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The asymmetric unit of the title compound, C14H14F4N2O4·H2O, contains two crystallographically independent organic molecules and two water molecules. The two 1,3-diazinane rings adopt a half-chair conformation and the dihedral angles between their mean planes and those of the benzene rings are 75.65 (4)° and 49.41 (3)° in the two molecules. The crystal structure is stabilized by intermolecular O—H...O and N—H...O hydrogen bonds.

In the title compound, C16H17N3S, the aminothiourea unit is nearly planar (r.m.s. deviation = 0.0425 Å), and is twisted with respect to the tolyl and phenyl rings by 57.84 (7) and 15.88 (14)°, respectively; the tolyl and phenyl rings are twisted by 65.64 (11)° to each other. Intermolecular N—H...S and weak C—H...S hydrogen bonds are present in the crystal structure.

In the title compound, C14H15F3N2O5, prepared by reaction of 2-hydroxybenzaldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and urea, the tetrapyrimidine ring adopts a half-chair conformation. The crystal structure is stabilized by five intermolecular hydrogen bonds, three O—H...O and two N—H...O, giving cyclic dimers (through three hydrogen bonds) which are further extended into a two-dimensional network.

The title compound, C16H20F3N3O4, was prepared by reaction of 4-(dimethylamino)benzaldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and urea. In the title molecule, the pyrimidine ring adopts a half-chair conformation and there is an intramolecular hydrogen bond (O—H...O). The crystal structure is stabilized by two types intermolecular hydrogen bonds (N—H...O and N—H...N).