4 results on '"Camci, Furkan"'
Search Results
2. Survival after Curative Treatment for Colon Cancer in Patients Younger than 50 Years of Age Showing a Different Outcome to the Prevailing Literature.
- Author
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Ozata, Ibrahim H., Karahan, Salih N., Sucu, Serkan, Ozoran, Emre, Tufekci, Tutku, Camci, Furkan, Cetin, Feyza, Narin, Arif E., Zenger, Serkan, Rencuzogullari, Ahmet, Bugra, Dursun, and Balik, Emre
- Subjects
COLON cancer ,COLORECTAL cancer ,STATISTICAL matching ,MUCINOUS adenocarcinoma ,OVERALL survival ,PROGRESSION-free survival - Abstract
Background: Colorectal cancer is the third most common and second deadliest cancer globally. Increasingly, early‑onset colorectal cancer is diagnosed in those under 50 years, leading to some countries advising screenings from ages 40 or 45 years. The ’position of the tumor, right or left, impacts the characteristics and prognosis of early‑onset colorectal cancer. Objectives: Investigating the 5‑year disease‑free and overall survival and histopathologic nature of left‑ and right‑sided early‑onset colorectal cancer. Design: Retrospective study. Setting: Koc University and VKF American Hospital. Materials (Patients) and Methods: Our population includes patients under 50 years with invasive colon cancer treated in two tertiary Turkish hospitals from 2014 to 2019. Of 178 patients, 74.3% had left‑sided tumors. Sample Size: One hundred and seventy‑eight patients. Main Outcome Measures: Histopathological features of left‑ and right‑sided colorectal tumors, and the 5‑year disease‑free and overall survival rate in patients under 50 years of age. Results: The 5‑year disease‑free survival was higher in right‑sided tumors(78.2% vs. 53.1%), but overallsurvival wassimilar. No significant histopathological differences were noted between left‑ and right‑sided tumors, but right‑sided tumors had more mucinous adenocarcinoma and high microsatellite instability (MSI). Conclusion: Our data did not show a difference in survival between right‑ and left‑sided tumors in the age group <50 years contrary to other published literature. Limitations: Retrospective nature and inclusion of a single center, which usually serves Turkiye population with a higher socioeconomic status. The retrospective nature of the study makes it susceptible to selection bias. The small sample size precludes robust group matching and diminishes the statistical power, increasing the risk of Type II errors. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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3. TrkB-mediated sustained neuroprotection is sex-specific and ERα dependent in adult mice following neonatal hypoxia ischemia.
- Author
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Chanana V, Hackett M, Deveci N, Aycan N, Ozaydin B, Cagatay NS, Hanalioglu D, Kintner DB, Corcoran K, Yapici S, Camci F, Eickhoff J, Frick KM, Ferrazano P, Levine JE, and Cengiz P
- Abstract
Background: Neonatal hypoxia ischemia (HI) related brain injury is one of the major causes of life-long neurological morbidities that result in learning and memory impairments. Evidence suggests that male neonates are more susceptible to the detrimental effects of HI, yet the mechanisms mediating these sex-specific responses to neural injury in neonates remain poorly understood. We previously tested the effects of treatment with a small molecule agonist of the tyrosine kinase B receptor (TrkB), 7,8-dihydroxyflavone (DHF) following neonatal HI and determined that females, but not males exhibit increased phosphorylation of TrkB and reduced apoptosis in their hippocampi. Moreover, these female-specific effects of the TrkB agonist were found to be dependent upon the expression of ERα. These findings demonstrated that TrkB activation in the presence of ERα comprises one pathway by which neuroprotection may be conferred in a female-specific manner. The goal of this study was to determine the role of ERα-dependent TrkB-mediated neuroprotection in memory and anxiety in young adult mice exposed to HI during the neonatal period., Methods: In this study we used a unilateral hypoxic ischemic (HI) mouse model. ERα
+/+ or ERα-/- mice were subjected to HI on postnatal day (P) 9 and mice were treated with either vehicle control or the TrkB agonist, DHF, for seven days following HI. When mice reached young adulthood, we used the novel object recognition, novel object location and open field tests to assess long-term memory and anxiety like behavior. The brains were then assessed for tissue damage using immunohistochemistry., Results: Neonatal DHF treatment prevented HI-induced decrements in recognition and location memory in adulthood in females, but not in males. This protective effect was absent in female mice lacking ERα. Thus, the female-specific and ERα-dependent neuroprotection conferred by DHF therapy after neonatal HI was associated with improved learning and memory outcomes in adulthood. Interestingly, DHF triggered anxiety like behavior in both sexes only in the mice that lacked ERα. When we assessed the severity of injury, we found that DHF therapy did not decrease the percent tissue loss in proportion to functional recovery. We additionally observed that the presence of ERα significantly reduced overall HI-associated mortality in both sexes., Conclusions: These observations provide evidence for a therapeutic role for DHF in which sustained recovery of memory in females is TrkB-mediated and ERα-dependent. However, the beneficial effects of DHF therapy did not include reduction of gross tissue loss but may be derived from the enhanced functioning of residual tissues in a cell-specific manner., Competing Interests: Competing interests This work was supported by R01NS111021 to Pelin Cengiz. Jon E. Levine is supported by R01DK121559-01, R21HD102172-01, and U24MH123422-01. Karyn M. Frick is supported by R01MH107886, Alzheimer’s Association ABA-22-973796, and multiple grants from the UWM Research Foundation and UWM Graduate School. Dr. Frick is a co-founder and the Chief Scientific Officer of Estrigenix Therapeutics, Inc., a company which aims to improve women’s health by developing safe, clinically proven treatments for the mental and physical effects of menopause. The rest of the authors do not have any conflicts of interests to declare.- Published
- 2023
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4. A novel scoring system for the early detection of anastomotic leakage: bedside leak score-a pilot study.
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Ozata IH, Bozkurt E, Sucu S, Karahan SN, Camci F, Cetin F, Ozoran E, Agcaoglu O, Balik E, and Bugra D
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Background: Anastomotic leakage is a major complication in colorectal surgery, resulting in significant morbidity and mortality rates. Despite substantial progress in surgical technique, anastomotic leakage rates remain stable. An early diagnosis of anastomotic leaks was proven to reduce adverse outcomes and improve survival., Objective: This study aims to find a novel scoring system for detecting anastomotic leaks using inflammatory and nutritional indicators after colorectal surgery. Our purpose was to analyze the diagnostic accuracy of leak scores ( ( CRP POD 3 ) ( CRP POD 1 ) ∗ preoperative albumin level ) in predicting postoperative complications., Design: The study included colorectal cancer patients who underwent curative surgery at Koc University Hospital between 2014 and 2018. Patients were categorized into two groups depending on the presence of anastomotic leaks and compared in terms of preoperative albumin levels, CRP levels in postoperative days 1 and 3, anastomotic leakage rates, length of hospital stay, and CRP quotient, which was calculated by dividing POD 3 CRP level to POD 1 CRP level. The bedside leak score is calculated by dividing the CRP quotient by the preoperative albumin level. The predictive value of bedside leak score, CRP quotient, and preoperative albumin levels in estimating anastomotic leakage was analyzed, and a cutoff value for the leak score was calculated., Results: A total of 184 patients were included in the study. The leak score, CRP POD 3-1 ratio, and preoperative albumin levels were found to successfully detect anastomotic leakage. The area under the curve for the leak score was calculated as 0.78. The optimal cutoff value was found to be 50.3 for the bedside leak score, which shows 90.9% sensitivity and 59.3% specificity., Conclusion: The leak score may represent a valuable diagnostic tool for detecting patients at risk for anastomotic leakage after colorectal surgery and planning a better strategy to reduce morbidity and mortality rates and associated costs. However, further multicenter studies with large cohorts are necessary to confirm these results., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Ozata, Bozkurt, Sucu, Karahan, Camci, Cetin, Ozoran, Agcaoglu, Balik and Bugra.)
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- 2023
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