facilities -- Management -- Safety and security measures, Company business management, Health
Abstract

One week after second vaccinations were administered, an outbreak of B.1.1.7 lineage severe acute respiratory syndrome coronavirus 2 infections occurred in a long-term care facility in Berlin, Germany, affecting 16/20 [...]

Published
2021
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47. A time-resolved proteomic and prognostic map of COVID-19

Author

Kleinschmidt, Malte, Heim, Katrin M., Millet, Belén, Meyer-Arndt, Lil, Hübner, Ralf H., Andermann, Tim, Doehn, Jan M., Opitz, Bastian, Sawitzki, Birgit, Grund, Daniel, Radünzel, Peter, Schürmann, Mariana, Zoller, Thomas, Alius, Florian, Knape, Philipp, Breitbart, Astrid, Li, Yaosi, Bremer, Felix, Pergantis, Panagiotis, Schürmann, Dirk, Temmesfeld-Wollbrück, Bettina, Wendisch, Daniel, Brumhard, Sophia, Haenel, Sascha S., Conrad, Claudia, Georg, Philipp, Eckardt, Kai-Uwe, Lehner, Lukas, Kruse, Jan M., Ferse, Carolin, Körner, Roland, Spies, Claudia, Edel, Andreas, Weber-Carstens, Steffen, Krannich, Alexander, Zvorc, Saskia, Li, Linna, Behrens, Uwe, Schmidt, Sein, Rönnefarth, Maria, Dang-Heine, Chantip, Röhle, Robert, Lieker, Emma, Kretzler, Lucie, Wirsching, Isabelle, Wollboldt, Christian, Wu, Yinan, Schwanitz, Georg, Hillus, David, Kasper, Stefanie, Olk, Nadine, Horn, Alexandra, Briesemeister, Dana, Treue, Denise, Hummel, Michael, Corman, Victor M., Drosten, Christian, von Kalle, Christof, Demichev, Vadim, Tober-Lau, Pinkus, Lemke, Oliver, Nazarenko, Tatiana, Thibeault, Charlotte, Whitwell, Harry, Röhl, Annika, Freiwald, Anja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Aulakh, Simran Kaur, Helbig, Elisa T., Stubbemann, Paula, Lippert, Lena J., Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B., Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J., Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Mittermaier, Mirja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S., Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Enghard, Philipp, Zelezniak, Aleksej, Campbell, Archie, Hayward, Caroline, Porteous, David J., Marioni, Riccardo E., Uhrig, Alexander, Müller-Redetzky, Holger, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A., Tancevski, Ivan, Timms, John F., Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Ralser, Markus, and Kurth, Florian

Published
2021
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48. CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Author

Doehn, Jan-Moritz, Tabeling, Christoph, Biesen, Robert, Saccomanno, Jacopo, Madlung, Elena, Pappe, Eva, Gabriel, Frieder, Kurth, Florian, Meisel, Christian, Corman, Victor M., Hanitsch, Leif G., Treskatsch, Sascha, Heim, Kathrin, Stegemann, Miriam S., Ruwwe-Glösenkamp, Christoph, Müller-Redetzky, Holger C., Uhrig, Alexander, Somasundaram, Rajan, Spies, Claudia, von Bernuth, Horst, Hofmann, Jörg, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Sander, Leif E., and Hübner, Ralf-Harto

Published
2021
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50. Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

Author

Wyler, Emanuel, Mösbauer, Kirstin, Franke, Vedran, Diag, Asija, Gottula, Lina Theresa, Arsiè, Roberto, Klironomos, Filippos, Koppstein, David, Hönzke, Katja, Ayoub, Salah, Buccitelli, Christopher, Hoffmann, Karen, Richter, Anja, Legnini, Ivano, Ivanov, Andranik, Mari, Tommaso, Del Giudice, Simone, Papies, Jan, Praktiknjo, Samantha, Meyer, Thomas F., Müller, Marcel Alexander, Niemeyer, Daniela, Hocke, Andreas, Selbach, Matthias, Akalin, Altuna, Rajewsky, Nikolaus, Drosten, Christian, and Landthaler, Markus

Published
2021
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