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In solar physics, a long-unanswered question is whether or not there are local dynamos acting in sunspot regions. Here we report an observed pattern of magnetic evolution that makes the sunspots alive with ample complexity and energy. This anomalous pattern manifests as peculiar bipolar magnetic emergences (BMEs), exhibiting the following characteristics: (1) the BMEs persistently appear beyond the penumbra, encircling the sunspot in an end-to-end configuration; (2) each BME gradually grows and separates its two polarities along an arc trajectory centered on the sunspot; (3) a circular brightening belt is manifested in the ultraviolet/extreme-ultraviolet radiations during the BMEs’ evolution; and (4) the sunspot regions with such an evolution pattern often exhibit vigorous solar activity, such as homogeneous major flares. The magnetic evolving pattern and relevant flare activity indicate the presence of a local dynamo, and we characterize it as a twisting-reconnecting dynamo.

As a large-scale motion on the Sun, the meridional flow plays an important role in determining magnetic structure and strength and solar cycle. However, the meridional flow near the solar poles is still unclear. The Hinode observations show that the magnetic flux density in polar caps decreases from the lower latitudes to the poles. Using a surface flux transport model, we simulate the global radial magnetic field to explore the physical process leading to the observed polar magnetic distribution pattern. For the first time, the high-resolution observations of the polar magnetic fields observed by Hinode are used to directly constrain the simulation. Our simulation reproduces the observed properties of the polar magnetic fields, suggesting the existence of a counter-cell meridional flow in the solar polar caps with a maximum amplitude of about 3 m s ^−1 .

As a relatively active region, the ephemeral region (ER) exhibits a highly complex pattern of magnetic flux emergence. We aim to study in detail the secondary flux emergences (SFEs), which we define as bipoles that appear close to ERs and finally coalesce with ERs after a period of time. We study SFEs during the whole process, from the emergence to the decay of five ERs observed by the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory. The maximum unsigned magnetic flux for each ER is around 10 ^20 Mx. Each ER has tens of SFEs with an average emerging magnetic flux of approximately 5 × 10 ^18 Mx. The frequency of normalized magnetic flux for all the SFEs follows a power-law distribution with an index of −2.08. The majority of SFEs occur between the positive and negative polarities of an ER, and their growth time is concentrated within 1 hr. The magnetic axis of SFE is found to exhibit a random distribution in the five ERs. We suggest that the relationship between SFEs and ERs can be understood by regarding the photospheric magnetic field observations as cross sections of an emerging magnetic structure. Tracking the evolution of ERs, we propose that these SFEs in ERs may have emerged consequentially from the bundle of flux tubes of ERs and that SFEs are partially emerged Ω-loops.

Diagnosing the spatiotemporal pattern of magnetic flux on the Sun is vital for understanding the origin of solar magnetism and activity. Here, we report a new form of flux appearance, magnetic outbreak, using observations with an extremely high spatial resolution of 0.″16 from the 1.6 m Goode Solar Telescope at the Big Bear Solar Observatory. Magnetic outbreak refers to an early growth of unipolar magnetic flux and its later explosion into fragments, in association with plasma upflow and exploding granulations; each individual fragment has flux of 10 ^16 –10 ^17 Mx, moving apart with a velocity of 0.5–2.2 km s ^−1 . The magnetic outbreak takes place in the hecto-Gauss region of pore moats. In this study, we identify six events of magnetic outbreak during 6 hr observations over an approximately 40″ × 40″ field of view. The newly discovered magnetic outbreak might be the first evidence of the long-anticipated convective blowup.

Fairness-related decision making is an important issue in the field of decision making. Traditional theories emphasize the roles of inequity aversion and reciprocity, whereas recent research increasingly shows that emotion plays a critical role in this type of decision making. In this review, we summarize the influences of three types of emotions (i.e., the integral emotion experienced at the time of decision making, the incidental emotion aroused by a task-unrelated dispositional or situational source, and the interaction of emotion and cognition) on fairness-related decision making. Specifically, we first introduce three dominant theories that describe how emotion may influence fairness-related decision making (i.e., the wounded pride/spite model, affect infusion model, and dual-process model). Next, we collect behavioral and neural evidence for and against these theories. Finally, we propose that future research on fairness-related decision making should focus on inducing incidental social emotion, avoiding irrelevant emotion when regulating, exploring the individual differences in emotional dispositions, and strengthening the ecological validity of the paradigm.

Hyperandrogenism is a core factor in the series of reproductive and endocrine metabolic disorders involved in polycystic ovary syndrome (PCOS). Abnormalities in enzymatic activity and the expression of ovarian granular cell layer P450arom and theca cell P450c17α can lead to an atypical environment of local ovarian hormones, including excessive androgen levels. Rat models prepared with letrozole exhibit similar endocrine and histological changes to those that occur in human PCOS. We used such a model to study the role of electro-acupuncture (EA) in regulating ovarian P450arom and P450c17α enzymatic activity and mRNA expression in PCOS rats. Female Sprague Dawley (SD) rats aged 42 days were randomly divided into 3 groups (control, PCOS, and PCOS EA) consisting of 10 rats each. The PCOS and PCOS EA groups were administered a gavage of 1.0 mg/kg(-1) of letrozole solution once daily for 21 consecutive days. Beginning in the ninth week, the PCOS EA group was administered low-frequency EA treatment daily for 14 consecutive days. After the treatment, we obtained the following results. The estrous cycles were restored in 8 of the 10 rats in the PCOS EA group, and their ovarian morphologies and ultrastructures normalized. The peripheral blood measurements (with ELISA) showed significantly decreased androgens (i.e., androstenedione and testosterone) with significantly increased estrogens (i.e., estrone, estradiol) and increased P450arom with decreased P450C17α. Immunohistochemistry and Western blotting methods showed enhanced expression of ovarian granular cell layer P450arom as well as decreased expression of theca cell layer P450C17α. Fluorescence quantitative PCR methods showed enhanced expression of ovarian granular cell layer P450arom mRNA as well as decreased expression of theca cell layer P450C17α mRNA. These results may help explain the effects of electro-acupuncture in changing the local ovarian hyperandrogenic environment and improving reproductive and endocrine metabolic disorders in PCOS.

Bone-targeted polymeric nanoparticles for alendronate delivery based on Poly (lactic-co-glycolic acid) conjugated chitosan (CS-PLGA) and alendronate conjugated PLGA (Alen-PLGA) are fabricated and their superior performances are evaluated. The nanoparticles exhibited sustained Alen release without obvious burst release and good cytocompatibility against MC3T3 cells. Alen-modified nanoparticles demonstrated a high affinity to hydroxyapatite, which is the main mineral component of bone, indicating their feasibility for bone-targeted delivery. In addition, unlike nanoparticles without Alen, Alen-modified nanoparticles were preferentially taken up by MC3T3 cells, compared to HDF cells, revealing their specific uptake for osteoblast-like cells. Thus, the Alen-modified nanoparticles can potentially be developed as bone-targeted carriers for osteoporosis treatment.

Background Placebo and sham acupuncture are common control strategies in acupuncture studies. However, the perception and practice of these approaches in acupuncturists are poorly documented. Objective To investigate knowledge of, attitude towards and practice of sham and/or placebo acupuncture among Chinese acupuncturists. Method A cross-sectional survey conducted in six different tertiary care hospitals of traditional Chinese medicine in Beijing, China. A total of 92 licensed acupuncturists were asked to complete a predesigned and structured questionnaire on-site. Results A response rate of 92.4% (n=85) was achieved. Almost all participants (99%, n=84) had moderate knowledge about sham and/or placebo acupuncture, but only a minority (27%, n=23) reported an excellent understanding. The general attitude towards sham and/or placebo acupuncture was positive. Most respondents (99%, n=84) thought such controls were necessary and the majority (81%, n=69) believed they were feasible in acupuncture research. More than two-thirds of participants (71%, n=60) had applied sham and/or placebo acupuncture, but only a few (8%, 5/60) used it as the most common control strategy in clinical trials. Conclusions The result of our survey suggests that Chinese acupuncturists have a moderate knowledge of, and a positive attitude towards, sham and/or placebo acupuncture. Research into sham and/or placebo acupuncture is limited in comparison with other control strategies. Therefore, an in-service education programme for acupuncturists and standardisation of sham and/or placebo acupuncture need to be developed. [ABSTRACT FROM AUTHOR]

Photospheric bright points (PBPs) and chromospheric bright points (CBPs) reflect the cross sections of magnetic flux tubes at different heights of the lower solar atmosphere. We aim to study the fine 3D structures and transportation dynamics of the magnetic flux tubes using G-band and simultaneous Ca ii H image-series from the Solar Optical Telescope (SOT) on board Hinode. A 3D track-while-detect method is proposed to detect and track PBPs and CBPs. The mean values of equivalent diameters, maximum intensity contrasts, transverse velocities, motion ranges, motion types, and diffusion indices of PBPs and CBPs are 180 ± 20 and 210 ± 30 km, and , 1.6 ± 0.8 and 2.7 ± 1.4 km s−1, 1.5 ± 0.6 and 1.7 ± 0.8, 0.8 ± 0.2 and 0.6 ± 0.2, and 1.7 ± 0.7 and 1.3 ± 0.7, respectively. Moreover, the ratios of each CBP characteristics to its corresponding PBP are derived to explore the change rates of the flux tubes. The corresponding ratios are 1.2 ± 0.2, 1.2 ± 0.1, 1.9 ± 0.1, 1.4 ± 0.3, 0.7 ± 0.2, and 0.9 ± 0.4, respectively. The statistical results imply that the majority magnetic flux tubes expand slightly with increasing solar height, look brighter than their surroundings, show a higher transverse velocity, a wider motion range, and a more erratic path, but the majority of the flux tubes diffuse slightly slower. The phenomenon might be explained by the conservation of momentum combined with a decrease in density. The more erratic path leads to a swing or twist of the flux tubes and therefore guides magnetohydrodynamic waves. [ABSTRACT FROM AUTHOR]

The solar inter-network magnetic field is the weakest component of solar magnetism, but it contributes most of the solar surface magnetic flux. The study of its origin has been constrained by the inadequate tempospatial resolution and sensitivity of polarization observations. With dramatic advances in spatial resolution and detecting sensitivity, the solar spectropolarimetry provided by the Solar Optical Telescope on board Hinode in an interval from the solar minimum to maximum of cycle 24 opens an unprecedented opportunity to study the cyclic behavior of the solar inter-network magnetic field. More than 1000 Hinode magnetograms observed from 2007 January to 2014 August are selected in the study. It has been found that there is a very slight correlation between sunspot number and magnetic field at the inter-network flux spectrum. From solar minimum to maximum of cycle 24, the flux density of the solar inter-network field is invariant, at 10 ± 1 G. The observations suggest that the inter-network magnetic field does not arise from flux diffusion or flux recycling of solar active regions, thereby indicating the existence of a local small-scale dynamo. Combining the full-disk magnetograms observed by the Solar and Heliospheric Observatory/Michelson Doppler Imager and the Solar Dynamics Observatory/Helioseismic and Magnetic Imager in the same period, we find that the area ratio of the inter-network region to the full disk of the Sun apparently decreases from solar minimum to maximum but always exceeds 60%, even in the phase of solar maximum. [ABSTRACT FROM AUTHOR]

Purpose: To examine the effectiveness of combination therapy of electroacupuncture and tolterodine in treating female patients with mixed urinary incontinence., Materials and Methods: Seventy-one women with mixed urinary incontinence were recruited to receive electroacupuncture therapy or combination therapy with electroacupuncture and tolterodine 2 mg orally twice a day for 8 weeks. In electroacupuncture therapy, the acupoints, including BL32 (Ci Liao), BL35 (Hui Yang), SP6 (San Yin Jiao), and ST36 (Zu San Li), were selected with the stimulation of a low-frequency (20 Hz) disperse-dense wave. The International Consultation on Incontinence Questionnaire score, the number of incontinence episodes, and urine leakage were measured before and after the treatment to evaluate the effect., Results: Response rates were 73.5% and 78.4% in electroacupuncture therapy group and in the combination therapy group respectively. No significant differences were found when group outcomes were compared. The International Consultation on Incontinence Questionnaire score, the number of incontinence episodes, and urine leakage improved significantly (P < .001) after 8 weeks compared with baseline values in both groups. Significantly more patients in the combination therapy group experienced more than 50% reduction in the number of incontinent episodes than in the electroacupuncture group (75.7% vs 58.8%, P < .01). They also had significantly less urine leakage than those in electroacupuncture therapy group (11.2 ± 7.6 g vs 15 ± 9.1 g) (P < .05)., Conclusions: The effect of electroacupuncture for female mixed urinary incontinence may be enhanced by tolterodine.