Search

Introduction: Abnormal lipid metabolism, one of the hallmarks in cancer, has gradually emerged as a novel target for cancer treatment. As organelles that store and release excess lipids, lipid droplets (LDs) resemble "gears" and facilitate cancer development in the body. Aim: This review discusses the life cycle of LDs, the relationship between abnormal LDs and cancer hallmarks, and the application of LDs in theragnostic and clinical contexts to provide a contemporary understanding of the role of LDs in cancer. Methods: A systematic literature search was conducted in PubMed and SPORTDiscus. Retrieve and summarize clinical trials of drugs that target proteins associated with LD formation using the Clinical Trials website. Create a schematic diagram of lipid droplets in the tumor microenvironment using Adobe Illustrator. Conclusion: As one of the top ten hallmarks of cancer, abnormal lipid metabolism caused by excessive generation of LDs interrelates with other hallmarks. The crosstalk between excessive LDs and intracellular free fatty acids (FFAs) promotes an inflammatory environment that supports tumor growth. Moreover, LDs contribute to cancer metastasis and cell death resistance in vivo. Statins, as HMGCR inhibitors, are promising to be the pioneering commercially available anti‐cancer drugs that target LD formation. [ABSTRACT FROM AUTHOR]

• A composite high-resolution monsoon precipitation record over the mid-YRV. • Centennial-scale oscillations in EASM rainfall related to solar activity and ENSO. • An anti-phase relationship of monsoon rainfall between the mid-YRV and tropical WNP. • A new EAP index calculated as the difference between monsoon rainfall in the mid-YRV and WNP. • A strong correlation between the EAP and SOI index. Meteorological observations reveal an inverse relationship of summer monsoon rainfall between the tropical western North Pacific (WNP) and middle Yangtze River Valley (mid-YRV) on interannual and intraseasonal timescales. This seesaw-like pattern, named the East Asian-Pacific (EAP) pattern, is one of the major teleconnections that affect summer precipitation in the mid-YRV. However, due to the scarcity of long and continuous instrumental data, the behavior and mechanism of the EAP pattern on a long timescale are poorly understood. Here, we present a composite high-resolution summer monsoon rainfall record from 230 BC to 1810 AD, based on 1221 δ 18 O measurements and 22 230Th dates from two stalagmites (EB1 and EB5) in Shenqi Cave over the mid-YRV. Our new record shows that monsoon rainfall in the mid-YRV varies at a dominant periodicity of ∼100 years, probably linked to solar activity and ENSO variability. The multi-centennial fluctuations in the EB record, broadly consistent with the North Hemisphere temperature reconstruction, display strong similarities to two stalagmite δ 18 O records from nearby Heshang and Luoshui caves. To represent the integrated hydroclimate variations over the mid-YRV, we extracted the first principal component (PC1) of these three cave δ 18 O records by using the principal component analysis. We reveal a striking inverse relationship of wet/dry conditions between the mid-YRV and tropical WNP, suggesting that changes in the EAP pattern have an important impact on centennial-scale monsoon precipitation changes. Furthermore, we compile monsoon rainfall records from the mid-YRV and WNP to reconstruct a new EAP index. This EAP index exhibits a strong correlation with the ENSO proxy, confirming that the ENSO variability may play a key role in modulating the monsoon rainfall in the mid-YRV through the EAP teleconnection. [ABSTRACT FROM AUTHOR]

Purposes: Domestic and international research has found that patients with advanced cancer prioritize increasing their quality of life above extending their lives with simple or intensive treatments. The current study investigates the pathways to improve patients' sense of well-being from the family, social, and individual levels, that is to say, it investigates the mediating roles of comprehending social support as well as psychological resilience in the relationship between family resilience and subjective well-being, and it also provides references for future intervention., Method: The Family Resilience Questionnaire (FRQ), General Well-being Schedule (GWB), Perceived Social Support Scale (PSSS), and the Chinese version of the Cornor-Davidson Resilience Scale 10-item (CD-RISC) were all completed by 338 patients with advanced cancer who took part in the study., Results: The study's findings demonstrated a significant and positive correlation between family resilience, subjective well-being, perceived social support, and psychological resilience. Additionally, there was a significant direct effect of family resilience on subjective well-being as well as a mediating and chain mediating effect between perceived social support and psychological resilience. The findings of this study will be very helpful in the future when it comes to enhancing the quality of life for patients with advanced cancer through intervention., Conclusion: Subjective well-being can be influenced directly by the family resilience of advanced cancer patients, or indirectly through the psychological resilience and perceived social support., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Yang, He, Li, Zhao, Wang, Zhang, Qiao, Cui, Lin and Guan.)