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489 results on '"Diette, Gregory B"'

2. Clinical Phenotypes of Atopy and Asthma in COPD A Meta-analysis of SPIROMICS and COPDGene

Author

Putcha, Nirupama, Fawzy, Ashraf, Matsui, Elizabeth C, Liu, Mark C, Bowler, Russ P, Woodruff, Prescott G, O'Neal, Wanda K, Comellas, Alejandro P, Han, MeiLan K, Dransfield, Mark T, Wells, J Michael, Lugogo, Njira, Gao, Li, Talbot, C Conover, Hoffman, Eric A, Cooper, Christopher B, Paulin, Laura M, Kanner, Richard E, Criner, Gerard, Ortega, Victor E, Barr, R Graham, Krishnan, Jerry A, Martinez, Fernando J, Drummond, M Bradley, Wise, Robert A, Diette, Gregory B, Hersh, Craig P, and Hansel, Nadia N

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Tobacco Smoke and Health, Lung, Clinical Research, Tobacco, Asthma, Chronic Obstructive Pulmonary Disease, Respiratory, Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome, Biological Variation, Population, Disease Management, Female, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Male, Middle Aged, Molecular Epidemiology, Prevalence, Pulmonary Disease, Chronic Obstructive, Risk Factors, Smoking, Status Asthmaticus, asthma COPD overlap, atopy, COPD, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundLittle is known about the concordance of atopy with asthma COPD overlap. Among individuals with COPD, a better understanding of the phenotypes characterized by asthma overlap and atopy is needed to better target therapies.Research questionWhat is the overlap between atopy and asthma status among individuals with COPD, and how are categories defined by the presence of atopy and asthma status associated with clinical and radiologic phenotypes and outcomes in the Genetic Epidemiology of COPD Study (COPDGene) and Subpopulation and Intermediate Outcome Measures in COPD Study (SPIROMICS)?Study design and methodsFour hundred three individuals with COPD from SPIROMICS and 696 individuals from COPDGene with data about specific IgEs to 10 common allergens and mixes (simultaneous assessment of combination of allergens in similar category) were included. Comparison groups were defined by atopic and asthma status (neither, atopy alone, atopic asthma, nonatopic asthma, with atopy defined as any positive specific IgE (≥0.35 KU/L) to any of the 10 allergens or mixes and asthma defined as self-report of doctor-diagnosed current asthma). Multivariable regression analyses (linear, logistic, and zero inflated negative binomial where appropriate) adjusted for age, sex, race, lung function, smoking status, pack-years smoked, and use of inhaled corticosteroids were used to determine characteristics of groups and relationship with outcomes (exacerbations, clinical outcomes, CT metrics) separately in COPDGene and SPIROMICS, and then adjusted results were combined using meta-analysis.ResultsThe prevalence of atopy was 35% and 36% in COPD subjects from SPIROMICS and COPDGene, respectively, and less than 50% overlap was seen between atopic status with asthma in both cohorts. In meta-analysis, individuals with nonatopic asthma had the most impaired symptom scores (effect size for St. George's Respiratory Questionnaire total score, 4.2; 95% CI, 0.4-7.9; effect size for COPD Assessment Test score, 2.8; 95% CI, 0.089-5.4), highest risk for exacerbations (incidence rate ratio, 1.41; 95% CI, 1.05-1.88) compared with the group without atopy or asthma. Those with atopy and atopic asthma were not at increased risk for adverse outcomes.InterpretationAsthma and atopy had incomplete overlap among former and current smokers with COPD in COPDGene and SPIROMICS. Nonatopic asthma was associated with adverse outcomes and exacerbation risk in COPD, whereas groups having atopy alone and atopic asthma had less risk.

Published
2020

3. Occupational Exposures Are Associated with Worse Morbidity in Patients with Chronic Obstructive Pulmonary Disease

Author

Paulin, Laura M, Diette, Gregory B, Blanc, Paul D, Putcha, Nirupama, Eisner, Mark D, Kanner, Richard E, Belli, Andrew J, Christenson, Stephanie, Tashkin, Donald P, Han, MeiLan, Barr, R Graham, and Hansel, Nadia N

Subjects
Clinical Research, Prevention, Tobacco Smoke and Health, Tobacco, Chronic Obstructive Pulmonary Disease, Lung, Respiratory, Good Health and Well Being, Aged, Disease Progression, Effect Modifier, Epidemiologic, Female, Humans, Male, Middle Aged, Multivariate Analysis, Occupational Exposure, Pulmonary Disease, Chronic Obstructive, Quality of Life, Smoking, chronic obstructive pulmonary disease, occupational exposure, work-related, quality of life, job exposure matrix, SPIROMICS Research Group, Medical and Health Sciences, Respiratory System
Abstract

RationaleLinks between occupational exposures and morbidity in individuals with established chronic obstructive pulmonary disease (COPD) remain unclear.ObjectivesTo determine the impact of occupational exposures on COPD morbidity.MethodsA job exposure matrix (JEM) determined occupational exposure likelihood based on longest job in current/former smokers (n = 1,075) recruited as part of the Subpopulations and Intermediate Outcomes in COPD Study, of whom 721 had established COPD. Bivariate and multivariate linear regression models estimated the association of occupational exposure with COPD, and among those with established disease, the occupational exposure associations with 6-minute-walk distance (6MWD), the Modified Medical Research Council Dyspnea Scale (mMRC), the COPD Assessment Test (CAT), St. George's Respiratory Questionnaire (SGRQ), 12-item Short-Form Physical Component (SF-12), and COPD exacerbations requiring health care utilization, adjusting for demographics, current smoking status, and cumulative pack-years.Measurements and main resultsAn intermediate/high risk of occupational exposure by JEM was found in 38% of participants. In multivariate analysis, those with job exposures had higher odds of COPD (odds ratio, 1.44; 95% confidence interval, 1.04-1.97). Among those with COPD, job exposures were associated with shorter 6MWDs (-26.0 m; P = 0.006); worse scores for mMRC (0.23; P = 0.004), CAT (1.8; P = 0.003), SGRQ (4.5; P = 0.003), and SF-12 Physical (-3.3; P

Published
2015

6. Validation of Parental Reports of Asthma Trajectory, Burden, and Risk by Using the Pediatric Asthma Control and Communication Instrument

Author

Okelo, Sande O, Eakin, Michelle N, Riekert, Kristin A, Teodoro, Alvin P, Bilderback, Andrew L, Thompson, Darcy A, Loiaza-Martinez, Antonio, Rand, Cynthia S, Thyne, Shannon, Diette, Gregory B, and Patino, Cecilia M

Subjects
Asthma, Prevention, Pediatric, Lung, Pediatric Research Initiative, Clinical Research, Respiratory, Adolescent, Adult, Child, Child, Preschool, Communication, Cost of Illness, Cross-Sectional Studies, Female, Forced Expiratory Volume, Humans, Infant, Male, Parents, Quality of Life, Risk Factors, Surveys and Questionnaires, Risk, Children, Burden, Trajectory, Survey, Validation, PACCI, Patient-reported outcomes
Abstract

BackgroundDespite a growing interest, few pediatric asthma questionnaires assess multiple dimensions of asthma morbidity, as recommended by national asthma guidelines, or use patient-reported outcomes.ObjectiveTo evaluate a questionnaire that measures multiple dimensions of parent-reported asthma morbidity (Direction, Bother, and Risk).MethodsWe administered the Pediatric Asthma Control and Communication Instrument (PACCI) and assessed asthma control (PACCI Control), quality of life, and lung function among children who presented for routine asthma care. The PACCI was evaluated for discriminative validity.ResultsA total of 317 children participated (mean age, 8.2 years; 58% boys; 44% African American). As parent-reported PACCI Direction changed from "better" to "worse," we observed poorer asthma control (P < .001), mean Pediatric Asthma Caregiver Quality of Life Questionnaire (PACQLQ) scores (P < .001), and FEV1% (P = .025). Linear regression showed that, for each change in PACCI Direction, the mean PACQLQ score decreased by -0.6 (95% CI, -0.8 to -0.4). As parent-reported PACCI Bother changed from "not bothered" to "very bothered," we observed poorer asthma control (P < .001) and lower mean PACQLQ scores (P < .001). Linear regression showed that, for each change in PACCI Bother category, the mean PACQLQ score decreased by -1.1 (95% CI, -1.3 to -0.9). Any reported PACCI Risk event (emergency department visit, hospitalization, or use of an oral corticosteroid) was associated with poorer asthma control (P

Published
2014

8. Obstructive Lung Disease and Exposure to Burning Biomass Fuel in the Indoor Environment

Author

Diette, Gregory B, Accinelli, Roberto A, Balmes, John R, Buist, A Sonia, Checkley, William, Garbe, Paul, Hansel, Nadia N, Kapil, Vikas, Gordon, Stephen, Lagat, David K, Yip, Fuyuen, Mortimer, Kevin, Perez-Padilla, Rogelio, Roth, Christa, Schwaninger, Julie M, Punturieri, Antonello, and Kiley, James P

Subjects
Health Effects of Indoor Air Pollution, Chronic Obstructive Pulmonary Disease, Asthma, Lung, Health Effects of Household Energy Combustion, Clinical Research, Pediatric Research Initiative, Climate-Related Exposures and Conditions, Aetiology, 2.2 Factors relating to the physical environment, Respiratory, Affordable and Clean Energy, Cardiorespiratory Medicine and Haematology
Abstract

It is estimated that up to half of the world's population burns biomass fuel (wood, crop residues, animal dung and coal) for indoor uses such as cooking, lighting and heating. As a result, a large proportion of women and children are exposed to high levels of household air pollution (HAP). The short and long term effects of these exposures on the respiratory health of this population are not clearly understood. On May 9-11, 2011 NIH held an international workshop on the "Health Burden of Indoor Air Pollution on Women and Children," in Arlington, VA. To gather information on the knowledge base on this topic and identify research gaps, ahead of the meeting we conducted a literature search using PubMed to identify publications that related to HAP, asthma, and chronic obstructive pulmonary disease (COPD). Abstracts were all analyzed and we report on those considered by the respiratory sub study group at the meeting to be most relevant to the field. Many of the studies published are symptom-based studies (as opposed to objective measures of lung function or clinical examination etc.) and measurement of HAP was not done. Many found some association between indoor exposures to biomass smoke as assessed by stove type (e.g., open fire vs. liquid propane gas) and respiratory symptoms such as wheeze and cough. Among the studies that examined objective measures (e.g. spirometry) as a health outcome, the data supporting an association between biomass smoke exposure and COPD in adult women are fairly robust, but the findings for asthma are mixed. If an association was observed between the exposures and lung function, most data seemed to demonstrate mild to moderate reductions in lung function, the pathophysiological mechanisms of which need to be investigated. In the end, the group identified a series of scientific gaps and opportunities for research that need to be addressed to better understand the respiratory effects of exposure to indoor burning of the different forms of biomass fuels.

Published
2012

9. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Author

Torgerson, Dara G, Ampleford, Elizabeth J, Chiu, Grace Y, Gauderman, W James, Gignoux, Christopher R, Graves, Penelope E, Himes, Blanca E, Levin, Albert M, Mathias, Rasika A, Hancock, Dana B, Baurley, James W, Eng, Celeste, Stern, Debra A, Celedón, Juan C, Rafaels, Nicholas, Capurso, Daniel, Conti, David V, Roth, Lindsey A, Soto-Quiros, Manuel, Togias, Alkis, Li, Xingnan, Myers, Rachel A, Romieu, Isabelle, Van Den Berg, David J, Hu, Donglei, Hansel, Nadia N, Hernandez, Ryan D, Israel, Elliott, Salam, Muhammad T, Galanter, Joshua, Avila, Pedro C, Avila, Lydiana, Rodriquez-Santana, Jose R, Chapela, Rocio, Rodriguez-Cintron, William, Diette, Gregory B, Adkinson, N Franklin, Abel, Rebekah A, Ross, Kevin D, Shi, Min, Faruque, Mezbah U, Dunston, Georgia M, Watson, Harold R, Mantese, Vito J, Ezurum, Serpil C, Liang, Liming, Ruczinski, Ingo, Ford, Jean G, Huntsman, Scott, Chung, Kian Fan, Vora, Hita, Li, Xia, Calhoun, William J, Castro, Mario, Sienra-Monge, Juan J, del Rio-Navarro, Blanca, Deichmann, Klaus A, Heinzmann, Andrea, Wenzel, Sally E, Busse, William W, Gern, James E, Lemanske, Robert F, Beaty, Terri H, Bleecker, Eugene R, Raby, Benjamin A, Meyers, Deborah A, London, Stephanie J, Mexico City Childhood Asthma Study (MCAAS), Gilliland, Frank D, Children's Health Study (CHS) and HARBORS study, Burchard, Esteban G, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Martinez, Fernando D, Childhood Asthma Research and Education (CARE) Network, Weiss, Scott T, Childhood Asthma Management Program (CAMP), Williams, L Keoki, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Barnes, Kathleen C, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Ober, Carole, and Nicolae, Dan L

Subjects
Mexico City Childhood Asthma Study, Children's Health Study (CHS) and HARBORS study, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments, Childhood Asthma Research and Education (CARE) Network, Childhood Asthma Management Program, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Humans, Asthma, Genetic Predisposition to Disease, Risk, African Americans, European Continental Ancestry Group, Hispanic Americans, Caribbean Region, North America, Genome-Wide Association Study, Genetic Loci, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Genes & Environments, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.

Published
2011

11. Tackling NCD in LMIC: Achievements and Lessons Learned From the NHLBI–UnitedHealth Global Health Centers of Excellence Program

Author

Rubinstein, Adolfo, He, Jiang, Alam, Dewan S., Peters, David H., Wu, Yangfeng, Yan, Lijing L., Merson, Michael, Ramirez, Manuel, Caballero, Benjamin, Xavier, Denis, Yusuf, Salim, Prabhakaran, Dorairaj, Narayan, K.M. Venkat, Kimaiyo, Sylvester, Velazquez, Eric, Denman, Catalina A., Cornejo, Elsa, de Zapien, Jill, Rosales, Cecilia, Miranda, J. Jaime, Gilman, Robert H., Levitt, Naomi, Gaziano, Thomas A., Ghannem, Hassen, Laatikainen, Tiina, Rabadan-Diehl, Cristina, Engelgau, Michael M., Belis, Deshiree, Sampson, Uchechukwu, Smith, Richard, Dianis, Nancy L., Wolbach, Tracy L., Matta, Gabriela, Gutierrez, Laura, Elorriaga, Natalia, Poggio, Rosana, Irazola, Vilma, Bazzano, Lydia, Bhuiya, Abbas, Wazed, Abdul, Khan, Alfazal, Siddiquee, Ali T., Islam, Anwar, Khan, Jahangir A.M., Uddin, Jasim, Hasan, Khaled, Khanam, Masuma A., Yunus, Mohammad, Chowdhury, Muhammad A.H., Monalisa, Nazratun N., Alam, Nurul, Streatfield, Peter K., Ahmed, Shyfuddin, Parvin, Sonia, Ali, Taslim, Niessen, Louis W., Hossain, Mohammad D., Koehlmoos, Tracey L.P., Standing, Hilary, Lucas, Henry, Bleich, Sara N., Anderson, Gerard F., Trujillo, Antonio J., Mirelman, Andrew J., Hao, Jesse, Zhang, Jing, Tian, Maoyi, Huang, Polly, Luo, Rong, Fang, Weigang, Li, Xian, Feng, Xiangxian, Li, Zhifang, Deal, Kelly, Peterson, Eric, DeLong, Elizabeth, Zhou, Bo, Shi, Jingpu, Neal, Bruce, Jan, Stephen, Li, Nicole, McMahon, Stephen, Zhang, Jianxin, Sun, Jixin, Elliot, Paul, Zhao, Yi, Zhang, Yuhong, Yao, Chen, Sun, Ningling Huang, Han, Qide, Shen, Ruqun, Niu, Wenyi, Wang, Yanfang, Ke, Yang, Huang, Yining, Leeder, Stephen, Lopez, Alan, Zhang, Ruijuan, Yu, Yan, Roman, Ana V., Mendoza, Carlos, Roche, Dina, Mejicano, Gabriela, Cordova, Maria A., Kroker, Maria F., Fort, Meredith, Letona, Paola, Kanter, Rebecca, Garcia, Regina, Murillo, Sandra, Chacon, Violeta, Montero, Rafael, Lopez, Erika J., Peña, Liz, Castro, Maricruz, Dengo, Ana L., Ulate, Emilce, Alvarado, Nadia, Sibrian, Josefina, Alegria, Astarte, Gutierrez, Ana M., Fontes, Flavia, Sigamani, Alben, Kamath, Deepak, Xavier, Freeda, Deepthi, K.B., Anupama, M., Mathu, Nandini, George, Nisha, Rahul, Pranjali, Pais, Prem, Girish, Preeti, Thomas, Seena, Usha, T., Thomas, Tinku, Joshi, Rajnish, Chidambaram, N., Gupta, Rajeev, Chow, Clara, Pogue, Janice, O'Donnell, Martin, Devereaux, P.J., Misquith, Dominic, Agrawal, Twinkle, Fathima, Farah N., Reddy, Kolli Srinath, Shivashankar, Roopa, Ajay, Vamadevan S., Khan, Hassan M., Kadir, M. Masood, Masood, Muhammad Q., Fatmi, Zafar, Krishnan, Anand, Singh, Kavita, Tandon, Nikhil, Khadgawat, Rajesh, Menon, V. Usha, Sethi, Bipin Kumar, Unnikrishnan, A.G., Hutcheson, Mark L., Ali, Mohammed K., Cunningham, Solveig A., Patel, Shivani A., Gujral, Unjali, Desai, Ankush, Mohan, Deepa, Pradeepa, R. Guha, Mohan, V., Viswanathan, Vijay, Sahay, Rakesh, Shah, Seema, Bantwal, Ganapathi, Varthakavi, Premlata K., Nair, Manisha, Akwanalo, Constantine, Lagat, David, Barasa, Felix, Koech, Myra, Sugut, Wilson, Korir, Belinda, Mosol, Priscah, Ali, Shamim, Sherman, Charles B., Carter, Jane, Bloomfield, Gerald, Binanay, Cynthia, Vedanthan, Rajesh, Bernabé-Ortiz, A., León-Velarde, F., Smith, George D., Málaga, Germán, García, Héctor H., Casas, Juan P., Sacksteder, Katherine, Smeeth, Liam, Huicho, Luis, Rivera, María, Gamboa, Raúl, Ebrahim, Shah, Montori, Víctor M., Wise, Robert A., Checkley, William, Diette, Gregory B., Nojilana, Beatrice, Majikela-Dlangamandla, Buyelwa, Sylvester, Carmelita, Malan, Johanna, Murphy, Katherine, Steyn, Krisela, van Niekerk, Lindi, Mash, Robert, Puoane, Thandi, Kim, Grace, Pandya, Ankur, Abrahams-Gessel, Shafika, Rhode, Hilary, Pather, Michael, Andrade, Alvaro R., Garcia, Beatriz, Velasco, Carlos, Medina, David, Bravo, Delia, Munguia, Diana, Bateman, Eric, Castro, Francisco, Schneider, Helen, Ibarra, Ilse, Zulu, Jabulisiwe, Felix, Joel, Tribe, Karla, Bobrow, Kirsten, Fairall, Lara, Folb, Naomi, Murillo, Norma, Pacheco, Norma, Rodriguez, Paloma, Navarro, Paola, Flores, Reyna, Van Zyl Smit, Richard, Meddoza, Rosario, Surka, Sameer, Van Haght, Serena, Hernandez, Yanira, Tsolekile, Lungiswa, Jeridi, Gouider, Harrabi, Imed, Maatoug, Jihen, Boughammoura, Lamia, Chaieb, Larbi, Mrizek, Nejib, Gaha, Rafika, Limam, Khalifa, Amimi, Souad, Gaha, Karima, Gamra, Habib, Al'Absi, Mustafa, Vartiainen, Erkki, Moore, Cornelius, Spillan, Debi, Cooper, Kristiane, Mitchell, Megan, Kirby, Ruth, Gao, Yunling, Aluko, Emmanuel, Sampson, Uchechukwu K., Miranda, Jaime, and Bloomfield, Gerald S.

Published
2016
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12. The Relationship Between Socioeconomic Status and CV Risk Factors: The CRONICAS Cohort Study of Peruvian Adults

Author

Bernabé-Ortiz, Antonio, Casas, Juan P., Smith, George Davey, Ebrahim, Shah, García, Héctor H., Gilman, Robert H., Huicho, Luis, Málaga, Germán, Miranda, J. Jaime, Montori, Víctor M., Smeeth, Liam, Checkley, William, Diette, Gregory B., León-Velarde, Fabiola, Rivera, María, Wise, Robert A., Sacksteder, Katherine, Quispe, Renato, Benziger, Catherine P., Bazo-Alvarez, Juan Carlos, and Howe, Laura D.

Published
2016
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13. Characteristics Associated With Antihypertensive Treatment and Blood Pressure Control: A Population-Based Follow-Up Study in Peru

Author

Bernabé-Ortiz, Antonio, Casas, Juan P., Smith, George Davey, Ebrahim, Shah, García, Héctor H., Gilman, Robert H., Huicho, Luis, Málaga, Germán, Miranda, J. Jaime, Montori, Víctor M., Smeeth, Liam, Checkley, William, Diette, Gregory B., León-Velarde, Fabiola, Rivera, María, Wise, Robert A., Sacksteder, Katherine, Zavala-Loayza, J. Alfredo, Benziger, Catherine Pastorius, Cárdenas, María Kathia, and Carrillo-Larco, Rodrigo M.

Published
2016
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18. A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes

Author

Sharma, Sunita, Zhou, Xiaobo, Thibault, Derek M., Himes, Blanca E., Liu, Andy, Szefler, Stanley J., Strunk, Robert, Castro, Mario, Hansel, Nadia N., Diette, Gregory B., Vonakis, Becky M., Adkinson, N. Franklin, Jr., Avila, Lydiana, Soto-Quiros, Manuel, Barraza-Villareal, Albino, Lemanske, Robert F., Jr., Solway, Julian, Krishnan, Jerry, White, Steven R., Cheadle, Chris, Berger, Alan E., Fan, Jinshui, Boorgula, Meher Preethi, Nicolae, Dan, Gilliland, Frank, Barnes, Kathleen, London, Stephanie J., Martinez, Fernando, Ober, Carole, Celedón, Juan C., Carey, Vincent J., Weiss, Scott T., and Raby, Benjamin A.

Published
2014
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25. Urbanisation but not biomass fuel smoke exposure is associated with asthma prevalence in four resource-limited settings

Author

Gaviola, Chelsea, Miele, Catherine H, Wise, Robert A, Gilman, Robert H, Jaganath, Devan, Miranda, J Jaime, Bernabe-Ortiz, Antonio, Hansel, Nadia N, Checkley, William, Casas, Juan P, Smith, George Davey, Ebrahim, Shah, García, Héctor H, Huicho, Luis, Málaga, Germán, Montori, Víctor M, Smeeth, Liam, Diette, Gregory B, Huicho, Luis, León-Velarde, Fabiola, Rivera, María, García, Héctor H, and Sacksteder, Katherine

Published
2016
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27. Contribution of modifiable risk factors for hypertension and type-2 diabetes in Peruvian resource-limited settings

Author

Bernabé-Ortiz, Antonio, Carrillo-Larco, Rodrigo M, Gilman, Robert H, Checkley, William, Smeeth, Liam, Miranda, J Jaime, Casas, Juan P, Davey Smith, George, Ebrahim, Shah, García, Héctor H, Huicho, Luis, Málaga, Germán, Montori, Víctor M, Diette, Gregory B, Huicho, Luis, León-Velarde, Fabiola, Rivera, María, Wise, Robert A, and Sacksteder, Katherine

Published
2016
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40. Home indoor pollutant exposures among inner-city children with and without asthma

Author

Diette, Gregory B., Hansel, Nadia N., Buckley, Timothy J., Curtin-Brosnan, Jean, Eggleston, Peyton A., Matsui, Elizabeth C., McCormack, Meredith C., Williams, D'Ann L., and Breysse, Patrick N.

Subjects
Asthma in children -- Research, Asthma in children -- Environmental aspects, Asthma in children -- Genetic aspects, Asthma in children -- Demographic aspects
Abstract

BACKGROUND: Evidence for environmental causes of asthma is limited, especially among African Americans. To look for systematic differences in early life domestic exposures between inner-city preschool children with and without asthma, we performed a study of home indoor air pollutants and allergens. METHODS: Children 2-6 years of age were enrolled in a cohort study in East Baltimore, Maryland. From the child&apos;s bedroom, air was monitored for 3 days for particulate matter [less than or equal to] 2.5 and [less than or equal to] 10 [micro]m in aerodynamic diameter ([PM.sub.25], [PM.sub.10]), nitrogen dioxide, and ozone. Median baseline values were compared for children with (n = 150) and without (n = 150) asthma. Housing characteristics related to indoor air pollution were assessed by caregiver report and home inspection. In addition, indoor allergen levels were measured in settled dust. RESULTS: Children were 58% male, 91% African American, and 88% with public health insurance. Housing characteristics related to pollutant exposure and bedroom air pollutant concentrations did not differ significantly between asthmatic and control subjects [median: [PM.sub.25], 28.7 vs. 28.5 [micro]g/[m.sup.3]; [PM.sub.10], 43.6 vs. 41.4 [micro]g/[m.sup.3]; [NO.sub.2], 21.6 vs. 20.9 ppb; [O.sub.3], 1.4 vs. 1.8 ppb; all p > 0.05]. Settled dust allergen levels (cat, dust mite, cockroach, dog, and mouse) were also similar in bedrooms of asthmatic and control children. CONCLUSIONS: Exposures to common home indoor pollutants and allergens are similar for inner-city preschool children with and without asthma. Although these exposures may exacerbate existing asthma, this study does not support a causative role of these factors for risk of developing childhood asthma. KEY WORDS: African American, air pollution, allergens, asthma, particulate matter, pediatric, urban. Environ Health Perspect 115:1665-1669 (2007). doi:10.1289/ehp.10088 available via http://dx.doi.org/ [Online 27 July 2007], Asthma is common among children in the United States, especially those who are racial/ethnic minorities living in inner cities (Centers for Disease Control and Prevention 2004). Although definitive causes of [...]

Published
2007

45. Is risk-adjustor selection more important than statistical approach for provider profiling? Asthma as an example

Author

Huang, I-Chan, Dominici, Francesca, Frangakis, Constantine, Diette, Gregory B., Damberg, Cheryl L., and Wu, Albert W.

Subjects
Patient satisfaction -- Research -- Methods, Risk assessment -- Methods -- Research, Medical care -- Quality management, Asthma -- Care and treatment -- Research, Health, Care and treatment, Research, Methods
Abstract

Objectives. To examine how the selections of different risk adjustors and statistical approaches affect the profiles of physician groups on patient satisfaction. Data sources. Mailed patient surveys. Patients with asthma [...]

Published
2005

49. Chronic exposure to biomass fuel is associated with increased carotid artery intima-media thickness and a higher prevalence of atherosclerotic plaque

Author

Painschab, Matthew S, Davila-Roman, Victor G, Gilman, Robert H, Vasquez-Villar, Angel D, Pollard, Suzanne L, Wise, Robert A, Miranda, J Jaime, Checkley, William, Bernabé-Ortiz, Antonio, Casas, Juan P, Smith, George Davey, Ebrahim, Shah, Gamboa, Raúl, García, Héctor H, Málaga, Germán, Montori, Víctor M, Smeeth, Liam, and Diette, Gregory B

Published
2013
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