45 results on '"DI GIROLAMO, MARCO"'
Search Results
2. MRI and MR voiding cystourethrography in the evaluation of male primary bladder neck obstruction: preliminary experience
- Author
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Di Girolamo, Marco, Mariani, Simone, Barelli, Giulia Marta, Rosati, Elisa, Trucchi, Alberto, and Laghi, Andrea
- Published
- 2022
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3. Features and follow-up of patients affected by noninflammatory myocarditis after coronavirus disease 2019 vaccination
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Corradetti, Sara, Sclafani, Matteo, Mistrulli, Raffaella, Gallo, Giovanna, Pagannone, Erika, Di Girolamo, Marco, Autore, Camillo, Battistoni, Allegra, and Volpe, Massimo
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- 2023
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4. Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidoses
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De Lillo, Antonella, De Angelis, Flavio, Di Girolamo, Marco, Luigetti, Marco, Frusconi, Sabrina, Manfellotto, Dario, Fuciarelli, Maria, and Polimanti, Renato
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- 2019
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5. Epigenetic profiling of Italian patients identified methylation sites associated with hereditary transthyretin amyloidosis
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De Lillo, Antonella, Pathak, Gita A., De Angelis, Flavio, Di Girolamo, Marco, Luigetti, Marco, Sabatelli, Mario, Perfetto, Federico, Frusconi, Sabrina, Manfellotto, Dario, Fuciarelli, Maria, and Polimanti, Renato
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- 2020
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6. Italian registry of cardiac magnetic resonance
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Ligabue, Guido, Mancini, Andrea, Palmieri, Francesco, Restaino, Gennaro, Puppini, Giovanni, Centonze, Maurizio, Toscano, Wiliam, Tessa, Carlo, Faletti, Riccardo, Conti, Massimo, Scardapane, Arnaldo, Galea, Salvatore, Liguori, Carlo, Pagliacci, Marzio, Lumia, Domenico, di Girolamo, Marco, Romagnoli, Andrea, Guarise, Alessandro, Cirillo, Stefano, Gagliardi, Biagio, Borghi, Claudia, Quarenghi, Matteo, Contin, Franco, Scaranello, Fiorenzo, Tartaro, Armando, Marinucci, Carlo, Monti, Lorenzo, Francone, Marco, Di Cesare, Ernesto, Cademartiri, Filippo, Pontone, Gianluca, Lovato, Luigi, Matta, Gildo, Secchi, Francesco, Maffei, Erica, Pradella, Silvia, Carbone, Iacopo, Marano, Riccardo, Bacigalupo, Lorenzo, Chiodi, Elisabetta, Donato, Rocco, Sbarbati, Stefano, De Cobelli, Francesco, and di Renzi, Paolo
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- 2014
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7. The role of contrast enhanced computed tomography in the diagnosis of necrotizing fasciitis and comparison with the laboratory risk indicator for necrotizing fasciitis (LRINEC)
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Carbonetti, Francesco, Cremona, Antonio, Carusi, Valentina, Guidi, Marco, Iannicelli, Elsa, Di Girolamo, Marco, Sergi, Daniela, Clarioni, Alvise, Baio, Giulio, Antonelli, Giulio, Fratini, Luca, and David, Vincenzo
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- 2016
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8. MRI in the evaluation of facial dermal fillers in normal and complicated cases
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Di Girolamo, Marco, Mattei, Mauro, Signore, Alberto, and Grippaudo, Francesca Romana
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- 2015
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9. Diffusion-weighted MRI in thymomas
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Carbonetti, Francesco and Di Girolamo, Marco
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- 2016
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10. Widespread renal polycystosis induced by crizotinib
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Di Girolamo, Marco, Paris, Ida, Carbonetti, Francesco, Onesti, Elisa Concetta, Socciarelli, Fabio, and Marchetti, Paolo
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- 2015
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11. Lymphopenia in patients affected by SARS-CoV-2 infection is caused by margination of lymphocytes in large bowel: an [18F]FDG PET/CT study.
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Signore, Alberto, Lauri, Chiara, Colandrea, Marzia, Di Girolamo, Marco, Chiodo, Erika, Grana, Chiara Maria, Campagna, Giuseppe, and Aceti, Antonio
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LARGE intestine ,LEUCOCYTES ,BLOOD cell count ,LYMPHOPENIA ,LYMPHOCYTE subsets ,LYMPHOCYTES ,LYMPHOCYTE count - Abstract
Background: To investigate the cause of lymphopenia in patients with newly diagnosed COVID-19, we measured [
18 F]FDG uptake in several tissues, including the ileum, right colon, and caecum at diagnosis and after recovery and correlated these measurements with haematological parameters. Methods: We studied, by [18 F]FDG PET/CT, 18 newly diagnosed patients with COVID-19. Regions of interest were drawn over major organs and in the terminal ileum, caecum, and right colon, where the bowel wall was evaluable. Five patients were re-examined after recovery, and three of them also performed a white blood cell scan with99m Tc-HMPAO-WBC on both occasions. Complete blood count was performed on both occasions, and peripheral blood lymphocyte subsets were measured at diagnosis. Data were analysed by a statistician. Results: Patients had moderate severity COVID-19 syndrome. Basal [18 F]FDG PET/CT showed focal lung uptake corresponding to hyperdense areas at CT. We also found high spleen, ileal, caecal, and colonic activity as compared to 18 control subjects. At recovery, hypermetabolic tissues tended to normalize, but activity in the caecum remained higher than in controls. Regression analyses showed an inverse correlation between CD4 + lymphocytes and [18 F]FDG uptake in the caecum and colon and a direct correlation between CD8 + lymphocytes and [18 F]FDG uptake in lungs and bone marrow. WBC scans showed the presence of leukocytes in the caecum and colon that disappeared at recovery. Conclusions: These findings indicate that lymphopenia in COVID-19 patients is associated with large bowel inflammation supporting the hypothesis that CD4 + lymphocytes migrate to peripheral lymphoid tissues in the bowel. [ABSTRACT FROM AUTHOR]- Published
- 2022
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12. Pulmonary embolism and computed tomography angiography: Characteristic findings and technical advices.
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MUSCOGIURI, EMANUELE, DI GIROLAMO, MARCO, DE DOMINICIS, CHIARA, PISANO, ANDREA, PALMISANO, CLAUDIA, MUSCOGIURI, GIUSEPPE, and LAGHI, ANDREA
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PULMONARY embolism , *ANGIOGRAPHY , *COMPUTED tomography , *DIAGNOSTIC imaging , *HIGH resolution imaging - Abstract
Pulmonary embolism (PE) is a condition due to blood clots obstructing pulmonary arteries, often related to deep venous thrombosis (DVT). PE can be responsible for acute and even life-threatening clinical situations and it may also lead to chronic sequelae such as chronic thromboembolic pulmonary hypertension (CTEPH). Signs and symptoms associated to PE may overlap those of many other diseases (e.g. chest pain, dyspnea, etc.), therefore an accurate clinical evaluation is mandatory before referring the patient to the most appropriate imaging technique. Pulmonary angiography (PA) has been traditionally considered the gold standard regarding the diagnosis of PE and it is also useful regarding the treatment of said condition. However, PA is an invasive technique, implying all the known risks concerning endovascular procedures. Nowadays, computed tomography angiography (CTA) is considered the imaging technique of choice regarding the diagnosis of PE. This technique is readily-available in most centers and it is able to provide high resolution images, although it implies the administration of ionizing radiations and iodinated contrast medium. Conventional CTA has further been improved with the use of ECG-gated protocols, aimed to reduce motion artifacts due to heartbeat and to evaluate other causes of sudden onset chest pain. Moreover, another interesting technique is dual energy computed tomography (DECT), which allows to elaborate iodine maps, allowing to detect areas of hypoperfusion due to the presence of emboli in pulmonary arteries. This review is aimed to describe the main findings related to PE with an emphasis on CTA, also discussing technical aspects concerning image acquisition protocol. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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13. Imaging of β-Cell Mass and Insulitis in Insulin-Dependent (Type 1) Diabetes Mellitus
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Di Gialleonardo, Valentina, de Vries, Erik F. J., Di Girolamo, Marco, Quintero, Ana M., Dierckx, Rudi A. J. O., and Signore, Alberto
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- 2012
14. Methanol carbonylation to methyl formate catalyzed by strongly basic resins
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Di Girolamo, Marco, Lami, Massimo, Marchionna, Mario, Sanfilippo, Domenico, Andreoni, Marco, Galletti, Anna Maria Raspolli, and Sbrana, Glauco
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- 1996
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15. Selective synthesis of isobutanol by means of the Guerbet reaction: Part 2. Reaction of methanol/ethanol and methanol/ethanol/ n-propanol mixtures over copper based/MeONa catalytic systems
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Carlini, Carlo, Di Girolamo, Marco, Macinai, Alessandro, Marchionna, Mario, Noviello, Marilena, Raspolli Galletti, Anna Maria, and Sbrana, Glauco
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- 2003
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16. Acidic and basic ion exchange resins for industrial applications
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Di Girolamo, Marco and Marchionna, Mario
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- 2001
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17. Amiloidosi da transtiretina (ATTR): l'altra faccia della medaglia.
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Perfetto, Federico, Cappelli, Francesco, Farsetti, Silvia, Dimarcantonio, Elio, Casagrande, Silvia, Di Gioia, Massimo, Di Girolamo, Marco, and Bergesio, Franco
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AMYLOIDOSIS ,RADIONUCLIDE imaging ,PERIPHERAL neuropathy ,RNA ,BIOPSY - Abstract
TTR amyloidosis: the other side of the coin Transthyretin amyloidosis (ATTR) is becoming an emerging clinical entity, and is currently the most common form of systemic amyloidosis. ATTR consists of two distinct diseases depending on whether the amyloid fibrils derive from the intact molecule of TTR (ATTR wild-type or senile systemic amyloidosis) or from different mutations occurred in the TTR molecule gene (ATTRm). Total-body scintigraphy with diphosphonates has greatly improved the diagnosis in patients with isolated cardiac involvement for both ATTRm and ATTRwt, thus avoiding the need of endomiocardial biopsy in cases without serum and/or urinary monoclonal component (MC). Heart failure alone, or associated with peripheral and autonomic neuropathy, are the main clinical symptoms in these patients. Particular attention must be paid in order to exclude hypertrophic cardiomiopathy or light chain (AL) forms in patients with MC. Today, besides hepatic transplantation, which is almost reserved to patients with early Val30Met neuropathy, many new therapeutic alternatives can be offered to these patients. Tafamidis, a TTR-stabilizer that has recently proved to be effective in cardiac forms of both ATTRm and ATTRwt, is now ready for clinical use. In addition, drugs silencing the TTR messenger RNA should soon be available for treatment. The many therapeutic opportunities available today for ATTR, strenghten even more the need for an early diagnosis of the disease both in ATTRm and ATTRwt. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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18. Clinical Impact of Highly Purified, Whey Proteins in Patients Affected With Colorectal Cancer Undergoing Chemotherapy: Preliminary Results of a Placebo-Controlled Study.
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Mazzuca, Federica, Roberto, Michela, Arrivi, Giulia, Sarfati, Elena, Schipilliti, Francesca Matilde, Crimini, Edoardo, Botticelli, Andrea, Di Girolamo, Marco, Muscaritoli, Maurizio, and Marchetti, Paolo
- Published
- 2019
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19. Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis.
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Iorio, Andrea, De Angelis, Flavio, Di Girolamo, Marco, Luigetti, Marco, Pradotto, Luca G., Mazzeo, Anna, Frusconi, Sabrina, My, Filomena, Manfellotto, Dario, Fuciarelli, Maria, and Polimanti, Renato
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TRANSTHYRETIN ,AMYLOIDOSIS ,GENETIC disorders ,GENE expression ,SKELETAL muscle - Abstract
Background: Transthyretin (TTR) amyloidosis is a hereditary disease with a complex genotype-phenotype correlation. We conducted a literature survey to define the clinical landscape of TTR amyloidosis across populations worldwide. Then, we investigated whether the genetically determined TTR expression differs among human populations, contributing to the differences observed in patients. Polygenic scores for genetically determined TTR expression in 14 clinically relevant tissues were constructed using data from the GTEx (Genotype-Tissue Expression) project and tested in the samples from the 1,000 Genomes Project. Results: We observed differences among the ancestral groups and, to a lesser extent, among the investigated populations within the ancestry groups. Scandinavian populations differed in their genetically determined TTR expression of skeletal muscle tissue with respect to Southern Europeans (p = 6.79*10
-6 ). This is in line with epidemiological data related to Swedish and Portuguese TTR Val30Met endemic areas. Familial amyloidotic cardiomyopathy (TTR deposits occur primarily in heart tissues) presents clinical variability among human populations, a finding that agrees with the among-ancestry diversity of genetically determined TTR expression in heart tissues (i.e., Atrial Appendage p = 4.55*10-28 ; Left Ventricle p = 6.54*10-35 ). Conclusions: Genetically determined TTR expression varied across human populations. This might contribute to the genotype-phenotype correlation of TTR amyloidosis. [ABSTRACT FROM AUTHOR]- Published
- 2017
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20. 5GEx: realising a Europe-wide multi-domain framework for software-defined infrastructures.
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Bernardos, Carlos J., Gerö, Balázs Péter, Di Girolamo, Marco, Kern, András, Martini, Barbara, and Vaishnavi, Ishan
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5G networks ,TELECOMMUNICATION ,INTERNET ,SOFTWARE-defined networking ,CLOUD computing - Abstract
Market fragmentation has resulted in a multitude of network and cloud/data center operators, each focused on different countries, regions and technologies. This makes it difficult and costly to create infrastructure services spanning multiple domains, such as virtual connectivity or compute resources. In this article, we discuss the goals and work being done within the 5GEx (5G Exchange) project in realising a Europe-wide multi-domain platform. This platform aims at enabling cross-domain orchestration of services over multiple administrations or over multi-domain single administrations in the context of emerging 5G networking. The 5GEx vision is based on introducing a unification via network function virtualisation/software-defined networking compatible multi-domain orchestration for networks, clouds and services. We describe the motivation and 5GEx vision, the adopted architecture and the next steps in terms of implementation and experimentation. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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- 2016
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21. Metronomic Chemotherapy Is Effective and Well Tolerated in Relapsed/Refractory Elderly Patients with Aggressive B- and T-Cell Lymphomas
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Cox, Maria Christina, Cavalieri, Elena, Bianchi, maria Paola, Porrini, Raffaele, Naso, Virginia, di Girolamo, Marco, Prosperi, Daniela, di Landro, Francesca, and Tafuri, Agostino
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- 2015
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22. Most recent common ancestor of TTR Val30Met mutation in Italian population and its potential role in genotype-phenotype correlation.
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Iorio, Andrea, De Angelis, Flavio, Di Girolamo, Marco, Luigetti, Marco, Pradotto, Luca, Mauro, Alessandro, Manfellotto, Dario, Fuciarelli, Maria, and Polimanti, Renato
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PROTEIN metabolism disorders ,RHEUMATOLOGY ,GLOMERULAR filtration rate ,AMYLOIDOSIS treatment ,AUTOSOMAL recessive polycystic kidney ,PHENOTYPES - Abstract
Introduction: Transthyretin (TTR)-related amyloidosis is characterized by autosomal transmission of amyloidogenic mutated TTR. Val30Met is one of the most common amyloidogenic TTR mutations, showing a worldwide distribution with phenotypic heterogeneity among human populations. Multiple founder mutations for Val30Met foci have been hypothesized and the different origins may explain the phenotypic variability. The aim of our study is to determine the origin of Italian Val30Met and to analyze the genetic relationship of other Val30Met foci. Methods: We analyzed the origin of Italian Val30Met through 11 microsatellite markers around the TTR gene in 29 patients and 34 healthy controls. Results: Our genetic analysis showed an estimated age of origin of 34-36 generations ago for the Italian Val30Met. Comparing Italian Val30Met haplotypes with those from Sweden and Portugal highlights relevant differences that seem to be consistent with an independent origin of Italian Val30Met mutation. This genetic evidence agrees with the disease phenotypic variation in these populations. Discussion and conclusions: Italian Val30Met mutation should have originated before the Portuguese and Swedish Val30Met ones (which arose through independent mutational events). This indicates a genetic diversity in the surrounding regions of three different Val30Met mutations, supporting the hypothesis that TTR non-coding regions may contribute to phenotypic heterogeneity. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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23. Diagnosis and management of dermal filler complications in the perioral region.
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Grippaudo, Francesca Romana, Di Girolamo, Marco, Mattei, Mauro, Pucci, Eugenio, and Grippaudo, Cristina
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ARTIFICIAL implant complications , *FILLER materials , *LIP surgery , *MAGNETIC resonance imaging , *ADRENOCORTICAL hormones , *HORMONE therapy , *ANTIBIOTICS , *THERAPEUTICS - Abstract
Background: Lip augmentation with injectable materials is a popular aesthetic procedure. When complications occur, patients often ignore which material was implanted, thus making subsequent treatments difficult. This study aims to present the diagnosis and management of dermal filler complications in the perioral region. Study design: The Medical charts of 26 patients with filler complications in the oral region were reviewed. All patients were submitted to High Frequency Ultrasound, often complemented by Magnetic Resonance Imaging (MRI) and White Blood Cell Scintigraphy, to evaluate filler characteristics and complication types. Antibiotic, corticosteroid or surgical treatment was therefore planned. Results: Imaging always identified dermal fillers in the oral region, distinguishing among infections, fibrosis, granulomatous inflammation and product migration. Nine patients received surgery, ten received medical treatments, six received both, and one refused treatment. Eighty percent of the patients presented an improvement after three- year follow-up. Conclusions: Complications of oral region fillers are similar in clinical presentation but differ in etiology, therefore necessitating different clinical approaches. Imaging techniques add useful information for treatment planning. [ABSTRACT FROM AUTHOR]
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- 2014
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24. ACUTE MYOCARDITIS FOLLOWING COVID-19 VACCINATION: A PECULIAR CASE SERIES.
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Corradetti, Sara, Sclafani, Matteo, Mistrulli, Raffaella, Gallo, Giovanna, Pagannone, Erika, Di Girolamo, Marco, Autore, Camillo, Volpe, Massimo, and Battistoni, Allegra
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- 2022
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25. In silico analysis of TTR gene (coding and non-coding regions, and interactive network) and its implications in transthyretin-related amyloidosis.
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Polimanti, Renato, Di Girolamo, Marco, Manfellotto, Dario, and Fuciarelli, Maria
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BIOINFORMATICS , *AMYLOID , *TRANSTHYRETIN , *AMYLOIDOSIS , *CODING theory - Abstract
Introduction: Transthyretin (TTR)-related amyloidosis is a life-threatening disease. Currently, several questions about the pathogenic mechanisms of TTR-related amyloidosis remain unanswered. Methods: We have investigated various TTR-related issues using different in silico approaches. Results: Using an amino acid similarity-based analysis, we have indicated the most relevant TTR secondary structures in determining mutation impact. Our amyloidogenic propensity analysis of TTR missense substitutions has highlighted a similar pattern for wild-type and mutated TTR amino β acid sequences. However, some mutations present differences with respect to the general distribution. We have identified non-coding variants in cis-regulatory elements of the TTR gene, and our analysis on V122I-related haplotypes has indicated differences in non-coding regulatory variants, suggesting differences among V122I carriers. The analysis of methylation status indicated CpG sites that may affect TTR expression. Finally, our interactive network analysis revealed functional partners of TTR that may play a modifier role in the pathogenesis of TTR-related amyloidosis. Discussion and conclusion: Our data provided new insights into the pathogenesis of TTR-related amyloidosis that, if they were to be confirmed through experimental investigations, could significantly improve our understanding of the disease. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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26. Accuracy of High-Resolution MRI with Lumen Distention in Rectal Cancer Staging and Circumferential Margin Involvement Prediction.
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Iannicelli, Elsa, Di Renzo, Sara, Ferri, Mario, Pilozzi, Emanuela, Di Girolamo, Marco, Sapori, Alessandra, Ziparo, Vincenzo, and David, Vincenzo
- Published
- 2014
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27. Functional variation of the transthyretin gene among human populations and its correlation with amyloidosis phenotypes.
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Polimanti, Renato, Di Girolamo, Marco, Manfellotto, Dario, and Fuciarelli, Maria
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TRANSTHYRETIN , *AMYLOIDOSIS , *PHENOTYPES , *GENOTYPE-environment interaction , *GENOMES - Abstract
Introduction: Heterogeneity in the genotype-phenotype correlation of transthyretin (TTR)-related amyloidosis has been reported, suggesting that other factors may interact with disease-causing mutations. Additional genetic variants in the TTR gene and its surrounding regions may influence disease phenotype. To explore this hypothesis, we analyzed the TTR variation among human populations to identify functional inter-ethnic differences that could influence the TTR-related amyloidosis. Methods: Using the 1000 Genomes Project database, we analyzed a 20 kb region in 1092 apparently healthy individuals who belonged to 14 human populations. In silico analyses were performed to determine the functional impact of genetic variants. Results: These analyses showed that significant ethnic differences are present in the TTR gene, and some differences may affect TTR gene function. Specifically, the non-coding variants potentially associated with regulatory function showed a significant diversity between African and non-African individuals. Discussion and conclusions: Our results highlighted that cis-regulatory variants may contribute to the cardiac TTR-related amyloidosis observed in patients carrier of Val122Ile mutation, the most common in population with African origin. Indeed, non-coding variants differentiated in Africans are, in some cases, located in binding sites of transcription factors involved in cardiac development and function (i.e. E2F3_2, REST, and TEAD). [ABSTRACT FROM AUTHOR]
- Published
- 2013
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28. CD38 Ligation in Peripheral Blood Mononuclear Cells of Myeloma Patients Induces Release of Protumorigenic IL-6 and Impaired Secretion of IFNγ Cytokines and Proliferation.
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Fedele, Giorgio, Di Girolamo, Marco, Recine, Umberto, Palazzo, Raffaella, Urbani, Francesca, Horenstein, Alberto L., Malavasi, Fabio, and Ausiello, Clara Maria
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CD38 antigen , *MYELOMA proteins , *INTERLEUKIN-6 , *INTERLEUKIN-18 , *CYTOKINES , *CELL proliferation - Abstract
CD38, a surface receptor that controls signals in immunocompetent cells, is densely expressed by cells of multiple myeloma (MM). The immune system of MM patients appears as functionally impaired, with qualitative and quantitative defects in T cell immune responses. This work answers the issue whether CD38 plays a role in the impairment of T lymphocyte response. To this aim, we analyzed the signals implemented by monoclonal antibodies (mAb) ligation in peripheral blood mononuclear cells (PBMC) obtained from MM patients and compared to benign monoclonal gammopathy of undetermined significance (MGUS). PBMC from MM both failed to proliferate and secrete IFNγ induced by CD38 ligation while it retained the ability to respond to TCR/CD3. The impaired CD38-dependent proliferative response likely reflects an arrest in the progression of cell cycle, as indicated by the reduced expression of PCNA. CD38 signaling showed an enhanced ability to induce IL-6 secretion. PBMC from MM patients displays a deregulated response possibly due to defects of CD38 activation pathways and CD38 may be functionally involved in the progression of this pathology via the secretion of high levels of IL-6 that protects neoplastic cells from apoptosis. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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29. Energy-Efficient Cloud Computing.
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BERL, ANDREAS, GELENBE, EROL, DI GIROLAMO, MARCO, GIULIANI, GIOVANNI, DE MEER, HERMANN, MINH QUAN DANG, and PENTIKOUSIS, KOSTAS
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CLOUD computing ,ENERGY consumption ,INFORMATION technology ,COMPUTER systems ,COMPUTER science - Abstract
Energy efficiency is increasingly important for future information and communication technologies (ICT), because the increased usage of ICT, together with increasing energy costs and the need to reduce green house gas emissions call for energy-efficient technologies that decrease the overall energy consumption of computation, storage and communications. Cloud computing has recently received considerable attention, as a promising approach for delivering ICT services by improving the utilization of data centre resources. In principle, cloud computing can be an inherently energy-efficient technology for ICT provided that its potential for significant energy savings that have so far focused on hardware aspects, can be fully explored with respect to system operation and networking aspects. Thus this paper, in the context of cloud computing, reviews the usage of methods and technologies currently used for energy-efficient operation of computer hardware and network infrastructure. After surveying some of the current best practice and relevant literature in this area, this paper identifies some of the remaining key research challenges that arise when such energy-saving techniques are extended for use in cloud computing environments. [ABSTRACT FROM PUBLISHER]
- Published
- 2010
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30. Ocular Involvement in Hereditary Amyloidosis.
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Minnella, Angelo Maria, Rissotto, Roberta, Antoniazzi, Elena, Di Girolamo, Marco, Luigetti, Marco, Maceroni, Martina, Bacherini, Daniela, Falsini, Benedetto, Rizzo, Stanislao, and Obici, Laura
- Subjects
AMYLOIDOSIS ,AMYLOID beta-protein precursor ,CARRIER proteins ,DELAYED diagnosis ,PROTEIN conformation ,AMYLOID ,AMYLOID beta-protein - Abstract
The term amyloidosis describes a group of rare diseases caused by protein conformation abnormalities resulting in extracellular deposition and accumulation of insoluble fibrillar aggregates. So far, 36 amyloid precursor proteins have been identified, and each one is responsible for a specific disease entity. Transthyretin amyloidosis (ATTRv) is one of the most common forms of systemic and ocular amyloidosis, due to the deposition of transthyretin (TTR), which is a transport protein mainly synthesized in the liver but also in the retinal pigment epithelial cells. ATTRv amyloidosis may be misdiagnosed with several other conditions, resulting in a significant diagnostic delay. Gelsolin and keratoepithelin are other proteins that, when mutated, are responsible for a systemic amyloid disease with significant ocular manifestations that not infrequently appear before systemic involvement. The main signs of ocular amyloid deposition are in the cornea, irido-corneal angle and vitreous, causing complications related to vasculopathy and neuropathy at the local level. This review aims at describing the main biochemical, histopathological and clinical features of systemic amyloidosis associated with eye involvement, with particular emphasis on the inherited forms. We discuss currently available treatments, focusing on ocular involvement and specific ophthalmologic management and highlighting the importance of a prompt treatment for the potential sight-threatening complications derived from amyloid deposition in ocular tissues. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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31. ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country.
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Luigetti, Marco, Guglielmino, Valeria, Antonini, Giovanni, Casali, Carlo, Ceccanti, Marco, Chiappini, Maria Grazia, De Giglio, Laura, Di Lazzaro, Vincenzo, Di Muzio, Antonio, Goglia, Mariangela, Inghilleri, Maurizio, Leonardi, Luca, Massa, Roberto, Pennisi, Elena Maria, Petrucci, Antonio, Proietti, Emanuela, Rispoli, Marianna, Sabatelli, Mario, and Di Girolamo, Marco
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DELAYED diagnosis ,GENERAL practitioners ,DISEASE prevalence ,AMYLOIDOSIS ,MEDICAL specialties & specialists - Abstract
Hereditary transthyretin amyloidosis (ATTRv, v for variant) prevalence in Italy, a non-endemic region, has been established by ATTRv amyloidosis Italian Registry. However, values of prevalence were extremely heterogeneous, considering different regions. To properly establish the prevalence of the disease in the Lazio region, a survey was sent to university regional hospitals and to main regional hospitals, in order to collect all affected patients regularly followed. We identified 100 ATTRv patients and, considering a Lazio population of 5.8/million, we estimated a ATTRv prevalence of 17.2/million. The ATTRv amyloidosis Italian Registry reported a prevalence of 8.0/million in Lazio, while our survey showed a value of double this. Our survey documented a high-prevalence for a non-endemic country. The increased awareness of the disease among general practitioners and medical specialists is a fundamental step to reduce the diagnostic delay and start an effective treatment of this disease. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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32. Morphological and functional evaluation of intrapericardial cyst as a cause of severe right heart failure: dual source computed tomography and magnetic resonance imaging.
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Bastarrika, Gorka, De Cecco, Carlo N, Arraiza, Maria, Pueyo, Jesus, Rabago, Gregorio, Di Girolamo, Marco, Enrici, Michelangelo Maurizi, and David, Vincenzo
- Published
- 2009
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33. SPMO 8301 High resolution sonography in carpal tunnel syndrome
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Iannicelli, Elsa, Chianta, Giuliana L.A., Salvini, Vittorio, Di Girolamo, Marco, Drudi, Francesco M., and Passariello, Roberto
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- 1997
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34. Hepatitis C virus and mixed cryoglobulinaemias
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Galli, Massimo, Monti, Giuseppe, Monteverde, Angelo, Invernizzi, Fulvio, Pietrogrande, Maurizio, Di Girolamo, Marco, Mazzaro, Cesare, Migliaresi, Sergio, Mussini, Cirillo, Ossi, Elena, and Renoldi, Piero
- Published
- 1992
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35. Multi-Modality Imaging Approach in a Challenging Case of Surgically Corrected Partial Anomalous Pulmonary Venous Return and Atrial Tachycardia Treated With Radiofrequency Ablation.
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Muscogiuri E, Di Girolamo M, Adduci C, Francia P, and Laghi A
- Abstract
Pulmonary anomalous venous return (PAPVR) is defined as a congenital anomaly in which at least one but not all of the pulmonary veins abnormally drain into a systemic vein or directly into the right atrium. Signs and symptoms related to this condition are due to the hemodynamic abnormalities secondary to left-to-right shunt and the possible presence of other associated cardiac anomalies (e.g., sinus venous atrial septal defect). Therefore, depending on the extent of the shunt, the clinical presentation of PAPVR is variable, ranging from asymptomatic patients to patients affected by severe heart failure with right-sided volume overload. PAPVR with a clinically significant shunt should be referred for surgical correction with different techniques depending on the presence of associated cardiac anomalies. We are presenting a case of partial anomalous venous return (PAPVR) in a 66-year-old man who underwent surgery 26 years ago to correct an anomalous venous connection between the right superior pulmonary vein (RSPV) and the superior vena cava (SVC) through a veno-atrial baffle. The patient was admitted to the emergency department due to atrial tachycardia. Trans-thoracic echocardiography (TTE) showed a dilated right ventricle (RV) with mild RV systolic dysfunction and pulmonary hypertension. Cardiac magnetic resonance (CMR) further confirmed the findings described by TTE and also demonstrated areas of fibrosis replacement in the hinge points. Cardiac computed tomography (CCT) was able to accurately depict and evaluate the surgically created veno-atrial baffle and also showed an anomalous connection between the left superior pulmonary vein (LSPV) and the brachiocephalic vein (BCV) through a vertical vein. The patient was successfully treated with radiofrequency ablation for his arrhythmia., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2021, Muscogiuri et al.)
- Published
- 2021
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36. An Incidental Diagnosis of SARS-CoV-2 Pneumonia With Magnetic Resonance Imaging.
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Di Girolamo M, Muscogiuri E, Zucchelli A, and Laghi A
- Abstract
The Coronavirus disease 2019 (COVID-19) is caused by the human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. The most common clinical findings related to COVID-19 are fever and cough, with the proportion of patients developing interstitial pneumonia. Other symptoms include dyspnea, expectoration, headache, anosmia, ageusia, myalgia and malaise. To date, the diagnostic criteria for COVID-19 include nasopharyngeal and oropharyngeal swabs. Computed tomography (CT) scans of the thorax showing signs of interstitial pneumonia are important in the management of respiratory disease and in the evaluation of lung involvement. In the literature, there are few cases of COVID-19 pneumonia diagnosis made using magnetic resonance imaging (MRI). In our report, we describe a case of accidental detection of findings related to interstitial pneumonia in a patient who underwent abdominal MRI for other clinical reasons. A 71-year-old woman was referred to our department for an MRI scan of the abdomen as her oncological follow-up. She was asymptomatic at the time of the examination and had passed the triage carried out on all the patients prior to diagnostic tests during the COVID-19 pandemic. The images acquired in the upper abdomen showed the presence of areas of altered signal intensity involving asymmetrically both pulmonary lower lobes, with a patchy appearance and a preferential peripheral subpleural distribution. We considered these features as highly suspicious for COVID-19 pneumonia. The nasopharyngeal swab later confirmed the diagnosis of SARS-CoV-2 infection. There are limited reports about MRI features of COVID-19 pneumonia, considering that high-resolution chest CT is the imaging technique of choice to diagnose pneumonia. Nevertheless, this clinical case confirmed that it is possible to detect MRI signs suggestive of COVID-19 pneumonia. The imaging features described could help in the evaluation of the lung parenchyma to assess the presence of signs suggestive of COVID-19 pneumonia, especially in asymptomatic patients during the pandemic phase of the disease., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2020, Di Girolamo et al.)
- Published
- 2020
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37. ATTRv amyloidosis Italian Registry: clinical and epidemiological data.
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Russo M, Obici L, Bartolomei I, Cappelli F, Luigetti M, Fenu S, Cavallaro T, Chiappini MG, Gemelli C, Pradotto LG, Manganelli F, Leonardi L, My F, Sampaolo S, Briani C, Gentile L, Stancanelli C, Di Buduo E, Pacciolla P, Salvi F, Casagrande S, Bisogni G, Calabrese D, Vanoli F, Di Iorio G, Antonini G, Santoro L, Mauro A, Grandis M, Di Girolamo M, Fabrizi GM, Pareyson D, Sabatelli M, Perfetto F, Rapezzi C, Merlini G, Mazzeo A, and Vita G
- Subjects
- Adult, Aged, Aged, 80 and over, Amyloid Neuropathies, Familial diagnosis, Amyloid Neuropathies, Familial genetics, Amyloid Neuropathies, Familial pathology, Cardiomyopathies epidemiology, Cardiomyopathies pathology, Female, Genotype, Humans, Italy epidemiology, Male, Middle Aged, Mutation, Phenotype, Polyneuropathies epidemiology, Polyneuropathies pathology, Prealbumin genetics, Prevalence, Registries, Amyloid Neuropathies, Familial epidemiology
- Abstract
Introduction: ATTRv amyloidosis is worldwide spread with endemic foci in Portugal and Sweden, Japan, Brazil, Maiorca, and Cyprus. A national Registry was developed to characterise the epidemiology and genotype-phenotype correlation of ATTRv amyloidosis in Italy and to allow a better planning of diagnostic and therapeutic services., Methods: Fifteen Italian referral centres for amyloidosis spread all over the country have contributed to the Registry., Results: Four-hundred-forty-seven subjects were enrolled, 187 asymptomatic carriers and 260 affected patients. Thirty-one different mutations were recorded. The seven most represented genetic variants were significantly different in terms of age at onset, clinical features and geographical distribution. National prevalence is 4.33/million with higher values in Southern Italy. Overall symptoms of polyneuropathy were present at disease onset in about half of the patients, symptoms of cardiomyopathy in a quarter of patients, the rest referring carpal tunnel syndrome, dysautonomia or lumbar spinal stenosis. 52.6% of patients were in FAP stage 1, 20.4% in stage 2 and 13.5% in stage 3, while 13.5% patients had no neuropathy, presenting only cardiological symptoms., Conclusions: We presented an epidemiological study based on collaboration among referral centres for ATTRv amyloidosis spread in all the Italian territory, using web-based Registry. It provided a detailed map of the regional distribution of the disease. The increased awareness of the disease among general practitioners and medical specialists has contributed to reduce the diagnostic delay and the rate of misdiagnosis. The Registry will allow to collect also future information about clinical and instrumental follow-up.
- Published
- 2020
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38. Evaluation of Prognostic Factors for Survival in Transverse Colon Cancer.
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Roberto M, Arrivi G, Lo Bianco F, Cascinu S, Gelsomino F, Caputo F, Cerma K, Ghidini M, Ratti M, Pizzo C, Ficorella C, Parisi A, Cortellini A, Urbano F, Calandrella ML, Dell'Aquila E, Minelli A, Fulgenzi CAM, Gariazzo L, Montori A, Pilozzi E, Di Girolamo M, Marchetti P, and Mazzuca F
- Abstract
Background: Although most of the analyses included transverse colon cancers (TCC) among right colon cancer (RCC), it is not completely clear if they present total similarities with RCC or if they have their specific features. Therefore, we present an observational study to evaluate clinicopathological characteristics and survival data of patients with TCC. Methods: We retrospectively reviewed 450 RCC, of whom 97 stages I-IV TCC were included in this multicenter study; clinicopathological and molecular parameters were analyzed to identify prognostic factors for disease-free survival (DFS) and overall survival (OS). Results: Most of TCC cases were male (61%), with ≤70 years old (62%), and good performance status (ECOG PS 0, 68%). According to WHO classification, 41 (49%) and 40 (48%) tumors were classified as well to moderate and poorly/undifferentiated respectively, regardless of mucinous component (30%). About molecular data, 8 (26%), 45 (63%), and 14 (24%) were MSI-H, KRAS wild-type, and BRAF V600E mutant, respectively. With a median follow-up of 34 months, there were 29 and 50 disease recurrences and deaths respectively. Charlson comorbidity index ≥5 was a significant prognostic factor for DFS (HR = 7.67, 95% CI 2.27-25.92). Colon obstruction/perforation (HR = 2.65, 95% CI 1.01-7.01), and BRAF mutant (HR = 3.03, 95% CI 0.97-9.50) cases showed a worst, despite not statistically significant, DFS. Whereas for OS, at the multivariate model, only tumor grade differentiation (HR = 5.26, 95% CI 1.98-14.01) and BRAF mutation status (3.71, 95% CI 1.07-12.89) were independent prognostic factors. Conclusions: Poorly/undifferentiated tumor grade and BRAF V600E mutation are independent prognostic factors for OS in TCC. Further prospective clinical trials are needed to better define TCC treatment in order to improve patient outcome.
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- 2020
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39. Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project.
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Bersano A, Scelzo E, Pantoni L, Morotti A, Erbetta A, Chiapparini L, Vitali P, Giaccone G, Caroppo P, Catania M, Obici L, Di Fede G, Gatti L, Tinelli F, Di Francesco JC, Piazza F, Ferrarese C, Gasparini M, Adobbati L, Bianchi-Marzoli S, Tremolada G, Sacco S, Mancuso M, Zedde ML, Godani M, Lanfranconi S, Pareyson D, Di Girolamo M, Motto C, Charidimou A, Boulouis G, and Parati EA
- Subjects
- Aged, Cerebral Hemorrhage, Cohort Studies, Humans, Italy, Magnetic Resonance Imaging, Phenotype, Cerebral Amyloid Angiopathy complications, Cerebral Amyloid Angiopathy diagnostic imaging, Cerebral Amyloid Angiopathy therapy
- Abstract
Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly patients. Although increasingly detected, a number of aspects including the pathophysiology, the clinical and neuroradiological phenotype, and the disease course are still under investigation. The incomplete knowledge of the disease limits the implementation of evidence-based guidelines on patient's clinical management and the development of treatments able to prevent or reduce disease progression. The SENECA (SEarchiNg biomarkErs of Cerebral Angiopathy) project is the first Italian multicenter cohort study aimed at better defining the disease natural history and identifying clinical and neuroradiological markers of disease progression. By a multidisciplinary approach and the collection of a large and well-phenotyped series and biorepository of CAA patients, the study is ultimately expected to improve the diagnosis and the knowledge of CAA pathophysiological mechanisms.
- Published
- 2020
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40. Hydro-MDCT for Gastric Adenocarcinoma Staging. A Comparative Study With Surgical and Histopathological Findings for Selecting Patients for Echo-endoscopy.
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DI Girolamo M, Carbonetti F, Bonome P, Grossi A, Mazzuca F, and Masoni L
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- Adult, Aged, Aged, 80 and over, Biopsy, Contrast Media, Endosonography methods, Female, Humans, Male, Middle Aged, Patient Selection, Preoperative Care, Retrospective Studies, Stomach Neoplasms surgery, Multidetector Computed Tomography methods, Multidetector Computed Tomography standards, Neoplasm Staging methods, Neoplasm Staging standards, Stomach Neoplasms diagnostic imaging, Stomach Neoplasms pathology
- Abstract
Background/aim: In local staging of gastric adenocarcinoma CT is the modality of choice. Less frequently used in a few selected patients is echo-endoscopy. Aim of this study was to evaluate the accuracy of hydro-multidetector-computed tomography (hydro-MDCT) in the evaluation of gastric adenocarcinomas with subsequent surgical and histopathological correlation to select cases for echo-endoscopy., Patients and Methods: A total of 65 patients with gastric adenocarcinomas, diagnosed by endoscopy and biopsy, underwent contrast-enhanced hydro-MDCT with subsequent tumor, nodes, metastases (TNM) classification. The distension of the gastric lumen was obtained after the oral administration of 500 ml of water., Results: Hydro-MDCT always detected gastric cancer and in 49/65 patients the assessment of T-parameter was identical to the histopathological results (accuracy: 75%). We found overstaging in 12 and understaging in 4 cases. N-parameter with MDCT was in agreement with histo-pathology in 69%of patients; in metastatic disease hydro-MDCT had an accuracy of 99%. Hydro-MDCT has proven to be a reliable diagnostic technique in evaluating gastric cancer T3-T4 stages in comparison to T1 and T2: in defining T2-stage we found the highest number of errors (37%)., Conclusion: Hydro-MDCT is a reliable technique in the preoperative staging of gastric adenocarcinoma. Echo-endoscopy could be particularly useful in doubtful cases to evaluate the muscularis propria infiltration (T2 vs. T3) and characterize the peri-gastric lymph nodes., (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2020
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41. Lean body mass wasting and toxicity in early breast cancer patients receiving anthracyclines.
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Mazzuca F, Onesti CE, Roberto M, Di Girolamo M, Botticelli A, Begini P, Strigari L, Marchetti P, and Muscaritoli M
- Abstract
Background: Sarcopenia refers to the reduction of both volume and number of skeletal muscle fibers. Lean body mass loss is associated with survival, quality of life and tolerance to treatment in cancer patients. The aim of our study is to analyse the association between toxicities and sarcopenia in early breast cancer patients receiving adjuvant treatment., Materials and Methods: Breast cancer patients who have received anthracycline-based adjuvant treatment were retrospectively enrolled. CT scan images performed before, during and after adjuvant chemotherapy were used to evaluate lean body mass at third lumbar vertebra level with the software Slice Omatic V 5.0., Results: 21 stage I-III breast cancer patients were enrolled. According to the skeletal muscle index at third lumbar vertebra cut-off ≤38.5 cm
2 /m2 , 8 patients (38.1%) were classified as sarcopenic before starting treatment, while 10 patients (47.6%) were sarcopenic at the end of treatment. A lower baseline L3 skeletal muscle index is associated with G3-4 vs G0-2 toxicities (33.4 cm2 /m2 (31.1-39.9) vs 40.5 cm2 /m2 (33.4-52.0), p = 0.028). Similarly skeletal muscle cross sectional area was significantly lower in patients with G3-4 toxicities (86.7 cm2 (82.6-104.7) vs 109.0 cm2 (83.3-143.9), p = 0.017). L3 skeletal muscle index is an independent predictor of severe toxicity ( p = 0.0282) in multivariate analysis., Conclusion: Lean body mass loss is associated with higher grade of toxicity in early breast cancer patients receiving adjuvant chemotherapy., Competing Interests: CONFLICTS OF INTEREST The authors declare to have no conflicts of interest.- Published
- 2018
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42. Hybrid imaging of musculoskeletal infections.
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Glaudemans AW, Prandini N, DI Girolamo M, Argento G, Lauri C, Lazzeri E, Muto M, Sconfienza LM, and Signore A
- Subjects
- Humans, Nuclear Medicine, Infections diagnostic imaging, Multimodal Imaging methods, Musculoskeletal Diseases diagnostic imaging
- Abstract
This review article highlights the role of radiological and nuclear medicine techniques in diagnosis of musculoskeletal infections with particular regard to hybrid imaging of osteomyelitis, prosthetic joint infections, sternal infections and spine infections. Authors conclude on the complementary role of the several techniques with indications for an appropriate diagnostic flow chart, in the light of the recent European Association of Nuclear Medicine guidelines on infection.
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- 2018
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43. Non-coding variants contribute to the clinical heterogeneity of TTR amyloidosis.
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Iorio A, De Lillo A, De Angelis F, Di Girolamo M, Luigetti M, Sabatelli M, Pradotto L, Mauro A, Mazzeo A, Stancanelli C, Perfetto F, Frusconi S, My F, Manfellotto D, Fuciarelli M, and Polimanti R
- Subjects
- Amyloidosis diagnosis, Female, Genotype, Heterozygote, Humans, Male, Prealbumin metabolism, Amyloidosis genetics, Mutation, Phenotype, Prealbumin genetics
- Abstract
Coding mutations in TTR gene cause a rare hereditary form of systemic amyloidosis, which has a complex genotype-phenotype correlation. We investigated the role of non-coding variants in regulating TTR gene expression and consequently amyloidosis symptoms. We evaluated the genotype-phenotype correlation considering the clinical information of 129 Italian patients with TTR amyloidosis. Then, we conducted a re-sequencing of TTR gene to investigate how non-coding variants affect TTR expression and, consequently, phenotypic presentation in carriers of amyloidogenic mutations. Polygenic scores for genetically determined TTR expression were constructed using data from our re-sequencing analysis and the GTEx (Genotype-Tissue Expression) project. We confirmed a strong phenotypic heterogeneity across coding mutations causing TTR amyloidosis. Considering the effects of non-coding variants on TTR expression, we identified three patient clusters with specific expression patterns associated with certain phenotypic presentations, including late onset, autonomic neurological involvement, and gastrointestinal symptoms. This study provides novel data regarding the role of non-coding variation and the gene expression profiles in patients affected by TTR amyloidosis, also putting forth an approach that could be used to investigate the mechanisms at the basis of the genotype-phenotype correlation of the disease.
- Published
- 2017
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44. Italian registry of cardiac magnetic resonance.
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Francone M, Di Cesare E, Cademartiri F, Pontone G, Lovato L, Matta G, Secchi F, Maffei E, Pradella S, Carbone I, Marano R, Bacigalupo L, Chiodi E, Donato R, Sbarbati S, De Cobelli F, di Renzi P, Ligabue G, Mancini A, Palmierir F, Restaino G, Puppini G, Centonze M, Toscano W, Tessa C, Faletti R, Conti M, Scardapane A, Galea S, Liguori C, Pagliacci M, Lumia D, di Girolamo M, Romagnoli A, Guarise A, Cirillo S, Gagliardi B, Borghi C, Quarenghi M, Contin F, Scaranello F, Tartaro A, Marinucci C, and Monti L
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Italy epidemiology, Male, Middle Aged, Prevalence, Utilization Review, Young Adult, Heart Diseases diagnosis, Heart Diseases epidemiology, Magnetic Resonance Imaging, Cine statistics & numerical data, Practice Patterns, Physicians' statistics & numerical data, Registries
- Abstract
Objectives: Forty sites were involved in this multicenter and multivendor registry, which sought to evaluate indications, spectrum of protocols, impact on clinical decision making and safety profile of cardiac magnetic resonance (CMR)., Materials and Methods: Data were prospectively collected on a 6-month period and included 3376 patients (47.2 ± 19 years; range 1-92 years). Recruited centers were asked to complete a preliminary general report followed by a single form/patient. Referral physicians were not required to exhibit any specific certificate of competency in CMR imaging., Results: Exams were performed with 1.5T scanners in 96% of cases followed by 3T (3%) and 1T (1%) magnets and contrast was administered in 84% of cases. The majority of cases were performed for the workup of inflammatory heart disease/cardiomyopathies representing overall 55.7% of exams followed by the assessment of myocardial viability and acute infarction (respectively 6.9% and 5.9% of patients). In 49% of cases the final diagnosis provided was considered relevant and with impact on patient's clinical/therapeutic management. Safety evaluation revealed 30 (0.88%) clinical events, most of which due to patient's preexisting conditions. Radiological reporting was recorded in 73% of exams., Conclusions: CMR is performed in a large number of centers in Italy with relevant impact on clinical decision making and high safety profile., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2014
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45. Sub-acute intramural haematoma of the ascending aorta.
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De Cecco CN, Di Girolamo M, Mancuso F, and David V
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- Aged, Aortic Dissection etiology, Aortic Dissection surgery, Aortic Aneurysm complications, Aortic Aneurysm surgery, Aortic Aneurysm, Thoracic complications, Aortic Aneurysm, Thoracic diagnosis, Aortic Aneurysm, Thoracic surgery, Aortic Diseases complications, Aortic Diseases surgery, Aortography methods, Blood Vessel Prosthesis Implantation, Hematoma complications, Hematoma surgery, Humans, Magnetic Resonance Angiography, Male, Predictive Value of Tests, Tomography, X-Ray Computed, Treatment Outcome, Aortic Aneurysm diagnosis, Aortic Diseases diagnosis, Hematoma diagnosis
- Abstract
We report the case of an ascending aorta aneurysm with intramural haematoma (IMH) in a patient with severe hypotension without history of thoracic pain or hypertension. Computed tomography angiography (CTA) and magnetic resonance angiography (MRA) demonstrated the presence of subacute IMH and also revealed sacciform aneurysm of the aortic arch. The patient refused hospitalization and one week later he underwent emergency aortic replacement for dissection. CTA is the technique of choice in acute aortic syndrome and magnetic resonance is helpful in IMH detection and age determination.
- Published
- 2010
- Full Text
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