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Impact experiments of large-caliber PELE with various inner-outer diameter ratio perforating RHA plate at low velocity were performed. Experimental results showed the size of perforated holes on plate, average diameter of damage area on witness plate, and number of behind-armor fragments will increase as d/D increasing from 0.72 to 0.84. Expansion and fragmentation of large-caliber PELE in this condition were also numerically studied with ANSYS Autodyn. Then, an analytical model accounting for an additional radial shock wave was presented to predict radial expansion velocity and fragmentation of jacket, as well as an empirical approach to estimate diameter of damage area. Calculation results by these approaches were in good agreement with experiments and numerical simulations. Further discussion revealed that Shock/rarefaction wave interactions behavior varying with inner-outer diameter ratio is an important mechanism resulting in different lateral effect by PELE projectiles with various configurations. Keywords: PELE, Enhanced lateral effect, Penetration mechanics, Behind-armor fragments

A hollow core micro-bottle cavity (HC-MBC) biosensor with high quality (Q) factor for DNA detection with low detection limit has been proposed and demonstrated. Whispering gallery mode (WGM) spectra with Q factor >106 are excited through high-precision coupling of tapered fiber and HC-MBC. An improved surface functionalization method is used at 70 °C to ensure binding of probe single-stranded DNA onto the inner surface of the HC-MBC with high effectiveness and stability. Based on the principle of base complementary pairing, efficient detection of DNA with different concentrations and sequences are realized. The detection volume and limit of the proposed biosensor are ∼ nL and pM, respectively. Single-nucleotide mismatch recognition is also achieved. Benefiting from its label free, compact size, real-time and low detection limit, the proposed biosensor has broad application prospects in bioengineering and medical diagnosis. [ABSTRACT FROM AUTHOR]

Infections with Salmonella spp. are a major health concern for humans and animals on a global scale. Although most cases of salmonellosis result in uncomplicated diarrhea, elderly and immunocompromised persons [...]

Background: Recurrence of hand, foot and mouth disease (HFMD) pandemics continues to threaten public health. Despite increasing awareness and efforts, effective vaccine and drug treatment have yet to be available. Probiotics have gained recognition in the field of healthcare worldwide, and have been extensively prescribed to babies and young children to relieve gastrointestinal (GI) disturbances and diseases, associated or not with microbial infections. Since the faecal-oral axis represents the major route of HFMD transmission, transient persistence of probiotic bacteria in the GI tract may confer some protection against HFMD and limit transmission among children., Methods: In this work, the antiviral activity of two commercially available probiotics, namely Lactobacillus reuteri Protectis (L. reuteri Protectis) and Lactobacillus casei Shirota (L. casei Shirota), was assayed against Coxsackieviruses and Enterovirus 71 (EV71), the main agents responsible for HFMD. In vitro infection set-ups using human skeletal muscle and colon cell lines were designed to assess the antiviral effect of the probiotic bacteria during entry and post-entry steps of the infection cycle., Results: Our findings indicate that L. reuteri Protectis displays a significant dose-dependent antiviral activity against Coxsackievirus type A (CA) strain 6 (CA6), CA16 and EV71, but not against Coxsackievirus type B strain 2. Our data support that the antiviral effect is likely achieved through direct physical interaction between bacteria and virus particles, which impairs virus entry into its mammalian host cell. In contrast, no significant antiviral effect was observed with L. casei Shirota., Conclusions: Should the antiviral activity of L. reuteri Protectis observed in vitro be translated in vivo, such probiotics-based therapeutic approach may have the potential to address the urgent need for a safe and effective means to protect against HFMD and limit its transmission among children.

Corynebacterium accolens is rarely isolated as a human pathogen. We describe here a case of C. accolens isolated from a breast abscess in a patient previously diagnosed with granulomatous mastitis. The possible association of Corynebacterium accolens and granulomatous mastitis in this patient is discussed.