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With the development of information technology, the application of a new generation of information technologies, such as big data, Internet Plus, and artificial intelligence, in the sports field is an emerging, novel trend. This paper examined the relevant research results and literature on physical education, computer science, pedagogy, management, and other disciplines, then used a self-made questionnaire to investigate the physical health status of Chinese college students. The big data were subsequently analyzed, which provided a scientific basis for the construction of an intelligent governance system for college students' physical health. Intelligent devices may be used to obtain big data resources, master the physical sports development and psychological status of college students, and push personalized sports prescriptions to solve the problems existing in college students' physical health. Research shows that there are four reasons for the continuous decline in Chinese college students' physical health levels. These are students' lack of positive exercise consciousness and healthy sports values (85.43%), a weak family sports concept and lack of physical exercise habits (62.76%), poor implementation of school sports policies (55.35%), and people's distorted sports value orientation (42.27%). Through the connecting effect of data, we can bring together the positive role of the government, school, society, family, and students so as to create an interlinked impact to promote students' physical health. The problems of insufficient platform utilization, lack of teaching resources, lagging research, and insufficient combination with big data in the intelligent governance of physical health of Chinese college students can be solved by building an intelligent governance system of physical health. Such a system would be composed of school infrastructure, data resources and technology processing, and intelligent service applications. Among these, school infrastructure refers to the material foundation and technical support. The material foundation includes perceptions, storage, computing, networks, and other equipment, and the technical support includes cloud computing, mobile Internet, the Internet of Things, artificial intelligence, and deep learning. Data resources refer to smart data, such as stadium data, physical health management data, and students' sports behavior data, which are mined from data resources such as students' physical development, physical health, and sports through big data technology and intelligent wearable devices. Intelligent managers provide efficient, intelligent, accurate, and personalized intelligent sports services for college students through data resource value mining, venue space-time optimization, health knowledge discovery, sports prescription pushes, etc. Finally, we put forward the development strategy for further deepening and improving the big data-driven intelligent governance system for college students' physical health. The intelligent governance system of physical health driven by big data and its development strategy can not only accurately guide and improve the physical health level of college students but also realize integrated teaching inside and outside physical education classes.

ObjectiveThis study aimed to analyze the influence of cheerleading on female college students’ physical self-esteem and mental health.Materials and MethodsIn total, 63 female college students from the University of Electronic Science and Technology of China were trained in cheerleading for 16 weeks. The scores of each sub-field of physical self-esteem and psychological symptoms were analyzed by using Physical Self-Perception Profile (PSPP) and Symptom Checklist 90 (SCL-90), respectively, at 0 and 16 weeks of the experiment.ResultsAfter 16 weeks of cheerleading exercise, female college students had significant differences in physical attractiveness (T = 4.18), physical quality (T = 4.39), and physical self-worth (T = 3.35) before and after the experiment (P < 0.01). There were significant differences in physical condition (T = 3.87) and athletic ability (T = 2.88) before and after the experiment (P < 0.05). Somatization (T = 6.485), obsessive-compulsive symptoms (T = 11.716), interpersonal sensitivity (T = 10.077), depression (T = 8.403), anxiety (T = 10.767), hostility (T = 10.866), terror (T = 9.260), paranoia (T = 10.414), psychosis (T = 9.610), sleep and eating disorders (T = 9.323), total symptom index (T = 13.245), and mean score of positive symptoms (T = 12.237) were significantly different (P < 0.01).ConclusionCheerleading can significantly improve the level of female college students’ physical self-esteem, especially the self-esteem level of physical attractiveness, physical quality, and physical self-worth. They also experienced significant improvement in their psychological disorders, especially somatization, depression, and sleep and eating disorders, which effectively improved their overall mental health.

Hypertrophic scar (HS) formation is a common complication that develops after skin injury; however, there are few effective and specific therapeutic approaches for HS. Emodin has previously been reported to inhibit mechanical stress-induced HS inflammation. Here, we investigated the molecular mechanisms underlying the inhibitory effects of emodin on HS formation. First, we conducted in vitro assays that revealed that emodin inhibited M1 and M2 polarization in rat macrophages. We subsequently established a combined rat model of tail HS and dorsal subcutaneous polyvinyl alcohol (PVA) sponge-induced wounds. Rats were treated with emodin or vehicle (DMEM). Tail scar specimens were harvested at 14, 28, and 42 days post-incision and subjected to H&E staining and Masson's trichrome staining. Histopathological analyses confirmed that emodin attenuated HS formation and fibrosis. Macrophages were separated from wound cells collected from the PVA sponge at 3 and 7 days after implantation. Flow cytometry analysis demonstrated that emodin suppressed in vivo macrophage recruitment and polarization at the wound site. Finally, we explored the molecular mechanisms of emodin in modulating macrophage polarization by evaluating the expression levels of selected effectors of the Notch and TGF-β pathways in macrophages isolated from PVA sponges. Western blot and qPCR assays showed that Notch1, Notch4, Hes1, TGF-β, and Smad3 were downregulated in response to emodin treatment. Taken together, our findings suggested that emodin attenuated HS formation and fibrosis by suppressing macrophage polarization, which is associated with the inhibition of the Notch and TGF-β pathways in macrophages.

The hosting of large-scale sports events not only brings significant economic benefits and cultural influence to cities and countries, promotes the construction and sustainable development of urban ecological environment, but also brings certain risks to the urban ecological environment. However, research on the issue of risk is still relatively inadequate. This paper uses the method of literature research and empirical analysis, through consulting relevant literature and data, analyzes the relationship between large-scale sports events and urban ecological environment and the risks brought by the urban ecological environment, and puts forward the corresponding preventive measures. It is found that the relationship between large-scale sports events and urban ecological environment is very important, and the two influence and promote each other. However, the hosting of largescale sports events may lead to problems such as water pollution, soil pollution, noise pollution and air pollution, and also consume a lot of resources and energy. In order to reduce the risk brought by large-scale sports events to the urban ecological environment, we should take measures such as comprehensive management, scientific planning, supervision and management, so as to protect the urban ecological environment and promote its sustainable development. Finally, taking the 2008 Beijing Olympic Games as an example, this paper analyzes the scientific practice of promoting urban ecological environment protection by large-scale sports events. The purpose of this study is to provide reference for preventing the risk brought by large-scale sports events to urban ecological environment, and also provide important theoretical and practical significance for the sustainable development of large-scale sports events. [ABSTRACT FROM AUTHOR]

Human adipose tissue stem cells (ATSCs) can differentiate into various types of cell in response to lineage-specific induction factors. Reprogramming cells using nuclear and cytoplasmic extracts derived from another type of somatic cell is an effective method of producing specific types of differentiated cell. In the present study, the ability of reprogrammed ATSCs to acquire epidermal keratinocyte properties following transient exposure to epidermal keratinocyte extracts was demonstrated. Reversibly permeabilized ATSCs were incubated for 1 h in nuclear and cytoplasmic extracts from epidermal keratinocytes, resealed with CaCl2 and cultured. ATSC reprogramming is demonstrated by nuclear uptake of epidermal keratinocyte extracts. After one week of exposure to extracts, ATSCs underwent changes in cell morphology, cell-specific genes were activated, and epidermal keratinocyte markers including K19 and K1/K10 (markers of stem cells and terminally differentiated keratinocytes, respectively) were expressed. This study indicates that the reprogramming of ATSCs using nuclear and cytoplasmic extracts from epidermal keratinocytes is a viable option for the production of specific types of cell. [ABSTRACT FROM AUTHOR]

Radiation therapy is the most widely used and effective treatment for orbital tumors, but it causes dry eye due to lacrimal gland damage. Induced pluripotent stem cell-derived conditioned medium (iPSC-CM) has been shown to rescue different types of tissue damage. The present study investigated the mechanism of the potential radioprotective effect of IPS cell-derived conditioned medium (iPSC-CM) on gamma-irradiation-induced lacrimal gland injury (RILI) in experimental mice. In this study, we found that iPSC-CM ameliorated RILI. iPSC-CM markedly decreased radiotherapy induced inflammatory processes, predominantly through suppressing p38/JNK signaling. Further signaling pathway analyses indicated that iPSC-CM could suppress Akt (Protein Kinase B, PKB) phosphorylation. High levels of midkine (MDK) were also found in iPSC-CM and could be involved in lacrimal gland regeneration by promoting cell migration and proliferation. Thus, our study indicates that inhibiting the p38/JNK pathway or increasing the MDK level might be a therapeutic target for radiation-induced lacrimal gland injury. [ABSTRACT FROM AUTHOR]

Aims: Innate immune and inflammatory responses are involved in myocardial ischaemia/reperfusion (I/R) injury. The interleukin-1 receptor (IL-1R)-mediated, MyD88-dependent nuclear factor kappa B (NF-κB) activation pathway plays an important role in the induction of innate immunity and inflammation. However, the role of the IL-1R–MyD88 pathway in myocardial I/R injury has not been thoroughly investigated. We hypothesized that inhibition of the interaction of IL-1R with MyD88 will attenuate myocardial ischaemic injury through reducing inflammatory responses. [ABSTRACT FROM PUBLISHER]