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This study aimed to develop a novel ureasil–polyether transdermal hybrid matrix (U-PEO) loaded with Annona muricata concentrated extract (AMCE), which exhibits potent anti-inflammatory activity. The extract was obtained by maceration, a method that allowed for the extraction of a high concentration of flavonoids (39.27 mg/g of extract). In vivo tests demonstrated that 10 mg/kg of AMCE inhibited inflammation for 6 h. The physicochemical characterization of U-PEO with AMCE was conducted via a thermogravimetric analysis (TGA), while its surface was recorded using atomic force microscopy (AFM). The in vitro macroscopic swelling and release tests demonstrated the hydrophilic profile of the material and the percentage of AMCE released. The TGA results demonstrated that the system exhibited physical compatibility due to the thermal stability of U-PEO. Additionally, the AFM analysis revealed a rough and porous surface, with a particular emphasis on the system with AMCE. The release resulted in the liberation of 23.72% of AMCE within 24 h. Finally, the preclinical tests demonstrated that U-PEO with AMCE was also capable of effectively inhibiting inflammation for 6 h, a duration comparable to that of a commercial formulation. The results permit the advancement of the study towards the development of a transdermal system, thereby rendering its application in clinical studies feasible. [ABSTRACT FROM AUTHOR]

Curcumin (CUR) is a natural compound that can be combined with miconazole (MCZ) to improve vulvovaginal candidiasis (VVC) caused by Candida albicans treatment's efficacy. This study aimed to develop ureasil–polyether (U-PEO) vaginal ovules loaded with CUR and MCZ for the treatment of VVC. Physicochemical characterization was performed by thermogravimetry (TGA), differential thermal analysis (DTA), Fourier transform infrared spectroscopy (FTIR), and in vitro release. Antifungal assays were used to determine minimum inhibitory concentrations (MICs) and synergism between CUR and MCZ, and the activity of U-PEO ovules were performed by microdilution and agar diffusion. TGA results showed high thermal stability of the hybrid ovules. In DTA, the amorphous character of U-PEO and a possible interaction between CUR and MCZ were observed. FTIR showed no chemical incompatibility between the drugs. In vitro release resulted in 80% of CUR and 95% of MCZ released within 144 h. The MICs of CUR and MCZ were 256 and 2.5 µg/mL, respectively. After combining the drugs, the MIC of MCZ decreased four-fold to 0.625 µg/mL, while that of CUR decreased eight-fold to 32 µg/mL. Synergism was confirmed by the fractional inhibitory concentration index (FICI) equal to 0.375. U-PEO alone showed no antifungal activity. U-PEO/MCZ and U-PEO/CUR/MCZ ovules showed the greatest zones of inhibition (≥18 mm). The results highlight the potential of the ovules to be administered at a lower frequency and at reduced doses compared to available formulations. [ABSTRACT FROM AUTHOR]

Copyright of Agricultural Research in the Tropics / Pesquisa Agropecuária Tropical is the property of Pesquisa Agropecuaria Tropical and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective  Many newborns are investigated and empirically treated for suspected early-onset sepsis (EOS). This study aimed to describe neonatologists' self-identified risk thresholds for investigating and treating EOS and assess the consistency of these thresholds with clinical decisions. Study Design  Voluntary online survey, available in two randomized versions, sent to neonatologists from 20 centers of the Brazilian Network on Neonatal Research. The surveys included questions about thresholds for investigating and treating EOS and presented four clinical scenarios with varying calculated risks. In survey version A, only the scenarios were presented, and participants were asked if they would order a blood test or start antibiotics. Survey version B presented the same scenarios and the risk of sepsis. Clinical decisions were compared between survey versions using chi-square tests and agreement between thresholds and clinical decisions were investigated using Kappa coefficients. Results  In total, 293 surveys were completed (145 survey version A and 148 survey version B). The median risk thresholds for blood test and antibiotic treatment were 1:100 and 1:25, respectively. In the high-risk scenario, there was no difference in the proportion choosing antibiotic therapy between the groups. In the moderate-risk scenarios, both tests and antibiotics were chosen more frequently when the calculated risks were included (survey version B). In the low-risk scenario, there was no difference between survey versions. There was poor agreement between the self-described thresholds and clinical decisions. Conclusion  Neonatologists overestimate the risk of EOS and underestimate their risk thresholds. Knowledge of calculated risk may increase laboratory investigation and antibiotic use in infants at moderate risk for EOS. Key Points Neonatologists overestimate the risk of EOS. There is wide variation in diagnostic/treatment thresholds for EOS. Clinical decision on EOS is not consistent with risk thresholds. Knowledge of risk may increase investigation and treatment of EOS. [ABSTRACT FROM AUTHOR]

Background: The hematology of turtles of the Amazon, such as the Arrau turtle (Podocnemis expansa), has not been well described in the literature. Referencing how to collect and analyze blood samples is fundamental for the medical practice of these exotic animals. Objectives: The aim of this study was to evaluate the hematologic parameters of Arrau turtles of the Amazon to determine the best anticoagulant (EDTA, citrate, or sodium heparin) and cytologic stain (Giemsa, Quick Panoptic, or Rosenfeld) for use with this species. Methods: Blood samples from eight turtles were collected. Three blood smears were made using blood without anticoagulant, and the rest of the sample was distributed in three tubes, containing EDTA, citrate, and sodium heparin, for erythrogram and leukogram analyses. Results: All blood samples anticoagulated with EDTA showed marked hemolysis. Blood collected with citrate showed minimal hemolysis, and blood collected with sodium heparin did not have any hemolysis. Some analyses were not performed on blood containing EDTA because of the intense hemolysis. The erythrocyte variables were obtained and showed better results for blood samples in heparin. Blood smears without anticoagulant were appropriate for differential leukocyte counts with the three stain types, while blood with any of the anticoagulants made it difficult to differentiate leukocytes. Conclusions: Sodium heparin showed the best results and should be the anticoagulant of choice for hematologic studies in P expansa. All cytologic stains were efficient, allowing adequate identification of distinct cell groups. Leukocyte differentiation was assured and had better contrast using blood smears made from blood without an anticoagulant. [ABSTRACT FROM AUTHOR]

The estimate of the potential sugarcane productivity through agroclimatic models aids in the agricultural planning of the crops and the quantification of the yield for a given region. For these estimated values to be considered robust there is a need for validating the performance of such models in different areas and agricultural varieties. Hence, the aim of this study was to validate the Agro-Ecological Zone (AEZ) method with fifteen sugarcane varieties in the region of the Vale do São Patrício, state of Goiás, Brazil. We evaluated the data referring to the cane-plant (one-and-a-half-year sugarcane), as well as the first and second sugarcane ratoons (both with one-year cycles) in an irrigated and dry farming system. The productivities obtained in dry farming were corrected due to the occurrence of a water deficit in the crop. The results indicated that the AEZ method presented productivity estimates more satisfactory for the one-year cultivation cycles (ratoon cycles) for all varieties studied, with the model adjusting best to the CTC15 variety (RMSE = 8.70 t ha-1; MAE = 6.05 t ha-1; d = 0.99). [ABSTRACT FROM AUTHOR]

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Copyright of Revista IRRIGA - Brazilian Journal of Irrigation & Drainage is the property of Revista IRRIGA (Brazilian Journal of Irrigation & Drainage) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Potassium (K) is closely associated to the improvement of sugarcane quality, acting in the conversion of reducing sugar (RS) to recoverable sugars (TRS). The present study aimed to evaluate the effect of different levels of K-fertilization on the yield and technological quality of sugarcane ratoons grown under edaphoclimatic conditions in the Brazilian central region. The experiment was carried out using the sugarcane variety CTC-4, in a Distrofic Latosols, medium texture (270 g clay kg−1). The study was arranged in a randomized complete block design, with five treatments (0; 50; 100; 150 and 200 kg K2O ha−1), and five replicates. Potassium content in soil and plant, biometric variables, stalk yield and the technological quality at harvest were evaluated. The 200 kg ha−1 dose increased the K content in 160, 156, 56 and 3% in 0–0.20 and 0.20–0.40 m layers at 180 and 360 days after budding (DAB), respectively, promoting greater absorption of the nutrient by plants (X ̅ = 15.22 g kg−1). The higher potassium absorption reflected in yield gains, with an increasing of 7.9%, compared to the control treatment, yielding 100.37 t ha−1. However, soil K fertilization did not affect the technological quality of the sugarcane ratoon. Abbreviations: K: potassium; RS: reducing sugars; TRS: recoverable sugars; DAB: days after budding; SB: Sum of Bases; CEC: Cation Exchange Capacity; V: Saturation Base; Kcl: potassium chloride; AWC: Available water capacity; PC: Pol percent in sugarcane; Brix: total soluble solids; dRYL: Dystrophic Red Yellow Latosol; eRYA: Eutrophic Red Yellow Argisol. [ABSTRACT FROM AUTHOR]

Copyright of Engenharia na Agricultura is the property of Engenharia na Agricultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

For the efficient use of regional water resources is imperative that na adequate irrigation management be done, such as that based on the monitoring of water content in the soil. For this, different sensors can be used, however, for greater reliability of the information, these need to be calibrated for each solo. The objective was to calibrate a reflectometry probe type in the Frequency Domain (FDR) for a Oxisoil, clayey. Six access tubes were installed in the soil, forming a grid of 5 * 2 m, two tubes for each humidity level (saturated, wet and dry). Soil moisture readings were taken with the equipment for each soil layer (0.10 m - 0.60 m) in each tube. Immediately after the completion of the readings, we proceeded to the soil sampling for determination of moisture and gravimetric density. Volumetric moisture (Θv, m³ m-3) in each soil layer was determined by multiplying the gravimetric moisture by the mean soil density (kg m-3). The FDR probe is suitable for determining the moisture from a calibration for the soil of interest. The model that best fit was the potential model, following the results of other authors. [ABSTRACT FROM AUTHOR]

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Copyright of Global Science & Technology is the property of Global Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Agrociencia is the property of Colegio de Postgraduados and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Climate variables can influence the both productivity and quality of the commercial product of sugarcane crop. This study aimed to evaluate the influence of thermal time, negative degree-days and water deficit on productivity and industrial quality of sugarcane for the Goiás Brazilian Savanna region. The data of productivity and industrial quality were obtained in the field (Plant Centro Álcool®) and climate data in the weather station. Thermal time and the accumulation of negative degree-days in cycles showed significant correlations with the yield. The highest (340 mm) and the lowest (158 mm) accumulated water deficit blade not reflected in lower productivity and greater, respectively. Relative evapotranspiration (rET) was equal at 1.0 in more than 50% of the studied period, in which not were found significant correlations between the rET<1 with the productivity and industrial quality. We found significant correlations between rates of degree-days and negative degree-days with productivity rates; however, there was a low correlation between the water deficit rates and productivity. The total recoverable sugars rates and total soluble solids showed maximum accumulation point only in function of degree-day rates. We conclude that the thermal time has greater influence on yield decrease of sugarcane with different harvest cycles, significantly contributing to the accumulation of sugars in the stem. [ABSTRACT FROM AUTHOR]

Copyright of Revista Agrotecnologia is the property of Universidade Estadual de Goias and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Cientifica is the property of Fundacao de Apoio a Pesquisa e Extensao and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Agricultural Research in the Tropics / Pesquisa Agropecuária Tropical is the property of Pesquisa Agropecuaria Tropical and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Global Science & Technology is the property of Global Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Global Science & Technology is the property of Global Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In Cerrado, due to the dry season, the use of irrigation is fundamental to guarantee up to 3 harvests per year. However, it is a technique with a high cost of equipment implantation and maintenance. Thus, the researches with new technologies to reduce these costs must be constant. It is known that the use of straw on soil surface reduces water evaporation. So, the objective of this study was to compare the economic viability of a central pivot irrigated area, with and without straw on soil surface with soybean, corn and industrial tomato in Cristalina-GO, Brazil. Production costs were calculated using the software Amazonsaf. In it, the technical coefficients of production were inserted, and the financial indicators were calculated as: Net Present Value (VPL), Internal Rate of Return (TIR), Cost Benefit (B/C), Payback and Gross Revenue ratio (RB). The results showed that there was economic viability independent of the soil management used. The VPL was R$2,129.82 ha-1.year-1 and R$2,294.95 ha-1.year-1, the TIR was 131.09% and 162.55%, B/C was 1.56 and 1.64, for conventional and no-tillage, respectively. And PayBack was 3 years and RB was R$5,901.06 ha-1.year-1. It was observed that in the system of direct planting there was a reduction in the implantation cost of 4.23% of and reduction of 22.5% with energy. [ABSTRACT FROM AUTHOR]

The objective of this study is to evaluate the growth of pequi trees in function of irrigation and organic fertilization. A total of 96 pequi plants (6-8 years of age), spaced 5 x 5 m, were used in a randomized blocks experiment with six plots and for repetitions. Four treatments were evaluated: IF = Irrigation with fertilization, IWF = Irrigation without fertilization, WIF = Without irrigation with fertilization, and WIWF = Without irrigation and without fertilization, in subdivided plots. The irrigation system was microsprinklers. The volume of water applied was estimated by the evapotranspiration of pequi trees. Cover fertilizations were performed in Nov/2014 using composting material and Yorim, and in Nov/2015 using tanned cattle manure and chicken litter. The growth was monthly evaluated by the height and the stem perimeter, and the canopy was evaluated in a 7.1 years old orchard. Leaf temperature and transpiration were evaluated by sap flow in irrigated and non-irrigated trees. The pequi tree did not respond to treatments in terms of height and stem perimeter. Irrigation provided trees with larger canopy areas. When irrigated, the leaf temperature of pequi trees remained below average air temperatures, independently of dry or rainy periods. Without irrigation, plants presented water stress during the dry season. Under rainy conditions, the mean transpiration of the pequi tree was 24.09 L d-1 per plant. When irrigated, it was on average 42.29 L d-1 per plant. [ABSTRACT FROM AUTHOR]

Copyright of Acta Agronómica is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Bosque (03048799) is the property of Facultad de Ciencias Forestales, Universidad Austral de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Facultad Nacional de Agronomía Medellín is the property of Universidad Nacional de Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Revista Brasileira de Engenharia Agricola e Ambiental - Agriambi is the property of Revista Brasileira de Engenharia Agricola e Ambiental and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Global Science & Technology is the property of Global Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Brasileira de Engenharia Agricola e Ambiental - Agriambi is the property of Revista Brasileira de Engenharia Agricola e Ambiental and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Scientiarum: Agronomy is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

• Economic returns and yield were analyzed under levels of irrigation for common beans. • Sowing dates and water management need to be evaluated for higher yield. • Irrigation ensures yield stability and food production throughout growing seasons. • Irrigation in the rainfed season had water with higher availability from the river. • The minimum selling prices were the trigger for implementation of pivot central system. Irrigation improves yield, but can create conflicts with other water uses during dry periods. Based on this, the aim of this study is to assess the economic returns provided by irrigation of common beans during the rainfed season in Central Brazil. Common bean yield was simulated for 30 growing seasons using the crop model DSSAT-CROPGRO-Drybean, with parameters calibrated for the cultivar Pérola. The yield simulations considered sowing dates from Nov. 01 to Jan. 01 at each 15 days, and four water managements: rainfed and irrigation starting at 70, 50 and 30% of the total soil water available (TSWA). Yield and irrigation costs were obtained from official institutes that assess net revenue considering sales prices from R$ 1.33 to R$ 5.00 per kg. The rainfed system yield ranged from 500 to 3000 kg ha−1. The irrigation at 70, 50 and 30% of TWSA increased yield, respectively, from 26.7 to 41.4%, from 5.5 to 14.5%, and from 0.4 to 2.4% in relation to the rainfed system with ranges depending on sowing dates. The average demand of 53 mm cycle−1 (range between 0 to 100 mm cycle−1) was required by the water management 70% of TSWA. However, the 50% of TSWA required an average demand of 19 mm cycle−1, and the 30% of TSWA in most growing seasons did not require irrigation. The net revenue was affected by sales prices and sowing dates (preferentially early sowing). A minimum sales price ranging from R$ 1.85 to R$ 2.83 per kg is required, according to the water management and the sowing date, for an internal return rate higher than 12%. Irrigation at 70% of TSWA provided a similar or better economic index and a higher yield than the rainfed system. It is an interesting water management option because water is used when the river water level is higher, ensuring yield stability and food production. [ABSTRACT FROM AUTHOR]

Soybean-maize cropping system is highly dependent on climate condition, especially water deficit, across Brazil, affecting yield, food production and farmers profit. Based on that, the aim of this study was to evaluate the food production and economic viability for soybean and maize for single and soybean-maize off-season production system considering sowing dates, soil types and yield gaps in the Midwestern region. The yield was simulated using FAO-Zone agroecological model. Official yield statistics were used to validate the crop model and to estimate yield gap. We consider single soybean (SS c), single maize (SM c), and soybean-maize off-season systems (SM cs), simulating yield for 35 growing seasons (1981–2015) and six sowing dates (Oct. 01–Dec. 15 for single soybean and single maize; and Jan. 09–Mar. 26 for maize off-season, after soybean harvest). Total production was obtained in function of yield, yield gap, soil type and production intensity. Farmers profit was obtained based on net revenue using independent random function (5000 interactions) for yield, sales price and production costs. The SS c had the largest scenarios with positive net revenue, while SM cs had higher net revenue, reaching R$ 7400.00 ha−1, but with lowest risk for early sowing dates (soybean sowed in Oct. 01 and Oct. 15, and maize off-season in Jan. 09 and Jan. 24). The SM c had higher risk and lower food production in the region. The maximum gross energy production was 2663 billion MJ in SM cs sown soybean on Oct. 01. The SS c had a stable production of gross energy across the sowing dates, with values around 1900 billion MJ. The production of crude protein was similar among SM cs and SS c across sowing dates. The higher crude protein production occurred in the sowing date Oct. 15 for SM cs , with 33.9 billion kg, while SS c produced 32.9 billion kg. The highest net revenue was obtained for the SM cs in the early sowing dates. Nevertheless, the SM cs produced the highest amount of gross energy than single crop systems, but with a very similar crude protein level than SS c. Thus, farmers can be encouraged to grow SM cs to improve food production in early sowing dates. However, public incentive policies through insurance against water deficit can guarantee minimal economic returns and reduce production risks for maize off-season, especially when soybean was sowing late by delay at beginning of rain. • Yield gaps should be reduced to improve food production and economic profit. • Single and double cropping were evaluated for food production and economic profit. • In double cropping, early sowing dates lead to the highest economic returns. • Double cropping produced more gross energy than single cropping. • Double cropping had similar crude protein production to a single soybean cropping. [ABSTRACT FROM AUTHOR]

The incidence of breast cancer has been increasing over the last four decades, although the mortality rate has decreased. Endocrine therapy and chemotherapy are the most used options for cancer treatment but several obstacles are still attributed to these therapies. Smart materials, such as nanocarriers for targeting, delivery and release of active ingredients, sensitive to intrinsic-stimuli (pH-responsive, redox-responsive, enzyme- responsive, and thermo-responsive) and extrinsic-stimuli (ultrasound-responsive, magnetic-responsive, light-responsive) have been studied as a novel strategy in breast cancer therapy. Cyclodextrins (CDs) are used in the design of these stimuli-responsive drug carrier and delivery systems, either through inclusion complexes with hydrophobic molecules or covalent bonds with large structures to generate new materials. The present work aims to gather and integrate recent data from in vitro and in vivo preclinical studies of CD-based stimuli- responsive systems to contribute to the research in treating breast cancer. All drug carriers showed high in vitro release rates in the presence of a stimulus. The stimuli-responsive nanoplatforms presented biocompatibility and satisfactory results of IC 50 , inhibition of cell viability and antitumor activity against several breast cancer cell lines. Additionally, these systems led to a significant reduction in drug dosages, which encouraged possible clinical studies for better alternatives to traditional antitumor therapies., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Objective: To assess the accuracy of sweat conductivity among newborns and very young infants., Design: Prospective, population-based, diagnostic test accuracy study., Setting: Public Statewide Newborn Screening Programme where the incidence rate of cystic fibrosis (CF) is ≈1:11 000., Patients: Newborns and very young infants with positive two-tiered immunoreactive trypsinogen., Interventions: Sweat conductivity and sweat chloride were performed simultaneously, on the same day and facility by independent technicians, with the cut-off values of 80 mmol/L and 60 mmol/L, respectively., Main Outcome Measures: Sensitivity, specificity, positive and negative predictive values (PPV and NPV), overall accuracy, positive and negative likelihood ratios (+LR, -LR) and post (sweat conductivity (SC)) test probability were calculated to assess SC performance., Results: 1193 participants were included, 68 with and 1108 without CF, and 17 with intermediate values. The mean (SD) age was 48 (19.2) days, ranging from 15 to 90 days. SC yielded sensitivity of 98.5% (95% CI 95.7 to 100), specificity of 99.9% (95% CI 99.7 to 100), PPV of 98.5% (95% CI 95.7 to 100) and NPV of 99.9% (95% CI 99.7 to 100), overall accuracy of 99.8% (95% CI 99.6 to 100), +LR of 1091.7 (95% CI 153.8 to 7744.9) and -LR of 0.01 (95% CI 0.00 to 0.10). After a positive and negative sweat conductivity result, the patient's probability of CF increases around 350 times and drops to virtually zero, respectively., Conclusion: Sweat conductivity had excellent accuracy in ruling in or ruling out CF after positive two-tiered immunoreactive trypsinogen among newborns and very young infants., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)

We aimed to evaluate the efficacy and safety of mepolizumab (MEP) in the management of hypereosinophilic syndrome (HES). A systematic search was performed, and articles published until March 2021 were analyzed. The primary efficacy results evaluated were hospitalization rate related to HES, morbidity (new or worsening), relapses/failure, treatment-related adverse effects, prednisone dosage ≤10 mg/day for ≥8 weeks, and eosinophil count <600/μL for ≥8 weeks. A meta-analysis was conducted, when appropriate. Three randomized controlled trials (RCTs), with a total of 255 patients, were included. The studies contemplated the use of MEP 300 mg/SC or 750 mg/IV. According to the evaluation of the proposed outcomes, when relapse rates/therapeutic failures were assessed, there was a 26% reduction with MEP 300 mg/SC (RD=-0.26; 95% CI: -0.44 to -0.08; p=0.04) and 48% reduction with MEP 750 mg/IV (RD=-0.48; 95% CI: -0.67, -0.30; p<0.00001). For the outcomes, prednisone dosage ≤10 mg/day for ≥8 weeks was 48% (RD=0.48; 95% CI: 0.35 to 0.62; p<0.00001), and the eosinophil count <600/μL for ≥8 weeks was 51% (RD=0.51; 95% CI: 0.38 to 0.63; p<0.00001), both showed a reduction with MEP 300 mg/IV and 750 mg/IV. No statistically significant differences in treatment-related adverse effects outcomes were observed for either dosage (RD=0.09; 95% CI: -0.05 to 0.24; p=0.20; RD=0.09; 95% CI: -0.11 to 0.29; p=0.39). Despite the positive effects observed for the studied outcomes, the exact significance remains unclear.

Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in particular. Over the past decades, new classes of anticoagulants have been developed, such as factor Xa inhibitors and direct thrombin inhibitors, which significantly changed the therapeutic arsenal against VTE, due to their efficacy and safety when compared with the conventional treatment. The focus of this review was on evaluating the role of these new anticoagulants in this clinical context.

Purpose: To evaluate the effects of different concentrations of an anesthetic association in giant amazon turtles (Podocnemis expansa)., Methods: Twenty healthy P. expansa of both sexes weighing between 1.0 and 1.5kg commercially bred in the Araguaia River Valley, Goias, Brazil, were separated into two groups (G1 n=10 and G2 n=10). Each group received a respective protocol: P1= acepromazine (0.5 mg/kg IM) and propofol (5 mg/kg IV) and P2 = acepromazine (0.5 mg/kg IM) and propofol (10 mg/kg IV). The acepromazine was administered in the left thoracic member and the propofol in the cervical vertebral sinus. Assessments were made of the anesthetic parameters of locomotion, muscle relaxation, response to pain stimuli in the right thoracic and pelvic members and heartbeat., Results: The anesthetic induction time was the same for both protocols (P1 and P2); however the P2 effects were of a longer duration., Conclusion: The sedation achieved with both protocols (P1 and P2) were satisfactory for the biological sample collection, physical examinations and minor surgeries on this species.