86 results on '"Bouvier L"'
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2. Effect of swirl flow on whey protein fouling and cleaning in a straight duct
- Author
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Bouvier, L., Fargnier, I., Lalot, S., and Delaplace, G.
- Published
- 2019
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3. Predicting the distribution of whey protein fouling in a plate heat exchanger using the kinetic parameters of the thermal denaturation reaction of β-lactoglobulin and the bulk temperature profiles
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Blanpain-Avet, P., André, C., Khaldi, M., Bouvier, L., Petit, J., Six, T., Jeantet, R., Croguennec, T., and Delaplace, G.
- Published
- 2016
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4. Effect of calcium content and flow regime on whey protein fouling and cleaning in a plate heat exchanger
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Khaldi, M., Blanpain-Avet, P., Guérin, R., Ronse, G., Bouvier, L., André, C., Bornaz, S., Croguennec, T., Jeantet, R., and Delaplace, G.
- Published
- 2015
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5. Theme 10 - Disease Stratification and Phenotyping of Patients.
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Moglia, C., Calvo, A., Grassano, M., Gallone, S., Brodini, G., DeMarco, G., Salamone, P., Fuda, G., Casale, F., Brunetti, M., Sbaiz, L., Cugnasco, P., Vasta, R., Bombaci, A., Manera, U., Canosa, A., Traynor, B., Chio', A., Bouvier, L., and McKinley, S.
- Subjects
AMYOTROPHIC lateral sclerosis ,MOTOR neuron diseases ,COUGH - Abstract
TBK1 mutation spectrum in an extended European patient cohort with frontotemporal dementia and amyotrophic lateral sclerosis human mutation. 20 Geronimo AM, Martin A, Simmons Z. Inertial sensing of step kinematics in ambulatory patients with ALS and related motor neuron diseases. Arterial blood gas analysis: base excess and carbonate are predictive of noninvasive ventilation adaptation and survival in amyotrophic lateral sclerosis. [Extracted from the article]
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- 2022
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6. Analysis of a territorial approach to the delivery of nursing home care services based on historical data
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Lahrichi, N., Lapierre, S. D., Hertz, A., Talib, A., and Bouvier, L.
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- 2006
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7. Thermal and structural heterogeneities during cooking of a starch-based product by a non-intrusive ring sensor
- Author
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Guérin, R., Delaplace, G., Bouvier, L., Debreyne, P., Furling, O., Beudon, D., and Leuliet, J.C.
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- 2007
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8. Dimensional analysis for planetary mixer: Mixing time and Reynolds numbers
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Delaplace, G., Thakur, Rajeev K., Bouvier, L., André, C., and Torrez, C.
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- 2007
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9. Determination of mixing time by colourimetric diagnosis—Application to a new mixing system
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Delaplace, G., Bouvier, L., Moreau, A., Guérin, R., and Leuliet, J-C
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- 2004
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10. Chromosome doubling of pear haploid plants and homozygosity assessment using isozyme and microsatellite markers
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Bouvier, L., Guérif, Ph., Djulbic, M., Durel, Ch.-E., Chevreau, E., and Lespinasse, Y.
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- 2002
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11. Theme 10 - DISEASE STRATIFICATION AND PHENOTYPING OF PATIENTS.
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Bouvier, L., McKinley, S., Truong, J., Genge, A., Dupré, N., Dionne, A., Kalra, S., Yunusova, Y., Lukac, M., Luben, H., Kanade, Y., Simmons, Z., Martin, A., Geronimo, A., Scheier, Z., Clark, A., Keegan, M., Erb, K., Remington, E., and Chew, S.
- Subjects
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AMYOTROPHIC lateral sclerosis , *TROPONIN I , *NEUROMUSCULAR diseases - Abstract
Cardiac troponin T is elevated and increases longitudinally in ALS patients. Upper extremity 3-dimensional reachable workspace assessment in amyotrophic lateral sclerosis by Kinect sensor. [Extracted from the article]
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- 2021
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12. Two methods of haploidization in pear, Pyrus communis L.: greenhouse seedling selection and in situ parthenogenesis induced by irradiated pollen
- Author
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Bouvier, L., Zhang, Y.-X., and Lespinasse, Y.
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- 1993
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13. LE MONT-CENIS: SOUVENIRS DE VOYAGE
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Bouvier, L.
- Published
- 1888
14. Influence of Rheological Behavior of Purely Viscous Fluids on Analytical Residence Time Distribution in Straight Tubes.
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Delaplace, G., Thakur, R. K., Bouvier, L., Leprêtre, C., Ilnyzckyj, C., André, C., and Nouar, C.
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- 2008
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15. Determination of Mixing Times with Helical Ribbon Impeller for Non-Newtonian Viscous Fluids Using an Advanced Imaging Method.
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Chhabra, R. P., Bouvier, L., Delaplace, G., Cuvelier, G., Domenek, S., and André, C.
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- 2007
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16. Oryzalin as an Efficient Agent for Chromosome Doubling of Haploid Apple Shoots in vitro.
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Bouvier, L., Fillon, F. R., and Lespinasse, Y.
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PLANT genetics , *APPLES , *PLANT genetics -- Technique , *ANTIMITOTIC agents , *HAPLOIDY , *PLANT shoots - Abstract
In an outbreeding species such as apple, haploid plants may be especially useful in breeding programmes for the production of homozygous material. However, methods must be available to induce chromosome doubling in the haploid plants. Two antimitotic agents, colchicine and oryzalin, were compared as regards their efficiency in inducing chromosome doubling of in vitro haploid apple shoots. Three colchicine levels (0.025, 0.25 and 1.25 mm) and three oryzalin levels (5, 15 and 30 μM) were evaluated. Three techniques were also used and compare& Survival rate and chromosome counts were determined. Differences were observed between the two antimitotic agents and between the three techniques. This study demonstrates that oryzalin could be a better choice than colchicine for chromosome doubling on haploid apple shoots in vitro. [ABSTRACT FROM AUTHOR]
- Published
- 1994
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17. Microspore Embryogenesis Induced by Low Gamma Dose Irradiation in Apple.
- Author
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Zhang, Y. X., Bouvier, L., and Lespinasse, Y.
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GENETIC polymorphisms , *IRRADIATION , *PLANT embryology , *MICROSPHERES , *PLANT genetics , *ANTHER - Abstract
Flower buds and extracted anthers of two apple genotypes, 'Golden Delicious' -- a previously known non-androgenic genotype --, and 'Topred' -- a known androgenic genotype , were irradiated by gamma-rays at doses ranging from 5 to 20 Gy, after 0 to 5 weeks of cold pre-treatment (3 °C). When the extracted anthers were irradiated, both microspore embryogenesis and callogenesis were limited for the two genotypes. For 'Golden Delicious', androgenic embryogenesis was induced from the flower buds irradiated at 10 to 20 Gy and after 3 to 5 weeks of cold pre-treatment. For 'Topred', androgenic embryogenesis was slightly improved after flower bud irradiation at 5 to 10 Gy following cold pre-treatment from 0 to 3 weeks; it was limited after 5 weeks of cold pre-treatment. [ABSTRACT FROM AUTHOR]
- Published
- 1992
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18. Socioeconomic Correlates of Attitudes toward Abortion in Rhode Island: 1971.
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Rao, S. L. N. and Bouvier, L. F.
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ABORTION ,RELIGIONS ,EDUCATION ,SOCIAL factors ,SOCIOECONOMIC factors ,PRO-choice movement ,PRO-life movement ,PROTESTANTS ,CATHOLICS - Abstract
The article presents a study that analyzes the attitudes of the public toward abortion in Rhode Island, with regard to socioeconomic correlates. The study makes use of the information collected in the 1971 follow-up survey of the cumulative sample of the Rhode Island Health Study, to ascertain attitudes on abortion. The study shows that education and religion were the most important variables in causing differentials in attitudes toward abortion, indicating a greater extent of approval from the better educated and the Protestants to the less educated and the Catholics.
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- 1974
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19. Two methods of haploidization in pear, Pyrus communis L.: greenhouse seedling selection and in situ parthenogenesis induced by irradiated pollen.
- Author
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Bouvier, L., Zhang, Y.-X., and Lespinasse, Y.
- Abstract
Seedlings of 12 crosses involving pear varieties or hybrids were observed for the presence of haploid plants. On the basis of phenotypic characteristics, 17 plants corresponded to the haploid condition and, of these, 12 were determined by chromosome counting to be haploid (2n=x=17). In addition, and in order to induce in situ parthenogenesis, several pear varieties were pollinated with a selected clone carrying a homozygous dominant marker gene for the colour of red. This pollen had previously been irradiated with γ-rays of cobalt 60 at 0, 200, 250 and 500 Grays. The immature embryos were cultured in vitro, whereby 1 haploid and two mixoploid plants were obtained. Numerous diploid plants with the maternal phenotype were also obtained, and their genetic origin was subsequently studied by means of isozyme analysis. [ABSTRACT FROM AUTHOR]
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- 1994
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20. Immigration and the stable population model.
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Espenshade, Thomas J., Bouvier, Leon F., Arthur, W. Brian, Espenshade, T J, Bouvier, L F, and Arthur, W B
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POPULATION ,EMIGRATION & immigration ,DEMOGRAPHY ,CHILDBIRTH ,IMMIGRANTS ,REPRODUCTION - Abstract
This paper reports on work aimed at extending stable population theory to include immigration. its central findings is that, as long as fertility is below replacement, a constant number and age distribution of immigrants (with fixed fertility and mortality schedules) lead to a stationary population. Neither the level of the net reproduction rate nor the size of the annual immigration affects this conclusion; a stationary population eventually emerges. How this stationary population is created is studied, as is the generational distribution of the constant annual stream of births and of the total population. It is also shown that immigrants and their early descendants may have fertility well above replacement (as long as later generations adopt and maintain fertility below replacement), and the outcome will still be a long-run stationary population. [ABSTRACT FROM AUTHOR]
- Published
- 1982
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21. The three R's: residence, religion, and reproduction.
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Weller, Robert H., Bouvier, Leon F., Weller, R H, and Bouvier, L F
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RELIGION ,REPRODUCTION ,FAMILY size ,CHURCH membership ,DEMOGRAPHY ,ATTITUDE (Psychology) ,CHRISTIANITY ,FAMILIES ,FERTILITY ,JEWS ,PRAYER ,STATISTICAL sampling ,CITY dwellers ,RESIDENTIAL patterns ,SOCIOECONOMIC factors ,FAMILY planning - Abstract
Survey research data collected in Rhode Island over a three year interval are used to test six propositions: 1) Suburbanites have higher family size than central city residents. 2) Any differences in family size between Catholics and non-Catholics are larger in central city than in suburban areas. 3) Within religious categories, suburbanites attend church more regularly. 4) Among Catholics, suburban residence is associated with less frequent Communion reception. 5) Among Catholics, church attendance frequency is positively associated with family size. Among non- Catholics no relationship exists. 6) The frequency with which Catholics receive Communion is more strongly associated positively with family size than is church attendance frequency. Propositions 1, 2 and 5 are rejected. Propositions 4 and 6 are accepted. Proposition 3 is accepted for non-Catholics only. [ABSTRACT FROM AUTHOR]
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- 1972
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22. Synthesis of nucleoside and pentose monophosphates by acid phosphatase over-producing whole cells
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Lewkowicz, E., Medici, R., Garaycoechea, J.I., Valino, A.L., Canepa, G., Bouvier, L., Pereira, C., and Iribarren, A.
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- 2009
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23. Effect of the calcium/protein molar ratio on β-lactoglobulin denaturation kinetics and fouling phenomena.
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Khaldi, M., Croguennec, T., André, C., Ronse, G., Jimenez, M., Bellayer, S., Blanpain-Avet, P., Bouvier, L., Six, T., Bornaz, S., Jeantet, R., and Delaplace, G.
- Subjects
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CALCIUM , *LACTOGLOBULINS , *DENATURATION of proteins , *PLATE heat exchangers , *DAIRY industry - Abstract
Understanding the mechanism of whey protein fouling along a plate heat exchanger is a challenging issue in the dairy industry. The influence of the calcium/protein molar ratio on β-lactoglobulin (β-LG) denaturation and its consequence both on fouling mass along the plate heat exchanger and the structure of the fouling layer were studied. The experimental design was defined by varying the calcium/protein molar ratio from 2.3 to 22.9 and fixing the total concentration of calcium at 100 ppm. Results established that both the β-LG denaturation rate constants and the distribution of fouling in the plate heat exchanger were strongly impacted by the calcium/protein molar ratio. Structural analysis provided evidence that the fouling layer evolved from a thin and dense structure at low calcium/protein molar ratio towards a thicker and more open structure at higher calcium/protein molar ratio. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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24. Evaluation of residual oil saturation after waterflood in a carbonate reservoir
- Author
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Bouvier, L [Total-CFP, Saint-Remy-les-Chevreuse (France). Petrophysics Dept.]
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- 1994
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25. Efficacy of LSVT LOUD ® on Phonatory Control and Voice Quality in Patients with Primary Progressive Apraxia of Speech: Case Studies.
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Choi YNC, Martel-Sauvageau V, Breton M, Lavoie M, Laforce R Jr, and Bouvier L
- Abstract
Primary progressive apraxia of speech (PPAOS) is a neurodegenerative syndrome characterized by the progressive and initially isolated or predominant onset of difficulties in the planning/programming of movements necessary for speech production and can be accompanied by dysarthria. To date, no study has used an evidence-based treatment to address phonation control in patients with PPAOS. The aim of this study was to evaluate the feasibility and efficacy of LSVT LOUD
® as a treatment for phonatory control in speakers with PPAOS. Three speakers with PPAOS received LSVT LOUD® therapy, and changes in phonatory control, voice quality and prosody were measured immediately, and one, four and eight weeks after the end of the treatment. Overall, the results suggest that the treatment is feasible and could improve voice quality, intensity, and control in some patients with PPAOS. The generalization of the results is also discussed.- Published
- 2024
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26. Speech timing and monosyllabic diadochokinesis measures in the assessment of amyotrophic lateral sclerosis in Canadian French.
- Author
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Bouvier L, McKinlay S, Truong J, Genge A, Dupré N, Dionne A, Kalra S, and Yunusova Y
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- Humans, Canada, Speech Production Measurement methods, Language, Speech, Amyotrophic Lateral Sclerosis complications
- Abstract
Purpose: The primary objective of this study was to determine if speech and pause measures obtained using a passage reading task and timing measures from a monosyllabic diadochokinesis (DDK) task differ across speakers of Canadian French diagnosed with amyotrophic lateral sclerosis (ALS) presenting with and without bulbar symptoms, and healthy controls. The secondary objective was to determine if these measures can reflect the severity of bulbar symptoms., Method: A total of 29 Canadian French speakers with ALS (classified as bulbar symptomatic [ n = 14] or pre-symptomatic [ n = 15]) and 17 age-matched healthy controls completed a passage reading task and a monosyllabic DDK task (/pa/ and /ta/), for up to three follow-up visits. Measures of speaking rate, total duration, speech duration, and pause events were extracted from the passage reading recordings using a semi-automated speech and pause analysis procedure. Manual analysis of DDK recordings provided measures of DDK rate and variability., Result: Group comparisons revealed significant differences ( p = < .05) between the symptomatic group and the pre-symptomatic and control groups for all passage measures and DDK rates. Only the DDK rate in /ta/ differentiated the pre-symptomatic and control groups. Repeated measures correlations revealed moderate correlations (r
rm = > 0.40; p = < 0.05) between passage measures of total duration, speaking rate, speech duration, and number of pauses, and ALSFRS-R total and bulbar scores, as well as between DDK rate and ALSFRS-R total score., Conclusion: Speech and pause measures in passage and timing measures in monosyllabic DDK tasks might be suitable for monitoring bulbar functional symptoms in French speakers with ALS, but more work is required to identify which measures are sensitive to the earliest stages of the disease.- Published
- 2024
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27. Amyotrophic Lateral Sclerosis-Bulbar Dysfunction Index-Remote: Test-Retest and Interrater Reliability of Candidate Items.
- Author
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Bouvier L, Green JR, Tapia CB, Tilton-Bolowsky V, Maffei MF, Fless Z, Seaver K, Huynh A, Gutz SE, Martino R, Abrahao A, Berry J, Zinman L, and Yunusova Y
- Subjects
- Humans, Reproducibility of Results, Neurologic Examination, Deglutition, Severity of Illness Index, Amyotrophic Lateral Sclerosis diagnosis
- Abstract
Purpose: The primary aim of this study was to establish the reliability of candidate items as a step in the development of the Amyotrophic Lateral Sclerosis-Bulbar Dysfunction Index-Remote (ALS-BDI-Remote), a novel tool being developed for the detection and monitoring of bulbar signs and symptoms in remote settings., Method: The set of candidate items included 40 items covering three domains: cranial nerve examination, auditory-perceptual evaluation, and functional assessment. Forty-eight participants diagnosed with ALS and exhibiting a range of bulbar disease severity were included. Data collection for each participant took place on Zoom over three sessions. During Session 1, the participants were instructed to adjust their Zoom settings and to optimize their recording environment (e.g., lighting, background noise). Their cognition and eating were screened to determine their ability to follow instructions and their eligibility to perform the swallowing and chewing tasks. During Session 2, two speech-language pathologists (SLPs) administered the tool consecutively to determine the items' interrater reliability. During Session 3, one of the SLPs readministered the tool within 2 weeks of Session 1 to assess test-retest reliability. The reliability of each item was estimated using weighted kappa and the percentage of agreement. To be considered reliable, the items had to reach a threshold of 0.5 weighted kappa or 80% percentage agreement (if skewed distribution of the scores) for both interrater and test-retest reliability., Results: In total, 33 of the 40 candidate items reached the reliability cutoff for both reliability analyses. All assessment domains included reliable items. Items requiring very good visualization of structures or movements were generally less reliable., Conclusions: This study resulted in the selection of reliable items to be included in the next version of the ALS-BDI-Remote, which will undergo psychometric evaluation (reliability, validity, and responsiveness analyses). Additionally, the results contributed to our understanding of the remote administration of SLP assessments for telehealth applications.
- Published
- 2023
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28. 3D Video Tracking Technology in the Assessment of Orofacial Impairments in Neurological Disease: Clinical Validation.
- Author
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Jafari D, Simmatis L, Guarin D, Bouvier L, Taati B, and Yunusova Y
- Subjects
- Animals, Dogs, Algorithms, Biomechanical Phenomena physiology, Speech physiology, Nervous System Diseases
- Abstract
Purpose: This study sought to determine whether clinically interpretable kinematic features extracted automatically from three-dimensional (3D) videos were correlated with corresponding perceptual clinical orofacial ratings in individuals with orofacial impairments due to neurological disorders., Method: 45 participants (19 diagnosed with motor neuron diseases [MNDs] and 26 poststroke) performed two nonspeech tasks (mouth opening and lip spreading) and one speech task (repetition of a sentence "Buy Bobby a Puppy") while being video-recorded in a standardized lab setting. The color video recordings of participants were assessed by an expert clinician-a speech language pathologist-on the severity of three orofacial measures: symmetry, range of motion (ROM), and speed. Clinically interpretable 3D kinematic features, linked to symmetry, ROM, and speed, were automatically extracted from video recordings, using a deep facial landmark detection and tracking algorithm for each of the three tasks. Spearman correlations were used to identify features that were significantly correlated ( p value < .05) with their corresponding clinical scores. Clinically significant kinematic features were then used in the subsequent multivariate regression models to predict the overall orofacial impairment severity score., Results: Several kinematic features extracted from 3D video recordings were associated with their corresponding perceptual clinical scores, indicating clinical validity of these automatically derived measures. Different patterns of significant features were observed between MND and poststroke groups; these differences were aligned with clinical expectations in both cases., Conclusions: The results show that kinematic features extracted automatically from simple clinical tasks can capture characteristics used by clinicians during assessments. These findings support the clinical validity of video-based automatic extraction of kinematic features.
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- 2023
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29. Speech rate increase in primary progressive apraxia of speech and its cost on articulatory accuracy.
- Author
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Bouvier L, Monetta L, and Martel-Sauvageau V
- Subjects
- Humans, Language, Speech, Speech Production Measurement, Apraxias diagnosis, Neurodegenerative Diseases
- Abstract
Impaired articulation (e.g., articulatory accuracy) and prosody (e.g., slow speech rate) are considered primary diagnostic criterions for apraxia of speech both in neurodegenerative and post-stroke contexts. The primary aim of this study was to investigate the ability of participants with primary progressive apraxia of speech (PPAOS), a neurodegenerative disease characterised by initially isolated progressive apraxia of speech, to increase speech rate and the interaction between articulatory accuracy and speech rate. The secondary aim was to investigate the effect of syllable frequency and structure on this interaction. Four speakers with PPAOS, and four sex- and age-matched healthy speakers (HS) read eight two-syllable words embedded two times in a ten-syllable carrier phrase. Syllable frequency and structure were manipulated for the first syllable of the target words and controlled for the second syllable. All sentences were produced at three different target speech rates (conditions): habitual, regular (five syllables/second), and fast (seven syllables/second). Prosodic measures for target words and sentences were computed based on acoustic analysis of speech rate. Articulatory measures for words and sentences were rated based on a perceptual assessment of articulatory accuracy. Results show slower speech rate and reduced articulatory accuracy in speakers with PPAOS compared to HS. Results suggest that speakers with PPAOS also have limited ability to increase their speech rate. Finally, results suggest that articulatory complexity influences speech rate but that the cost of speech rate increase on articulatory accuracy varies greatly across speakers with PPAOS and is not necessarily related to the extent of the increase when measured in a highly structured sentence production task. Theoretical and clinical implications of these findings are discussed.
- Published
- 2022
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30. Heterogeneity of repetition abilities in logopenic variant primary progressive aphasia.
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Macoir J, Martel-Sauvageau V, Bouvier L, Laforce R, and Monetta L
- Abstract
The differential diagnosis of primary progressive aphasia (PPA) is challenging due to overlapping clinical manifestations of the different variants of the disease. This is particularly true for the logopenic variant of PPA (lvPPA), in which such overlap was reported with regard to impairments in repetition abilities. In this study, four individuals with lvPPA underwent standard neuropsychological and language assessments. The influence of psycholinguistic variables on their performance of in word, nonword and sentence repetition tasks was also specifically explored. Some level of heterogeneity was found in cognitive functions and in language. The four participants showed impairment in sentence repetition in which their performance was negatively affected by semantic reversibility and syntactic complexity. This study supports the heterogeneity of lvPPA with respect to the cognitive and linguistic status of participants. It also shows that sentence repetition is influenced not only by length, but also by semantic reversibility and syntactic complexity, two psycholinguistic variables known to place additional demands on phonological working memory., Competing Interests: Disclosure: The authors report no conflicts of interest.
- Published
- 2021
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31. A Preliminary Look Into the Clinical Evolution of Motor Speech Characteristics in Primary Progressive Apraxia of Speech in Québec French.
- Author
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Bouvier L, Monetta L, Vitali P, Laforce R Jr, and Martel-Sauvageau V
- Subjects
- Humans, Prospective Studies, Quebec, Speech, Aphasia, Primary Progressive, Apraxias diagnosis
- Abstract
Purpose This study aimed to track changes in acoustical and perceptual features of motor speech in patients with phonetic and prosodic primary progressive apraxia of speech (PPAOS) in Québec French over an 18-month period. Method A prospective multiple-case series with multiple testing periods, including four participants with a diagnosis of PPAOS, was conducted. Participants were 0.5-4 years postonset of disease at baseline. They underwent comprehensive motor speech and language assessments and cognitive screening every 6 months for up to 18 months. Acoustical and perceptual analyses of motor speech were conducted. Results Results showed a considerable impairment in motor speech abilities for patients with PPAOS at all time points and a significant decrease in performance for almost all articulatory and prosodic measures over time. Passage reading and diadochokinesis seemed particularly promising for the tracking of changes in PPAOS motor speech characteristics and PPAOS classification. Quantifying length of speech runs made it possible to distinguish phonetic from prosodic PPAOS. Finally, the patients who evolved to phonetic PPAOS developed aphasia, and the two with prosodic PPAOS showed greater motor symptoms such as unequivocal dysarthria. Conclusion This study extends the growing literature on PPAOS and its subtypes by describing specific changes in articulatory and prosodic abilities over a period of at least 6 months, which are important for the diagnosis and management of PPAOS.
- Published
- 2021
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32. Influence of the design of fresh-cut food washing tanks on the growth kinetics of Pseudomonas fluorescens biofilms.
- Author
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Bouvier L, Cunault C, Faille C, Dallagi H, Wauquier L, and Bénézech T
- Abstract
Mitigation of cross-contamination of fresh-cut food products at the washing step was studied by investigating how the vat design would affect the biofilm contamination surfaces. Hygienic design features such as no horizontal surfaces and only open angles exceeding 100° were proposed. The flow organization (velocity streamlines, wall shear stresses, and dynamics of the flow) was identified by means of computational fluid dynamics (CFD) calculation. Pseudomonas fluorescens PF1 biofilm growth kinetics were then mapped. The change in some geometrical features induced a better flow organization reducing "dead zones". This significantly changed the biofilm growth kinetics, delaying the detection of biofilms from 20 hr to 24 hr. Critical areas such as welds, corners, and interfaces appeared far less prone to strong bacterial development. This would mean milder or less chemicals required at the washing step and faster and easier cleaning., Competing Interests: The authors declare no competing interests., (© 2021 The Authors.)
- Published
- 2021
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33. Progressive apraxia of speech in Quebec French speakers: A case series.
- Author
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Bouvier L, Monetta L, Laforce RJ, Vitali P, Bocti C, and Martel-Sauvageau V
- Subjects
- Humans, Language, Quebec, Speech, Aphasia, Primary Progressive, Apraxias diagnosis
- Abstract
Background: The term progressive apraxia of speech (PAOS) is used to describe speakers presenting with isolated or dominant apraxia of speech in the context of a neurodegenerative syndrome, including primary progressive apraxia of speech (PPAOS) and dominant progressive apraxia of speech (DAOS), respectively. Its motor speech profile has been increasingly explored in the last decade, but description remains vague and very English oriented, although the effect of speakers' language on motor speech phenotypes is increasingly recognized. Although some studies suggest that speakers presenting with isolated PAOS (PPAOS) versus dominant PAOS with concomitant aphasia (DAOS) should be differentiated, distinct characteristics of the two presentations are unclear. Furthermore, a careful description of their clinical presentation in languages other than English is required., Aims: To describe the motor speech characteristics of Quebec French-speaking participants with prominent PAOS and to explore the communication profile of those presenting more specifically with isolated PAOS (PPAOS), and with dominant PAOS and concomitant aphasia (DAOS)., Methods & Procedures: A thorough effort to recruit all speakers presenting with PAOS in the larger population areas of the province of Quebec was conducted over a 3-year span. A total of nine participants with PAOS (pwPAOS; PPAOS = 5, DAOS = 4) underwent a comprehensive language and motor speech assessment, and a cognitive screening. Their performance was compared with 30 matched healthy controls., Outcomes & Results: As a group, pwPAOS differed from healthy speakers on all acoustic and perceptual measures. The PPAOS and PAOS subgroups were similar on several measures, but participants from the PPAOS subgroup tended to perform better on articulatory measures and maximum speech rate tasks., Conclusions & Implications: This study provides an in-depth analysis of motor speech characteristics of PAOS in Quebec French speakers and adds further evidence for the differentiation of PPAOS and DAOS. Combining simple perceptual and acoustic analyses represent a promising approach to distinguish the two variants and identify treatment targets. What this paper adds What is already known on this subject Progressive apraxia of speech (PAOS) is a neurodegenerative syndrome characterized by progressive and initially isolated or dominant apraxia of speech (primary progressive apraxia of speech [PPAOS] and dominant progressive apraxia of speech [DAOS], respectively). Studies mostly report articulatory and prosodic deficits in PAOS, but concomitant deficits such as dysarthria and executive dysfunction are also reported. The description of motor speech skills in PAOS remains vague and English-oriented. Studies suggest that speakers presenting with isolated PAOS vs dominant PAOS with concomitant aphasia should be differentiated, but distinct characteristics of the two presentations are unclear. What this study adds to existing knowledge To the best of the authors' knowledge, this study is the first to report transversal data of Quebec-French participants with PPAOS and DAOS. Moreover, this study is a first step towards identifying potential characteristics that could facilitate the diagnosis of PPAOS and DAOS in Quebec French. It makes a significant contribution to our understanding of progressive apraxia of speech in different cultural languages. What are the potential or actual clinical implications of this work? This study also initiates the search for sensitive tasks for the diagnosis of those speakers (which is an important process), in addition to identifying the core characteristics of PAOS, DAOS, and PPAOS in the development of an assessment battery for this population., (© 2021 Royal College of Speech and Language Therapists.)
- Published
- 2021
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34. Methods to Investigate the Global Atmospheric Microbiome.
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Dommergue A, Amato P, Tignat-Perrier R, Magand O, Thollot A, Joly M, Bouvier L, Sellegri K, Vogel T, Sonke JE, Jaffrezo JL, Andrade M, Moreno I, Labuschagne C, Martin L, Zhang Q, and Larose C
- Abstract
The interplay between microbes and atmospheric physical and chemical conditions is an open field of research that can only be fully addressed using multidisciplinary approaches. The lack of coordinated efforts to gather data at representative temporal and spatial scales limits aerobiology to help understand large scale patterns of global microbial biodiversity and its causal relationships with the environmental context. This paper presents the sampling strategy and analytical protocols developed in order to integrate different fields of research such as microbiology, -omics biology, atmospheric chemistry, physics and meteorology to characterize atmospheric microbial life. These include control of chemical and microbial contaminations from sampling to analysis and identification of experimental procedures for characterizing airborne microbial biodiversity and its functioning from the atmospheric samples collected at remote sites from low cell density environments. We used high-volume sampling strategy to address both chemical and microbial composition of the atmosphere, because it can help overcome low aerosol and microbial cell concentrations. To account for contaminations, exposed and unexposed control filters were processed along with the samples. We present a method that allows for the extraction of chemical and biological data from the same quartz filters. We tested different sampling times, extraction kits and methods to optimize DNA yield from filters. Based on our results, we recommend supplementary sterilization steps to reduce filter contamination induced by handling and transport. These include manipulation under laminar flow hoods and UV sterilization. In terms of DNA extraction, we recommend a vortex step and a heating step to reduce binding to the quartz fibers of the filters. These steps have led to a 10-fold increase in DNA yield, allowing for downstream omics analysis of air samples. Based on our results, our method can be integrated into pre-existing long-term monitoring field protocols for the atmosphere both in terms of atmospheric chemistry and biology. We recommend using standardized air volumes and to develop standard operating protocols for field users to better control the operational quality.
- Published
- 2019
- Full Text
- View/download PDF
35. L'apport critique de l'évaluation de la communication dans le diagnostic précoce de l'apraxie primaire progressive de la parole.
- Author
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Bouvier L, Monetta L, Laforce R, Verret L, and Martel-Sauvageau V
- Subjects
- Communication, Disease Progression, Humans, Speech Disorders diagnosis, Apraxias diagnosis, Early Diagnosis, Language Disorders diagnosis
- Abstract
Primary progressive apraxia of speech (PPAoS) is a neurodegenerative syndrome characterized by speech apraxia at its onset; as it progresses, it often evolves into total mutism. Even though this syndrome is increasingly recognized, its early differential diagnostic is still complex. The objective of this study was to illustrate why a fine evaluation of speech and language is essential for the differential diagnosis of PPAoS. This longitudinal case study presents the progression of a PPAoS patient over a period of 5 years. Periodic neurological and speech-language assessments were carried out to follow the progression of neurological, memory, language and speech symptoms. The different diagnostic labels established over time were also reported. The evolution of the patient's communication profile was characterized by a preservation of language components and episodic memory, in parallel with a progressive deterioration of speech which gradually reduced intelligibility, and was associated with signs of spasticity, resulting in a complete anarthria. This case study sheds light upon the evolution of a patient with PPAoS. A better understanding of the clinical profile and progression of PPAoS is necessary in order to improve early diagnosis and adequate care for these patients.
- Published
- 2018
- Full Text
- View/download PDF
36. Language disturbances after non-thalamic subcortical stroke: a review of the literature.
- Author
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Bouvier L, Groulx B, Martel-Sauvageau V, and Monetta L
- Subjects
- Aphasia etiology, Aphasia psychology, Basal Ganglia Diseases complications, Basal Ganglia Diseases psychology, Humans, Language Disorders etiology, Language Disorders psychology, Stroke complications, Stroke psychology
- Abstract
Language disorders following subcortical non-thalamic stroke show great variability across literature and a well-defined profile in these aphasic disturbances is yet to be established. The lack of recent and consistent literature on the subject complicates the management of subcortical aphasia. The aim of this study is to review the literature describing oral language disturbances following subcortical non-thalamic stoke affecting the basal ganglia and the surrounding white matter. A review of the literature of three databases (PubMed, PsycNet and LLBA), identifying research articles from 1997 to 2015, was completed. The quality of the selected studies was assessed using the Checklist for the assessment of methodological quality. Twenty-two articles met criteria for review and oral language assessment data were extracted for 114 subjects. The results suggest a predominance of deficits in more complex and demanding language levels (ex. discourse, syntax) and in language production (vs comprehension). Rapid recovery is expected, especially for lexical-semantic and receptive deficits. These findings show the importance of a complete oral language evaluation after subcortical stoke and provide recent data relative to expected deficits and recovery to guide clinicians in the management of these patients. They also suggest that a descriptive approach of the deficits may be more efficient and accurate than the use of a traditional classification of aphasia.
- Published
- 2017
- Full Text
- View/download PDF
37. A novel stage-specific glycosomal nucleoside diphosphate kinase from Trypanosoma cruzi.
- Author
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Los Milagros Camara M, Bouvier L, Reigada C, Digirolamo FA, Saye M, and Pereira CA
- Subjects
- Isoenzymes, Life Cycle Stages, Microbodies enzymology, Phylogeny, Protein Domains, Protozoan Proteins genetics, Trypanosoma cruzi genetics, Trypanosoma cruzi physiology, Chagas Disease parasitology, Energy Metabolism, Nucleoside-Diphosphate Kinase genetics, Trypanosoma cruzi enzymology
- Abstract
Nucleoside diphosphate kinases (NDPK) are key enzymes involved in the intracellular nucleotide maintenance in all living organisms, especially in trypanosomatids which are unable to synthesise purines de novo. Four putative NDPK isoforms were identified in the Trypanosoma cruzi Chagas, 1909 genome but only two of them were characterised so far. In this work, we studied a novel isoform from T. cruzi called TcNDPK3. This enzyme presents an atypical N-terminal extension similar to the DM10 domains. In T. cruzi, DM10 sequences targeted other NDPK isoform (TcNDPK2) to the cytoskeleton, but TcNDPK3 was localised in glycosomes despite lacking a typical peroxisomal targeting signal. In addition, TcNDPK3 was found only in the bloodstream trypomastigotes where glycolytic enzymes are very abundant. However, TcNDPK3 mRNA was also detected at lower levels in amastigotes suggesting regulation at protein and mRNA level. Finally, 33 TcNDPK3 gene orthologs were identified in the available kinetoplastid genomes. The characterisation of new glycosomal enzymes provides novel targets for drug development to use in therapies of trypanosomatid associated diseases.
- Published
- 2017
- Full Text
- View/download PDF
38. [Cultivating confidence: a way forward in the face of therapeutic deadlocks].
- Author
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Ouhayoun B, Coussegal F, and Bouvier L
- Subjects
- Aftercare, Communication, Female, Humans, Middle Aged, Nurse-Patient Relations, Nursing, Team, Self Concept, Defense Mechanisms, Psychiatric Nursing methods, Psychotherapy, Schizophrenia nursing, Schizophrenic Psychology
- Abstract
The aftercare centre is a therapeutic tool which sometimes enables situations of therapeutic deadlock to be overcome. By focusing on the long term, the patient is able to undertake a sustainable transformation of their relationship with themselves and with others. However, this challenging work cannot be carried out without a foundation of respect for the caregiving teams with regard to their therapeutic capacity as well as trust in their partners., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
39. Canadian Stroke Best Practice Recommendations: Mood, Cognition and Fatigue Following Stroke practice guidelines, update 2015.
- Author
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Eskes GA, Lanctôt KL, Herrmann N, Lindsay P, Bayley M, Bouvier L, Dawson D, Egi S, Gilchrist E, Green T, Gubitz G, Hill MD, Hopper T, Khan A, King A, Kirton A, Moorhouse P, Smith EE, Green J, Foley N, Salter K, and Swartz RH
- Subjects
- Canada epidemiology, Female, Humans, Incidence, Male, Program Development standards, Stroke complications, Stroke epidemiology, Cognition Disorders etiology, Fatigue etiology, Mood Disorders etiology, Practice Guidelines as Topic, Stroke therapy
- Abstract
Every year, approximately 62 000 people with stroke and transient ischemic attack are treated in Canadian hospitals, and the evidence suggests one-third or more will experience vascular-cognitive impairment, and/or intractable fatigue, either alone or in combination. The 2015 update of the Canadian Stroke Best Practice Recommendations: Mood, Cognition and Fatigue Module guideline is a comprehensive summary of current evidence-based recommendations for clinicians in a range of settings, who provide care to patients following stroke. The three consequences of stroke that are the focus of the this guideline (poststroke depression, vascular cognitive impairment, and fatigue) have high incidence rates and significant impact on the lives of people who have had a stroke, impede recovery, and result in worse long-term outcomes. Significant practice variations and gaps in the research evidence have been reported for initial screening and in-depth assessment of stroke patients for these conditions. Also of concern, an increased number of family members and informal caregivers may also experience depressive symptoms in the poststroke recovery phase which further impact patient recovery. These factors emphasize the need for a system of care that ensures screening occurs as a standard and consistent component of clinical practice across settings as stroke patients transition from acute care to active rehabilitation and reintegration into their community. Additionally, building system capacity to ensure access to appropriate specialists for treatment and ongoing management of stroke survivors with these conditions is another great challenge., (© 2015 World Stroke Organization.)
- Published
- 2015
- Full Text
- View/download PDF
40. Damage in agitated vessels of large visco-elastic particles dispersed in a highly viscous fluid.
- Author
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Bouvier L, Moreau A, Line A, Fatah N, and Delaplace G
- Subjects
- Bioreactors, Models, Theoretical, Particle Size, Rotation, Cooking methods, Viscosity
- Abstract
Unlabelled: Many food recipes entail several homogenization steps for solid particles in hot or cold viscous liquids, such as pureed fruit and sugar, jam or sauce with mushroom pieces. Unfortunately, these unavoidable processes induce damage to the solid particles. To date, little is known of the extent and nature of the damage caused. Consequently, few clear guidelines are available for monitoring solid particle integrity when mixing solid/liquid suspensions in an agitated tank. In this study, an attempt is made to quantify the impact of various physical parameters including the influence of the rotational speed of the impeller and the processing time on particle attrition, when a suspension of large visco-elastic particles in a highly viscous fluid is mixed under isothermal condition. Pectin gel particles were immerged in a viscous liquid and homogenized for various times and rotational speeds, while the evolution of the particle's morphological parameters was monitored. Then, a set of dimensionless numbers governing the attrition mechanism is established and some empirical process relationships are proposed to correlate these numbers to the morphological characteristics and mass balance ratios. From the conditions observed, it is clear that 2 dimensionless ratios could be responsible for a change in the damaging mechanisms. These 2 ratios are the Froude and impeller rotation numbers. Finally, in the conditions tested, mass balance ratios appear to be mainly sensitive to the impeller rotational number, while the shape ratios are both impacted by the Froude and impeller rotational numbers., Practical Application: Damage to solid particles suspended in a stirred vessel reduce the final product quality in industrial cooking processes. Examples of this are fruit in jam or sauces with mushroom pieces. The attrition phenomenon was measured and the influences of the impeller rotational speed and processing time were evaluated quantitatively in function of dimensionless numbers. This study contributes key elements for the monitoring of damage to solids with a view to retaining solid integrity., (© 2011 Institute of Food Technologists®)
- Published
- 2011
- Full Text
- View/download PDF
41. Trypanosoma cruzi nucleoside diphosphate kinase 1 ( TcNDPK1) has a broad nuclease activity.
- Author
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Miranda MR, Canepa GE, Bouvier LA, and Pereira CA
- Subjects
- Adenosine Diphosphate metabolism, Adenosine Triphosphate metabolism, Amino Acid Sequence, Animals, Conserved Sequence, DNA, Protozoan metabolism, DNA, Superhelical metabolism, Hot Temperature, Magnesium metabolism, Nucleoside-Diphosphate Kinase chemistry, Nucleoside-Diphosphate Kinase genetics, Phylogeny, Recombinant Proteins genetics, Recombinant Proteins metabolism, Sequence Alignment, Time Factors, Trypanosoma cruzi classification, Trypanosoma cruzi genetics, Nucleoside-Diphosphate Kinase metabolism, Trypanosoma cruzi enzymology
- Abstract
Here, we present the characterization of a trypanosomatid nucleoside diphosphate kinase (TcNDPK1) exhibiting nuclease activity. This is the first identification of a NDPK with this property in trypanosomatid organisms. The recombinant TcNDPK1 protein cleaves not only linear DNA, but also supercoiled plasmid DNA. Additionally, TcNDPK1 is capable of degrading Trypanosoma cruzi genomic DNA. ATP or ADP did not affect the nuclease activity, while the absence of Mg2+ completely inhibits this activity. NDPK and nuclease activities were inhibited at the same temperature, suggesting the presence of related catalytic sites. Furthermore, phenogram analysis showed that TcNDPK1 is close to Drosophila melanogaster and human NDPKs. The unspecific nuclease activity could suggest a participation in cellular processes such as programmed cell death.
- Published
- 2008
- Full Text
- View/download PDF
42. Population growth impacts of zero net international migration.
- Author
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Bouvier LF, Poston DL, and Zhai NB
- Subjects
- Americas, Developed Countries, North America, Population, Research, United States, Demography, Emigration and Immigration, Population Dynamics, Population Growth, Statistics as Topic, Terminology as Topic
- Abstract
"In a country such as the United States, the contribution of net international migration to overall population change overshadows the contribution of natural increase.... Some analysts have assumed that if the same number of people leave and enter the country each year, then the effect of net international migration will be zero. This article examines that assumption and shows that it is fallacious. Examining the direct, indirect, total, and negative demographic impacts of zero net international migration through simulations with demographic data, we demonstrate that zero net international migration is not the same and therefore does not have the same demographic results and implications as zero international migration. We conclude that zero net international migration should not be confused with zero international migration.", (excerpt)
- Published
- 1997
43. Zero net international migration: what does it really mean?
- Author
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Bouvier LF, Poston DL, and Zhai NB
- Subjects
- Americas, Demography, Developed Countries, Europe, Germany, North America, Population, Population Dynamics, United States, Emigration and Immigration, Population Density, Public Policy
- Abstract
"The idea of ¿zero net migration' is gaining increasing currency. It has been assumed that if there is balance between the number of immigrants and emigrants, migration will have no impact on a country's population size. However, this article demonstrates that zero net migration is not necessarily the same as zero migration, and can result in a higher population than would have occurred without any migration at all." The examples of Germany and the United States are presented., (excerpt)
- Published
- 1995
44. Phase 1 study of recombinant human CD4-immunoglobulin G therapy of patients with AIDS and AIDS-related complex.
- Author
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Hodges TL, Kahn JO, Kaplan LD, Groopman JE, Volberding PA, Amman AJ, Arri CJ, Bouvier LM, Mordenti J, and Izu AE
- Subjects
- AIDS-Related Complex blood, AIDS-Related Complex immunology, Acquired Immunodeficiency Syndrome blood, Acquired Immunodeficiency Syndrome immunology, Adult, Antigens, Viral drug effects, Antigens, Viral isolation & purification, Biological Availability, CD4 Immunoadhesins blood, Dose-Response Relationship, Drug, Humans, Injections, Intramuscular, Injections, Intravenous, Kinetics, Leukocyte Count, Lymphocytes, Male, Middle Aged, Recombinant Proteins therapeutic use, AIDS-Related Complex drug therapy, Acquired Immunodeficiency Syndrome drug therapy, CD4 Immunoadhesins therapeutic use
- Abstract
The safety and pharmacokinetics of recombinant CD4-immunoglobulin G (rCD4-IgG) were evaluated in a phase 1 study with dose escalation. A total of 16 patients, 6 with AIDS and 10 with AIDS-related complex, were evaluated at two university-affiliated hospital clinics. rCD4-IgG was administered once weekly for 12 weeks to four patients each at doses of 0.03, 0.1, 0.3, and 1.0 mg/kg of body weight. Dosing was intravenous for two patients in the 1.0-mg/kg dose group and intramuscular for the remaining patients. Dosing was intravenous for two patients in the 1.0-mg/kg dose group and intramuscular for the remaining patients. Pharmacokinetic, toxicity, and immunologic variables were monitored with all patients. Administration of rCD4-IgG was well tolerated, with no important clinical or immunologic toxicities noted. No subjects required dose reduction or discontinuation of therapy due to toxicity. No consistent changes were seen in human immunodeficiency virus antigen levels in serum or CD4 lymphocyte populations. The volume of distribution was small, and compared with that of rCD4, the half-life of the hybrid molecule was markedly prolonged following intramuscular or intravenous administration. The rate and extent of absorption following intramuscular dosing were variable. Intramuscular administration of rCD4-IgG appears to be inferior to intravenous dosing from a pharmacokinetic standpoint, with lower peak concentrations and variable absorption. After intravenous administration, peak concentrations of rCD4-IgG in serum (20 to 24 micrograms/ml) that have shown antiviral activity in vitro against more sensitive clinical isolates of human immunodeficiency virus were achieved. The peak concentrations in serum after intramuscular administration were below these levels. Treatment with rCD4-IgG was well tolerated at the doses administered to patients in this study but did not result in significant changes in CD4 lymphocyte counts or p24 antigen levels in serum.
- Published
- 1991
- Full Text
- View/download PDF
45. Immigration and rising U.S. fertility: a prospect of unending population growth.
- Author
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Bouvier L
- Subjects
- Americas, California, Culture, Demography, Developed Countries, North America, Population, Population Characteristics, Population Dynamics, Research, Statistics as Topic, United States, Black or African American, Censuses, Emigration and Immigration, Ethnicity, Evaluation Studies as Topic, Fertility, Forecasting, Hispanic or Latino, Population Growth, Transients and Migrants, White People
- Published
- 1991
46. [Immigration, population change, and the American mosaic].
- Author
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Bouvier L
- Subjects
- Age Factors, Americas, Culture, Demography, Developed Countries, North America, Population, Population Characteristics, Research, Statistics as Topic, United States, Age Distribution, Emigration and Immigration, Ethnicity, Fertility, Forecasting, Mortality, Population Dynamics, Public Policy
- Abstract
"This article looks at the relationships among immigration, fertility and mortality to explain the changes that have occurred and will continue to occur in the population of the United States. Emphasis centers on the recent past, the present and the first half of the 21st century. It is pointed out that the nation will undergo major changes in its age and ethnic composition in the near future because of the aging of the baby boom generation and the continued high level of immigration from Latin America and Asia.... In the paper's conclusion, alternative policy options are considered." (SUMMARY IN ENG AND SPA), (excerpt)
- Published
- 1990
47. Emigration as an auxiliary method of population control.
- Author
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Espenshade TJ and Bouvier LF
- Subjects
- Developing Countries, Population Density, Demography, Emigration and Immigration, Models, Theoretical, Politics, Population, Population Control, Population Dynamics, Population Growth, Public Policy, Research
- Published
- 1985
48. America's baby boom generation: the fateful bulge.
- Author
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Bouvier LF
- Subjects
- Age Factors, Americas, Demography, Developed Countries, Fertility, North America, Population, Population Characteristics, Population Dynamics, Research, Sex Factors, Statistics as Topic, United States, Age Distribution, Birth Rate, Education, Population Growth, Sex Distribution
- Published
- 1980
49. Immigration to the U.S.: the unfinished story.
- Author
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Bouvier LF and Gradner RW
- Subjects
- Americas, Culture, Developed Countries, Developing Countries, Economics, North America, Population, Socioeconomic Factors, United States, Demography, Emigration and Immigration, Ethnicity, Population Characteristics, Population Dynamics
- Published
- 1986
50. The invisible hand in San Francisco.
- Author
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Adams J, Bouvier L, Davis C, Gardner B, Haupt A, Kent M, Molajo D, Merrick T, Scully J, and Van Der Tak J
- Subjects
- Americas, California, Demography, Developed Countries, Developing Countries, Education, North America, Public Policy, Sex Education, United States, Congresses as Topic, Population, Population Dynamics
- Published
- 1986
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