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222 results on '"Caprnda, Martin"'

3. Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort

Author

Skerenova, Maria, Cibulka, Michal, Dankova, Zuzana, Holubekova, Veronika, Kolkova, Zuzana, Lucansky, Vincent, Dvorska, Dana, Kapinova, Andrea, Krivosova, Michaela, Petras, Martin, Baranovicova, Eva, Baranova, Ivana, Novakova, Elena, Liptak, Peter, Banovcin, Peter, Bobcakova, Anna, Rosolanka, Robert, Janickova, Maria, Stanclova, Andrea, Gaspar, Ludovit, Caprnda, Martin, Prosecky, Robert, Labudova, Monika, Gabbasov, Zufar, Rodrigo, Luis, Kruzliak, Peter, Lasabova, Zora, Matakova, Tatiana, and Halasova, Erika

Published
2024
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8. Flavonoids against the SARS-CoV-2 induced inflammatory storm

Author

Liskova, Alena, Samec, Marek, Koklesova, Lenka, Samuel, Samson M., Zhai, Kevin, Al-Ishaq, Raghad Khalid, Abotaleb, Mariam, Nosal, Vladimir, Kajo, Karol, Ashrafizadeh, Milad, Zarrabi, Ali, Brockmueller, Aranka, Shakibaei, Mehdi, Sabaka, Peter, Mozos, Ioana, Ullrich, David, Prosecky, Robert, La Rocca, Giampiero, Caprnda, Martin, Büsselberg, Dietrich, Rodrigo, Luis, Kruzliak, Peter, and Kubatka, Peter

Published
2021
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11. Implications of flavonoids as potential modulators of cancer neovascularity

Author

Liskova, Alena, Koklesova, Lenka, Samec, Marek, Varghese, Elizabeth, Abotaleb, Mariam, Samuel, Samson Mathews, Smejkal, Karel, Biringer, Kamil, Petras, Martin, Blahutova, Dana, Bugos, Ondrej, Pec, Martin, Adamkov, Marian, Büsselberg, Dietrich, Ciccocioppo, Rachele, Adamek, Mariusz, Rodrigo, Luis, Caprnda, Martin, Kruzliak, Peter, and Kubatka, Peter

Published
2020
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14. The effect of Betanin parenteral pretreatment on Jejunal and pulmonary tissue histological architecture and inflammatory response after Jejunal ischemia-reperfusion injury

Author

Toth, Stefan, Jonecova, Zuzana, Maretta, Milan, Curgali, Kristina, Kalpakidis, Theodoros, Pribula, Martin, Kusnier, Matus, Fagova, Zuzana, Fedotova, Julia, La Rocca, Giampiero, Rodrigo, Luis, Caprnda, Martin, Zulli, Anthony, Ciccocioppo, Rachele, Mechirova, Eva, and Kruzliak, Peter

Published
2019
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19. Adipokines in neurovascular diseases

Author

Opatrilova, Radka, Caprnda, Martin, Kubatka, Peter, Valentova, Vanda, Uramova, Sona, Nosal, Vladimir, Gaspar, Ludovit, Zachar, Lukas, Mozos, Ioana, Petrovic, Daniel, Dragasek, Jozef, Filipova, Slavomira, Büsselberg, Dietrich, Zulli, Anthony, Rodrigo, Luis, Kruzliak, Peter, and Krasnik, Vladimir

Published
2018
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23. Latest Updates on Lipid Management

Author

Egom, Emmanuel Eroume-A., Pharithi, Rebabonye B., Hesse, Soressa, Starr, Neasa, Armstrong, Richard, Sulaiman, Habitha Mohammed, Gazdikova, Katarina, Mozos, Ioana, Caprnda, Martin, Kubatka, Peter, Kruzliak, Peter, Khan, Barkat, Gaspar, Ludovit, and Maher, Vincent M. G.

Published
2019
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30. Understanding Loss to Follow-Up in AMD Patients Receiving VEGF Inhibitor Therapy: Associated Factors and Underlying Reasons.

Author

Kusenda, Pavol, Caprnda, Martin, Gabrielova, Zuzana, Kukova, Natalia, Pavlovic, Samuel, and Stefanickova, Jana

Subjects
*VASCULAR endothelial growth factor antagonists, *MACULAR degeneration, *LOGISTIC regression analysis, *PATIENT compliance, *AGE groups
Abstract

Background: In patients with wet age-related macular degeneration (AMD), loss to follow-up (LTFU) leads to unplanned interruptions in therapy and the risk of visual loss. Methods: This retrospective and prospective case–control cohort study compared AMD patients with (LTFU YES) and without (LTFU NO) LTFU during anti-VEGF treatment over 12 years. LTFU was defined as missing any treatment or monitoring visits, or not scheduling follow-ups for six months. Results: Significant differences between LTFU NO (n = 298) and LTFU YES (n = 174) groups were age, treatment phase, baseline and final best-corrected visual acuity (BCVA), type of anti-VEGF drug, treatment switch, commuting distance, and escort during commuting. A multivariate logistic regression analysis identified the need for an escort during the commuting and treatment phase as the only significant difference. The four most common reasons for LTFU were general health worsening (21.8%), patient-missed appointments (16.7%), COVID-19-related issues (14.9%), and treatment dissatisfaction (8.6%). Conclusions: The factors associated with increased LTFU rates were older age, inactive treatment phase, lower baseline and final BCVA, bevacizumab treatment, monotherapy, longer travelling distance, and commuting with an escort. According to the multivariate logistic regression analysis, only the escort during the commuting and treatment phases was significant. These findings could direct research to explore social support in treatment adherence and highlight the importance of treatment phases in practice. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection.

Author

Novotny, Tomas, Staffa, Robert, Tomandl, Josef, Krivka, Tomas, Kruzliak, Peter, Tomandlova, Marie, Slaby, Ondrej, Sponiar, Jan, Caprnda, Martin, Gaspar, Ludovit, Rodrigo, Luis, Mozos, Ioana, Kubicek, Lubos, Biros, Ernest, Vlachovsky, Robert, Radova, Lenka, and Konieczna, Anna

Abstract

Objective: The purpose of our study was to describe perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery, to compare the kinetics in the open abdominal aortic aneurysm (AAA) repair and aortobifemoral bypass for aortoiliac occlusive disease (AIOD), and to evaluate the ability of PCT to detect intestinal ischaemia. Methods: A prospective non-randomized observational cohort study in 80 patients (62 men and 18 women) undergoing elective aortic surgery was performed. Serum PCT was measured at baseline and defined intraoperative and postoperative timepoints up to postoperative day 7. MRI contrast-enhanced imaging was used to detect intestinal ischaemia. Results: The comparison of the AAA and AIOD cohort did not show any significant difference in PCT levels. Patients with intestinal ischaemia had higher serum PCT at multiple timepoints postoperatively. The most accurate timepoints for early diagnosis were postoperative day 3, followed by 24 h after declamping of the vascular reconstruction, and postoperative day 7. The sensitivity and negative predictive values were 100% in all mentioned timepoints. However, event at the best timepoint the specificity was 89% and the positive predictive value 43%. Conclusions: Procalcitonin levels in the postoperative period at proper timepoints might help to detect postoperative intestinal ischaemia. The limitation of this marker is its low specificity for intestinal ischaemia and low positive predictive value. The highest value of this marker is that it can rule out this complication because normal PCT levels mean that intestinal ischaemia is very unlikely. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Endothelin-1 Gene Polymorphisms rs5370, rs1476046, and rs3087459 are not Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

Author

Šeruga Maja, Kariž Stojan, Makuc Jana, Završnik Matej, Cilenšek Ines, Gazdikova Katarina, Caprnda Martin, Kruzliak Peter, and Petrovič Daniel

Subjects
type 2 diabetes mellitus, diabetic nephropathy, endothelin-1 gene polymorphisms, Medicine
Abstract

Background: Diabetic nephropathy (DN) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Several lines of evidence implicate the endothelin (ET) system in the pathophysiology of DN. The aim of the present study was to analyze if genetic polymorphisms of the ET-1 (EDN1) gene affect susceptibility to DN in Caucasians with T2DM.

Published
2017
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35. Glycemic Variability and Vascular Complications in Patients with Type 2 Diabetes Mellitus

Author

Caprnda Martin, Mesarosova Dasa, Ortega Pablo Fabuel, Krahulec Boris, Egom Emmanuel, Rodrigo Luis, Kruzliak Peter, Mozos Ioana, and Gaspar Ludovit

Subjects
glycemic variability, MAGE index, diabetes mellitus complications, Medicine
Abstract

Background: Presence of macro- and microvascular complications in patients with diabetes mellitus (DM) is not only related to chronic hyperglycemia represented by glycated hemoglobin (HbA1c) but also to acute glycemic fluctuations (glycemic variability, GV). The association between GV and DM complications is not completely clear. Aim of our study was to evaluate GV by MAGE index in patients with type 2 DM and to verify association of MAGE index with presence of macro- and microvascular DM complications.

Published
2017
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36. Modulating Effects of Cholecalciferol Treatment on Estrogen Deficiency-Induced Anxiety-Like Behavior of Adult Female Rats

Author

Fedotova Julia, Zarembo Daria, Dragasek Jozef, Caprnda Martin, Kruzliak Peter, and Dudnichenko Tatyana

Subjects
cholecalciferol, anxiety, behavior, estradiol, ovariectomy, monoamines, Medicine
Abstract

Background: Vitamin D can be one of the candidate substances that are used as additional supplementation in the treatment of anxiety-related disorders in women with estrogen imbalance.

Published
2017
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37. The Impact of Hyperglycemia on VEGF Secretion in Retinal Endothelial Cells

Author

Caprnda Martin, Kubatka Peter, Saxena Sandeep, Valaskova Jela, Stefanickova Jana, Kobyliak Nazarii, Zulli Anthony, and Kruzliak Peter

Subjects
VEGF, glucose, diabetic retinopathy, retinal endothelial cell, retina, Medicine
Abstract

Background: Diabetic retinopathy is a serious sight-threatening complication which is manifested by excessive angiogenesis in diabetic patients.

Published
2017
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45. Facing the Challenges in the COVID-19 Pandemic Era: From Standard Treatments to the Umbilical Cord-Derived Mesenchymal Stromal Cells as a New Therapeutic Strategy.

Author

Russo, Eleonora, Corrao, Simona, Di Gaudio, Francesca, Alberti, Giusi, Caprnda, Martin, Kubatka, Peter, Kruzliak, Peter, Miceli, Vitale, Conaldi, Pier Giulio, Borlongan, Cesario Venturina, and La Rocca, Giampiero

Subjects
SARS-CoV-2, COVID-19 pandemic, STROMAL cells, COVID-19, AVIAN influenza, ADULT respiratory distress syndrome
Abstract

Coronavirus disease 2019 (COVID-19), the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which counts more than 650 million cases and more than 6.6 million of deaths worldwide, affects the respiratory system with typical symptoms such as fever, cough, sore throat, acute respiratory distress syndrome (ARDS), and fatigue. Other nonpulmonary manifestations are related with abnormal inflammatory response, the "cytokine storm", that could lead to a multiorgan disease and to death. Evolution of effective vaccines against SARS-CoV-2 provided multiple options to prevent the infection, but the treatment of the severe forms remains difficult to manage. The cytokine storm is usually counteracted with standard medical care and anti-inflammatory drugs, but researchers moved forward their studies on new strategies based on cell therapy approaches. The perinatal tissues, such as placental membranes, amniotic fluid, and umbilical cord derivatives, are enriched in mesenchymal stromal cells (MSCs) that exert a well-known anti-inflammatory role, immune response modulation, and tissue repair. In this review, we focused on umbilical-cord-derived MSCs (UC-MSCs) used in in vitro and in vivo studies in order to evaluate the weakening of the severe symptoms, and on recent clinical trials from different databases, supporting the favorable potential of UC-MSCs as therapeutic strategy. [ABSTRACT FROM AUTHOR]

Published
2023
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