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OBJETIVO: Determinar a sensibilidade, a especificidade e o risco de eventos cardiovasculares em pacientes com Duke-escore (DE) baixo, intermediário e alto risco, em comparação com a presença (ou não) de defeitos de perfusão à cintilografia do miocárdio. MÉTODOS: Estudo prospectivo, consecutivo, com 173 pacientes com 2 ou mais fatores de risco para doença arterial coronariana (DAC), que foram submetidos à cintilografia de perfusão do miocárdio com tetrofosmin marcado com tecnécio-Tc 99m (CPM) e ao teste ergométrico (aplicando-se o DE), de um bairro de Curitiba, entre janeiro de 2003 a fevereiro de 2004. Os pacientes tiveram seguimento de 13±1 meses e 162 completaram o acompanhamento. Foi avaliada a presença de morte, angina, infarto agudo do miocárdio, angioplastia coronariana e revascularização do miocárdio. RESULTADOS: A média do DE dos pacientes que apresentaram eventos (18) foi de -0,27 (95% IC= -3,97 a +3,91) e daqueles livres de eventos (144) foi de +4,92 (95% IC= +4,03 a +5,81), com pOBJECTIVE: The purpose was to determine the sensitivity, the specificity and a year-long risk of subsequent cardiovascular events in patients with low, intermediate and high risk prognostic Duke treadmill score (DTS) in comparison with the presence (or not) of the myocardial perfusion defects on radionuclide images. METHODS: A prospective study, with 173 consecutive patients with 02 or more risk factors to coronary artery disease (CAD), who underwent to exercise single photon - emission computed tomographic myocardial perfusion images using technetium-99m tetrophosmin (SPECT) and treadmill test (with DTS), from one neighbourhood of Curitiba city, between January 2003 and February 2004, were followed up for cardiac-cause mortality and major cardiac events. Follow-up was performed in 13± 1 months and in 162 patients was complete. RESULTS: The DTS mean those patients with cardiac event (18) over a year was -0.27 (95% CI= -3.97 to +3.91) and those free cardiac event patients (144) was +4.92 (95% CI= +4.03 to +5.81), with p