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The article presents a study which describes the dynamic Neural Network Ozone Retrieval System (NNORSY)-based ozone profile climatology. The study compares output ozone profiles, correlative measurements and lidar stations in an effort to explore the geophysical soundness of the climatology. It also illustrates the ozone profile measurement data sets and the NNORSY processing scheme.

BACKGROUND: Living around industrial sites may expose young children to lead and cause elevated blood lead levels (BLLs). Systematic screening for childhood lead poisoning is necessarily invasive but may be appropriate, depending on children's exposure levels. Our objective was to assess the performance of several decision support tools for determining the need for systematic BLL screening in children around industrial sites. METHOD: We used several exposure models to predict BLLs: the pharmacokinetic model IEUBK, the InVS dose model, and an empirical relation (Lewin, 1999) between soil concentrations and BLLs. We tested the BLLs (percentage of children with a BLL >100 mug/l) that they predicted as well as threshold levels of soil pollution (200, 400, 500 ppm) for 71 situations for which the literature reports both environmental soil concentrations and BLLs in children aged 0-6 years. The tools' performance (sensitivity and specificity) was assessed by the rate of 'correct' (mass screening or not) decisions, judged retrospectively on the basis of measured BLLs, for different tolerated percentages of children with elevated BLLs. RESULTS: Decision support systems based on soil pollution levels were not adequately protective. The IEUBK and (updated) InVS mechanistic exposure models were the most effective in this setting. CONCLUSION: Exposure models may provide decision support if sufficient data about environmental contamination and dietary intake are available. Absolute performance measurement nonetheless remains difficult, in view of the limitations of the input data. [ABSTRACT FROM AUTHOR]

We retrospectively analyzed overall survival and survival after progression in 91 patients with low-grade follicular lymphoma (LGFL). Histological subtype was B in 75 patients and C in 16 patients. Twelve patients with localized disease received involved-field radiotherapy; seven patients without bulky disease had no initial therapy. The remaining 72 patients received long-term chlorambucil (9 patients), MOPP or COPBleo (42 patients), or a CHOP-derived regimen (21 patients). Forty-two patients (46%) achieved a complete remission (CR) and 28 patients (31%) achieved a partial remission; 48 of these 70 patients relapsed or progressed. Nineteen of the other 21 patients with stable LGFL progressed. Two other patients failed to respond and rapidly died. Thirty-two of the 67 patients with progressive or relapsed LGFL have died. Median overall survival was 111 months. Age > or = 70 years, male sex, B symptoms, histological subtype follicular mixed-cell NHL, tumor size > or = 10 cm, number of extranodal sites of disease > or = 2, pleural effusion, and Ann Arbor stage III or IV were found to adversely influence overall survival. Failure-free survival < 24 months, failure to achieve a CR after the progression, initial histological subtype follicular mixed cell, initial Ann Arbor stage III or IV, and initial tumoral size > or = 10 cm were found to adversely influence survival after progression. Our results suggest that most prognostic factors for overall survival in LGFL are related to histological subtype or tumor burden. Some initial adverse prognostic factors for survival may be also associated with a poor survival after progression. [ABSTRACT FROM AUTHOR]

Background: To test whether rates of emergency telephone calls for asthma attacks are associated with contextual socioeconomic deprivation in the Strasbourg metropolitan area (France). Methods: Two mobile emergency medical service networks provided all data for 2000-2005 about emergency calls for asthma attacks, georeferenced by census block. Contextual deprivation was measured for each census block by a composite index, constructed by principal component analysis. Emergency call rates were calculated for each census block and for different age groups. Empirical Bayesian smoothing was used to reduce the instability of outlying rates. Results: Positive spatial autocorrelation was detected in both the health and the socioeconomic datasets. In all age groups, rates of calls for asthma attacks increased linearly with deprivation. Correlation coefficients between these two factors varied according to age group: 0.53 for the group aged 0-9 years, 0.46 for 10-19 years, 0.65 for 20-39 years, 0.70 for 40-64 years, 0.68 for 65 and older, and 0.77 for the age-standardised incidence ratio. These correlation coefficients were highly significant (p<0.01), even after spatial autocorrelation was taken into account. Conclusion: The socioeconomic gradients observed are consistent with those observed for severe forms of asthma and asthma hospitalisations in Western countries. [ABSTRACT FROM AUTHOR]

An abstract of the article "Acidic mammalian chitinase is not a critical target for allergic airway disease in mice," by Fitz and colleagues is presented.

Abstract: Introduction: The Aphekom project aimed to provide new, clear, and meaningful information on the health effects of air pollution in Europe. Among others, it assessed the health and monetary benefits of reducing short and long-term exposure to particulate matter (PM) and ozone in 25 European cities. Method: Health impact assessments were performed using routine health and air quality data, and a common methodology. Two scenarios were considered: a decrease of the air pollutant levels by a fixed amount and a decrease to the World Health Organization (WHO) air quality guidelines. Results were economically valued by using a willingness to pay approach for mortality and a cost of illness approach for morbidity. Results: In the 25 cities, the largest health burden was attributable to the impacts of chronic exposure to PM2.5. Complying with the WHO guideline of 10μg/m3 in annual mean would add up to 22months of life expectancy at age 30, depending on the city, corresponding to a total of 19,000 deaths delayed. The associated monetary gain would total some €31billion annually, including savings on health expenditures, absenteeism and intangible costs such as well-being, life expectancy and quality of life. Conclusion: European citizens are still exposed to concentrations exceeding the WHO recommendations. Aphekom provided robust estimates confirming that reducing urban air pollution would result in significant health and monetary gains in Europe. This work is particularly relevant now when the current EU legislation is being revised for an update in 2013. [Copyright &y& Elsevier]

Competing Interests: Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: V. C. reports nonfinancial support from Actelion; personal fees and nonfinancial support from Boehringer Ingelheim; personal fees from Bayer/MSD; other from Gilead; personal fees from Novartis; personal fees, nonfinancial support, and other from Roche SAS; personal fees and nonfinancial support from Sanofi; personal fees from Promedior; other from Celgene; personal fees from Galapagos; other from Galecto, personal fees from Astra Zeneca; personal fees from ReImagine; personal fees from Soun; personal fees from BMS; personal fees from PPDi; personal fees from IQVIA; personal fees from Exepi; and personal fees from Shionogi; none of which were related to this work. P.-Y. B. reports grants from Laboratoire Boehringer Ingelheim and Laboratoire Roche and personal fees from Laboratoire Boehringer Ingelheim and Laboratoire Roche, outside the submitted work. H. N. reports grants from Boehringer Ingelheim and Roche/Genentech and personal fees from Actelion Pharmaceuticals, Boehringer Ingelheim, Galapagos, and Roche/Genentech, outside the submitted work. Y. U. reports personal fees from Boehringer Ingelheim and Roche and grants and nonfinancial support from Oxyvie, outside the submitted work. None declared (P. B., M. P. d. C., Y. A., J. L. P., C. P., B. Z., V. B., B. H., A. M., M. M., S. B., C. D., Y. T.-L., E. H.).

This study investigated the role of language-related abilities in emotion comprehension among young people with non-specific intellectual developmental disorders (NS-IDDs). Forty children and adolescents with NS-IDDs completed tasks assessing emotion comprehension, receptive vocabulary, verbal reasoning skills, and verbal working memory. Results showed that emotion comprehension was better predicted by comprehension of abstract words and verbal working memory, and that these two predictors were themselves predicted by verbal reasoning skills. These results therefore suggest a link between emotion understanding and verbal reasoning, which could be mediated by abstract vocabulary and verbal working memory. These findings provide insight into the relationships between emotion comprehension and language-related abilities in NS-IDDs.

This study investigated young children's ability to draw psychological and nonpsychological inferences during reading comprehension. Whereas nonpsychological inferences require the retrieval of general background knowledge, psychological inferences rely on more contextualised knowledge relating to mental states. Based on several pretests, children, who were able to read fluently, aged 7-8 years (second graders; n = 42) and 8-9 years (third graders; n = 46) were assigned to either a skilled comprehenders group or a less skilled comprehenders group, based on their listening comprehension. They were then given short stories to read, followed by comprehension questions. Some questions required the drawing of psychological or nonpsychological inferences. Generalized linear mixed models revealed that (a) psychological inferences were more difficult to generate than nonpsychological inferences for all the children, skilled and less skilled comprehenders alike, (b) both types of inference skills (psychological and nonpsychological) were associated with similar improvements as grade level increased, and (c) less skilled comprehenders had greater difficulty than skilled comprehenders generating psychological and nonpsychological inferences. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Objectives: This article argues that community healthcare clinics managed by dedicated medical professionals who are familiar with the special needs of the local community may serve as effective alternatives to centralized hospitals and medical facilities, which may be disconnected from these local communities., Background: The literature indicates that socioeconomic factors that affect an individual's ability to seek medical help when needed can cause vulnerability to public health emergencies. These factors include belonging to lower income populations, being African American, being dependent due to age (below 18 or above 65) or disability, being an immigrant, English-language ability, access to transportation means, and the strength of an individual's social network., Method: This study aims at developing a multifaceted methodology to identify optimal locations for deployment of temporary healthcare clinics to address health disparity issues among socially vulnerable populations, especially during pandemics and public health crises. This case study looks at the Health Enterprise Zone (HEZ) in Baltimore and ranks Census tracts based on their vulnerability, using two novel health vulnerability indices and considering their locations., Results: Using the proposed methodology, the optimal tracts within the HEZ are identified as potential locations for deploying temporary healthcare clinics., Conclusion: The analysis of vulnerabilities to public health emergencies based on socioeconomic factors can assist in identifying potential locations for setting up temporary healthcare clinics with the goal of assisting socially vulnerable populations during outbreaks and pandemics.

Baltimore, Maryland's entrenched racial residential segregation renders the city's world-class medical facilities and services inaccessible to many Black residents living in its most divested neighborhoods. Arguing the need for post-pandemic health care facilities to address health inequities as a practice of care-giving, this article describes a project funded by the National Institutes of Health (NIH) to define a novel, transdisciplinary methodology for identifying ideal vacant sites for conversion into community clinics in Baltimore's most vulnerable neighborhoods. Positioning architecture as a social determinant of health, this paper suggests ethical and methodological reorientations toward a compassionate approach to clinic design and placement.

We studied comprehension of emotion versus concrete/abstract words in Down syndrome (DS). Study 1 compared 26 participants with DS and 26 typically developing (TD) children matched on verbal ability. Results showed no difference between groups. Study 2 assessed whether chronological age (CA) and (non)verbal abilities predicted developmental trajectories of comprehension in 36 children with DS and 143 TD children. For the latter, these variables predicted comprehension of all three word types. For the former, receptive vocabulary predicted comprehension of all word types, but CA and nonverbal reasoning only predicted comprehension of concrete words. This suggests that people with DS have no specific emotional lexicon deficit. Supporting their general lexical development would help them access abstract and emotional meanings., (©AAIDD.)

According to the Declarative/Procedural Model, the lexicon depends on declarative memory while grammar relies on procedural memory. Furthermore, procedural memory underlies the sequential processing of language. Thus, this system is important for predicting the next item in a sentence. Verb processing represents a good candidate to test this assumption. Semantic representations of verbs include information about the protagonists in the situations they refer to. This semantic knowledge is acquired implicitly and used during verb processing, such that the processing of a verb preactivates its typical patients (e.g., the window for break ). Thus, determining how the patient typicality effect appears during children's cognitive development could provide evidence about the memory system that is dedicated to this effect. Two studies are presented in which French children aged 6-10 and adults made grammaticality judgments on 80 auditorily presented sentences. In Experiment 1, the verb was followed by a typical patient or by a less typical patient. In Experiment 2, grammatical sentences were constructed such that the verb was followed either by a typical patient or by a noun that could not be a patient of that verb. The typicality effect occurs in younger children and is interpreted in terms of developmental invariance. We suggest that this effect may depend on procedural memory, in line with studies that showed that meaning is necessary to allow procedural memory to learn the sequence of words in a sentence., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Stefaniak, Baltazart and Declercq.)

The current Covid-19 outbreak poses many challenges on hospital organisation and patient care. Our hospital lies at the epicentre of the Belgian epidemic. On April 1st, a total of 235 Covid-19 patients had been admitted to our hospital. This demanded an unprecedented adaptation of our hospital organisation, and we have met many clinical issues in the care for Covid-19 patients. In this article, we share our experience in the handling of some of the practical and organisational issues in the care for Covid-19 patients.

Although the use of metaphors is a central component of language, the processes that sustain their comprehension have yet to be specified. Work in the fields of both metaphors and implicit learning suggests that implicit learning abilities facilitate the comprehension of metaphors. However, to date, no study has directly explored the relationships between the understanding of metaphors and so-called implicit learning tasks. We used a meaning decision task comparing literal, metaphorical and meaningless expressions to assess metaphor understanding and a probabilistic serial reaction time task for assessing implicit learning. Our results show that implicit learning positively predicts the time gap between responses to literal and metaphorical expressions and negatively predicts the difference between metaphorical and meaningless expressions. Thus, when confronted with novel metaphors, participants with higher implicit learning abilities are better able to identify that the expressions have some meaning. These results are interpreted in the context of metaphor understanding and psycholinguistic theories., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality., Objectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter., Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori-selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis., Results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced., Conclusions: Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5.