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Your search keyword '"Cardinale, Francesco"' showing total 324 results
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324 results on '"Cardinale, Francesco"'

4. Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry

Author

Drexler, Richard, Ben-Haim, Sharona, Bien, Christian G, Borger, Valeri, Cardinale, Francesco, Carpentier, Alexandre, Cendes, Fernando, Chandra, Sarat, Clusmann, Hans, Colon, Albert, de Curtis, Marco, Delev, Daniel, Didato, Giuseppe, Dührsen, Lasse, Farah, Jibril Osman, Guenot, Marc, Ghatan, Saadi, Haegelen, Claire, Hamer, Hajo, Hauptmann, Jason S, Jeffree, Rosalind L, Kalbhenn, Thilo, Kegele, Josua, Krayenbühl, Niklaus, Lang, Johannes, Mathon, Bertrand, Naros, Georgios, Onken, Julia, Panov, Fedor, Raftopoulos, Christian, Ricklefs, Franz L, Rijkers, Kim, Rizzi, Michele, Rössler, Karl, Schijns, Olaf, Schneider, Ulf C, Spyrantis, Andrea, Strzelczyk, Adam, Stodieck, Stefan, Tripathi, Manjari, Vadera, Sumeet, Alonso-Vanegas, Mario A, Vaz, José Géraldo Ribero, Wellmer, Jörg, Wehner, Tim, Westphal, Manfred, and Sauvigny, Thomas

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Brain Disorders, Epilepsy, Neurosciences, Clinical Research, Neurodegenerative, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.4 Surgery, epilepsy, epilepsy surgery, temporal lobe epilepsy, outcome, benchmark, seizure outcome, amygdalohippocampectomy, anteromedial resection, Psychology, Clinical sciences, Biological psychology
Abstract

Introduction: Optimizing patient safety and quality improvement is increasingly important in surgery. Benchmarks and clinical quality registries are being developed to assess the best achievable results for several surgical procedures and reduce unwarranted variation between different centers. However, there is no clinical database from international centers for establishing standardized reference values of patients undergoing surgery for mesial temporal lobe epilepsy. Design: The Enhancing Safety in Epilepsy Surgery (EASINESS) study is a retrospectively conducted, multicenter, open registry. All patients undergoing mesial temporal lobe epilepsy surgery in participating centers between January 2015 and December 2019 are included in this study. The patient characteristics, preoperative diagnostic tools, surgical data, postoperative complications, and long-term seizure outcomes are recorded. Outcomes: The collected data will be used for establishing standardized reference values ("benchmarks") for this type of surgical procedure. The primary endpoints include seizure outcomes according to the International League Against Epilepsy (ILAE) classification and defined postoperative complications. Discussion: The EASINESS will define robust and standardized outcome references after amygdalohippocampectomy for temporal lobe epilepsy. After the successful definition of benchmarks from an international cohort of renowned centers, these data will serve as reference values for the evaluation of novel surgical techniques and comparisons among centers for future clinical trials. Clinical trial registration: This study is indexed at clinicaltrials.gov (NT 04952298).

Published
2021

6. Predictors of hyperkinetic seizures

Author

Menghi, Veronica, Bisulli, Francesca, Cardinale, Francesco, Vignatelli, Luca, Zenesini, Corrado, Mai, Roberto, Proserpio, Paola, Francione, Stefano, Sartori, Ivana, Tinuper, Paolo, and Nobili, Lino

Published
2022
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9. Cortical Connectivity Response to Hyperventilation in Focal Epilepsy: A Stereo-EEG Study.

Author

Ferri, Lorenzo, Mason, Federico, Di Vito, Lidia, Pasini, Elena, Michelucci, Roberto, Cardinale, Francesco, Mai, Roberto, Alvisi, Lara, Zanuttini, Luca, Martinoni, Matteo, and Bisulli, Francesca

Subjects
PARTIAL epilepsy, NON-REM sleep, EPILEPTIFORM discharges, SEIZURES (Medicine), PEOPLE with epilepsy
Abstract

Hyperventilation (HV) is an activation technique performed during clinical practices to trigger epileptiform activities, supporting the neurophysiological evaluation of patients with epilepsy. Although the role of HV has often been questioned, especially in the case of focal epilepsy, no studies have ever assessed how cortical structures respond to such a maneuver via intracranial EEG recordings. This work aims to fill this gap by evaluating the HV effects on the Stereo-EEG (SEEG) signals from a cohort of 10 patients with drug-resistant focal epilepsy. We extracted multiple quantitative metrics from the SEEG signals and compared the results obtained during HV, awake status, non-REM sleep, and seizure onset. Our findings show that the cortical connectivity, estimated via the phase transfer entropy (PTE) algorithm, strongly increases during the HV maneuver, similar to non-REM sleep. The opposite effect is observed during seizure onset, as ictal transitions involve the desynchronization of the brain structures within the epileptogenic zone. We conclude that HV promotes a conductive environment that may facilitate the propagation of epileptiform activities but is not sufficient to trigger seizures in focal epilepsy. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Unruptured Versus Ruptured AVMs: Outcome Analysis from a Multicentric Consecutive Series of 545 Surgically Treated Cases

Author

Cenzato, Marco, Tartara, Fulvio, D'Aliberti, Giuseppe, Bortolotti, Carlo, Cardinale, Francesco, Ligarotti, Gianfranco, Debernardi, Alberto, Fratianni, Alessia, Boccardi, Edoardo, Stefini, Roberto, Zenga, Francesco, Boccaletti, Riccardo, Lanterna, Andrea, Pavesi, Giacomo, Ferroli, Paolo, Sturiale, Carmelo, Ducati, Alessandro, Cardia, Andrea, Piparo, Maurizio, Valvassori, Luca, and Piano, Mariangela

Published
2018
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16. Increasing volume and complexity of pediatric epilepsy surgery with stable seizure outcome between 2008 and 2014: A nationwide multicenter study

Author

Barba, Carmen, Specchio, Nicola, Guerrini, Renzo, Tassi, Laura, De Masi, Salvatore, Cardinale, Francesco, Pellacani, Simona, De Palma, Luca, Battaglia, Domenica, Tamburrini, Gianpiero, Didato, Giuseppe, Freri, Elena, Consales, Alessandro, Nozza, Paolo, Zamponi, Nelia, Cesaroni, Elisabetta, Di Gennaro, Giancarlo, Esposito, Vincenzo, Giulioni, Marco, Tinuper, Paolo, Colicchio, Gabriella, Rocchi, Raffaele, Rubboli, Guido, Giordano, Flavio, Lo Russo, Giorgio, Marras, Carlo Efisio, and Cossu, Massimo

Published
2017
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21. Neurological morbidity of surgery for suprasylvian operculoinsular epilepsy.

Author

d'Orio, Piergiorgio, Squarza, Silvia, Revay, Martina, Cardinale, Francesco, Castana, Laura, Sartori, Ivana, Tassi, Laura, Lo Russo, Giorgio, and Cossu, Massimo

Abstract

Objective: The objective of this study was to identify risk factors associated with surgery‐related neurological morbidity in patients with drug‐resistant epilepsy undergoing suprasylvian operculoinsular resections. As secondary outcomes, we also analyzed the risk factors for ischemic lesion (IL) of corona radiata and seizure recurrence. Methods: A retrospective analysis was conducted on a cohort of patients who underwent suprasylvian operculoinsular resections for drug‐resistant epilepsy. The association of several presurgical, surgical, and postsurgical factors with both primary (persistent neurological deficits) and secondary (structural abnormalities on postoperative magnetic resonance imaging [MRI] and seizure recurrence) postoperative outcomes was investigated with univariate and multivariate statistical analysis. Results: The study included a total of 65 patients; 46.2% of patients exhibited postoperative neurological deficits, but only 12.3% experienced persistent deficits. On postoperative MRI, IL in the corona radiata and corticospinal tract Wallerian degeneration (CSTWd) were seen in 68% and 29% of cases, respectively. Only CSTWd was significantly associated with persistent neurological deficits (relative risk [RR] = 2.6). Combined operculoinsular resection (RR = 3.62) and surgery performed on the left hemisphere (RR =.37) were independently associated with IL in the corona radiata. Variables independently associated with CSTWd were the presence of malacic components in the IL (RR = 1.96), right central operculum resection (RR = 1.79), and increasing age at surgery (RR = 1.03). Sixty‐two patients had a postoperative follow‐up > 12 months (median = 56, interquartile range = 30.75–73.5), and 62.9% were in Engel class I at last outpatient control. The risk of seizure recurrence was reduced by selective opercular resection (RR =.25) and increased by the histological diagnosis of aspecific gliosis (RR = 1.39). Significance: This study provides insights into the risk factors associated with surgery‐related neurological morbidity, as well as further evidence on the postoperative occurrence of subcortical injury and seizure recurrence in epileptic patients undergoing suprasylvian operculoinsular resections. The findings highlighted in this study may be useful to better understand the processes supporting the increased surgical risk in the operculoinsular region. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Language lateralization mapping (reversibly) masked by non-dominant focal epilepsy: a case report.

Author

Abarrategui, Belén, Mariani, Valeria, Rizzi, Michele, Berta, Luca, Scarpa, Pina, Zauli, Flavia Maria, Squarza, Silvia, Banfi, Paola, d'Orio, Piergiorgio, Cardinale, Francesco, Del Vecchio, Maria, Caruana, Fausto, Avanzini, Pietro, and Sartori, Ivana

Subjects
PARTIAL epilepsy, FOCAL cortical dysplasia, DYSPLASIA, TEMPORAL lobe, CEREBRAL dominance, NEUROANATOMY, FUNCTIONAL magnetic resonance imaging, NEUROLINGUISTICS, EPILEPTIFORM discharges
Abstract

Language lateralization in patients with focal epilepsy frequently diverges from the left-lateralized pattern that prevails in healthy right-handed people, but the mechanistic explanations are still a matter of debate. Here, we debate the complex interaction between focal epilepsy, language lateralization, and functional neuroimaging techniques by introducing the case of a right-handed patient with unaware focal seizures preceded by aphasia, in whom video-EEG and PET examination suggested the presence of focal cortical dysplasia in the right superior temporal gyrus, despite a normal structural MRI. The functional MRI for language was inconclusive, and the neuropsychological evaluation showed mild deficits in language functions. A bilateral stereo-EEG was proposed confirming the right superior temporal gyrus origin of seizures, revealing how ictal aphasia emerged only once seizures propagated to the left superior temporal gyrus and confirming, by cortical mapping, the left lateralization of the posterior language region. Stereo-EEG-guided radiofrequency thermocoagulations of the (right) focal cortical dysplasia not only reduced seizure frequency but led to the normalization of the neuropsychological assessment and the "restoring" of a classical left-lateralized functional MRI pattern of language. This representative case demonstrates that epileptiform activity in the superior temporal gyrus can interfere with the functioning of the contralateral homologous cortex and its associated network. In the case of presurgical evaluation in patients with epilepsy, this interference effect must be carefully taken into consideration. The multimodal language lateralization assessment reported for this patient further suggests the sensitivity of different explorations to this interference effect. Finally, the neuropsychological and functional MRI changes after thermocoagulations provide unique cues on the network pathophysiology of focal cortical dysplasia and the role of diverse techniques in indexing language lateralization in complex scenarios. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Epilepsy surgery of “low grade epilepsy associated neuroepithelial tumors”: A retrospective nationwide Italian study

Author

Giulioni, Marco, Marucci, Gianluca, Pelliccia, Veronica, Gozzo, Francesca, Barba, Carmen, Didato, Giuseppe, Villani, Flavio, Di Gennaro, Giancarlo, Quarato, Pier Paolo, Esposito, Vincenzo, Consales, Alessandro, Martinoni, Matteo, Vornetti, Gianfranco, Zenesini, Corrado, Efisio Marras, Carlo, Specchio, Nicola, De Palma, Luca, Rocchi, Raffaele, Giordano, Flavio, Tringali, Giovanni, Nozza, Paolo, Colicchio, Gabriella, Rubboli, Guido, Lo Russo, Giorgio, Guerrini, Renzo, Tinuper, Paolo, Cardinale, Francesco, and Cossu, Massimo

Published
2017
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