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Your search keyword '"Dembińska–Kieć, Aldona"' showing total 131 results
Start Over Author "Dembińska–Kieć, Aldona" Publication Type Academic Journals
131 results on '"Dembińska–Kieć, Aldona"'

3. Insulin resistance determines a differential response to changes in dietary fat modification on metabolic syndrome risk factors: the LIPGENE study

Author

Yubero-Serrano, Elena M, Delgado-Lista, Javier, Tierney, Audrey C, Perez-Martinez, Pablo, Garcia-Rios, Antonio, Alcala-Diaz, Juan F, Castaño, Justo P, Tinahones, Francisco J, Drevon, Christian A, Defoort, Catherine, Blaak, Ellen E, Dembinska-Kieć, Aldona, Risérus, Ulf, Lovegrove, Julie A, Perez-Jimenez, Francisco, Roche, Helen M, and Lopez-Miranda, Jose

Published
2015
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6. Gene–nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects

Author

Perez-Martinez, Pablo, Garcia-Rios, Antonio, Delgado-Lista, Javier, Gjelstad, Ingrid M.F., Gibney, James, Kieć-Wilk, Beata, Camargo, Antonio, Helal, Olfa, Karlström, Brita, Blaak, Ellen E., Hall, Wendy, Risérus, Ulf, Dembińska-Kieć, Aldona, Defoort, Catherine, Saris, Wim H.M., Lovegrove, Julie A., Drevon, Christian A., Roche, Helen M., and Lopez-Miranda, Jose

Published
2013
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14. The effect of β-carotene and its derivatives on cytotoxicity, differentiation, proliferative potential and apoptosis on the three human acute leukemia cell lines: U-937, HL-60 and TF-1

Author

Sacha, Tomasz, Zawada, Magdalena, Hartwich, Jadwiga, Lach, Zofia, Polus, Anna, Szostek, Marta, Zdziƚowska, Edyta, Libura, Marta, Bodzioch, Marek, Dembińska-Kieć, Aldona, Skotnicki, Aleksander B., Góralczyk, Regina, Wertz, Karin, Riss, Georges, Moele, Christopher, Langmann, Thomas, and Schmitz, Gerd

Published
2005
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26. 17beta-estradiol- and lipopolysaccharide-induced changes in nitric oxide, tumor necrosis factor-alpha and vascular endothelial growth factor release from RAW 264.7 macrophages.

Author

Tomaszewska, Agnieszka, Guevara, Ibeth, Wilczok, Tadeusz, Dembińska-Kieć, Aldona, and Dembińska-Kieć, Aldona

Subjects
ESTRADIOL, ENDOTOXINS, NITRIC oxide, TUMOR necrosis factors, MACROPHAGES, RNA analysis, ANIMAL experimentation, CELL lines, COMPARATIVE studies, CULTURE media (Biology), ESTROGEN antagonists, GENES, RESEARCH methodology, MEDICAL cooperation, MICE, OXIDOREDUCTASES, RESEARCH, EVALUATION research, VASCULAR endothelial growth factors, LIPOPOLYSACCHARIDES
Abstract

The present study investigated the effect of 17beta-estradiol (17betaE(2)) and lipopolysaccharide (LPS) on the release and expression of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor (VEGF) in the macrophage cell line RAW 264.7. The cells were pre-incubated with 17betaE(2) at physiological as well as supraphysiological concentrations (12.5-1000 pg/ml) and subsequently activated with LPS (100 ng/ml). The changes in NO, TNF-alpha and VEGF release into culture medium and also their gene expression in cells were assessed. A concentration-dependent inhibitory effect of 17betaE(2) on NO and TNFalpha release was observed at low physiological concentrations, whereas the VEGF gene expression and protein levels were upregulated by 17betaE(2) in RAW 264.7 cells. [ABSTRACT FROM AUTHOR]

Published
2003
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27. Cechy spektrum zaburzeń dwubiegunowych u osób otyłych.

Author

Siwek, Marcin, Dudek, Dominika, Jaeschke, Rafał, Dembińska-Kieć, Aldona, Witkowski, Leszek, Arciszewska, Aleksandra, Hebal, Ferdynand, Matłok, Maciej, Malczewska-Malec, Małgorzata, Wnęk, Dominika, Pilecki, Maciej W., Major, Piotr, Epa, Roksana, and Rybakowski, Janusz

Abstract

Aim: The relationships between obesity and bipolar spectrum disorders (BSD) are unclear. Thus, the aim of our study were to approximate the prevalence of soft bipolar features in patients seeking treatment for obesity. Methods: We performed a nested case-control study (cases: 90 patients with the mean BMI=38.1±7.0 [range: 30.1-62.5]; controls: 70 healthy volunteers with the mean BMI=21.6±2.1 [range: 18.5-24.9]). The participants were screened for the BSD symptoms with the Mood Disorder Questionnaire. Results: Patients with obesity were significantly more likely to score ≥7 pts. on the MDQ 25.6% vs. 8.6%; p=0.01). In comparison to non-obese individuals, the obese patients scored significantly higher in MDQ section I and on the MDQ items referring to the 'irritability-racing thoughts' dimension of hypomania. The multiple logistic regression analysis revealed that obesity had been significantly related to the odds of obtaining =7 pts. on the MDQ section 1 (odds ratio [OR] = 2.07; 95% confidence interval [CI]: 1.17-3.63), and marginally significantly related to experiencing periods of 'ups' and 'downs'(OR = 1.67; 95% CI: 1.00-2.81). Conclusions: Our study adds to previous suggestions that obesity may be significantly related to the BSD. However, the clinical implications of this finding need to be determined in further studies, performed in accordance with the paradigm of evidence based medicine (EBM). [ABSTRACT FROM AUTHOR]

Published
2015
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29. Influence of fatty acids on mitochondrial metabolism of adipocyte progenitors and endothelial cells.

Author

Knapp, Anna, Czech, Urszula, Góralska, Joanna, Śliwa, Agnieszka, Gruca, Anna, Kieć-Wilk, Beata, Awsiuk, Magdalena, Thiele, Christoph, Dudek, Wojciech, and Dembińska-Kieć, Aldona

Subjects
FATTY acids, MITOCHONDRIAL membranes, FAT cells, ENDOTHELIUM, OBESITY, CELL populations, ADIPOSE tissues, MEMBRANE potential
Abstract

Context: In obesity, the cells are exposed to excessive amounts of nutrients, especially free fatty acids (FFAs) that induce a variety of metabolic changes. Objective: We investigated the effect of FFAs on the mitochondrial function in different cell populations under stress conditions. Methods: Human adipose tissue progenitor cells (SVF) or endothelial cells (HUVECs) were incubated with 30 μM of selected saturated or unsaturated FFA for 24 h, at times supplemented with 5ng/mL tumour necrosis factor alpha (TNF α) for the last 4 h. Changes in oxygen respiration rate, mitochondrial membrane potential (mitoMP) and total ATP content were monitored. Results: Saturated palmitic acid demonstrated no effect, while a selection of unsaturated FFAs ameliorated metabolism of the progenitor SVF cells. TNF α either did not affect or nullified some of the favourable FFA-induced effects. Conclusions: The mitoMP was the most sensitive parameter reflecting positive impact of the unsaturated FFA on the adipose SVF cells' metabolism. [ABSTRACT FROM AUTHOR]

Published
2012
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31. Nutrigenomika, angiogeneza a otyłość.

Author

Kieć-Wilk, Beata, Dudek, Wojciech, and Dembińska-Kieć, Aldona

Subjects
NEOVASCULARIZATION, ADIPOSE tissues, FETAL development, TUMOR growth, GROWTH factors
Abstract

W niniejszej pracy omówiono poznane mechanizmy i związek zachodzący między angiogenezą, wybranymi składnikami pokarmu -- nutrientami -- a mechanizmami prowadzącymi do rozwoju tkanki tłuszczowej. [ABSTRACT FROM AUTHOR]

Published
2006

39. Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects.

Author

Płatek, Teresa, Polus, Anna, Góralska, Joanna, Raźny, Urszula, Dziewońska, Agnieszka, Micek, Agnieszka, Dembińska-Kieć, Aldona, Solnica, Bogdan, Malczewska-Malec, Małgorzata, Skrzypski, Marek, and Kołodziejski, Paweł A.

Subjects
FIBROBLAST growth factor receptors, VASCULAR endothelial growth factors, VASCULAR endothelial growth factor receptors, ADIPOKINES, FIBROBLAST growth factors, DNA microarrays, BROWN adipose tissue, EPIGENETICS
Abstract

We hypothesised that epigenetics may play an important role in mediating fibroblast growth factor 21 (FGF21) resistance in obesity. We aimed to evaluate DNA methylation changes and miRNA pattern in obese subjects associated with high serum FGF21 levels. The study included 136 participants with BMI 27–45 kg/m2. Fasting FGF21, glucose, insulin, GIP, lipids, adipokines, miokines and cytokines were measured and compared in high serum FGF21 (n = 68) group to low FGF21 (n = 68) group. Human DNA Methylation Microarrays were analysed in leukocytes from each group (n = 16). Expression of miRNAs was evaluated using quantitative PCR-TLDA. The study identified differentially methylated genes in pathways related to glucose transport, insulin secretion and signalling, lipid transport and cellular metabolism, response to nutrient levels, thermogenesis, browning of adipose tissue and bone mineralisation. Additionally, it detected transcription factor genes regulating FGF21 and fibroblast growth factor receptor and vascular endothelial growth factor receptor pathways regulation. Increased expression of hsa-miR-875-5p and decreased expression of hsa-miR-133a-3p, hsa-miR-185-5p and hsa-miR-200c-3p were found in the group with high serum FGF21. These changes were associated with high FGF21, VEGF and low adiponectin serum levels. Our results point to a significant role of the epigenetic regulation of genes involved in metabolic pathways related to FGF21 action. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Enhanced GIP Secretion in Obesity Is Associated with Biochemical Alteration and miRNA Contribution to the Development of Liver Steatosis.

Author

Góralska, Joanna, Raźny, Urszula, Polus, Anna, Dziewońska, Agnieszka, Gruca, Anna, Zdzienicka, Anna, Dembińska-Kieć, Aldona, Solnica, Bogdan, Micek, Agnieszka, Kapusta, Maria, Słowińska-Solnica, Krystyna, and Malczewska-Malec, Małgorzata

Abstract

Nutrient excess enhances glucose-dependent insulinotropic polypeptide (GIP) secretion, which may in turn contribute to the development of liver steatosis. We hypothesized that elevated GIP levels in obesity may affect markers of liver injury through microRNAs. The study involved 128 subjects (body mass index (BMI) 25–40). Fasting and postprandial GIP, glucose, insulin, and lipids, as well as fasting alanine aminotransferase (ALT), γ-glutamyltransferase (GGT), cytokeratin-18, fibroblast growth factor (FGF)-19, and FGF-21 were determined. TaqMan low density array was used for quantitative analysis of blood microRNAs. Fasting GIP was associated with ALT [β = 0.16 (confidence interval (CI): 0.01–0.32)], triglycerides [β = 0.21 (95% CI: 0.06–0.36], and FGF-21 [β = 0.20 (95%CI: 0.03–0.37)]; and postprandial GIP with GGT [β = 0.17 (95%CI: 0.03–0.32)]. The odds ratio for elevated fatty liver index (>73%) was 2.42 (95%CI: 1.02–5.72) for high GIP versus low GIP patients. The miRNAs profile related to a high GIP plasma level included upregulated miR-136-5p, miR-320a, miR-483-5p, miR-520d-5p, miR-520b, miR-30e-3p, and miR-571. Analysis of the interactions of these microRNAs with gene expression pathways suggests their potential contribution to the regulation of the activity of genes associated with insulin resistance, fatty acids metabolism, and adipocytokines signaling. Exaggerated fasting and postprandial secretion of GIP in obesity are associated with elevated liver damage markers as well as FGF-21 plasma levels. Differentially expressed microRNAs suggest additional, epigenetic factors contributing to the gut–liver cross-talk. [ABSTRACT FROM AUTHOR]

Published
2020
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