1. [Correlation between platelet count and CA-125 in ovarian cancer].
- Author
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Friebe Z, Watrowski R, Bembnista M, Rokowska A, Włosiińska J, and Dembińska M
- Subjects
- Adult, Aged, Female, Humans, Medical Records, Middle Aged, Neoplasm Staging, Ovarian Neoplasms complications, Ovarian Neoplasms drug therapy, Poland, Retrospective Studies, Risk Factors, Thrombocytosis drug therapy, CA-125 Antigen blood, Ovarian Neoplasms blood, Ovarian Neoplasms immunology, Platelet Count, Thrombocytosis immunology
- Abstract
Objective: To determine whether a correlation between platelet count and CA-125 exists, and to compare the mean levels of CA-125 in groups with normal and elevated platelet counts., Design: A retrospective analysis of the medical records concerning to 31 ovarian cancer inpatients, treated 1998-2002 with primary surgery and subsequent platinum-based chemotherapy at the Division of Gynecology, Department of Perinatology and Gynecology, University Medical School Poznań., Materials and Methods: 137 serum and whole blood samples collected from 31 ovarian cancer patients during their consecutive hospital stays., Results: There was a positive, moderate (r = 0.49) and highly significant (p < 0.0000001) correlation between platelet count and CA-125 levels. Thrombocytosis occurred in 45% patients before treatment, and in none when the 6th course of chemotherapy was given. In the thrombocytosis group, an average CA-125 level (913.5 U/ml) was significantly higher (p < 0.00001) then in the group with normal platelet count (103.7 U/ml)., Conclusions: Platelet count and CA-125 levels do correlate in blood samples taken from ovarian cancer patients at the same time.
- Published
- 2005