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Your search keyword '"Brenda P. Medellin"' showing total 1 results
Start Over Author "Brenda P. Medellin" Publication Type Academic Journals
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1. Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

Author

Eric B. Gibbs, Feiyue Lu, Bede Portz, Michael J. Fisher, Brenda P. Medellin, Tatiana N. Laremore, Yan Jessie Zhang, David S. Gilmour, and Scott A. Showalter

Subjects
Science
Abstract

The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in thetrans-to-cisisomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modifications by regulatory enzymes.

Published
2017
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