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296 results on '"Blazing, Michael"'

1. Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Author

Reith, Christina, Preiss, David, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Harper, Charlie, Holland, Lisa, Wilson, Kate, Roddick, Alistair J, Cannon, Christopher P, Clarke, Robert, Colhoun, Helen M, Durrington, Paul N, Goto, Shinya, Hitman, Graham A, Hovingh, G Kees, Jukema, J Wouter, Koenig, Wolfgang, Marschner, Ian, Mihaylova, Borislava, Newman, Connie, Probsfield, Jeffrey L, Ridker, Paul M, Sabatine, Marc S, Sattar, Naveed, Schwartz, Gregory G, Tavazzi, Luigi, Tonkin, Andrew, Trompet, Stella, White, Harvey, Yusuf, Salim, Armitage, Jane, Keech, Anthony, Simes, John, Collins, Rory, Baigent, Colin, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, O'Connell, Rachel, Amarenco, Pierre, Arashi, Hiroyuki, Barter, Philip, Betteridge, D John, Blazing, Michael, Blauw, Gerard J, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Bulbulia, Richard, Byington, Robert, Clearfield, Michael, Cobbe, Stuart, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Fellström, Bengt, Flather, Marcus, Ford, Ian, Franzosi, Maria Grazia, Fuller, John, Furberg, Curt, Glynn, Robert, Goldbourt, Uri, Gordon, David, Gotto, Jr, Antonio, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Haynes, Richard, Holdaas, Hallvard, Hopewell, Jemma, Jardine, Alan, Kastelein, John JP, Kean, Sharon, Kearney, Patricia, Kitas, George, Kjekshus, John, Knatterud, Genell, Knopp, Robert H, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Robertson, Michele, Sacks, Frank, Schmieder, Roland, Serruys, Patrick, Sever, Peter, Shaw, John, Shepherd, James, Simpson, Lara, Sleight, Peter, Smeeth, Liam, Tobert, Jonathan, Tognoni, Gianni, Varigos, John, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Yamaguchi, Junichi, Young, Robin, and Zannad, Faiez

Published
2024
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3. Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

Author

Reith, Christina, Baigent, Colin, Blackwell, Lisa, Emberson, Jonathan, Spata, Enti, Davies, Kelly, Halls, Heather, Holland, Lisa, Wilson, Kate, Armitage, Jane, Harper, Charlie, Preiss, David, Roddick, Alistair, Keech, Anthony, Simes, John, Collins, Rory, Barnes, Elizabeth, Fulcher, Jordan, Herrington, William G, Kirby, Adrienne, Mihaylova, Borislava, O'Connell, Rachel, Amarenco, Pierre, Barter, Philip, Betteridge (deceased), D John, Blazing, Michael, Bosch, Jackie, Bowman, Louise, Braunwald, Eugene, Cannon, Christopher P, Clearfield, Michael, Cobbe, Stuart, Colhoun, Helen M, Dahlöf, Björn, Davis, Barry, de Lemos, James, Downs, John R, Durrington, Paul N, Fellström, Bengt, Ford, Ian, Franzosi, Maria Grazia, Fuller (deceased), John, Furberg, Curt, Glynn, Robert, Gordon, David, Gotto Jr, Antonio, Grimm, Richard, Gupta, Ajay, Hawkins, C Morton, Hitman, Graham A, Holdaas (deceased), Hallvard, Jardine, Alan, Jukema, J Wouter, Kastelein, John JP, Kean, Sharon, Kjekshus, John, Knatterud (deceased), Genell, Knopp (deceased), Robert H, Koenig, Wolfgang, Koren, Michael, Krane, Vera, Landray, Martin, LaRosa, John, Latini, Roberto, Lonn, Eva, Lucci, Donata, MacFadyen, Jean, Macfarlane, Peter, MacMahon, Stephen, Maggioni, Aldo, Marchioli, Roberto, Marschner, Ian, Moyé, Lemuel, Murphy, Sabina, Neil, Andrew, Nicolis, Enrico B, Packard, Chris, Parish, Sarah, Pedersen, Terje R, Peto, Richard, Pfeffer, Marc, Poulter, Neil, Pressel, Sara, Probstfield, Jeffrey, Rahman, Mahboob, Ridker, Paul M, Robertson, Michele, Sacks, Frank, Sattar, Naveed, Schmieder, Roland, Serruys, Patrick W, Sever, Peter, Shaw (deceased), John, Shepherd (deceased), James, Simpson, Lara, Sleight (deceased), Peter, Tavazzi, Luigi, Tognoni, Gianni, Tonkin, Andrew, Trompet, Stella, Wanner, Christoph, Wedel, Hans, Weis, Stephen, Welch, K Michael, White, Harvey, Wikstrand, John, Wilhelmsen, Lars, Wiviott, Stephen, Young, Robin, Yusuf, Salim, Zannad, Faiez, Arashi, Hiroyuki, Byington, Robert, Clarke, Robert, Flather, Marcus, Goldbourt, Uri, Goto, Shinya, Hopewell, Jemma, Hovingh, Kees, Kearney, Patricia, Kitas, George, Newman, Connie, Sabatine, Marc S, Schwartz, Greg, Smeeth, Liam, Tobert, Jonathan, Varigos, John, and Yamaguchi, Junichi

Published
2022
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16. Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)

Author

Bohula, Erin A., Wiviott, Stephen D., Giugliano, Robert P., Blazing, Michael A., Park, Jeong-Gun, Murphy, Sabina A., White, Jennifer A., Mach, Francois, Van de Werf, Frans, Dalby, Anthony J., White, Harvey D., Tershakovec, Andrew M., Cannon, Christopher P., and Braunwald, Eugene

Published
2017
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22. Growth differentiation factor 15 and cardiovascular risk: individual patient meta-analysis.

Author

Kato, Eri Toda, Morrow, David A, Guo, Jianping, Berg, David D, Blazing, Michael A, Bohula, Erin A, Bonaca, Marc P, Cannon, Christopher P, Lemos, James A de, Giugliano, Robert P, Jarolim, Petr, Kempf, Tibor, Newby, L Kristin, O'Donoghue, Michelle L, Pfeffer, Marc A, Rifai, Nader, Wiviott, Stephen D, Wollert, Kai C, Braunwald, Eugene, and Sabatine, Marc S

Subjects
GROWTH differentiation factors, HEART failure, CARDIOVASCULAR diseases risk factors, MAJOR adverse cardiovascular events, ACUTE coronary syndrome, STROKE
Abstract

Aims Levels of growth differentiation factor 15 (GDF-15), a cytokine secreted in response to cellular stress and inflammation, have been associated with multiple types of cardiovascular (CV) events. However, its comparative prognostic performance across different presentations of atherosclerotic cardiovascular disease (ASCVD) remains unknown. Methods and results An individual patient meta-analysis was performed using data pooled from eight trials including 53 486 patients. Baseline GDF-15 concentration was analyzed as a continuous variable and using established cutpoints (<1200 ng/L, 1200–1800 ng/L, > 1800 ng/L) to evaluate its prognostic performance for CV death/hospitalization for heart failure (HHF), major adverse cardiovascular events (MACE), and their components using Cox models adjusted for clinical variables and established CV biomarkers. Analyses were further stratified on ASCVD status: acute coronary syndrome (ACS), stabilized after recent ACS, and stable ASCVD. Overall, higher GDF-15 concentration was significantly and independently associated with an increased rate of CV death/HHF and MACE (P < 0.001 for each). However, while GDF-15 showed a robust and consistent independent association with CV death and HHF across all presentations of ASCVD, its prognostic association with future myocardial infarction (MI) and stroke only remained significant in patients stabilized after recent ACS or with stable ASCVD [hazard ratio (HR): 1.24, 95% confidence interval (CI): 1.17–1.31 and HR: 1.16, 95% CI: 1.05–1.28 for MI and stroke, respectively] and not in ACS (HR: 0.98, 95% CI: 0.90–1.06 and HR: 0.87, 95% CI: 0.39–1.92, respectively). Conclusion Growth differentiation factor 15 consistently adds prognostic information for CV death and HHF across the spectrum of ASCVD. GDF-15 also adds prognostic information for MI and stroke beyond clinical risk factors and cardiac biomarkers but not in the setting of ACS. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

Author

Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., McCagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Im, KyungAh, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.

Published
2015
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30. Outcomes of Patients With Acute Coronary Syndrome and Previous Coronary Artery Bypass Grafting (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy [PROVE IT-TIMI 22] and the Aggrastat to Zocor [A to Z] Trials)

Author

Brilakis, Emmanouil S., de Lemos, James A., Cannon, Christopher P., Wiviott, Stephen D., Murphy, Sabina A., Morrow, David A., Sabatine, Marc S., Banerjee, Subhash, Blazing, Michael A., Califf, Robert M., and Braunwald, Eugene

Published
2008
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33. Premature release of data from clinical trials of Ezetimibe

Author

Califf, Robert M., Harrington, Robert A., and Blazing, Michael A.

Subjects
United States
Abstract

The article discusses the circumstances that have been responsible for the premature release of data from clinical trials with regards to the efficacy and safety of drug Ezetimibe, as resulting in cancer. Ezetimibe has been found to modestly lower LDL cholesterol levels with no known side effects.

Published
2009

35. Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes

Author

Briel, Matthias, Schwartz, Gregory G., Thompson, Peter L., Lemos, James A. de, Blazing, Michael A., van Es, Gerrit-Anne, Kayikcioglu, Meral, Arntz, Hans-Richard, Hartog, Frank R. den, Veeger, Nic J.G.M., Colivicchi, Furio, Dupuis, Jocelyn, Okazaki, Shinya, Wright, R. Scott, Bucher, Heiner C., and Nordmann, Alain J.

Subjects
Coronary heart disease -- Care and treatment, Coronary heart disease -- Research, Statins -- Patient outcomes
Abstract

A study to evaluate relevant outcomes of patients from randomized controlled trials comparing early statin therapy with placebo or usual care at 1 and 4 months following acute coronary syndrome (ACS) is illustrated. Based on available evidence it is concluded that initiation of statin therapy within 14 days following onset of ACS does not reduce death, myocardial infarction, or stroke up to 4 months.

Published
2006

36. Prognostic value of serial B-type natriuretic peptide testing during follow-up of patients with unstable coronary artery disease

Author

Morrow, David A., Braunwald, Eugene, Lemos, James A. de, Califf, Robert M., Blazing, Michael A., Fox, Keith A.A., Sabatine, Marc S., White, Harvey D., Murphy, Sabina A., and Jarolim, Petr

Subjects
Natriuretic peptides -- Health aspects, Natriuretic peptides -- Research, Coronary heart disease -- Risk factors, Coronary heart disease -- Patient outcomes
Abstract

A study to determine whether concentrations of B-type natriuretic peptide (BNP) at study entry and at outpatient follow-up at 4 months and 12 months are associated with subsequent clinical outcomes is presented. Serial determinations of BNP levels during outpatient follow-up after acute coronary syndrome (ACS) predict the risk of death or new congestive heart failure (CHF).

Published
2005

37. Early intensive vs a delayed conservative simvastatin strategy in pateints with acute coronary syndromes: Phase Z of the A to Z trial

Author

Lemos, James A. de, White, Harvey D., Blazing, Michael A., Rouleau, Jean-Lucien, Wiviott, Stephen D., Pedersen, Terje, Lewis, Eldrin F., Gardner Laura H., Fox, Keith A. A., Mukherjee, Robin, Ramsey, Karen E., Palmisano, Joanne, Bilheimer, David W., Pfeffer, Marc A., Califf, Robert M., and Braunwald, Eugene

Subjects
Simvastatin -- Dosage and administration, Coronary heart disease -- Diagnosis, Coronary heart disease -- Prevention
Abstract

The early initiation of an intensive statin regimen with delayed inititation of a less intensive regimen in patients with acute coronary syndrome (ACS) is compared. Results reveal that among patients with ACS, the early initiation of an aggressive simvastatin regimen indicated a favorable trend toward reduction of major cardiovascular events.

Published
2004

38. Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-segment elevation acute coronary syndromes

Author

Petersen, John L., Goodman, Shaun G., Nessel, Christopher C., Mahaffey, Kenneth W., Langer, Anatoly, Harrington, Robert A., Hasselblad, Vic, Blazing, Michael A., Ferguson, James J., Antman, Elliott M., Le-Moigne-Amarani, Anne, Braunwald, Eugene, Lemos, James A. de, and Califf, Robert M.

Subjects
Heparin -- Dosage and administration, Heparin -- Comparative analysis, Enoxaparin -- Dosage and administration, Enoxaparin -- Comparative analysis, Coronary heart disease -- Care and treatment
Abstract

Unstable angina combined with non-ST-segment elevation myocardial infarction (UA/NSTEMI) acute coronary syndromes (ACS) is the most common manifestations of coronary heart disease that lead to death. More than twenty thousand patients were studied across the ACS spectrum, and it was found that enoxaparin is more effective than unfractionated heparin in preventing combined end point of death or myocardial infarction.

Published
2004

39. Safety and efficacy of enoxaparin vs. unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin

Author

Blazing, Michael A., Ardissino, Diego, Ramsey, Karen E., Braunwald, Eugene, Lemos, James A. de, DiBattiste, Peter M., Gardner, Laura H., Califf, Robert M., White, Harvey D., Palmisano, Joanne, Hasselblad, Vic, Fox, Keith A. A., Bilheimer, David W., Pfeffer, Marc A., Verheugt, Freek W. A., Snapinn, Steven M., and Lewis, Eldrin F.

Subjects
Coronary heart disease -- Care and treatment, Heparin -- Dosage and administration, Heparin -- Comparative analysis, Enoxaparin -- Dosage and administration, Enoxaparin -- Comparative analysis
Abstract

Tests were conducted to check the efficacy of the combination of enoxaparin and tirofiban in comparison with unfractionated heparin and tirofiban in patients with non-ST-elevation acute coronary syndromes (ACS). It was found that in patients receiving tirofiban and aspirin enoxaparin is a good alternative when compared to unfractionated heparin.

Published
2004

40. Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: Results of the comparative HDL efficacy and safety study (CHESS)

Author

Ballantyne, Christie M., Blazing, Michael A., Hunninghake, Donald B., Davidson, Michael H., Yuan, Zhong, DeLucca, Paul, Ramsey, Karen E., Hustad, Carolyn M., and Palmisano, Joanne

Subjects
Hypercholesterolemia -- Research, Simvastatin -- Research, Cholesterol, HDL -- Research, Health
Published
2003

41. Association of Apolipoprotein B–Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis: Distinguishing Between Particle Concentration, Type, and Content.

Author

Marston, Nicholas A., Giugliano, Robert P., Melloni, Giorgio E. M., Park, Jeong-Gun, Morrill, Valerie, Blazing, Michael A., Ference, Brian, Stein, Evan, Stroes, Erik S., Braunwald, Eugene, Ellinor, Patrick T., Lubitz, Steven A., Ruff, Christian T., and Sabatine, Marc S.

Published
2022
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43. The A-to-Z Trial: methods and reationale for a single trial investigating combined use of low-molecular-weight heparin with the glycoprotein IIb/IIIa inhibitor tirofiban and defining the efficacy of early aggressive simvastatin therapy

Author

Blazing, Michael A., Lemos, James A. de, Dyke, Christopher K., Califf, Robert M., Bilheimer, David, and Braunwald, Eugene

Subjects
Heart attack -- Drug therapy, Unstable angina -- Drug therapy, Anticholesteremic agents -- Evaluation, Health
Published
2001

44. Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy: A Meta-analysis

Author

Preiss, David, Seshasai, Sreenivasa Rao, Welsh, Paul, Murphy, Sabina A., Ho, Jennifer E., Waters, David D., DeMicco, David A., Barter, Philip, Cannon, Christopher P., Sabatine, Marc S., Braunwald, Eugene, Kastelein, John J., de Lemos, James A., Blazing, Michael A., Pedersen, Terje R., Tikkanen, Matti J., Sattar, Naveed, and Ray, Kausik K.

Published
2011
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