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6. Safety and efficacy of platelet glycoprotein VI inhibition in acute ischaemic stroke (ACTIMIS): a randomised, double-blind, placebo-controlled, phase 1b/2a trial

Author

Albucher, Jean François, Alonso, Angelika, Berrouschot, Jörg, Cordonnier, Charlotte, de Raedt, Sylvie, Desfontaines, Philippe, Doche, Emilie, Hemelsoet, Dimitri, Macian-Montoro, Francisco, Masjuan, Jaime, Obadia, Michael, Peeters, André, Pelz, Johann, Reiner, Peggy, Segura, Tomas, Serena, Joaquin, Sibon, Igor, Tembl, Jose I., Vannier, Stéphane, Zuber, Mathieu, Mazighi, Mikaël, Köhrmann, Martin, Lemmens, Robin, Lyrer, Philippe A, Molina, Carlos A, Richard, Sébastien, Toni, Danilo, Plétan, Yannick, Sari, Anouar, Meilhoc, Adeline, Jandrot-Perrus, Martine, Binay, Sophie, Avenard, Gilles, Comenducci, Andrea, Grouin, Jean-Marie, and Grotta, James C

Published
2024
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7. Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core

Author

Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Coskun, Oguzhan, Maria, Federico Di, Pizzuto, Silvia, Sgreccia, Alessandro, Benoit, Charline, Gorza, Lucas, Weisenburger-Lile, David, Jabeur, Waliyde, Maia, Tchikviladze, Evrard, Serge, Rodesch, Georges, Blanc, Raphaël, Obadia, Michael, Desilles, Jean-Philippe, Piotin, Michel, Seners, Pierre, Smajda, Stanislas, Escalard, Simon, Maier, Benjamin, Sabben, Candice, Redjem, Hocine, Mikaelmazhigi, Adwan, Grace, Delvoye, François, Raaisi, Amira Al, Boisseau, William, Eker, Omer, Cho, Tae-Hee, Derex, Laurent, Fontaine, Julia, Mechtouff, Laura, Nighoghossian, Norbert, Ong, Elodie, Rascle, Lucie, Riva, Roberto, Turjman, Françis, Laubacher, Morgane, Beyragued, Mehdi, Berthezene, Yves, Hermier, Marc, Roxanna, Ameli, Bani-Sadr, Alexandre, Filip, Andrea, Cappucci, Matteo, Bourcier, Romain, Duport, Benjamin Daumas, Alexandre, Pierre Louis, Lenoble, Cédric, Hubertdesal, Gaalon, Solène De, Guillon, Benoît, Preterre, Cécile, Tessier, Guillaume, Lionnet, Arthur, Gory, Benjamin, Humbertjean-Selton, Lisa, Anxionnat, René, Derelle, Anne-Laure, Liao, Liang, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Mione, Gioia, Lacour, Jean-Christophe, Douarinou, Marian, Micard, Emilien, Chen, Bailiang, Audibert, Gérard, Masson, Agnès, Alb, Lionel, Beaumont, Marine, Tabarna, Adriana, Voicu, Marcela, Barthel, Grégoire, Podar, Iona, Brezeanu, Madalina, Reitter, Marie, Zhu, François, Marnat, Gaultier, Liegey, Jean-Sébastien, Briau, Pierre, Papillon, Lisa, Sibon, Igor, Barreau, Xavier, Papaxanthos, Jean, Berge, Jérome, Debruxelles, Sabrina, Olindo, Stephane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Tourdias, Thomas, Courret, Thomas, Lucas, Ludovic, Milnerowicz, Malgorzata, Dargazanli, Cyril, Costalat, Vincent, Mourand, Isabelle, Arquizan, Caroline, Corti, Lucas, Adrien, Schiphorst, Ter, Federico, Cagnazzo, Derraz, Imad, Mahmoudi, Mehdi, Lefevre, Pierre-Henri, Gascou, Grégory, Spelle, Laurent, Caroff, Jildaz, Denier, Christian, Chalumeau, Vanessa, Mihalea, Cristian, Nicolaslegris, Ozanne, Augustin, Ikka, Leon, Chassin, Olivier, Gallas, Sophie, Venditti, Laura, Marianasarov, Cortese, Jonathan, Ferre, Jean-Christophe, Vannier, Stephane, Ronziere, Thomas, Veronica Lassalle, Maria, Gauvrit, Jean-Yves, Tracol, Clément, Boustia, Abdelghani Fakhreddine, Malrain, Cécile, Beaufreton, Edouard, Lapotre, Thibault, Alias, Quentin, Hissier, Julien, Guillen, Maud, Eugene, François, Chivot, Cyril, Courselle, Audrey, Ouin, Elisa, Lamy, Chantal, Delaforge, Kevin, Fernandez, Manuel, Vial, Jérémie, Laferte, Quentin, Desdoit, Xavier, Timsit, Serge, Jourdain, Aurore, Gentric, Jean-Christophe, Ognard, Julien, Viakhireva, Irina, Coris, Jordan, Prud'hon, Sabine, Merrien, François-Mathias, Marechal, Denis, Bruguet, Marie, Rousseau, Pierre Yves, Goas, Philippe, Boulanger, Marion, Touze, Emmanuel, Vivien, Denis, Barbier, Charlotte, Schneckenburger, Romain, Salaris, Fabrizio, Cogez, Julien, Guettier, Sophie, Porte, Estelle La, Bouchart, Jean, Mounayer, Charbel, Rouchaud, Aymeric, Saleme, Suzana, Forestier, Géraud, Clarencon, Frédéric, Rosso, Charlotte, Leder, Sara, Baronnet, Flore, Crozier, Sophie, Leger, Anne, Premat, Kevin, Eimad, Shotar, Lenck, Stéphanie, Sourour, Nader, Bottin, Laure, Ghazanfari, Sam, Yger, Marion, Alamowitch, Sonia, Delorme, Stephen, Wittwer, Aymeric, Vassilev, Christine, Naggara, Olivier, Turc, Guillaume, Hassen, Wagih Ben, Kerleroux, Basile, Trystram, Denis, Rodriguez-Regent, Christine, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Massardier, Evelyne, Triquenot, Aude, Lefebvre, Margaux, Burel, Julien, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Albucher, Jean-François, Calviere, Lionel, Olivot, Jean-Marc, Darcourt, Jean, Raposo, Nicolas, Bonneville, Fabrice, Bellanger, Guillaume, Fontaine, Louis, Tall, Philippe, Thalamas, Claire, Geerearts, Thomas, Grepon, Antoine Faurie, Bourdain, Frédéric, Bernady, Patricia, Ballan, Guillaume, Bannier, Stéphanie, Ellie, Emmanuel, Flabeau, Olivier, Potenza, Julia, Soulages, Antoine, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Lebras, Anthony, Adam, Sarah, Pegat, Benoit, Guen, Arnaud Le, Chedeville, François, Jouan, Jérémy, Demasles, Stéphanie, Richter, Johann Sebastian, Thierry Barroso, Bruno, Dahan, Camille, Gonnet, Alexis, Hubrecht, Régis, Lepine, Zoé, Castagnet, Hélène, Marasescu, Raluca, Heck, Olivier, Cuisenier, Pauline, Detante, Olivier, Wiki, Isabelle Favre, Bonaz, Clémentine, Garambois, Katia, Legris, Loic, Kastler, Adrian, Boubagra, Kamel, Berthet, Corentin, Charara, Stéphane, Wolff, Valérie, Pop, Raoul, Quenardelle, Véronique, Lauer, Valérie, Pierre-Paul, Irène, Roxanagheoca, Trzeciak, Malwina, Moulin, Solène, Tuan, Hua Vi, Pagano, Paolo, Doucet, Alexandre, Gelmini, Christophe, Manceau, Pierrefrançois, Paiusan, Laurentiu, Serre, Isabelle, Soize, Sébastien, Phuong Nguyen, Thi Ngoc, Sahnoun, Maher, Caucheteux, Nathalie, Ferrier, Anna, Zerroug, Abderrahim, Moreno, Ricardo, Chabert, Emmanuel, Lteif, Elie, Paulineparis, Bourgois, Nathalie, Raquin, Marie, Pasco-Papon, Anne, Girot, Jean Baptiste, Lecluse, Alderic, Godard, Sophie, L'allinec, Vincent, Janot, Kevin, Bibi, Richard, Gaudron, Marie, Bretonniere, Arnaud, Annan, Mariam, Ifergan, Héloïse, Boulouis, Grégoire, Pasi, Marco, Debiais, Séverine, Molinier, Elisabeth, Wietrich, Anthony, Ruche, Valérie, Lavandier, Karine, Bejot, Yannick, Lemogne, Brivale, Ricolfi, Fédéric, Baptiste, Laura, Thouant, Pierre, Duloquin, Gaulthier, Olivier Comby, Pierre, Charbonnier, Guillaume, Bonnet, Louise, Raybaud, Nicolas, Bouamra, Benjamin, Moulin, Thierry, Biondi, Alessandra, Finitsis, Stephanos, and Mazighi, Mikael

Published
2023
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8. Clinical Impact and Predictors of Diffusion Weighted Imaging (DWI) Reversal in Stroke Patients with Diffusion Weighted Imaging Alberta Stroke Program Early CT Score 0–5 Treated by Thrombectomy: Diffusion Weighted Imaging Reversal in Large Volume Stroke

Author

Panni, Pietro, Lapergue, Bertrand, Maïer, Benjamin, Finitsis, Stephanos, Clarençon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Blanc, Raphaël, Consoli, Arturo, Eugène, François, Vannier, Stéphane, Spelle, Laurent, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Saleme, Suzana, Macian, Francisco, Rosso, Charlotte, Naggara, Olivier, Turc, Guillaume, Ozkul-Wermester, Ozlem, Papagiannaki, Chrisanthi, Albucher, Jean-François, Darcourt, Jean, Le Bras, Anthony, Evain, Sarah, Wolff, Valérie, Pop, Raoul, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Arquizan, Caroline, and Gory, Benjamin

Published
2022
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9. Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Author

Piotin, Michel, Blanc, Raphael, Escalard, Hocine Redjem Simon, Desilles, Jean-Philippe, Delvoye, François, Smajda, Stanislas, Maier, Benjamin, Hebert, Solène, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Seners, Pierre, Raynouard, Igor, Corabianu, Ovide, de Broucker, Thomas, Manchon, Eric, Taylor, Guillaume, Ben Maacha, Malek, Thion, Laurie-Anne, Lecler, Augustin, Savatovsky, Julien, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger-Lile, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Nighoghossian, Norbert, Riva, Roberto, Eker, Omer, Turjman, Francis, Derex, Laurent, Cho, Tae-Hee, Mechtouff, Laura, Lukaszewicz, Anne Claire, Philippeau, Frédéric, Cakmak, Serkan, Blanc-Lasserre, Karine, Vallet, Anne-Evelyne, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Tourdias, Thomas, Liegey, Jean-Sebastien, Briau, Pierre, Pangon, Nicolas, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, Desal, Hubert, Guillon, Benoît, de Gaalon, Solène, Preterre, Cécile, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Riou-Comte, Nolwenn, Audibert, Gérard, Voicu, Marcela, Alb, Ionel, Reitter, Marie, Brezeanu, Madalina, Masson, Agnès, Tabarna, Adriana, Podar, Iona, Macian-montoro, Francisco, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Cagnazzo, Federico, ter Schiphorst, Adrien, Francois, Eugene, Vannier, Stéphane, Ferre, Jean-christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Samson, Yves, Rosso, Charlotte, Leger, Anne, Deltour, Sandrine, Clarencon, Frederic, Shotar, Eimad, Spelle, Laurent, Denier, Christian, Chassin, Olivier, Chalumeau, Vanessa, Caroff, Jildaz, Venditti, Laura, Naggara, Olivier, Hassen, Wagih Ben, Boulouis, Grégoire, Rodriguez-Régent, Christine, Trystram, Denis, Kerleroux, Basile, Turc, Guillaume, Domigo, Valérie, Lamy, Catherine, Birchenall, Julia, Isabel, Clothilde, Lun, François, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Olivot, Jean-Marc, Raposo, Nicolas, Bonneville, Fabrice, Albucher, Jean François, Calviere, Lionel, Darcourt, Jean, Tall, Philippe, Bellanger, Guillaume, Fontaine, Louis, Touze, Emmanuel, Barbier, Charlotte, Schneckenburger, Romain, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Timsit, Serge, Gentric, Jean-christophe, Ognard, Julien, Merrien, Francois Mathias, Wermester, Ozlem Ozkul, Massardier, Evelyne, Papagiannaki, Chrysanthi, Bourdain, Frédéric, Bernady, Patricia, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Wolff, Valérie, Pop, Raoul, Beaujeux, Rémi, Dan-Sorin, Mihoc, Manisor, Monica, Le Bras, Anthony, Evain, Sarah, Le Guen, Arnaud, Richter, Sebastian, Hubrecht, Regis, Demasles, Stéphanie, Barroso, Bruno, Sablot, Denis, Farouil, Geoffroy, Tardieu, Maxime, Smadja, Philippe, Aptel, Sabine, Seiler, Ian, Ducroux, Célina, Nourredine, Mikaïl, Haesebaert, Julie, Buisson, Marielle, Alesefir, Walid, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Diestro, Jose Danilo B., Eneling, Johanna, Gioia, Laura C., Iancu, Daniella, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Raymond, Jean, Roy, Daniel, Weill, Alain, and Poppe, Alexandre Y.

Published
2023
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10. The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study

Author

Charidimou, Andreas, Boulouis, Gregoire, Frosch, Matthew P, Baron, Jean-Claude, Pasi, Marco, Albucher, Jean Francois, Banerjee, Gargi, Barbato, Carmen, Bonneville, Fabrice, Brandner, Sebastian, Calviere, Lionel, Caparros, François, Casolla, Barbara, Cordonnier, Charlotte, Delisle, Marie-Bernadette, Deramecourt, Vincent, Dichgans, Martin, Gokcal, Elif, Herms, Jochen, Hernandez-Guillamon, Mar, Jäger, Hans Rolf, Jaunmuktane, Zane, Linn, Jennifer, Martinez-Ramirez, Sergi, Martínez-Sáez, Elena, Mawrin, Christian, Montaner, Joan, Moulin, Solene, Olivot, Jean-Marc, Piazza, Fabrizio, Puy, Laurent, Raposo, Nicolas, Rodrigues, Mark A, Roeber, Sigrun, Romero, Jose Rafael, Samarasekera, Neshika, Schneider, Julie A, Schreiber, Stefanie, Schreiber, Frank, Schwall, Corentin, Smith, Colin, Szalardy, Levente, Varlet, Pascale, Viguier, Alain, Wardlaw, Joanna M, Warren, Andrew, Wollenweber, Frank A, Zedde, Marialuisa, van Buchem, Mark A, Gurol, M Edip, Viswanathan, Anand, Al-Shahi Salman, Rustam, Smith, Eric E, Werring, David J, and Greenberg, Steven M

Published
2022
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11. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial

Author

Alonso, Angelika, Arquizan, Caroline, Barreau, Xavier, Beaujeux, Rémy, Behme, Daniel, Boeckh-Behrens, Tobias, Boehme, Christian, Boix, Martí, Boulouis, Grégoire, Bricout, Nicolas, Broc, Nicolas, Cereda, Carlo W., Chabert, Emmanuel, Cho, Tae-Hee, Cianfoni, Alessandro, Costalat, Vincent, Denier, Christian, Di Maria, Frederico, du Mesnil de Rochemont, Richard, Fearon, Patricia, Ferrier, Anna, Fischer, Sebastian, Gauberti, Maxime, Gaudron, Marie, Gimenez, Laetitia, Globas, Christoph, Görtler, Michael, Goyal, Mayank, Hilker-Roggendorf, Ruediger, Hill, Michael D., Hua, Vi Tuan, Humbertjean, Lisa, Jansen, Olav, Jung, Simon, Kägi, Georg, Kelly, Michael E., Kleffner, Ilka, Knoflach, Michael, Nedeltchev, Krassen, Krause, Lars Udo, Lappalainen, Kimmo, Lefebvre, Margaux, Leyon, Joe, Liao, Liang, Liegey, Jean-Sebastien, Loehr, Christian, Michel, Patrik, Nannoni, Stefania, Nicholson, Patrick, Nico, Lorena, Obadia, Michael, Ognard, Julien, Ogungbemi, Ayokunle, Olivot, Jean-Marc, Escalard, Simon, Pasi, Marco, Peeling, Lissa, Perez, Jane, Petersen, Martina, Piechowiak, Eike, Raposo, Roberto, Räty, Silja, Reitz, Sarah C., Remollo, Sebastià, Remonda, Luca, Rennie, Ian, Requena, Manuel, Riabikin, Alexander, Riva, Roberto, Rouchaud, Aymeric, Rosi, Andrea, Rubiera, Marta, Spelle, Laurent, Schnieder, Marlena, Schaafsma, Joanna D., Schubert, Tilman, Schulz, Jörg B., Siddiqui, Mohammed, Soize, Sébastien, Sonnberger, Michael, Touze, Emmanuel, Triquenot, Aude, Turc, Guillaume, Vieira, Lucy, Ben Hassen, Wagih, Wagner, Judith N., Wasser, Katrin, Weber, Johannes, Wenz, Holger, Weisenburger-Lile, David, Wodarg, Fritz, Wolff, Valérie, Wunderlich, Silke, Fischer, Urs, Kaesmacher, Johannes, Strbian, Daniel, Eker, Omer, Cognard, Christoph, Plattner, Patricia S, Bütikofer, Lukas, Mordasini, Pasquale, Deppeler, Sandro, Pereira, Vitor M, Albucher, Jean François, Darcourt, Jean, Bourcier, Romain, Benoit, Guillon, Papagiannaki, Chrysanthi, Ozkul-Wermester, Ozlem, Sibolt, Gerli, Tiainen, Marjaana, Gory, Benjamin, Richard, Sébastien, Liman, Jan, Ernst, Marielle Sophie, Boulanger, Marion, Barbier, Charlotte, Mechtouff, Laura, Zhang, Liqun, Marnat, Gaultier, Sibon, Igor, Nikoubashman, Omid, Reich, Arno, Consoli, Arturo, Lapergue, Bertrand, Ribo, Marc, Tomasello, Alejandro, Saleme, Suzana, Macian, Francisco, Moulin, Solène, Pagano, Paolo, Saliou, Guillaume, Carrera, Emmanuel, Janot, Kevin, Hernández-Pérez, María, Pop, Raoul, Schiava, Lucie Della, Luft, Andreas R, Piotin, Michel, Gentric, Jean Christophe, Pikula, Aleksandra, Pfeilschifter, Waltraud, Arnold, Marcel, Siddiqui, Adnan H, Froehler, Michael T, Furlan, Anthony J, Chapot, René, Wiesmann, Martin, Machi, Paolo, Diener, Hans-Christoph, Kulcsar, Zsolt, Bonati, Leo H, Bassetti, Claudio L, Mazighi, Mikael, Liebeskind, David S, Saver, Jeffrey L, and Gralla, Jan

Published
2022
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12. AMETIS Preplanned Ancillary Study: Impact of Agitation During Mechanical Thrombectomy Under Sedation.

Author

Tabillon, Caroline, Bernard, Rémy, Jacquens, Alice, Pommier, Maxime, Begard, Marc, Balança, Baptiste, Rapido, Francesca, Tavernier, Benoit, Molliex, Serge, Velly, Lionel, Verdonk, Franck, Lukaszewicz, Anne-Claire, Perrigault, Pierre-François, Albucher, Jean-François, Cognard, Christophe, Guyot, Adrien, Fernandez, Charlotte, Masgrau, Aurélie, Moreno, Ricardo, and Ferrier, Anna

Published
2025
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13. Galantamine combined with cognitive rehabilitation on post-stroke cognitive impairment: a proof-of-concept study.

Author

Planton, Mélanie, Nemmi, Federico, Pages, Berengère, Albucher, Jean-François, Raposo, Nicolas, Danet, Lola, Péran, Patrice, and Pariente, Jérémie

Subjects
COGNITIVE testing, CHOLINESTERASE inhibitors, STATISTICAL sampling, EPISODIC memory, EXECUTIVE function, TREATMENT effectiveness, RANDOMIZED controlled trials, ANXIETY, MAGNETIC resonance imaging, STROKE rehabilitation, COMBINED modality therapy, COGNITION disorders, NEUROPSYCHOLOGICAL tests, QUALITY of life, GALANTHAMINE, COGNITIVE therapy, COGNITIVE rehabilitation, MENTAL depression, EVALUATION
Abstract

Purpose: We conducted a proof-of-concept study to evaluate the effects of galantamine treatment versus placebo combined to cognitive rehabilitation (CR) after stroke. Materials and methods: In this 12-week, double blinded, randomized, controlled trial, patients were assigned to either combined approach of galantamine and CR (G-CR) or placebo and CR (P-CR). Primary outcome was the proportion of patients who crossed over from vascular cognitive disorder (VCD) to no-VCD at 12 weeks. Secondary outcomes included changes in cognition, mood, quality of life and the N-back fMRI paradigm, assessed at baseline, 6 and 12 weeks and after an 8-week washout period. Results: Ten patients were allocated to G-RC group, 12 to the P-RC group. After 12 weeks, 40.1% of all patients converted to no-VCD with similar proportions between groups. Both groups showed improvements in episodic and working memory, executive and quality of life after 6 weeks of CR. Decreased depression and anxiety were noted, and all benefits persisted after the washout period. An interaction effect was observed in the right parietal lobule during the N-back task. Conclusions: Interventions lead to improved cognition and distinct cortical reorganization without being able to establish correlation between neural changes and behavioral measures. [ABSTRACT FROM AUTHOR]

Published
2025
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14. Blood–brain barrier profile pretreatment is associated with hemorrhagic transformation after endovascular reperfusion.

Author

Leigh, Richard, Seners, Pierre, Rousseau, Vanessa, Christensen, Soren, Albucher, Jean‐François, Drif, Amel, Cognard, Christophe, Guenego, Adrien, Viguier, Alain, Sommet, Agnes, Raposo, Nicolas, Calviere, Lionel, Januel, Anne‐Christine, Mlynash, Michael, Bonneville, Fabrice, Gaudilliere, Brice, Thalamas, Claire, Sibon, Igor, Tourdias, Thomas, and Mazighi, Mikael

Subjects
PERFUSION magnetic resonance imaging, ENDOVASCULAR surgery, PERFUSION imaging, STANDARD deviations, THROMBECTOMY
Abstract

Background: While advances in endovascular thrombectomy (EVT) have led to high reperfusion rates, most patients treated with EVT do not avoid disability. Post‐reperfusion hemorrhagic transformation (HT) is a potential target for improving outcomes. This study examined pretreatment blood–brain barrier (BBB) disruption in tissue that would subsequently become part of the final infarct to evaluate its role in post‐EVT HT. Methods: This post hoc analysis of the FRAME study, which enrolled patients with anterior large vessel occlusion who received EVT within 6 hours of onset, included patients if they had successful pretreatment MRI perfusion weighted imaging (PWI) and underwent successful EVT. BBB disruption was measured as the percent signal change due to gadolinium leakage on the PWI source images prior to thrombectomy. Mean permeability derangement (MPD) was defined as the average of all voxels in the stroke core that are two standard deviations above normal. The primary outcome was hemorrhagic transformation with parenchymal hematoma (PH). Results: In total, 164 patients were included; mean age was 71 and 48% were female. PH occurred in 57 patients. Median MPD was 13.5% for patients with PH versus 3.6% for patients without (p < 0.0001). Elevated MPD was independently associated with PH with a 20% increased risk of PH for each 5% increase in MPD (OR 1.206; 95% CI 1.037:1.405; p = 0.0147, adjusted for NIHSS and procedure duration). Conclusions: Even in patients who are successfully recanalized in an early time window, pretreatment BBB disruption in regions that go on to infarct is associated with an increased risk of post‐EVT HT. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Infarct Core Growth During Interhospital Transfer For Thrombectomy Is Faster At Night

Author

Seners, Pierre, Mlynash, Michael, Sreekrishnan, Anirudh, Ter Schiphorst, Adrien, Arquizan, Caroline, Costalat, Vincent, Henon, Hilde, Bretzner, Martin, Heit, Jeremy J., Olivot, Jean-Marc, Lansberg, Maarten G., Albers, Gregory W., Schmitt, Perrine, Sablot, Denis, Lalu, Thibault, Bricout, Nicolas, Albucher, Jean-François, Cognard, Christophe, Cordonnier, Charlotte, Christensen, Soren, and Scheldeman, Lauranne

Published
2023
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19. ASCOD Phenotyping of Stroke With Anterior Large Vessel Occlusion Treated by Mechanical Thrombectomy

Author

Fontaine, Louis, Sibon, Igor, Raposo, Nicolas, Albucher, Jean-François, Mazighi, Michael, Rousseau, Vanessa, Darcourt, Jean, Thalamas, Claire, Drif, Amel, Sommet, Agnes, Viguier, Alain, Guenego, Adrien, Januel, Anne-Christine, Calvière, Lionel, Menegon, Patrice, Bonneville, Fabrice, Tourdias, Thomas, Albers, Gregory W., Cognard, Christophe, and Olivot, Jean-Marc

Published
2021
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20. Mismatch Profile Influences Outcome After Mechanical Thrombectomy

Author

Olivot, Jean-Marc, Albucher, Jean-François, Guenego, Adrien, Thalamas, Claire, Mlynash, Michael, Rousseau, Vanessa, Drif, Amel, Christensen, Soren, Sommet, Agnes, Viguier, Alain, Darcourt, Jean, Calvière, Lionel, Menegon, Patrice, Raposo, Nicolas, Januel, Anne-Christine, Bonneville, Fabrice, Tourdias, Thomas, Mazighi, Mikael, Sibon, Igor, Albers, Gregory W., and Cognard, Christophe

Published
2020
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22. Mismatch Profile Influences Outcome After Mechanical Thrombectomy

Author

Olivot, Jean-Marc, Albucher, Jean-François, Guenego, Adrien, Thalamas, Claire, Mlynash, Michael, Rousseau, Vanessa, Drif, Amel, Christensen, Soren, Sommet, Agnes, Viguier, Alain, Darcourt, Jean, Calvière, Lionel, Menegon, Patrice, Raposo, Nicolas, Januel, Anne-Christine, Bonneville, Fabrice, Tourdias, Thomas, Mazighi, Mikael, Sibon, Igor, Albers, Gregory W., and Cognard, Christophe

Published
2021
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23. Neuroimmune activation is associated with neurological outcome in anoxic and traumatic coma.

Author

Sarton, Benjamine, Tauber, Clovis, Fridman, Estéban, Péran, Patrice, Riu, Beatrice, Vinour, Hélène, David, Adrian, Geeraerts, Thomas, Bounes, Fanny, Minville, Vincent, Delmas, Clément, Salabert, Anne-Sophie, Albucher, Jean François, Bataille, Benoit, Olivot, Jean Marc, Cariou, Alain, Naccache, Lionel, Payoux, Pierre, Schiff, Nicholas, and Silva, Stein

Subjects
COMA, BRAIN injuries, CEREBRAL anoxia, TRANSLOCATOR proteins, POSITRON emission tomography, BRAIN anatomy
Abstract

The pathophysiological underpinnings of critically disrupted brain connectomes resulting in coma are poorly understood. Inflammation is potentially an important but still undervalued factor. Here, we present a first-in-human prospective study using the 18-kDa translocator protein (TSPO) radioligand 18F-DPA714 for PET imaging to allow in vivo neuroimmune activation quantification in patients with coma (n = 17) following either anoxia or traumatic brain injuries in comparison with age- and sex-matched controls. Our findings yielded novel evidence of an early inflammatory component predominantly located within key cortical and subcortical brain structures that are putatively implicated in consciousness emergence and maintenance after severe brain injury (i.e. mesocircuit and frontoparietal networks). We observed that traumatic and anoxic patients with coma have distinct neuroimmune activation profiles, both in terms of intensity and spatial distribution. Finally, we demonstrated that both the total amount and specific distribution of PET-measurable neuroinflammation within the brain mesocircuit were associated with the patient's recovery potential. We suggest that our results can be developed for use both as a new neuroprognostication tool and as a promising biometric to guide future clinical trials targeting glial activity very early after severe brain injury. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Functional and Structural Integrity of Frontoparietal Connectivity in Traumatic and Anoxic Coma

Author

Peran, Patrice, Malagurski, Briguitta, Nemmi, Federico, Sarton, Benjamine, Vinour, Hélène, Ferre, Fabrice, Bounes, Fanny, Rousset, David, Mrozeck, Segolène, Seguin, Thierry, Riu, Béatrice, Minville, Vincent, Geeraerts, Thomas, Lotterie, Jean Albert, Deboissezon, Xavier, Albucher, Jean François, Fourcade, Olivier, Olivot, Jean Marc, Naccache, Lionel, and Silva, Stein

Published
2020
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26. Post-stroke remodeling processes in animal models and humans

Author

Cirillo, Carla, Brihmat, Nabila, Castel-Lacanal, Evelyne, Le Friec, Alice, Barbieux-Guillot, Marianne, Raposo, Nicolas, Pariente, Jérémie, Viguier, Alain, Simonetta-Moreau, Marion, Albucher, Jean-François, Olivot, Jean-Marc, Desmoulin, Franck, Marque, Philippe, Chollet, François, and Loubinoux, Isabelle

Published
2020
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27. Evaluation of acute mechanical revascularization in minor stroke (NIHSS score ⩽ 5) and large vessel occlusion: The MOSTE multicenter, randomized, clinical trial protocol.

Author

Arquizan, Caroline, Lapergue, Bertrand, Gory, Benjamin, Labreuche, Julien, Henon, Hilde, Albucher, Jean-François, Sibon, Igor, Turc, Guillaume, Richard, Sebastien, Nouri, Nasreddine, Cognard, Christophe, Marnat, Gauthier, Naggara, Olivier, Di Maria, Federico, Duhamel, Alain, Jovin, Tudor, and Costalat, Vincent

Subjects
STROKE, STROKE patients, ISCHEMIC stroke, INTERNAL carotid artery, MEDICAL protocols, TRANSCRANIAL Doppler ultrasonography, NONINVASIVE ventilation
Abstract

Rationale: Mechanical thrombectomy (MT) has become the standard of care for patients with acute ischemic stroke secondary to large vessel occlusion (LVO) of the anterior circulation. Conversely, its benefit in patients with National Institutes of Health Stroke Scale (NIHSS) score ⩽ 5 is unproven. Aim: To demonstrate the superiority of immediate MT plus best medical treatment (BMT) compared to BMT (with secondary MT in case of deterioration) for increasing the rate of modified Rankin Scale (mRS) score ⩽ 1 at 90 days after minor stroke (NIHSS score ⩽ 5) and anterior circulation LVO. Sample size estimates: To detect an absolute increase of 10% (80% power) in the 90-day mRS score = 0–1 rate in the MT + BMT group, by assuming an mRS score = 0–1 rate of 60% in the BMT group and by considering two interim efficacy/futility analyses (after study completion by 274 and 548 patients), 824 patients must be included by 36 centers in France, Spain, and the USA. Methods and design: MOSTE is an international, multicenter, prospectively randomized into two parallel (1:1) arms, open-label, with blinded endpoint trial. Eligibility criteria are diagnosis of acute ischemic stroke within 23 h of last-seen-well, NIHSS score ⩽ 5, and LVO in the anterior circulation (intracranial internal carotid artery, M1 or M1-M2 segment of the middle cerebral artery). Study outcomes: The primary endpoint is the rate of excellent outcome at day 90 (mRS score = 0–1). Secondary endpoints include the rates of 90-day mRS score = 0–2 and score = 0, NIHSS score change, secondary MT, revascularization and infarct volume growth at 24 h, and quality of life and cognitive function at day 90. Safety outcomes (90-day all-cause mortality, procedural complications, symptomatic intracerebral hemorrhage, and rapid NIHSS score worsening) are recorded. Discussion: The MOSTE trial will determine MT efficacy and safety in patients with minor stroke and LVO in the anterior circulation. Trial registration: MOSTE Trial. NCT 03796468 [ABSTRACT FROM AUTHOR]

Published
2023
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28. Influence de la thrombolyse intraveineuse chez les patients traites par thrombectomie mecanique pour une occlusion M2: une analyse du registre etis

Author

Floch, Agathe Le, Clarencon, Frederic, Rouchaud, Aymeric, Khyeng, Maeva, Labreuche, Julien, Sibon, Igor, Boulouis, Gregoire, Gory, Benjamin, Richard, Sebastien, Caroff, Jildaz, Blanc, Raphael, Seners, Pierre, Eker, Omer, Cho, Tae-Hee, Consoli, Arturo, Bourcier, Romain, Guillon, Benoit, Dargazanli, Cyril, Arquizan, Caroline, Denier, Christian, Eugene, Francois, Vannier, Stephanie, Gentric, Jean-Christophe, Gauberti, Maxime, Nagarra, Olivier, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Cognard, Christophe, Albucher, Jean-Francois, Timsit, Serge, Bourdain, Frederic, Bras, Anthony Le, Richter, Sebastian, Moulin, Solene, Pop, Raoul, Heck, Olivier, Moreno, Ricardo, L'Allinec, Vincent, Lapergue, Bertrand, and Marnat, Gaultier

Published
2023
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29. Predictive Value of Susceptibility Vessel Sign for Arterial Recanalization and Clinical Improvement in Ischemic Stroke

Author

Darcourt, Jean, Withayasuk, Pattarawit, Vukasinovic, Ivan, Michelozzi, Caterina, Bellanger, Guillaume, Guenego, Adrien, Adam, Gilles, Roques, Margaux, Januel, Anne Christine, Tall, Philippe, Meyrignac, Olivier, Rousseau, Vanessa, Garcia, Cédric, Albucher, Jean François, Payrastre, Bernard, Bonneville, Fabrice, Olivot, Jean Marc, and Cognard, Christophe

Published
2019
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30. Factors Associated With Fast Early Infarct Growth in Patients With Acute Ischemic Stroke With a Large Vessel Occlusion.

Author

Seners, Pierre, Yuen, Nicole, Olivot, Jean-Marc, Mlynash, Michael, Heit, Jeremy J., Christensen, Soren, Escribano-Paredes, José Bernardo, Carrera, Emmanuel, Strambo, Davide, Michel, Patrik, Salerno, Alexander, Wintermark, Max, Hui Chen, Albucher, Jean-François, Cognard, Christophe, Sibon, Igor, Obadia, Michael, Savatovsky, Julien, Lansberg, Maarten G., and Albers, Gregory W.

Published
2023
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31. Association of intravenous thrombolysis and preinterventional reperfusion: a post hoc analysis of the SWIFT DIRECT trial.

Author

Mujanovic, Adnan, Eker, Omer, Marnat, Gaultier, Strbian, Daniel, Ijäs, Petra, Préterre, Cécile, Triquenot, Aude, Albucher, Jean François, Gauberti, Maxime, Weisenburger-Lile, David, Ernst, Marielle, Nikoubashman, Omid, Mpotsaris, Anastasios, Gory, Benjamin, Hua, Vi Tuan, Ribo, Marc, Liebeskind, David S., Dobrocky, Tomas, Meinel, Thomas R., and Buetikofer, Lukas

Subjects
STATISTICS, CONFIDENCE intervals, THROMBOLYTIC therapy, RISK assessment, TREATMENT effectiveness, THROMBECTOMY, REPERFUSION, LOGISTIC regression analysis, ODDS ratio, DATA analysis, SECONDARY analysis
Abstract

Background A potential benefit of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) is pre-interventional reperfusion. Currently, there are few data on the occurrence of pre-interventional reperfusion in patients randomized to IVT or no IVT before MT. Methods SWIFT DIRECT (Solitaire With the Intention For Thrombectomy Plus Intravenous t-PA vs DIRECT Solitaire Stent-retriever Thrombectomy in Acute Anterior Circulation Stroke) was a randomized controlled trial including acute ischemic stroke IVT eligible patients being directly admitted to a comprehensive stroke center, with allocation to IVT with MT versus MT alone. The primary endpoint of this analysis was the occurrence of pre-interventional reperfusion, defined as a preinterventional expanded Thrombolysis in Cerebral Infarction score of ≥2a. The effect of IVT and potential treatment effect heterogeneity were analyzed using logistic regression analyses. Results Of 396 patients, pre-interventional reperfusion occurred in 20 (10.0%) patients randomized to IVT with MT, and in 7 (3.6%) patients randomized to MT alone. Receiving IVT favored the occurrence of preinterventional reperfusion (adjusted OR 2.91, 95% CI 1.23 to 6.87). There was no IVT treatment effect heterogeneity on the occurrence of pre-interventional reperfusion with different strata of Randomization-to-Groin-Puncture time (p for interaction=0.33), although the effect tended to be stronger in patients with a Randomization-to-Groin-Puncture time >28 min (adjusted OR 4.65, 95% CI 1.16 to 18.68). There were no significant differences in rates of functional outcomes between patients with and without pre- interventional reperfusion. Conclusion Even for patients with proximal large vessel occlusions and direct access to MT, IVT resulted in an absolute increase of 6% in rates of pre- interventional reperfusion. The influence of time strata on the occurrence of pre- interventional reperfusion should be studied further in an individual patient data metaanalysis of comparable trials. Trial registration number clinicaltrials. gov NCT03192332. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Time to treatment with bridging intravenous alteplase before endovascular treatment: subanalysis of the randomized controlled SWIFT-DIRECT trial.

Author

Meinel, Thomas R., Kaesmacher, Johannes, Buetikofer, Lukas, Strbian, Daniel, Eker, Omer Faruk, Cognard, Christophe, Mordasini, Pasquale, Deppeler, Sandro, Mendes Pereira, Vitor, Albucher, Jean François, Darcourt, Jean, Bourcier, Romain, Guillon, Benoit, Papagiannaki, Chrysanthi, Costentin, Guillaume, Sibolt, Gerli, Räty, Silja, Gory, Benjamin, Richard, Sébastien, and Liman, Jan

Subjects
RESEARCH, CONFIDENCE intervals, ISCHEMIC stroke, FUNCTIONAL status, INTRACRANIAL hemorrhage, TIME, THROMBOLYTIC therapy, SURGERY, PATIENTS, REGRESSION analysis, TREATMENT delay (Medicine), TREATMENT effectiveness, THROMBECTOMY, DESCRIPTIVE statistics, RESEARCH funding, ENDOVASCULAR surgery, COMBINED modality therapy, ODDS ratio, TISSUE plasminogen activator, PREANESTHETIC medication, SECONDARY analysis, EVALUATION
Abstract

Background We hypothesized that treatment delays might be an effect modifier regarding risks and benefits of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT). Methods We used the dataset of the SWIFT-DIRECT trial, which randomized 408 patients to IVT+MT or MT alone. Potential interactions between assignment to IVT+MT and expected time from onset-to-needle (OTN) as well as expected time from door-to-needle (DTN) were included in regression models. The primary outcome was functional independence (modified Rankin Scale (mRS) 0-2) at 3 months. Secondary outcomes included mRS shift, mortality, recanalization rates, and (symptomatic) intracranial hemorrhage at 24 hours. Results We included 408 patients (IVT+MT 207, MT 201, median age 72 years (IQR 64-81), 209 (51.2%) female). The expected median OTN and DTN were 142 min and 54 min in the IVT+MT group and 129 min and 51 min in the MT alone group. Overall, there was no significant interaction between OTN and bridging IVT assignment regarding either the functional (adjusted OR (aOR) 0.76, 95% CI 0.45 to 1.30) and safety outcomes or the recanalization rates. Analysis of in-hospital delays showed no significant interaction between DTN and bridging IVT assignment regarding the dichotomized functional outcome (aOR 0.48, 95% CI 0.14 to 1.62), but the shift and mortality analyses suggested a greater benefit of IVT when in-hospital delays were short. Conclusions We found no evidence that the effect of bridging IVT on functional independence is modified by overall or in-hospital treatment delays. Considering its low power, this subgroup analysis could have missed a clinically important effect, and exploratory analysis of secondary clinical outcomes indicated a potentially favorable effect of IVT with shorter in-hospital delays. Heterogeneity of the IVT effect size before MT should be further analyzed in individual patient meta-analysis of comparable trials. Trial registration number URL: https://www. clinicaltrials.gov ; Unique identifier: NCT03192332 [ABSTRACT FROM AUTHOR]

Published
2023
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34. Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke: The AMETIS Randomized Clinical Trial.

Author

Chabanne, Russell, Geeraerts, Thomas, Begard, Marc, Balança, Baptiste, Rapido, Francesca, Degos, Vincent, Tavernier, Benoit, Molliex, Serge, Velly, Lionel, Verdonk, Franck, Lukaszewicz, Anne-Claire, Perrigault, Pierre-François, Albucher, Jean-François, Cognard, Christophe, Guyot, Adrien, Fernandez, Charlotte, Masgrau, Aurélie, Moreno, Ricardo, Ferrier, Anna, and Jaber, Samir

Published
2023
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37. Atypical thrombosis associated with VaxZevria® (AstraZeneca) vaccine: Data from the French Network of Regional Pharmacovigilance Centres

Author

Gras-Champel, Valérie, Liabeuf, Sophie, Baud, Mariette, Albucher, Jean-François, Benkebil, Mehdi, Boulay, Charlène, Bron, Anthony, El Kaddissi, Antoine, Gautier, Sophie, Geeraerts, Thomas, Girot, Marie, Grandvuillemin, Aurélie, Laujin, Hugo, Jonville-Béra, Annie-Pierre, Masmoudi, Kamel, Massardier, Evelyne, Micallef, Joëlle, Mounier, Céline, Montastruc, François, Pariente, Antoine, Perez, Justine, Raposo, Nicolas, Salvo, Francesco, Valnet-Rabier, Marie-Blanche, Vial, Thierry, and Massy, Nathalie

Published
2021
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38. Prevalence and characterization of cerebral small vessel disease in young adults with intracerebral hemorrhage.

Author

Periole, Charlotte, Blanc, Clémence, Calvière, Lionel, Fontaine, Louis, Viguier, Alain, Albucher, Jean-François, Chollet, François, Bonneville, Fabrice, Olivot, Jean-Marc, and Raposo, Nicolas

Subjects
CEREBRAL small vessel diseases, YOUNG adults, CEREBRAL hemorrhage, INTRACEREBRAL hematoma
Abstract

Background and aims: Cerebral small vessel disease (CSVD) is the main cause of intracerebral hemorrhage (ICH) in older individuals but has not been systematically studied in younger people. We aimed to evaluate the prevalence and characteristics of CSVD in young adults with symptomatic ICH. Methods: We conducted a cohort study of consecutive adults aged 18–50 years with non-traumatic ICH. All patients were evaluated with brain and vascular imaging. Using validated imaging markers (cerebral microbleeds (CMBs), white matter hyperintensities and/or lacunes), patients were categorized as having CSVD-related ICH or non-CSVD-related ICH. Factors associated with CSVD were evaluated using multivariable analyses. CSVD subtypes were characterized using pre-specified criteria. Results: Of 146 young adults with ICH (mean age = 37.7), CSVD was present in 41 patients (28.1%; 95% confidence interval (CI) = 21.0–36.1). In multivariable analysis, older age, male sex, and hypertension were independently associated with the presence of CSVD. Deep perforator arteriopathy (48.8%) and mixed CSVD (31.7%) were the most common CSVD subtypes. Conclusion: Our results suggest that CSVD is a frequent cause of ICH in young adults and provide new insights into the characterization of the disease. These findings may have important implications since the treatment and management differ from other causes of ICH. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial

Author

Mas, Jean-Louis, Trinquart, Ludovic, Leys, Didier, Albucher, Jean-François, Rousseau, Hervé, Viguier, Alain, Bossavy, Jean-Pierre, Denis, Béatrice, Piquet, Philippe, Garnier, Pierre, Viader, Fausto, Touzé, Emmanuel, Julia, Pierre, Giroud, Maurice, Krause, Denis, Hosseini, Hassan, Becquemin, Jean-Pierre, Hinzelin, Grégoire, Houdart, Emmanuel, Hénon, Hilde, Neau, Jean-Philippe, Bracard, Serge, Onnient, Yannick, Padovani, Raymond, and Chatellier, Gilles

Published
2008
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41. Long-Term Follow-Up Study of Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis Trial

Author

Mas, Jean-Louis, Arquizan, Caroline, Calvet, David, Viguier, Alain, Albucher, Jean-François, Piquet, Philippe, Garnier, Pierre, Viader, Fausto, Giroud, Maurice, Hosseini, Hassan, Hinzelin, Grégoire, Favrole, Pascal, Hénon, Hilde, Neau, Jean-Philippe, Ducrocq, Xavier, Padovani, Raymond, Milandre, Loic, Rouanet, François, Wolff, Valérie, Saudeau, Denis, Mahagne, Marie-Hélène, Sablot, Denis, Amarenco, Pierre, Larrue, Vincent, Beyssen, Bernard, Leys, Didier, Moulin, Thierry, Lièvre, Michel, and Chatellier, Gilles

Published
2014
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43. What predicts poor outcome after successful thrombectomy in early time window?

Author

Olivot, Jean-Marc, Heit, Jeremy J., Mazighi, Mikael, Raposo, Nicolas, Albucher, Jean François, Rousseau, Vanessa, Guenego, Adrien, Thalamas, Claire, Mlynash, Michael, Drif, Amel, Christensen, Soren, Sommet, Agnes, Viguier, Alain, Darcourt, Jean, Januel, Anne-Christine, Calviere, Lionel, Menegon, Patrice, Caparros, François, Bonneville, Fabrice, and Tourdias, Thomas

Subjects
SURGICAL complication risk factors, MORTALITY risk factors, HEART radiography, CONFIDENCE intervals, CEREBRAL revascularization, MULTIPLE regression analysis, NIH Stroke Scale, RISK assessment, DIAGNOSTIC imaging, THROMBECTOMY, DESCRIPTIVE statistics, ENDOVASCULAR surgery, ODDS ratio
Abstract

Background Half of the patients with large vessel occlusion (LVO)-related acute ischemic stroke (AIS) who undergo endovascular reperfusion are dead or dependent at 3 months. We hypothesize that in addition to established prognostic factors, baseline imaging profile predicts outcome among reperfusers. Methods Consecutive patients receiving endovascular treatment (EVT) within 6 hours after onset with Thrombolysis In Cerebral Infarction (TICI) 2b, 2c and 3 revascularization were included. Poor outcome was defined by a modified Rankin scale (mRS) 3-6 at 90 days. No mismatch (NoMM) profile was defined as a mismatch (MM) ratio ≤1.2 and/or a volume <10 mL on pretreatment imaging. Results 187 patients were included, and 81 (43%) had a poor outcome. Median delay from stroke onset to the end of EVT was 259 min (IQR 209-340). After multivariable logistic regression analysis, older age (OR 1.26, 95% CI 1.06 to 1.5; p=0.01), higher National Institutes of Health Stroke Scale (NIHSS) (OR 1.15, 95% CI 1.06 to 1.25; p<0.0001), internal carotid artery (ICA) occlusion (OR 3.02, 95% CI 1.2 to 8.0; p=0.021), and NoMM (OR 4.87, 95% CI 1.09 to 22.8; p=0.004) were associated with poor outcome. In addition, post-EVT hemorrhage (OR 3.64, 95% CI 1.5 to 9.1; p=0.04) was also associated with poor outcome. Conclusions The absence of a penumbra defined by a NoMM profile on baseline imaging appears to be an independent predictor of poor outcome after reperfusion. Strategies aiming to preserve the penumbra may be encouraged to improve these patients' outcomes. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Methylphenidate modulates cerebral post-stroke reorganization

Author

Tardy, Jean, Pariente, Jérémie, Leger, Anne, Dechaumont-Palacin, Sophie, Gerdelat, Angélique, Guiraud, Vincent, Conchou, Fabrice, Albucher, Jean-François, Marque, Philippe, Franceries, Xavier, Cognard, Christophe, Rascol, Olivier, Chollet, François, and Loubinoux, Isabelle

Published
2006
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50. Rebleeding After Aneurysmal Subarachnoid Hemorrhage in Two Centers Using Different Blood Pressure Management Strategies.

Author

Calviere, Lionel, Gathier, Celine S., Rafiq, Marie, Koopman, Inez, Rousseau, Vanessa, Raposo, Nicolas, Albucher, Jean François, Viguier, Alain, Geeraerts, Thomas, Cognard, Christophe, Rinkel, Gabriel J. E., Vergouwen, Mervyn D. I., and Olivot, Jean-Marc

Subjects
SUBARACHNOID hemorrhage, BLOOD pressure, CEREBRAL vasospasm, HYPERTENSION, SYSTOLIC blood pressure, CEREBRAL ischemia
Abstract

Background: High systolic blood pressure (SBP) after aneurysmal subarachnoid hemorrhage (aSAH) has been associated with an increased risk of rebleeding. It remains unclear if an SBP lowering strategy before aneurysm treatment decreases this risk without increasing the risk of a delayed cerebral ischemia (DCI). Therefore, we compared the rates of in-hospital rebleeding and DCI among patients with aSAH admitted in two tertiary care centers with different SBP management strategies. Methods: Retrospective cohort study. Consecutive patients from Utrecht and Toulouse admitted within 24 h after the aSAH onset were enrolled. In Toulouse, the target SBP before aneurysm treatment was ≤140 mm Hg, while, in Utrecht, an increased SBP was only treated in extreme situations. We compared SBP levels, the incidence of rebleeding within 24 h after admission, and DCI during hospitalization. Results: We enrolled 373 patients in Utrecht and 149 in Toulouse. The mean SBP on admission was similar but lower in Toulouse 4h after admission (127.3 ± 17.4 vs. 138. ± 25.7 mmHg; p < 0.0001). After a median delay of 3.7 h (IQR, 2.3-7.4) from admission, 4 patients (3%) in Toulouse vs. 29 (8%) in Utrecht experienced a rebleeding. After adjustment for Prognosis on Admission of Aneurysmal Subarachnoid Hemorrhage (PAASH) score, aneurysm size, age, and delay from ictus to admission, the HR was 0.66 (95% CI: 0.23-1.92). Incidence of DCI was 18% in Toulouse and 25% in Utrecht (adjusted OR, 0.68; 95% CI: 0.41-1.11). Conclusion: Our results suggest that an intensive SBP lowering strategy between admission and aneurysm treatment does not decrease the risk of rebleeding and does not increase the risk of DCI compared to a more conservative strategy. [ABSTRACT FROM AUTHOR]

Published
2022
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