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1,600 results on '"Abid, Muhammad"'

1. Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities.

Author

Khera, Nandita, Ailawadhi, Sikander, Brazauskas, Ruta, Patel, Jinalben, Jacobs, Benjamin, Ustun, Celalettin, Ballen, Karen, Abid, Muhammad, Diaz Perez, Miguel, Al-Homsi, A, Hashem, Hasan, Hong, Sanghee, Munker, Reinhold, Schears, Raquel, Lazarus, Hillard, Ciurea, Stefan, Badawy, Sherif, Savani, Bipin, Wirk, Baldeep, LeMaistre, C, Bhatt, Neel, Beitinjaneh, Amer, Aljurf, Mahmoud, Sharma, Akshay, Cerny, Jan, Knight, Jennifer, Kelkar, Amar, Yared, Jean, Kindwall-Keller, Tamila, Winestone, Lena, Steinberg, Amir, Arnold, Staci, Seo, Sachiko, Preussler, Jaime, Hossain, Nasheed, Fingrut, Warren, Agrawal, Vaibhav, Hashmi, Shahrukh, Lehmann, Leslie, Wood, William, Rangarajan, Hemalatha, Saber, Wael, and Hahn, Theresa

Subjects
Humans, Hematopoietic Stem Cell Transplantation, Male, Female, Adult, Middle Aged, Ethnic and Racial Minorities, Adolescent, Child, Aged, Young Adult, Child, Preschool
Abstract

There has been an increase in volume as well as an improvement in overall survival (OS) after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if these changes have affected racial/ethnic minorities equally. In this observational study from the Center for International Blood and Marrow Transplant Research of 79 904 autologous (auto) and 65 662 allogeneic (allo) HCTs, we examined the volume and rates of change of autoHCT and alloHCT over time and trends in OS in 4 racial/ethnic groups: non-Hispanic Whites (NHWs), non-Hispanic African Americans (NHAAs), and Hispanics across 5 2-year cohorts from 2009 to 2018. Rates of change were compared using Poisson model. Adjusted and unadjusted Cox proportional hazards models examined trends in mortality in the 4 racial/ethnic groups over 5 study time periods. The rates of increase in volume were significantly higher for Hispanics and NHAAs vs NHW for both autoHCT and alloHCT. Adjusted overall mortality after autoHCT was comparable across all racial/ethnic groups. NHAA adults (hazard ratio [HR] 1.13; 95% confidence interval [CI] 1.04-1.22; P = .004) and pediatric patients (HR 1.62; 95% CI 1.3-2.03; P < .001) had a higher risk of mortality after alloHCT than NHWs. Improvement in OS over time was seen in all 4 groups after both autoHCT and alloHCT. Our study shows the rate of change for the use of autoHCT and alloHCT is higher in NHAAs and Hispanics than in NHWs. Survival after autoHCT and alloHCT improved over time; however, NHAAs have worse OS after alloHCT, which has persisted. Continued efforts are needed to mitigate disparities for patients requiring alloHCT.

Published
2024

16. Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients.

Author

Boyiadzis, Michael, Zhang, Mei-Jie, Chen, Karen, Abdel-Azim, Hisham, Abid, Muhammad, Aljurf, Mahmoud, Bacher, Ulrike, Badar, Talha, Badawy, Sherif, Battiwalla, Minoo, Bejanyan, Nelli, Bhatt, Vijaya, Brown, Valerie, Castillo, Paul, Cerny, Jan, Copelan, Edward, Craddock, Charles, Dholaria, Bhagirathbhai, Perez, Miguel, Ebens, Christen, Gale, Robert, Ganguly, Siddhartha, Gowda, Lohith, Grunwald, Michael, Hashmi, Shahrukh, Hildebrandt, Gerhard, Iqbal, Madiha, Jamy, Omer, Kharfan-Dabaja, Mohamed, Khera, Nandita, Lazarus, Hillard, Lin, Richard, Modi, Dipenkumar, Nathan, Sunita, Nishihori, Taiga, Patel, Sagar, Pawarode, Attaphol, Saber, Wael, Sharma, Akshay, Solh, Melhem, Wagner, John, Wang, Trent, Williams, Kirsten, Wirk, Baldeep, Zeidan, Amer, Hourigan, Christopher, Litzow, Mark, Kebriaei, Partow, de Lima, Marcos, Page, Kristin, Weisdorf, Daniel, and Winestone, Lena

Subjects
Adult, Humans, Transplantation, Homologous, Transplantation Conditioning, Neoplasm Recurrence, Local, Hematopoietic Stem Cell Transplantation, Leukemia, Myeloid, Acute, Retrospective Studies
Abstract

We investigated the impact of the number of induction/consolidation cycles on outcomes of 3113 adult AML patients who received allogeneic hematopoietic cell transplantation (allo-HCT) between 2008 and 2019. Patients received allo-HCT using myeloablative (MAC) or reduced-intensity (RIC) conditioning in first complete remission (CR) or with primary induction failure (PIF). Patients who received MAC allo-HCT in CR after 1 induction cycle had 1.3-fold better overall survival (OS) than 2 cycles to CR and 1.47-fold better than ≥3 cycles. OS after CR in 2 or ≥3 cycles was similar. Relapse risk was 1.65-fold greater in patients receiving ≥3 cycles to achieve CR. After RIC allo-HCT, the number of induction cycles to CR did not affect OS. Compared to CR in 1 cycle, relapse risk was 1.24-1.41-fold greater in patients receiving 2 or ≥3 cycles. For patients receiving only 1 cycle to CR, consolidation therapy prior to MAC allo-HCT was associated with improved OS vs. no consolidation therapy. Detectable MRD at the time of MAC allo-HCT did not impact outcomes while detectable MRD preceding RIC allo-HCT was associated with an increased risk of relapse. For allo-HCT in PIF, OS was significantly worse than allo-HCT in CR after 1-3 cycles.

Published
2023

24. Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort Study

Author

Bhatt, Neel S, Sharma, Akshay, St Martin, Andrew, Abid, Muhammad Bilal, Brown, Valerie I, Diaz Perez, Miguel Angel, Frangoul, Haydar, Gadalla, Shahinaz M, Herr, Megan M, Krem, Maxwell M, Lazarus, Hillard M, Martens, Michael J, Mehta, Parinda A, Nishihori, Taiga, Prestidge, Tim, Pulsipher, Michael A, Rangarajan, Hemalatha G, Williams, Kirsten M, Winestone, Lena E, Yin, Dwight E, Riches, Marcie L, Dandoy, Christopher E, and Auletta, Jeffery J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Stem Cell Research - Nonembryonic - Human, Stem Cell Research, Pediatric Research Initiative, Pediatric, Transplantation, Cancer, Clinical Research, Regenerative Medicine, Prevention, Good Health and Well Being, Adolescent, COVID-19, COVID-19 Testing, Child, Cohort Studies, Hematopoietic Stem Cell Transplantation, Humans, Oxygen, Young Adult, Covid-19, Early adolescent and young adult, Hematopoietic stem cell, Clinical Sciences, Immunology, Cardiovascular medicine and haematology
Abstract

Adult hematopoietic stem cell transplantation (HSCT) recipients are at a high risk of adverse outcomes after COVID-19. Although children have had better outcomes after COVID-19 compared to adults, data on risk factors and outcomes of COVID-19 among pediatric HSCT recipients are lacking. We describe outcomes of HSCT recipients who were ≤21 years of age at COVID-19 diagnosis and were reported to the Center for International Blood and Marrow Transplant Research between March 27, 2020, and May 7, 2021. The primary outcome was overall survival after COVID-19 diagnosis. We determined risk factors of COVID-19 as a secondary outcome in a subset of allogeneic HSCT recipients. A total of 167 pediatric HSCT recipients (135 allogeneic; 32 autologous HSCT recipients) were included. Median time from HSCT to COVID-19 was 15 months (interquartile range [IQR] 7-45) for allogeneic HSCT recipients and 16 months (IQR 6-59) for autologous HSCT recipients. Median follow-up from COVID-19 diagnosis was 53 days (range 1-270) and 37 days (1-179) for allogeneic and autologous HSCT recipients, respectively. Although COVID-19 was mild in 87% (n = 146/167), 10% (n = 16/167) of patients required supplemental oxygen or mechanical ventilation. The 45-day overall survival was 95% (95% confidence interval [CI], 90-99) and 90% (74-99) for allogeneic and autologous HSCT recipients, respectively. Cox regression analysis showed that patients with a hematopoietic cell transplant comorbidity index (HCT-CI) score of 1-2 were more likely to be diagnosed with COVID-19 (hazard ratio 1.95; 95% CI, 1.03-3.69, P = .042) compared to those with an HCT-CI of 0. Pediatric and early adolescent and young adult HSCT recipients with pre-HSCT comorbidities were more likely to be diagnosed with COVID-19. Overall mortality, albeit higher than the reported general population estimates, was lower when compared with previously published data focusing on adult HSCT recipients.

Published
2022

25. Sensitivity enhancement for moisture content detection using modified microstrip patch antennas

Author

Muhammad Talha Khan, Xian Qi Lin, Abid Muhammad Khan, and Zhe Chen

Subjects
Physics, QC1-999
Abstract

A modified slotted microstrip patch sensor antenna has been developed for sensitivity enhancement to measure the moisture content of leaves. The design incorporates a rectangular slot positioned above the feed of a rectangular patch antenna. The antenna achieves resonant frequency at a lower range than the operating frequency of a traditional patch antenna without slot while maintaining a miniaturized form factor. To evaluate the sensitivity of the proposed modified slotted patch antenna, the variation in the resonant frequency and the reflection coefficient (S11) is observed with the sample under test (SUT), i.e., leaf is placed above the patch. A comparative analysis with regard to sensitivity and shift in frequency is performed between the designed antenna structures. The designed antenna is fabricated on a 0.8 mm F4B substrate in order to resonate within the 2.40–2.80 GHz range under unloaded conditions. The antenna’s sensitivity is tested by performing parametric analysis with respect to the permittivity of the leaf ranging from 20 to 30. The experimental results reveal that the sensitivity of the proposed patch antenna is enhanced by a factor of 1.67 as compared to traditional patch antenna for the four levels of SUT, demonstrating an enhanced sensitivity in detecting the moisture content of leaves.

Published
2024
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27. Cardiomegaly: Navigating the uncharted territories of heart failure - A multimodal radiological journey through advanced imaging, pathophysiological landscapes, and innovative therapeutic frontiers

Author

Iqbal, Muhammad Khalid, Ambreen, Alia, Mujahid, Muhammad, Zarlashat, Yusra, Abid, Muhammad, Yasin, Ayesha, Ullah, Muhammad Naeem, Shahzad, Raheel, Harlina, Putri Widyanti, Khan, Shahid Ullah, Alissa, Mohammed, Algopishi, Uthman Balgith, and Almubarak, Hassan Ali

Published
2024
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35. Switching to Outcome-Based Education (OBE) System, a Paradigm Shift in Engineering Education

Author

Zamir, Muhammad Zunair, Abid, Muhammad Irfan, Fazal, Muhammad Rayyan, Qazi, Muhammad Ali Aqdas Rehman, and Kamran, Muhammad

Abstract

Contribution: This study compares the outcome-based education (OBE) system with the traditional teaching--learning methods. A detailed analysis regarding the effectiveness of these techniques at Riphah International University (RIU), Faisalabad Campus is presented. Background: Education is becoming more demanding in terms of students' learning. In the same way, teaching methods are becoming more systematic and outcome-oriented. Pakistan has turned out to be a full signatory of the Washington Accord, and Pakistan Engineering Council (PEC) has directed all engineering institutions to implement the described OBE system. Intended Outcomes: The aim of this work is to investigate the advantages and drawbacks of both teaching methods. Also, it reveals the strengths of the OBE system to improve future students' learning. Application Design: The analysis is performed by considering the student's feedback, average learning scores, letter grades, and overall class impact as the main driving factors toward the comprehensive system's evaluation. The data for two consecutive batches under OBE and non-OBE systems is collected and compared. Reliability and validity tests were also performed for the data validation. Findings: The overall transformation from non-OBE to OBE has proved the new educational system superlative in student learning, subject delivery, and teaching technique.

Published
2022
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37. Real-world and clinical trial outcomes in large B-cell lymphoma with axicabtagene ciloleucel across race and ethnicity

Author

Locke, Frederick L., Siddiqi, Tanya, Jacobson, Caron A., Ghobadi, Armin, Ahmed, Sairah, Miklos, David B., Perales, Miguel-Angel, Munoz, Javier, Fingrut, Warren B., Pennisi, Martina, Gauthier, Jordan, Shadman, Mazyar, Gowda, Lohith, Mirza, Abu-Sayeef, Abid, Muhammad Bilal, Hong, Sanghee, Majhail, Navneet S., Kharfan-Dabaja, Mohamed A., Khurana, Arushi, Badar, Talha, Lin, Yi, Bennani, N. Nora, Herr, Megan M., Hu, Zhen-Huan, Wang, Hai-Lin, Baer, Anjani, Baro, Elande, Miao, Harry, Spooner, Clare, Xu, Hairong, and Pasquini, Marcelo C.

Published
2024
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