1. Untargeted lipidomics reveals racial differences in lipid species among women
- Author
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Ghazaleh Pourali, Liang Li, Kayla R. Getz, Myung Sik Jeon, Jingqin Luo, Chongliang Luo, and Adetunji T. Toriola
- Subjects
Lipidomics ,Lipids ,Non-Hispanic Black ,Non-Hispanic White ,Body Mass Index ,Women ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Understanding the biological mechanisms underlying racial differences in diseases is crucial to developing targeted prevention and treatment. There is, however, limited knowledge of the impact of race on lipids. To address this, we performed comprehensive lipidomics analyses to evaluate racial differences in lipid species among 506 non-Hispanic White (NHW) and 163 non-Hispanic Black (NHB) women. Plasma lipidomic profiling quantified 982 lipid species. We used multivariable linear regression models, adjusted for confounders, to identify racial differences in lipid species and corrected for multiple testing using a Bonferroni-adjusted p-value
- Published
- 2024
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