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The inhibitory effect of D and L-polynucleotides of a given length (40-50n) on the catalytic activity of DNA polymerase β isolated from chromatin cells of acute myeloid leukemia HL-60 was evaluated. The synthesized L enantiomer was found to have a higher inhibitory activity than the synthesized and isolated D enantiomers of polynucleotides. The work also proposes a biophysical model that describes this effect.

In the present study, we for the first time reveal risk factors for nosocomial aggression in different categories of the psychiatric patients, depending on the nosology and gender. We analyzed data on 275 patients who committed socially dangerous acts, declared insane and sent to inpatient involuntary treatment. We highlighted the general socio-demographic and psychological factors of nosocomial aggression in male psychiatric patients regardless of nosology. We identified the risk factors for nosocomial aggression in patients with schizophrenia and organic mental disorder depending on gender. We differentiate the risk factors of regime requirements violations in the first six months of compulsory treatment and throughout the hospital treatment. The controlling and accounting of all the risk factors of nosocomial aggression can lead to increased levels of safety and reduce the incidence of aggression.

Interaction between organic and inorganic materials is very actual both for understanding their nature and for some applications. One of directions in this area is functionalization and sensibilization of semiconductor surfaces by organic compounds for solar energy conversion. The main goal of this research is to demonstrate the possibility for immobilization of some photofunctional organic compounds on an inorganic silicon substrate at the room temperature. In particular, we have prepared a new B12–Si hybrid with the solar conversion efficiency up to Eff = 3.75% at the room temperature by chemical deposition of vitamin B12 on the patterned silicon substrate. Here, we report the correlation between morphology and functionality, as well as deposition mode for B12–Si hybrids.