1. Antiproliferative Constituents of Geopropolis from the Bee Melipona scutellaris.
- Author
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da Cunha MG, Rosalen PL, Franchin M, de Alencar SM, Ikegaki M, Ransom T, and Beutler JA
- Subjects
- Animals, Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Propolis chemistry, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacology, Bees chemistry, Cell Proliferation drug effects, Coumarins isolation & purification, Coumarins pharmacology
- Abstract
Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type coumarins 5,7-dihydroxy-6-(3-methyl-2-butenyl)-8-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-propyl-coumarin (1) and 5,7-dihydroxy-6-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-phenylcoumarin (2), along with five known coumarins, mammeigin (3), hydroxymammeigin (4), mammeisin (5), cinnamoyloxy-mammeisin (6), and mammein (7), and the prenylated benzophenone ent-nemorosone (8). Among the isolated compounds, 5 and 7 showed the highest cell growth inhibition against COLO205 (GI50 9.7 and 10.7 µM, respectively) and KM12 (GI50 12.0 and 10.9 µM, respectively). The presence of these compounds suggests that plants of Clusiaceae family, especially the genera Kielmeyera and Clusia, are likely to be major sources of geopropolis produced by M. scutellaris., (Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2016
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