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868 results on '"Caldwell D"'

1. Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1

Author

Edavana VK, Yu X, Dhakal IB, Williams S, Ning B, Cook IT, Caldwell D, Falany CN, and Kadlubar S

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Vineetha Koroth Edavana1, Xinfeng Yu1, Ishwori B Dhakal1, Suzanne Williams1, Baitang Ning2, Ian T Cook3, David Caldwell1, Charles N Falany3, Susan Kadlubar11Division of Medical Genetics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA; 2Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; 3Department of Pharmacology, University of Alabama, Birmingham, AL, USAAbstract: Fulvestrant (Faslodex™) is a pure antiestrogen that is approved to treat hormone receptor-positive metastatic breast cancer in postmenopausal women. Previous studies have demonstrated that fulvestrant metabolism in humans involves cytochromes P450 and UDP-glucuronosyltransferases (UGTs). To date, fulvestrant sulfation has not been characterized. This study examined fulvestrant sulfation with nine recombinant sulfotransferases and found that only SULT1A1 and SULT1E1 displayed catalytic activity toward this substrate, with Km of 4.2 ± 0.99 and 0.2 ± 0.16 µM, respectively. In vitro assays of 104 human liver cytosols revealed marked individual variability that was highly correlated with β-naphthol sulfation (SULT1A1 diagnostic substrate; r = 0.98, P < 0.0001), but not with 17ß-estradiol sulfation (SULT1E1 diagnostic substrate; r = 0.16, P = 0.10). Fulvestrant sulfation was correlated with both SULT1A1*1/2 genotype (P value = 0.023) and copy number (P < 0.0001). These studies suggest that factors influencing SULT1A1/1E1 tissue expression and/or enzymatic activity could influence the efficacy of fulvestrant therapy.Keywords: fulvestrant, sulfotransferase, genotype, copy number

Published
2011

8. Campaign 9 of the K2 Mission : Observational Parameters, Scientific Drivers, and Community Involvement for a Simultaneous Space- and Ground-based Microlensing Survey

Author

Henderson, Calen B., Poleski, Radosław, Penny, Matthew, Street, Rachel A., Bennett, David P., Hogg, David W., Gaudi, B. Scott, Zhu, W., Barclay, T., Barentsen, G., Howell, S. B., Mullally, F., Udalski, A., Szymański, M. K., Skowron, J., Mróz, P., Kozłowski, S., Wyrzykowski, Ł., Pietrukowicz, P., Soszyński, I., Ulaczyk, K., Pawlak, M., Sumi, T., Abe, F., Asakura, Y., Barry, R. K., Bhattacharya, A., Bond, I. A., Donachie, M., Freeman, M., Fukui, A., Hirao, Y., Itow, Y., Koshimoto, N., Li, M. C. A., Ling, C. H., Masuda, K., Matsubara, Y., Muraki, Y., Nagakane, M., Ohnishi, K., Oyokawa, H., Rattenbury, N., Saito, To., Sharan, A., Sullivan, D. J., Tristram, P. J., Yonehara, A., Bachelet, E., Bramich, D. M., Cassan, A., Dominik, M., Jaimes, R. Figuera, Horne, K., Hundertmark, M., Mao, S., Ranc, C., Schmidt, R., Snodgrass, C., Steele, I. A., Tsapras, Y., Wambsganss, J., Bozza, V., Burgdorf, M. J., Jørgensen, U. G., Novati, S. Calchi, Ciceri, S., D’Ago, G., Evans, D. F., Hessman, F. V., Hinse, T. C., Husser, T.-O., Mancini, L., Popovas, A., Rabus, M., Rahvar, S., Scarpetta, G., Skottfelt, J., Southworth, J., Unda-Sanzana, E., Bryson, S. T., Caldwell, D. A., Haas, M. R., Larson, K., McCalmont, K., Packard, M., Peterson, C., Putnam, D., Reedy, L., Ross, S., Van Cleve, J. E., Akeson, R., Batista, V., Beaulieu, J.-P., Beichman, C. A., Bryden, G., Ciardi, D., Cole, A., Coutures, C., Foreman-Mackey, D., Fouqué, P., Friedmann, M., Gelino, C., Kaspi, S., Kerins, E., Korhonen, H., Lang, D., Lee, C.-H., Lineweaver, C. H., Maoz, D., Marquette, J.-B., Mogavero, F., Morales, J. C., Nataf, D., Pogge, R. W., Santerne, A., Shvartzvald, Y., Suzuki, D., Tamura, M., Tisserand, P., and Wang, D.

Published
2016

10. Kepler K2 Campaign 9 – II. First space-based discovery of an exoplanet using microlensing.

Author

Specht, D, Poleski, R, Penny, M T, Kerins, E, McDonald, I, Lee, Chung-Uk, Udalski, A, Bond, I A, Shvartzvald, Y, Zang, Weicheng, Street, R A, Hogg, D W, Gaudi, B S, Barclay, T, Barentsen, G, Howell, S B, Mullally, F, Henderson, C B, Bryson, S T, and Caldwell, D A

Subjects
PARALLAX, PLANETARY mass, ORIGIN of planets, SPACE telescopes, GALACTIC bulges
Abstract

We present K2-2016-BLG-0005Lb, a densely sampled, planetary binary caustic-crossing microlensing event found from a blind search of data gathered from Campaign 9 of the Kepler K2 mission (K2 C9). K2-2016-BLG-0005Lb is the first bound microlensing exoplanet discovered from space-based data. The event has caustic entry and exit points that are resolved in the K2 C9 data, enabling the lens-source relative proper motion to be measured. We have fitted a binary microlens model to the Kepler data and to simultaneous observations from multiple ground-based surveys. Whilst the ground-based data only sparsely sample the binary caustic, they provide a clear detection of parallax that allows us to break completely the microlensing mass-position-velocity degeneracy and measure the planet's mass directly. We find a host mass of 0.58 ± 0.04 M⊙ and a planetary mass of 1.1 ± 0.1 MJ. The system lies at a distance of 5.2 ± 0.2 kpc from Earth towards the Galactic bulge, more than twice the distance of the previous most distant planet found by Kepler. The sky-projected separation of the planet from its host is found to be 4.2 ± 0.3 au which, for circular orbits, deprojects to a host separation |$a = 4.4^{+1.9}_{-0.4}$|  au and orbital period |$P = 13^{+9}_{-2}$|  yr. This makes K2-2016-BLG-0005Lb a close Jupiter analogue orbiting a low-mass host star. According to current planet formation models, this system is very close to the host mass threshold below which Jupiters are not expected to form. Upcoming space-based exoplanet microlensing surveys by NASA's Nancy Grace Roman Space Telescope and, possibly, ESA's Euclid mission, will provide demanding tests of current planet formation models. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Kepler's Optical Phase Curve of the Exoplanet HAT-P-7b

Author

Borucki, W. J., Koch, D., Jenkins, J., Sasselov, D., Gilliland, R., Batalha, N., Latham, D. W., Caldwell, D., Basri, G., Brown, T., Christensen-Dalsgaard, J., Cochran, W. D., DeVore, E., Dunham, E., Dupree, A. K., Gautier, T., Geary, J., Gould, A., Howell, S., Kjeldsen, H., Lissauer, J., Marcy, G., Meibom, S., Morrison, D., and Tarter, J.

Published
2009
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28. Present Status of the SuperCDMS program

Author

Akerib, D. S., Bailey, C. N., Bauer, D. A., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Cooley, J., Cushman, P., DeJongh, F., Dragowsky, M. R., Duong, L., Figueroa-Feliciano, E., Filippini, J., Golwala, S. R., Grant, D. R., Hall, J., Hennings-Yeomans, R., Holmgren, D., Huber, M. E., Irwin, K. D., Mahapatra, R., Mirabolfathi, N., Nelson, H., Novak, L., Ogburn, R. W., Pyle, M., Qiu, X., Ramberg, E., Rau, W., Reisetter, A., Saab, T., Sadoulet, B., Sander, J., Schmitt, R. L., Schnee, R. W., Seitz, D. N., Serfass, B., Sundqvist, K. M., Tomada, A., Yellin, S., Yoo, J., and Young, B. A.

Published
2008
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29. Status of the Cryogenic Dark Matter Search Experiment

Author

Ahmed, Z., Akerib, D. S., Attisha, M. J., Bailey, C. N., Baudis, L., Bauer, D. A., Brink, P. L., Brusov, P. P., Bunker, R., Cabrera, B., Caldwell, D. O., Chang, C. L., Cooley, J., Crisler, M. B., Cushman, P., Daal, M., DeJongh, F., Dixon, R., Dragowsky, M. R., Duong, L., Ferril, R., Figueroa-Feliciano, E., Filippini, J., Gaitskell, R. J., Golwala, S. R., Grant, D. R., Hennings-Yeomans, R., Holmgren, D., Huber, M. E., Kamat, S., Leclercq, S., Mahapatra, R., Mandic, V., Meunier, P., Mirabolfathi, N., Nelson, H., Ogburn, R. W., Pyle, M., Qiu, X., Ramberg, E., Rau, W., Reisetter, A., Ross, R. R., Saab, T., Sadoulet, B., Sander, J., Schnee, R. W., Seitz, D. N., Serfass, B., Sundqvist, K. M., Thompson, J.-P. F., Wang, G., Yellin, S., Yoo, J., and Young, B. A.

Published
2008
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30. The X-Ray Telescope (XRT) for the Hinode Mission

Author

Golub, L., DeLuca, E., Austin, G., Bookbinder, J., Caldwell, D., Cheimets, P., Cirtain, J., Cosmo, M., Reid, P., Sette, A., Weber, M., Sakao, T., Kano, R., Shibasaki, K., Hara, H., Tsuneta, S., Kumagai, K., Tamura, T., Shimojo, M., McCracken, J., Carpenter, J., Haight, H., Siler, R., Wright, E., Tucker, J., Rutledge, H., Barbera, M., Peres, G., and Varisco, S.

Published
2007
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33. Effect of the seaweed Ascophyllum nodosum on lambs during forced walking and transport

Author

Archer, G.S., Friend, T.H., Caldwell, D., Ameiss, K., and Krawczel, P.D.

Subjects
Lambs -- Research, Lambs -- Food and nutrition, Lambs -- Physiological aspects, Marine algae as food -- Environmental aspects, Marine algae as food -- Research, Animal locomotion -- Research, Zoology and wildlife conservation
Abstract

The objective of this study was to determine the effect of feeding Ascophyllum nodosum (ANOD) to lambs at 0 (control), 0.5, 1, or 2% of DMI/d for 2 wk on lamb physiology in response to forced walking and transport during hot weather. Forty-four lambs (26 kg [+ or -] 4.3) were used, and each lamb swallowed 3 gelatin capsules filled with ANOD or their normal 16% CP, pelleted grain ration twice daily, with the amount of ANOD dependent on the treatment. The amount of ANOD did not affect ear canal temperature or cortisol concentrations during 60 min of forced walking. The range between the minimum and maximum ear canal temperature for each lamb during 12 h of transport was narrower in lambs receiving the 2% ANOD than the control group (P = 0.05), and the 2% ANOD group also had lower (P = 0.05) ear canal temperatures than the control group during hot periods of transport. After 4 (P = 0.09) and 8 h (P = 0.05) of transport, the control group tended to have greater cortisol concentrations than the 2% ANOD group. Many differences among treatments were found in plasma protein, albumin, calcium, phosphorus, glucose, blood urea nitrogen, aspartate aminotransferase, magnesium, sodium, potassium, and chloride concentrations posttransport; mainly, the control and 0.5% ANOD groups had greater (P < 0.05) concentrations than the other 2 treatments. Aldosterone concentrations were greater in the control and 0.5% ANOD group than in the 1 and 2% ANOD groups before transport, whereas the concentrations were not different after transport, suggesting pretransport concentrations were lowered by supplementation. The 1 and 2% ANOD groups lost more BW than the control group as a result of transport (P = 0.04). After transport, no differences were observed in the latency for lambs to drink, eat, or lay. There was a suppression of the IgG and IgM antibody responses at 4 and 7 d after administration of ovalbumin, with greater ANOD supplementation rates suppressing antibody response the greatest. Although ANOD decreased ear canal temperature in hot periods of transport, stabilized electrolyte concentrations, and decreased cortisol throughout transport, it also suppressed the antibody response indicating that the effect of ANOD on immune function merits further investigation. Key words: Ascophyllum nodosum, exercise, immune, lamb, seaweed, temperature

Published
2007

38. The transition region and coronal explorer

Author

Handy, B.N., Acton, L.W., Kankelborg, C.C., Wolfson, C.J., Akin, D.J., Bruner, M.E., Caravalho, R., Catura, R.C., Chevalier, R., Duncan, D.W., Edwards, C.G., Feinstein, C.N., Freeland, S.L., Friedlaender, F.M., Hoffmann, C.H., Hurlburt, N.E., Jurcevich, B.K., Katz, N.L., Kelly, G.A., Lemen, J.R., Levay, M., Lindgren, R.W., Mathur, D.P., Meyer, S.B., Morrison, S.J., Morrison, M.D., Nightingale, R.W., Pope, T.P., Rehse, R.A., Schrijver, C.J., Shine, R.A., Shing, L., Strong, K.T., Tarbell, T.D., Title, A.M., Torgerson, D.D., Golub, L., Bookbinder, J.A., Caldwell, D., Cheimets, P.N., Davis, W.N., Deluca, E.E., McMullen, R.A., Warren, H.P., Amato, D., Fisher, R., Maldonado, H., and Parkinson, C.

Published
1999
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41. Dark Matter Search Results from the CDMS II Experiment

Author

Ahmed, Z., Akerib, D. S., Arrenberg, S., Bailey, C. N., Balakishiyeva, D., Baudis, L., Bauer, D. A., Brink, P. L., Bruch, T., Bunker, R., Cabrera, B., Caldwell, D. O., Cooley, J., Cushman, P., Daal, M., DeJongh, F., Dragowsky, M. R., Duong, L., Fallows, S., Figueroa-Feliciano, E., Filippini, J., Fritts, M., Golwala, S. R., Grant, D. R., Hall, J., Hennings-Yeomans, R., Hertel, S. A., Holmgren, D., Hsu, L., Huber, M. E., Kamaev, O., Kiveni, M., Kos, M., Leman, S. W., Mahapatra, R., Mandic, V., McCarthy, K. A., Mirabolfathi, N., Moore, D., Nelson, H., Ogburn, R. W., Phipps, A., Pyle, M., Qiu, X., Ramberg, E., Rau, W., Reisetter, A., Saab, T., Sadoulet, B., Sander, J., Schnee, R. W., Seitz, D. N., Serfass, B., Sundqvist, K. M., Tarka, M., Wikus, P., Yellin, S., Yoo, J., Young, B. A., and Zhang, J.

Published
2010
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48. The first cryogenic dark matter experiment

Author

Barnes, Jr., P. D., Da Silva, A., Aubourg, É., Akerib, D. S., Bauer, D., Borden, D., Cabrera, B., Caldwell, D. O., Chugg, B., Cummings, A., Dougherty, B. L., Emes, J., Gray, M., Hale, D., Haller, E. E., Irwin, K. D., Lange, A. E., Lu, A., Margulies, S., Penn, M. J., Pomansky, A. A., Pritychenko, B. V., Ross, R. R., Sadoulet, B., Shutt, T., Smith, A., Smith, G., Stockwell, W., Taylor, J., White, S., Witherell, M., Wolgast, R. C., Yellin, S., and Young, B. A.

Published
1993
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