Search

Ionic gradients play a crucial role in the physiology of the human body, ranging from metabolism in cells to muscle contractions or brain activities. To monitor these ions, inexpensive, label-free chemical sensing devices are needed. Field-effect transistors (FETs) based on silicon (Si) nanowires or nanoribbons (NRs) have a great potential as future biochemical sensors as they allow for the integration in microscopic devices at low production costs. Integrating NRs in dense arrays on a single chip expands the field of applications to implantable electrodes or multifunctional chemical sensing platforms. Ideally, such a platform is capable of detecting numerous species in a complex analyte. Here, we demonstrate the basis for simultaneous sodium and fluoride ion detection with a single sensor chip consisting of arrays of gold-coated SiNR FETs. A microfluidic system with individual channels allows modifying the NR surfaces with self-assembled monolayers of two types of ion receptors sensitive to sodium and fluoride ions. The functionalization procedure results in a differential setup having active fluoride- and sodium-sensitive NRs together with bare gold control NRs on the same chip. Comparing functionalized NRs with control NRs allows the compensation of non-specific contributions from changes in the background electrolyte concentration and reveals the response to the targeted species.

Background: Computed tomography (CT) automatic tube current modulation (ATCM) systems and iterative reconstruction (IR) play an important role in CT radiation dose optimization. How the two can best be used together is one of the challenges faced by radiology professionals. Aim: To determine optimum settings of ATCM noise index (NI) together with adaptive statistic iterative reconstruction (ASIR) for a general electric (GE) scanner that aims to achieve similar image quality to the standard protocol used in the hospital (Smart mA technique with NI of 11.57 and 30% ASIR reconstruction) with a lower dose. Methods: Different NI and ASIR levels were set for scans of a phantom. Objective image quality assessments in terms of noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), low-contrast detectability (LCD), and modulation transfer function (MTF) were carried out in an anthropomorphic chest and a Catphan 700 phantom. Subjective image quality assessment was also performed with five readers to confirm whether the image quality of the new protocols was adequate. Result and Conclusion: SNR and CNR increased with the strength of ASIR, and decreased with higher NI settings. The MTF improved slightly for higher dose levels and from filtered back projection (FBP) to higher strength of ASIR. LCD improved with ASIR compared to FBP and with higher strengths of ASIR. Qualitative scoring ranged between 3.0 and 4.6. A moderate degree of reliability was found between scoring. Use of NI 15.04 with 70% ASIR can reduce dose by 41% compared to the standard protocol of NI 11.57 with 30% ASIR without degradation of image quality.

The CT dose index (CTDIvol) is the dosimetric quantity used for multi-slice CT (MSCT) with beams  ⩽4 cm. Conversion factors (f size) based on patient size are applied to CTDIvol to adjust for differences in patient size and derive size-specific dose estimates (SSDE) relating to patient dose. The aim of this study is to: (1) investigate use of a similar technique to provide SSDE values for cone beam CT (CBCT) scans, (2) determine whether factors derived for narrow beam MSCT are suitable for CBCT, and (3) investigate the influence of CBCT parameters on f size values. Monte Carlo simulations were used to model an on-board imager system integrated into a Varian Truebeam linear accelerator, and to assess doses for imaging. The CTDIvol is unsuitable for CBCT dosimetry, thus the assessments were applied to the modification CTDIIEC, recommended by the international electrotechnical commission (IEC). Conversion factors (f size,CBCT) were derived for CBCT to allow adjustment of values for the absorbed dose in water (AD) averaged over the beam width in the middle of the phantoms. Values of AD were evaluated as for CTDI300 measured with a 30 cm long chamber in centres and peripheries of long water phantoms with diameters of 10–40 cm for head and body protocols. Three beam widths 8, 16, and 24 cm were used with tube potentials ranging from 80–140 kV, for full and partial rotation modes. In order to derive f size,CBCT values, calculated values for AD were normalized with respect to the weighted CTDIIEC assessed in standard CTDI phantoms and free-in-air. Variations in f size,CBCT with beam width were minimal, 1%–5%, but those with tube potential were greater for 80 kV at small diameters reaching 11%. Acquisition mode affected f size,CBCT values by up to 7%. Best-fit curves were derived from the f size,CBCT values and compared to those reported by AAPM TG–204 for MSCT. Conversion factors estimated from these curves for 120 kV were within  ±8% and  ±13% of the MSCT values over head and body diameters, respectively, representing the majority of the adult population. Therefore, the use of MSCT factors to convert CTDIIEC for CBCT scans may lead to under/overestimation of doses to patients by 5% and 6%, on average, for the head and body protocols, respectively. Best-fit curves of the results from this study provide values that could be used to convert CTDIIEC for specific water-equivalent diameter (Dw) to a SSDE. [ABSTRACT FROM AUTHOR]

Regular imaging is used throughout image guided radiation therapy to improve treatment delivery. In order for treatment procedures to be optimized, the doses delivered by imaging exposures should be taken into account. CT dosimetry methods based on the CT dose index (CTDI), measured with a 100 mm long pencil ionization chamber (CTDI100) in standard phantoms, are not designed for cone-beam CT (CBCT) imaging systems used in radiotherapy, therefore a modified version has been proposed for CBCT by the International Electrotechnical Commission (CTDIIEC). Monte Carlo simulations based on a Varian On-Board Imaging system were used to derive conversion coefficients that enable organ doses for ICRP reference phantoms to be determined from the CTDIIEC for different scan protocols and different beam widths (80–320) mm. A dose–width product calculated by multiplying the CTDIIEC by the width of the CBCT beam is proposed as a quantity that can be used for estimating effective dose. The variation in coefficients with CBCT beam width was studied. Coefficients to allow estimation of effective doses were derived, namely 0.0034 mSv (mGy cm)−1 for the head, 0.0252 mSv (mGy cm)−1 for the thorax, 0.0216 mSv (mGy cm)−1 for the abdomen and 0.0150 mSv (mGy cm)−1 for the pelvis, and these may be applicable more generally to other CBCT systems in radiotherapy. If data on effective doses are available, these can be used in making judgements on the contributions to patient dose from imaging, and thereby assist in optimization of the treatment regimes. The coefficients can also be employed in converting dosimetry data recorded in patient records into quantities relating directly to patient doses. [ABSTRACT FROM AUTHOR]

Cone-beam CT (CBCT) scans utilised for image guided radiation therapy (IGRT) procedures have become an essential part of radiotherapy. The aim of this study was to assess organ and effective doses resulting from new CBCT scan protocols (head, thorax, and pelvis) released with a software upgrade of the kV on-board-imager (OBI) system. Organ and effective doses for protocols of the new software (V2.5) and a previous version (V1.6) were assessed using Monte Carlo (MC) simulations for the International Commission on Radiological Protection (ICRP) adult male and female reference computational phantoms. The number of projections and the mAs values were increased and the size of the scan field was extended in the new protocols. Influence of these changes on organ and effective doses of the scans was investigated. The OBI system was modelled in EGSnrc/BEAMnrc, and organ doses were estimated using EGSnrc/DOSXYZnrc. The MC model was benchmarked against experimental measurements. Organ doses resulting from the V2.5 protocols were higher than those of V1.6 for organs that were partially or fully inside the scans fields, and increased by (3–13)%, (10–77)%, and (13–21)% for the head, thorax, and pelvis protocols for both phantoms, respectively. As a result, effective doses rose by 14%, 17%, and 16% for the male phantom, and 13%, 18%, and 17% for the female phantom for the three scan protocols, respectively. The scan field extension for the V2.5 protocols contributed significantly in the dose increases, especially for organs that were partially irradiated such as the thyroid in head and thorax scans and colon in the pelvic scan. The contribution of the mAs values and projection numbers was minimal in the dose increases, up to 2.5%. The field size extension plays a major role in improving the treatment output by including more markers in the field of view to match between CBCT and CT images and hence setting up the patient precisely. Therefore, a trade-off between the risk and benefits of CBCT scans should be considered, and the dose increases should be monitored. Several recommendations have been made for optimisation of the patient dose involved for IGRT procedures. [ABSTRACT FROM AUTHOR]

In 2012 IRPA established a task group (TG) to identify key issues in the implementation of the revised eye lens dose limit. The TG reported its conclusions in 2013. In January 2015, IRPA asked the TG to review progress with the implementation of the recommendations from the early report and to collate current practitioner experience. This report presents the results of a survey on the view of the IRPA professionals on the new limit to the lens of the eye and on the wider issue of tissue reactions. Recommendations derived from the survey are presented. This report was approved by IRPA Executive Council on 31 January 2017. [ABSTRACT FROM AUTHOR]

Automatic tube current modulation (ATCM) systems to aid in optimizing dose and image noise have become standard on computed tomography (CT) scanners over the last decade. ATCM systems of the main vendors modulate tube current in slightly different ways, with some using a control parameter related to image noise (e.g. Toshiba, GE) while others use a quality reference image mAs (e.g. Siemens). The translation of clinical protocols including ATCM operation between CT scanners from different manufacturers in order to obtain similar levels of image quality with optimized exposure variables has become an important issue. In this study, cylindrical phantoms of different sizes representing small, average and large patients, have been combined into one phantom, which has been scanned on Siemens, Toshiba and GE CT scanners with the full ranges of ATCM image quality settings. The volume weighted CT dose index (CTDIvol) and image noise over each section of the phantom were recorded for every setting. Relationships between the image quality level settings, and CTDIvol and measured image noise were analysed in order to investigate ATCM performance. Equations were developed from fits of the data to enable CTDIvol and image noise to be expressed in terms of the image quality parameters for different size phantoms on each scanner. The Siemens scanner protocol was chosen as the reference, as it avoided high doses for large patients, while allowing full modulation of tube current for patients of all sizes, and so was considered to provide optimized performance. The equations derived were used to equate the noise parameters on Toshiba and GE scanners to the quality reference mAs on the Siemens scanner, so that clinical protocols incorporating similar levels of optimization could be obtained on the three CT scanners. [ABSTRACT FROM AUTHOR]

Cone beam computed tomography (CBCT) systems are fitted to radiotherapy linear accelerators and used for patient positioning prior to treatment by image guided radiotherapy (IGRT). Radiotherapists’ and radiographers’ knowledge of doses to organs from CBCT imaging is limited. The weighted CT dose index for a reference beam of width 20 mm (CTDIw,ref) is displayed on Varian CBCT imaging equipment known as an On-Board Imager (OBI) linked to the Truebeam linear accelerator. This has the potential to provide an indication of organ doses. This knowledge would be helpful for guidance of radiotherapy clinicians preparing treatments. Monte Carlo simulations of imaging protocols for head, thorax and pelvic scans have been performed using EGSnrc/BEAMnrc, EGSnrc/DOSXYZnrc, and ICRP reference computational male and female phantoms to derive the mean absorbed doses to organs and tissues, which have been compared with values for the CTDIw,ref displayed on the CBCT scanner console. Substantial variations in dose were observed between male and female phantoms. Nevertheless, the CTDIw,ref gave doses within  ±21% for the stomach and liver in thorax scans and 2  ×  CTDIw,ref can be used as a measure of doses to breast, lung and oesophagus. The CTDIw,ref could provide indications of doses to the brain for head scans, and the colon for pelvic scans. It is proposed that knowledge of the link between CTDIw for CBCT should be promoted and included in the training of radiotherapy staff. [ABSTRACT FROM AUTHOR]

A function called Gx(L) was introduced by the International Commission on Radiation Units and Measurements (ICRU) Report–87 to facilitate measurement of cumulative dose for CT scans within long phantoms as recommended by the American Association of Physicists in Medicine (AAPM) TG–111. The Gx(L) function is equal to the ratio of the cumulative dose at the middle of a CT scan to the volume weighted CTDI (CTDIvol), and was investigated for conventional multi-slice CT scanners operating with a moving table. As the stationary table mode, which is the basis for cone beam CT (CBCT) scans, differs from that used for conventional CT scans, the aim of this study was to investigate the extension of the Gx(L) function to CBCT scans. An On-Board Imager (OBI) system integrated with a TrueBeam linac was simulated with Monte Carlo EGSnrc/BEAMnrc, and the absorbed dose was calculated within PMMA, polyethylene (PE), and water head and body phantoms using EGSnrc/DOSXYZnrc, where the body PE body phantom emulated the ICRU/AAPM phantom. Beams of width 40–500 mm and beam qualities at tube potentials of 80–140 kV were studied. Application of a modified function of beam width (W) termed Gx(W), for which the cumulative dose for CBCT scans f (0) is normalized to the weighted CTDI (CTDIw) for a reference beam of width 40 mm, was investigated as a possible option. However, differences were found in Gx(W) with tube potential, especially for body phantoms, and these were considered to be due to differences in geometry between wide beams used for CBCT scans and those for conventional CT. Therefore, a modified function Gx(W)100 has been proposed, taking the form of values of f (0) at each position in a long phantom, normalized with respect to dose indices f 100(150)x measured with a 100 mm pencil ionization chamber within standard 150 mm PMMA phantoms, using the same scanning parameters, beam widths and positions within the phantom. f 100(150)x averages the dose resulting from a CBCT scan over the 100 mm length. Like the Gx(L) function, the Gx(W)100 function showed only a weak dependency on tube potential at most positions for the phantoms studied. The results were fitted to polynomial equations from which f (0) within the longer PMMA, PE, or water phantoms can be evaluated from measurements of f 100(150)x. Comparisons with other studies, suggest that these functions may be suitable for application to any CT or CBCT scan acquired with stationary table mode. [ABSTRACT FROM AUTHOR]

Many studies have shown that the computed tomography dose index (CTDI100) which is considered as a main dose descriptor for CT dosimetry fails to provide a realistic reflection of the dose involved in cone beam computed tomography (CBCT) scans. Several practical approaches have been proposed to overcome drawbacks of the CTDI100. One of these is the cumulative dose concept. The purpose of this study was to investigate four different approaches based on the cumulative dose concept: the cumulative dose (1) f(0,150) and (2) f(0,∞) with a small ionization chamber 20 mm long, and the cumulative dose (3) f100(150) and (4) f100(∞) with a standard 100 mm pencil ionization chamber. The study also aimed to investigate the influence of using the 20 and 100 mm chambers and the standard and the infinitely long phantoms on cumulative dose measurements. Monte Carlo EGSnrc/BEAMnrc and EGSnrc/DOSXYZnrc codes were used to simulate a kV imaging system integrated with a TrueBeam linear accelerator and to calculate doses within cylindrical head and body PMMA phantoms with diameters of 16 cm and 32 cm, respectively, and lengths of 150, 600, 900 mm. f(0,150) and f100(150) approaches were studied within the standard PMMA phantoms (150 mm), while the other approaches f(0,∞) and f100(∞) were within infinitely long head (600 mm) and body (900 mm) phantoms. CTDI∞ values were used as a standard to compare the dose values for the approaches studied at the centre and periphery of the phantoms and for the weighted values. Four scanning protocols and beams of width 20–300 mm were used. It has been shown that the f(0,∞) approach gave the highest dose values which were comparable to CTDI∞ values for wide beams. The differences between the weighted dose values obtained with the 20 and 100 mm chambers were significant for the beam widths <120 mm, but these differences declined with increasing beam widths to be within 4%. The weighted dose values calculated within the infinitely long phantoms with both the chambers for the beam widths ≤140 were within 3% of those within the standard phantoms, but the differences rose to be within 15% at wider beams. By comparing the approaches studied in this investigation with other methodologies taking into account the efficiency of the approach as a dose descriptor and the simplicity of the implementation in the clinical environment, the f(0,150) method may be the best for CBCT dosimetry combined with the use of correction factors. [ABSTRACT FROM AUTHOR]

Doses to the eyes of interventional radiologists and cardiologists could exceed the annual limit of 20 mSv proposed by the International Commission on Radiological Protection. Lead glasses of various designs are available to provide protection, but standard eye dosemeters will not take account of the protection they provide. The aim of this study has been to derive dose reduction factors (DRFs) equal to the ratio of the dose with no eyewear, divided by that when lead glasses are worn. Thirty sets of protective eyewear have been tested in x-ray fields using anthropomorphic phantoms to simulate the patient and clinician in two centres. The experiments performed have determined DRFs from simulations of interventional procedures by measuring doses to the eyes of the phantom representing the clinician, using TLDs in Glasgow, Scotland and with an electronic dosemeter in Gothenburg, Sweden. During interventional procedures scattered x-rays arising from the patient will be incident on the head of the clinician from below and to the side. DRFs for x-rays incident on the front of lead glasses vary from 5.2 to 7.6, while values for orientations similar to those used in the majority of clinical practice are between 1.4 and 5.2. Specialised designs with lead glass side shields or of a wraparound style with angled lenses performed better than lead glasses based on the design of standard spectacles. Results suggest that application of a DRF of 2 would provide a conservative factor that could be applied to personal dosemeter measurements to account for the dose reduction provided by any type of lead glasses provided certain criteria relating to design and consistency of use are applied. [ABSTRACT FROM AUTHOR]

The IEC has introduced a practical approach to overcome shortcomings of the CTDI100 for measurements on wide beams employed for cone beam (CBCT) scans. This study evaluated the efficiency of this approach (CTDIIEC) for different arrangements using Monte Carlo simulation techniques, and compared CTDIIEC to the efficiency of CTDI100 for CBCT. Monte Carlo EGSnrc/BEAMnrc and EGSnrc/DOSXYZnrc codes were used to simulate the kV imaging system mounted on a Varian TrueBeam linear accelerator. The Monte Carlo model was benchmarked against experimental measurements and good agreement shown. Standard PMMA head and body phantoms with lengths 150, 600, and 900 mm were simulated. Beam widths studied ranged from 20–300 mm, and four scanning protocols using two acquisition modes were utilized. The efficiency values were calculated at the centre (εc) and periphery (εp) of the phantoms and for the weighted CTDI (εw). The efficiency values for CTDI100 were approximately constant for beam widths 20–40 mm, where εc(CTDI100), εp(CTDI100), and εw(CTDI100) were 74.7  ±  0.6%, 84.6  ±  0.3%, and 80.9  ±  0.4%, for the head phantom and 59.7  ±  0.3%, 82.1  ±  0.3%, and 74.9  ±  0.3%, for the body phantom, respectively. When beam width increased beyond 40 mm, ε(CTDI100) values fell steadily reaching ~30% at a beam width of 300 mm. In contrast, the efficiency of the CTDIIEC was approximately constant over all beam widths, demonstrating its suitability for assessment of CBCT. εc(CTDIIEC), εp(CTDIIEC), and εw(CTDIIEC) were 76.1  ±  0.9%, 85.9  ±  1.0%, and 82.2  ±  0.9% for the head phantom and 60.6  ±  0.7%, 82.8  ±  0.8%, and 75.8  ±  0.7%, for the body phantom, respectively, within 2% of ε(CTDI100) values for narrower beam widths. CTDI100,w and CTDIIEC,w underestimate CTDI∞,w by ~55% and ~18% for the head phantom and by ~56% and ~24% for the body phantom, respectively, using a clinical beam width 198 mm. The CTDIIEC approach addresses the dependency of efficiency on beam width successfully and correction factors have been derived to allow calculation of CTDI∞. [ABSTRACT FROM AUTHOR]

Introduction: Values for the CTDIvol, which is displayed on scanner consoles, give doses relative to a phantom much larger than most Thai patients, and the CTDIvoldoes not take account of differences in patient size, which affect organ doses. Objective: The purpose of this study was to evaluate relationships for size specific dose estimate (SSDE) and volume weighted computed tomography (CT) dose index (CTDIvol) with patient size for CT scanners operating under automatic tube current modulation (ATCM). Methods: Retrospective data from 244 patients who had undergone abdomen and pelvis examination on GE and Siemens CT scanners were included in this study. The combination of anteroposterior (AP) and lateral dimensions at the level of the first lumbar vertebra (L1) was used to represent patient size. Image noise within the liver was measured, and values of the absorbed dose for organs covered by the primary beam such as the liver, stomach and kidney were calculated using methods described in the literature. Values of CTDIvolwere recorded and SSDE calculated according to the American Association of Physics in Medicine (AAPM) Report No.204. Linear regression models were used to evaluate the relationship between SSDE, CTDIvol, image noise and patient size. Results: SSDE is 20%-50% larger than the CTDIvol, with values for larger patients being more representative. Both the CTDIvoland image noise decreased with patient size for Siemens scanners, but the decline in SSDE was less significant. For the GE scanner, the CTDIvolwas a factor of 3-4 lower in small patients compared to larger ones, while the SSDE only decreased by a factor of two. Noise actually decreased slightly with patient size. Conclusion: Values of SSDE were similar to the doses calculated for the liver, stomach and kidney, which are covered by the primary beam, confirming that it provides a good estimate of organ-absorbed dose.