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This report describes the moral phenomena that students in an intensive Arabic study abroad program encountered as they tried to find speaking opportunities for themselves outside of institutional arrangements. The ways that participants went about speaking activities were accompanied by tensions that they had to deal with throughout the program. They found themselves obliged to consider values such as decisiveness, independence, and fairness as they tried to become better conversationalists, cultural insiders, and friends with the people they met. Additional research using the same analytic framework could reveal deeply practical insights for the benefit of language learners and practitioners.

The environmental and socio-economic impacts of the Nigerian Threatened Native Trees Project are presented. This project conducted propagation trials and developed a freely downloadable online Manual of Tree Propagation (MTP) for 55 native tree species, training 146 local experts (32 women and 114 men) during the period (November 2015—December 2022). We used Google Analytics and interviews to assess the impacts of this project from January 2018—July 2023 (iEcology). Results show that the MTP has been downloaded 1013 times, with the star apple Gambeya albida (76), gum tree Tetrapleura tetraptera (65) and bitter kola Garcinia kola (50) topping the list. These downloads were from 15 countries spread across the world. Interestingly, the seven African countries that downloaded the MTP are concentrated in the tropical belt with similar floristic composition. The native range of almost all the propagated species overlaps with these African countries, suggesting the adoption of our MTP, and practically demonstrating the conservation mantra of “think globally, act locally”. In addition, the MTP has been deployed for academic work (i.e., grey literature) and reforestation (e.g., covering c. 1200 ha in Nigeria). By revealing suitable propagation techniques and training local foresters, our approach could boost the utilization of native tree species for reforestation in Africa.

BACKGROUND: Cardiac function of critically ill patients with COVID-19 generally has been reported from clinically obtained data. Echocardiographic deformation imaging can identify ventricular dysfunction missed by traditional echocardiographic assessment. RESEARCH QUESTION: What is the prevalence of ventricular dysfunction and what are its implications for the natural history of critical COVID-19? STUDY DESIGN AND METHODS: This is a multicenter prospective cohort of critically ill patients with COVID-19. We performed serial echocardiography and lower extremity vascular ultrasound on hospitalization days 1, 3, and 8. We defined left ventricular (LV) dysfunction as the absolute value of longitudinal strain of < 17% or left ventricle ejection fraction (LVEF) of < 50%. Primary clinical outcome was inpatient survival. RESULTS: We enrolled 110 patients. Thirty-nine (35.5%) died before hospital discharge. LV dysfunction was present at admission in 38 patients (34.5%) and in 21 patients (36.2%) on day 8 (P = .59). Median baseline LVEF was 62% (interquartile range [IQR], 52%-69%), whereas median absolute value of baseline LV strain was 16% (IQR, 14%-19%). Survivors and nonsurvivors did not differ statistically significantly with respect to day 1 LV strain (17.9% vs 14.4%; P = .12) or day 1 LVEF (60.5% vs 65%; P = .06). Nonsurvivors showed worse day 1 right ventricle (RV) strain than survivors (16.3% vs 21.2%; P = .04). INTERPRETATION: Among patients with critical COVID-19, LV and RV dysfunction is common, frequently identified only through deformation imaging, and early (day 1) RV dysfunction may be associated with clinical outcome.

Background Abdominal aortic aneurysm (AAA) screening/surveillance is implemented widely. Those in AAA-surveillance are at high-risk of cardiovascular-events. We developed an intervention, called CRISP, using intervention-mapping, to reduce cardiovascular-risk in AAA-surveillance. This study tested the CRISP intervention in routine clinical-care. Methods The CRISP intervention, consisting of a nurse-led cardiovascular risk assessment and subsequent lifestyle change support using a self-care workbook and low-intensity nurse input was delivered in two screening/surveillance programmes. Those consenting to take part were followed-up with cardiovascular-assessments. Fidelity of intervention-delivery was assessed quantitatively/qualitatively. Results 40 men (mean age 75 ± 7 years) took part over four months and followed-up for a minimum six months. A sub-group of 25 patients and nine Health Care Professionals (HCPs) were interviewed. The median number of risk-factors that patients chose to focus on was two (range 0 to 4), with physical activity (n=17) being the most popular. Participants who had a ‘red light’ risk factor for stress, low mood, smoking or alcohol intake were offered a referral to appropriate services. Two were offered referral to mental-health services and took it up, three declined referrals to smoking or alcohol support services. The fidelity of intervention-delivery (a score intervention components delivered to each patient based on a score from 0 to 5, with 5 being highest delivery fidelity) was generally low. The highest mean score (on a 0-5 scale) for the nurse assessment was 1.5 for engaging the participant, lowest 0.5 for exploring the importance for selected lifestyle behaviours. In qualitative interviews, the intervention was liked by patients/HCPs. Based on qualitative interviews and observations, the low fidelity of intervention-delivery was due to intervention-training not being detailed. Conclusions CRISP can be delivered in AAA-surveillance, but fidelity of delivery is low. The intervention and its training need to be refined/tested before wider implementation. Registration ISRCTN9399399518/11/20).

Abstract Background Abdominal aortic aneurysm (AAA) is an important cardiovascular health problem. Ultrasound screening is proven to reduce AAA mortality and programmes have been implemented in some healthcare systems. Those who are identified as having a small AAA in screening enter into a surveillance programme to monitor AAA size. Individuals in AAA surveillance are at elevated risk of cardiovascular events, which is not currently addressed sufficiently. We aimed to develop a simple intervention to reduce cardiovascular risk, which could be embedded in AAA surveillance pathways. Methods Intervention mapping methods were used to co-develop the intervention with individuals with AAA, families/carers, and healthcare staff. We identified “targets for change” by synthesising research evidence and international guidelines and consulting with patients, caregivers and health service providers. We conducted a series of workshops to identify barriers to and facilitators of change and used taxonomies of behaviour change theories and techniques to match intervention strategies to each target. Further stakeholder involvement work helped refine the intervention. Results The developed intervention focusses on assessment and individually tailored discussion of risk factors, exchanging information, building motivation and action planning, followed by review of progress and problem-solving. Workbooks covering physical activity, diet, stress management, alcohol, smoking, blood pressure and mental health are provided to support behaviour change. The intervention is facilitated by trained healthcare professionals during the patient’s AAA screening appointment for the duration that they are in surveillance. Discussion The developed intervention will now be tested to assess whether it can be integrated with the current AAA screening programme. The developed intervention is a novel approach to reducing cardiovascular disease in the AAA population, it is also the first intervention which tries to do this in this population. Trial registration International Clinical Trial Registration: ISRCTN93993995.

Biomedical science students need to learn to code. Graduates face a future where they will be better prepared for research higher degrees and the workforce if they can code. Embedding coding in a biomedical curriculum comes with challenges. First, biomedical science students often experience anxiety learning quantitative and computational thinking skills and second biomedical faculty often lack expertise required to teach coding. In this study, we describe a creative coding approach to building coding skills in students using the packages of Processing and Arduino. Biomedical science students were taught by an interdisciplinary faculty team from Medicine and Health, Science and Architecture, Design and Planning. We describe quantitative and qualitative responses of students to this approach. Cluster analysis revealed a diversity of student responses, with a large majority of students who supported creative coding in the curriculum, a smaller but vocal cluster, who did not support creative coding because either the exercises were not sufficiently challenging or were too challenging and believed coding should not be in a Biomedical Science curriculum. We describe how two creative coding platforms, Processing and Arduino, embedded and used to visualize human physiological data, and provide responses to students, including those minority of students, who are opposed to coding in the curriculum This study found a variety of students responses in a final year capstone course of an undergraduate Biomedical Science degree where future pathways for students are either in research higher degrees or to the workforce with a future which will be increasingly data driven.

Museum education is a dynamic and evolving field, requiring a commitment to continuous professional growth and the integration of best practices as they develop. As the field has shifted towards creating participant-centered experiences that encourage active learning and dialogue, museum educators have been seeking new ways to enhance their practice and provide visitors with meaningful experiences. One such approach is the adoption of a coaching mindset, drawing on core competencies from the professional field of performance coaching to support museum educators. This article will explore how the effective application of five key coaching competencies, alongside a coaching mindset, can empower museum educators in their practice, improve their museum teaching, and enhance the visitor experience. By exploring the impact of coaching competencies and mindset on museum education practice, this article aims to contribute to a broader understanding of the potential benefits of utilizing coaching approaches in the field of museum education.

The notion of language learners as informed consumers developed by Cohen and White (2008) takes up the issue of how best to develop the knowledge, skills and awareness of language learners given the infinite variety of language learning opportunities. The informed consumer approach focused not only on developing awareness of both formal and informal learning environments, but also on enhancing the ability to critically appraise those opportunities and to optimise language learning within them. In this article we trace how the notion of language learners as informed consumers has been drawn on in innovative studies of technology-mediated language learning; a common focus of those studies has been on ways of fostering awareness of the potential of particular technology-mediated learning environments and the relevant knowledge and skills which would support the active and effective use of those environments. We show how strands of the informed consumer approach have been used to investigate expertise and affordances in electronic dictionary use (Levy & Steel, 2015) and the trajectories of distance learners of Chinese (Tasker, 2010). In the latter part of the article we consider the experiences and reflections of learners of Arabic in a study abroad context in Jordan as part of Project Perseverance; findings from that project open up new dimensions of what it means to be an informed consumer of language instruction in relation to specific situational and cultural norms and constraints. To conclude the article identifies not only the distinctive contribution of the informed consumer approach but also how it sheds light on the ways in which individuals seek out and curate personally meaningful sites for language learning within their life worlds.

As an embodied and spatial medium, virtual reality is proving an attractive proposition for robot teleoperation in hazardous environments. This paper examines a nuclear decommissioning scenario in which a simulated team of semi-autonomous robots are used to characterise a chamber within a virtual nuclear facility. This study examines the potential utility and impact of sonification as a means of communicating salient operator data in such an environment. However, the question of what sound should be used and how it can be applied in different applications is far from resolved. This paper explores and compares two sonification design approaches. The first is inspired by the theory of cognitive metaphor to create sonifications that align with socially acquired contextual and ecological understanding of the application domain. The second adopts a computationalist approach using auditory mappings that are commonplace in the literature. The results suggest that the computationalist approach outperforms the cognitive metaphor approach in terms of predictability and mental workload. However, qualitative data analysis demonstrates that the cognitive metaphor approach resulted in sounds that were more intuitive, and were better implemented for spatialisation of data sources and data legibility when there was more than one sound source.

We evaluated the performance of 12 lateral flow devices by assessing their analytical sensitivity for SARS-CoV-2 variant BA.2.86. Kits from ACON, Orient Gene, Xiamen Biotime, Getein, and SureScreen detected variant BA.2.86 to sufficient sensitivity levels, comparable to those observed with previous Omicron variants. The stocks of lateral flow devices currently held by the UK government do not currently need changing for deployment for this variant.

Arable field margins provide important floral resources for insect foragers. This study assessed the significance of cultivated margins and floristically enhanced margins, both English agri-environment scheme (AES) options, to foraging bumble bees (Bombus species). We examined plant foraging preferences in each habitat according to species and caste. Additionally, detailed botanical surveys were carried out to determine vascular plant densities on the study margins. Overall, our results emphasised the importance of spontaneous (Asteraceae) species emerging from the seed bank in the provision of forage across Bombus species and castes, and highlighted that Bombus foraging preferences appeared to be only weakly related to floral species densities. Although found only occasionally in high densities, the popularity of these dicots was likely due to high nectar sugar mass. Bombus queens were recorded relatively infrequently, implying that these habitats are failing to provide the preferred floral resources of all Bombus spp. queens. Queens that were observed were found to favour earlier-flowering species (e.g. Anchusa arvensis) and species with longer corollas (e.g. Vicia sativa). Worker bees across Bombus spp. showed high overlap in plant preferences (e.g. Cirsium arvense, Ononis spinosa). However, some variability in preferences between castes within a species were noted, for example, only B. terrestris/lucorum drones were found to forage on Crepis vesicaria in cultivated margins. Additionally, bumble bee abundance was only found to increase as dicot cover increased. Overall, our findings highlight the importance of continuing to utilise multiple AES types in order to fully support Bombus and other pollinating insect populations on farmland.

EYE OF THE STORM Modernism in Ukraine, 1900-1930s Royal Academy of Art, London, until October 13 EYE OF THE STORM Modernism in Ukraine, 1900-1930s KONSTANTIN AKINSHA, KATIA DENYSOVA AND OLENA [...]

Background: Grade 4 astrocytomas are usually incurable due to their diffusely infiltrative nature. Photodynamic therapy (PDT) is a promising therapeutic option, but external light delivery is impractical when cancer cells infiltrate unknown areas of normal brain. Hence the search for endogenous sources to generate light at cancer cells. In vitro, astrocytoma cells, transfected with firefly luciferase, can be killed by bioluminescence-mediated PDT (bPDT). This study asks if bPDT can suppress tumour growth In vivo, when all components of treatment are administered systemically. Methods: Transfected astrocytoma cells were injected subcutaneously or intra-cranially in athymic CD1 nu/nu mice. bPDT required ip bolus of mTHPC (photosensitiser) and delivery of the d-luciferin substrate over 7 days via an implanted osmotic pump. Control animals had no treatment, photosensitiser only or d-luciferin only. For subcutaneous tumours, size and BLI (light emitted after d-luciferin bolus) were measured before and every 2 days after PDT. For intracranial tumours, monitoring was weekly BLI. Results: For subcutaneous tumours, there was significant suppression of the tumour growth rate (P

The cognitive, educational and economic benefits of learning a second language have been well documented in the literature. This paper reports findings on perspectives of 13 stakeholders on the benefits of a case study about teaching Vietnamese to preschoolers in a regional early childhood context in Tasmania, Australia in 2017. Using a thematic approach in analysing 13 semi-structured interviews, five main themes on the benefits of the programme for the children identified were language development, cultural and global awareness, numeracy enhancement, reading engagement, and personal development. The results showed that participating educators and parents all had positive attitudes towards the early Vietnamese language programme, believed that there were many benefits and expressed a desire for its continuity. These findings suggest that there is a need and desire for second language education in early childhood in the Tasmanian context. Therefore, policy makers, educators and researchers should provide preschools access to learning and teaching resources of a language of their choice to benefit children's overall development and learning in early childhood, adolescence and beyond.

Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.

The end-Cretaceous bolide impact triggered the devastation of marine ecosystems. However, the specific kill mechanism(s) are still debated, and how primary production subsequently recovered remains elusive. We used marine plankton microfossils and eco-evolutionary modeling to determine strategies for survival and recovery, finding that widespread phagotrophy (prey ingestion) was fundamental to plankton surviving the impact and also for the subsequent reestablishment of primary production. Ecological selectivity points to extreme post-impact light inhibition as the principal kill mechanism, with the marine food chain temporarily reset to a bacteria-dominated state. Subsequently, in a sunlit ocean inhabited by only rare survivor grazers but abundant small prey, it was mixotrophic nutrition (autotrophy and heterotrophy) and increasing cell sizes that enabled the eventual reestablishment of marine food webs some 2 million years later.

The cause of the end-Cretaceous mass extinction is vigorously debated, owing to the occurrence of a very large bolide impact and flood basalt volcanism near the boundary. Disentangling their relative importance is complicated by uncertainty regarding kill mechanisms and the relative timing of volcanogenic outgassing, impact, and extinction. We used carbon cycle modeling and paleotemperature records to constrain the timing of volcanogenic outgassing. We found support for major outgassing beginning and ending distinctly before the impact, with only the impact coinciding with mass extinction and biologically amplified carbon cycle change. Our models show that these extinction-related carbon cycle changes would have allowed the ocean to absorb massive amounts of carbon dioxide, thus limiting the global warming otherwise expected from postextinction volcanism.

Health care personnel (HCP) caring for patients with coronavirus disease 2019 (COVID-19) might be at high risk for contracting SARS-CoV-2, the virus that causes COVID-19. Understanding the prevalence of and factors associated with SARS-CoV-2 infection among frontline HCP who care for COVID-19 patients are important for protecting both HCP and their patients. During April 3-June 19, 2020, serum specimens were collected from a convenience sample of frontline HCP who worked with COVID-19 patients at 13 geographically diverse academic medical centers in the United States, and specimens were tested for antibodies to SARS-CoV-2. Participants were asked about potential symptoms of COVID-19 experienced since February 1, 2020, previous testing for acute SARS-CoV-2 infection, and their use of personal protective equipment (PPE) in the past week. Among 3,248 participants, 194 (6.0%) had positive test results for SARS-CoV-2 antibodies. Seroprevalence by hospital ranged from 0.8% to 31.2% (median = 3.6%). Among the 194 seropositive participants, 56 (29%) reported no symptoms since February 1, 2020, 86 (44%) did not believe that they previously had COVID-19, and 133 (69%) did not report a previous COVID-19 diagnosis. Seroprevalence was lower among personnel who reported always wearing a face covering (defined in this study as a surgical mask, N95 respirator, or powered air purifying respirator [PAPR]) while caring for patients (5.6%), compared with that among those who did not (9.0%) (p = 0.012). Consistent with persons in the general population with SARS-CoV-2 infection, many frontline HCP with SARS-CoV-2 infection might be asymptomatic or minimally symptomatic during infection, and infection might be unrecognized. Enhanced screening, including frequent testing of frontline HCP, and universal use of face coverings in hospitals are two strategies that could reduce SARS-CoV-2 transmission.

Onion center rot is caused by at least four species of genus Pantoea (P. ananatis, P. agglomerans, P. allii, and P. stewartii subsp. indologenes). Critical onion pathogenicity determinants for P. ananatis were recently described, but whether those determinants are common among other onion-pathogenic Pantoea species remains unknown. In this work, we report onion pathogenicity determinants in P. stewartii subsp. indologenes and P. allii. We identified two distinct secondary metabolite biosynthetic gene clusters present separately in different strains of onion-pathogenic P. stewartii subsp. indologenes. One cluster is similar to the previously described HiVir phosphonate biosynthetic cluster identified in P. ananatis and another is a novel putative phosphonate biosynthetic gene cluster, which we named Halophos. The Halophos gene cluster was also identified in P. allii strains. Both clusters are predicted to be phosphonate biosynthetic clusters based on the presence of a characteristic phosphoenolpyruvate phosphomutase (pepM) gene. The deletion of the pepM gene from either HiVir or Halophos clusters in P. stewartii subsp. indologenes caused loss of necrosis on onion leaves and red onion scales and resulted in significantly lower bacterial populations compared with the corresponding wild-type and complemented strains. Seven (halB to halH) of 11 genes (halA to halK) in the Halophos gene cluster are required for onion necrosis phenotypes. The onion nonpathogenic strain PNA15-2 (P. stewartii subsp. indologenes) gained the capacity to cause foliar necrosis on onion via exogenous expression of a minimal seven-gene Halophos cluster (genes halB to halH). Furthermore, cell-free culture filtrates of PNA14-12 expressing the intact Halophos gene cluster caused necrosis on onion leaves consistent with the presence of a secreted toxin. Based on the similarity of proteins to those with experimentally determined functions, we are able to predict most of the steps in Halophos biosynthesis. Together, these observations indicate that production of the toxin phosphonate seems sufficient to account for virulence of a variety of different Pantoea strains, although strains differ in possessing a single but distinct phosphonate biosynthetic cluster. Overall, this is the first report of onion pathogenicity determinants in P. stewartii subsp. indologenes and P. allii. [Graphic: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.

Antibacterial foam dressing has been developed in recent years based on polymeric membranes and silver ions or silver nanoparticles as antibacterial components. However, silver ions or silver nanoparticles have cytotoxicity to humans. Herein, we used biocompatible multi-branched gold nanoparticles as an antimicrobial agent in polyurethane foam wound dressings. This study described a rapid and surfactant-free method for the preparation of multi-branched gold nanoparticles using hydroquinone as a reducing agent and chitosan as a stabilizer as well as assisted irradiation. The optimal procedure of polyurethane foam fabricated with high water absorption and small average pore size, achieved nearly 500% of absorptivity and 98 nm of pore size. The antibacterial effects of the multi-branched gold nanoparticles containing polyurethane foam against both Escherichia coli and Staphylococcus aureus were investigated. The results demonstrated that multi-branched gold nanoparticles can be used as a viable alternative to conventional antibiotics in wound dressings.