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Herbal medications are being widely used as dietary supplements worldwide. A large percentage of the population uses medicinal herbs to treat certain diseases or symptoms. This study is aimed to evaluate the knowledge, attitudes, and practices of the general population. This cross-sectional study was carried out in Makkah Province from November 30th to December 31st, 2021. Data were collected and analyzed using an online questionnaire, and the survey questionnaire was validated. Response to questions was analyzed with the SPSS program. A total of 391 participants participated. Most participants were male (54.7%), and the average age was between 35-44 years old. 78.6% had college or higher education, and 66% of the participants were from Makkah. Only 13.9% of the participants said they have very good knowledge of herbal medicine. In terms of attitude, more than 91% of the respondents agreed that herbal drugs have some value in treating diseases. 65% of the participants get their knowledge from social media and the internet; the rest are about friends, TV, the medical journal, and others. the study showed that most respondents had low experience in herbal medicine and relied heavily on the internet for information. On the other hand, there was a positive attitude toward using herbal medicine. The government and Food and Drug Administration must encourage institutions to devote functionally dedicated programs and activities to enhance public awareness of herbal medicine use. [ABSTRACT FROM AUTHOR]