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The eclipses seen in the radio emission of some pulsars can be invaluable to study the properties of the material from the companion stripped away by the pulsar. We present a study of six consecutive eclipses of PSR J0024–7204O in the globular cluster 47 Tucanae as seen by the MeerKAT radio telescope in the UHF (544–1088 MHz) band. A high scintillation state boosted the signal during one of the orbits and allowed a detailed study of the eclipse properties. We measure significant dispersion measure (DM) variations and detect strong scattering that seems to be the dominating mechanism of the eclipses at these frequencies. A complete drop in the linear polarization together with a small increase in the rotation measure suggests the presence of a magnetic field of |$\sim 2$|  mG. The study of multiple eclipses allowed us to measure difference in the lengths of the eclipses and DM differences of |$\sim 0.01$|  pc cm |$^{-3}$| in consecutive orbits. One orbit, in particular, shows a delay in recovery of the linear polarization and a visible delay in the arrival of the pulses caused by a stronger scattering event. We suggest that these are caused by a higher variance of density fluctuations during the event. [ABSTRACT FROM AUTHOR]

Using MeerKAT , we have discovered three new millisecond pulsars (MSPs) in the bulge globular cluster M62: M62H, M62I, and M62J. All three are in binary systems, which means all ten known pulsars in the cluster are in binaries. M62H has a planetary-mass companion with a median mass M c, med ∼ 3 MJ and a mean density of ρ ∼ 11 g cm−3. M62I has an orbital period of 0.51 d and a M c, med ∼ 0.15 M⊙. Neither of these low-mass systems exhibit eclipses. M62J has only been detected in the two Ultra High Frequency band (816 MHz) observations with a flux density S 816 = 0.08 mJy. The non-detection in the L-band (1284 MHz) indicates it has a relatively steep spectrum (β < −3.1). We also present 23-yr-long timing solutions obtained using data from the Parkes 'Murriyang', Effelsberg , and MeerKAT telescopes for the six previously known pulsars. For all these pulsars, we measured the second spin-period derivatives and the rate of change of orbital period caused by the gravitational field of the cluster, and their proper motions. From these measurements, we conclude that the pulsars' maximum accelerations are consistent with the maximum cluster acceleration assuming a core-collapsed mass distribution. Studies of the eclipses of the redback M62B and the black widow M62E at four and two different frequency bands, respectively, reveal a frequency dependence with longer and asymmetric eclipses at lower frequencies. The presence of only binary MSPs in this cluster challenges models which suggest that the MSP population of core-collapsed clusters should be dominated by isolated MSPs. [ABSTRACT FROM AUTHOR]

We report the results of an observational campaign using the Effelsberg 100-m telescope of the pulsars J1746−2849, J1746−2850, J1746−2856, and J1745−2912 located in the central molecular zone (CMZ) close to the Galactic Centre in order to study rotation measure (RM) variations. We report for the first time the RM value of PSR J1746−2850 to be −12234 ± 181 rad m−2. This pulsar shows significant variations of RM of 300–400 rad m−2 over the course of months to years that suggest a strongly magnetized environment. The structure function analysis of the RM of PSR J1746−2850 revealed a steep power-law index of |$1.87_{-0.3}^{+0.4}$| comparable to the value expected for isotropic turbulence. This pulsar also showed large dispersion measure (DM) variation of ∼50 pc cm−3 in an event lasting a few months where the RM increased by ∼200 rad m−2. The large difference in RM between PSR J1746−2849 and PSR J1746−2850 despite the small angular separation reveals the presence of a magnetic field of at least 70 μG in the CMZ and can explain the lack of polarization in the radio images of the region. These results contribute to our understanding of the magnetic field in the CMZ and show similarities between the RM behaviours of these pulsars and some fast radio bursts. [ABSTRACT FROM AUTHOR]

The most massive globular cluster in our Galaxy, Omega Centauri, is an interesting target for pulsar searches, because of its multiple stellar populations and the intriguing possibility that it was once the nucleus of a galaxy that was absorbed into the Milky Way. The recent discoveries of pulsars in this globular cluster and their association with known X-ray sources was a hint that, given the large number of known X-ray sources, there is a much larger undiscovered pulsar population. We used the superior sensitivity of the MeerKAT radio telescope to search for pulsars in Omega Centauri. In this paper, we present some of the first results of this survey, including the discovery of 13 new pulsars; the total number of known pulsars in this cluster currently stands at 18. At least half of them are in binary systems and preliminary orbital constraints suggest that most of the binaries have light companions. We also discuss the ratio between isolated and binaries pulsars, and how they were formed in this cluster. [ABSTRACT FROM AUTHOR]

Context. PSR J1910−5959A is a binary millisecond pulsar in a 0.837 day circular orbit around a helium white dwarf (HeWD) companion. The position of this pulsar is 6.3 arcmin (∼74 core radii) away from the optical centre of the globular cluster (GC) NGC 6752. Given the large offset, the association of the pulsar with the GC has been debated. Aims. We aim to obtain precise measurements of the masses of the stars in the system along with secular orbital parameters, which will help identify if the system belongs to the GC. Methods. We have made use of archival Parkes 64 m 'Murriyang' telescope data and carried out observations with the MeerKAT telescope with different backends and receivers over the last two decades. Pulse times of arrival were obtained from these using standard pulsar data reduction techniques and analysed using state-of-the-art Bayesian pulsar timing techniques. We also performed an analysis of the pulsar's total intensity and polarisation profile to understand the interstellar scattering along the line of sight, and we determined the pulsar's geometry by fitting the rotating vector model to the polarisation data. Results. We obtain precise measurements of several post-Keplerian parameters: the range, r = 0.202(6) T⊙, and shape, s = 0.999823(4), of the Shapiro delay, from which we infer: the orbital inclination to be 88.9−0.14+0.15 deg; the masses of the pulsar and the companion to be 1.55(7) M⊙ and 0.202(6) M⊙, respectively; a secular change in the orbital period Ṗb = −53−6.0+7.4 × 10−15 s s−1 that proves the GC association; and a secular change in the projected semi-major axis of the pulsar, ẋ = −40.7−8.2+7.3 × 10−16 s s−1, likely caused by the spin–orbit interaction from a misaligned HeWD spin, at odds with the likely isolated binary evolution of the system. We also discuss some theoretical models for the structure and evolution of white dwarfs in neutron star–white dwarf binaries, using PSR J1910−5959A's companion as a test bed. Conclusions. PSR J1910−5959A is a rare system for which several parameters of both the pulsar and the HeWD companion can be accurately measured. As such, it is a test bed for discriminating between alternative models of HeWD structure and cooling. [ABSTRACT FROM AUTHOR]

We present the polarization profiles of 22 pulsars in the globular cluster 47 Tucanae using observations from the MeerKAT radio telescope at UHF band (544–1088 MHz) and report precise values of dispersion measure (DM) and rotation measure (RM). We use these measurements to investigate the presence of turbulence in electron density and magnetic fields. The structure function of DM shows a break at ∼30 arcsec (∼0.6 pc at the distance of 47 Tucanae) that suggests the presence of turbulence in the gas in the cluster driven by the motion of wind-shedding stars. On the other hand, the structure function of RM does not show evidence of a break. This non-detection could be explained either by the limited number of pulsars or by the effects of the intervening gas in the Galaxy along the line of sight. Future pulsar discoveries in the cluster could help confirm the presence and localize the turbulence. [ABSTRACT FROM AUTHOR]

We report four new pulsars discovered in the core-collapsed globular cluster (GC) NGC 6624 by the TRAPUM Large Survey Project with the MeerKAT telescope. All of the new pulsars found are isolated. PSR J1823−3021I and PSR J1823−3021K are millisecond pulsars with period of respectively 4.319 and 2.768 ms. PSR J1823−3021J is mildly recycled with a period of 20.899 ms, and PSR J1823−3022 is a long period pulsar with a period of 2.497 s. The pulsars J1823−3021I, J1823−3021J, and J1823−3021K have position and dispersion measure (DM) compatible with being members of the GC and are therefore associated with NGC 6624. Pulsar J1823−3022 is the only pulsar bright enough to be re-detected in archival observations of the cluster. This allowed the determination of a timing solution that spans over two decades. It is not possible at the moment to claim the association of pulsar J1823−3022 with the GC given the long period and large offset in position (∼3 arcmin) and DM (with a fractional difference of 11 percent compared the average of the pulsars in NGC 6624). The discoveries made use of the beamforming capability of the TRAPUM backend to generate multiple beams in the same field of view which allows sensitive searches to be performed over a few half-light radii from the cluster centre and can simultaneously localize the discoveries. The discoveries reflect the properties expected for pulsars in core-collapsed GCs. [ABSTRACT FROM AUTHOR]

Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [[[Ca.sup.2+].sub.i]. Am J Physiol Cell Physiol 283: C42-C47, 2002; 10.1152/ajpcell. 00416.2001.--A brief high-frequency burst of action potentials results in a sustained force increase in skeletal muscle. The present study investigates whether this force potentiation is the result of a sustained increase of the free myoplasmic [[Ca.sup.2+]] ([[[Ca.sup.2+]].sub.i]). Single fibers from mouse flexor brevis muscles were stimulated with three impulses at 150 Hz (triplet) at the start of a 350-ms tetanus or in the middle of a 700-ms tetanus; the stimulation frequency of the rest of the tetanus ranged from 20 to 60 Hz. After the triplet, force was significantly (P < 0.05) increased between 17 and 20% when the triplet was given at the start of the tetanus and between 5 and 18% when the triplet was given in the middle (n = 7). However, during this potentiation, [[[Ca.sup.2+]].sub.i] was not consistently increased. Hence, the increased force following a high-frequency burst is likely due to changes in the myofibrillar properties. force potentiation; excitation contraction coupling; mechanical output; skeletal muscle; [Ca.sup.2+]

We describe the ongoing Relativistic Binary programme (RelBin), a part of the MeerTime large survey project with the MeerKAT radio telescope. RelBin is primarily focused on observations of relativistic effects in binary pulsars to enable measurements of neutron star masses and tests of theories of gravity. We selected 25 pulsars as an initial high priority list of targets based on their characteristics and observational history with other telescopes. In this paper, we provide an outline of the programme, and present polarization calibrated pulse profiles for all selected pulsars as a reference catalogue along with updated dispersion measures. We report Faraday rotation measures for 24 pulsars, twelve of which have been measured for the first time. More than a third of our selected pulsars show a flat position angle swing confirming earlier observations. We demonstrate the ability of the Rotating Vector Model, fitted here to seven binary pulsars, including the Double Pulsar (PSR J0737–3039A), to obtain information about the orbital inclination angle. We present a high time resolution light curve of the eclipse of PSR J0737–3039A by the companion's magnetosphere, a high-phase-resolution position angle swing for PSR J1141–6545, an improved detection of the Shapiro delay of PSR J1811–2405, and pulse scattering measurements for PSRs J1227–6208, J1757–1854, and J1811–1736. Finally, we demonstrate that timing observations with MeerKAT improve on existing data sets by a factor of, typically, 2–3, sometimes by an order of magnitude. [ABSTRACT FROM AUTHOR]

Using the state-of-the-art SKA precursor, the MeerKAT radio telescope, we explore the limits to precision pulsar timing of millisecond pulsars achievable due to pulse stochasticity (jitter). We report new jitter measurements in 15 of the 29 pulsars in our sample and find that the levels of jitter can vary dramatically between them. For some, like the 2.2 ms pulsar PSR J2241−5236, we measure an implied jitter of just ∼4 ns h−1, while others, like the 3.9 ms PSR J0636−3044, are limited to ∼100 ns h−1. While it is well known that jitter plays a central role to limiting the precision measurements of arrival times for high signal-to-noise ratio observations, its role in the measurement of dispersion measure (DM) has not been reported, particularly in broad-band observations. Using the exceptional sensitivity of MeerKAT, we explored this on the bright millisecond pulsar PSR J0437−4715 by exploring the DM of literally every pulse. We found that the derived single-pulse DMs vary by typically 0.0085 cm−3 pc from the mean, and that the best DM estimate is limited by the differential pulse jitter across the band. We postulate that all millisecond pulsars will have their own limit on DM precision which can only be overcome with longer integrations. Using high-time resolution filterbank data of 9 μs, we also present a statistical analysis of single-pulse phenomenology. Finally, we discuss optimization strategies for the MeerKAT pulsar timing program and its role in the context of the International Pulsar Timing Array. [ABSTRACT FROM AUTHOR]

The millisecond pulsar J1823−3021A is a very active giant pulse emitter in the globular cluster NGC 6624. New observations with the MeerKAT radio telescope have revealed 14350 giant pulses over 5 h of integration time, with an average wait time of about 1 s between giant pulses. The giant pulses occur in phases compatible with the ordinary radio emission, follow a power-law distribution with an index of −2.63 ± 0.02, and contribute 4 per cent of the total integrated flux. The spectral index of the giant pulses follows a Gaussian distribution centred around −1.9 with a standard deviation of 0.6 and is on average flatter than the integrated emission, which has a spectral index of −2.81 ± 0.02. The waiting times between the GPs are accurately described by a Poissonian distribution, suggesting that the time of occurrence of a GP is independent from the times of occurrence of other GPs. 76 GPs show multiple peaks within the same rotation, a rate that is also compatible with the mutual independence of the GP times of occurrence. We studied the polarization properties of the giant pulses finding, on average, linear polarization only at the 1 per cent level and circular polarization at the 3 per cent level, similar to the polarization percentages of the total integrated emission. In four cases, it was possible to measure the RM of the GPs that are highly variable and, in two cases, is inconsistent with the mean RM of the total integrated pulsar signal. [ABSTRACT FROM AUTHOR]

We report here on initial results from the Thousand-Pulsar-Array (TPA) programme, part of the Large Survey Project 'MeerTime' on the MeerKAT telescope. The interferometer is used in the tied-array mode in the band from 856 to 1712 MHz, and the wide band coupled with the large collecting area and low receiver temperature make it an excellent telescope for the study of radio pulsars. The TPA is a 5 year project, which aims at to observing (a) more than 1000 pulsars to obtain high-fidelity pulse profiles, (b) some 500 of these pulsars over multiple epochs, and (c) long sequences of single-pulse trains from several hundred pulsars. The scientific outcomes from the programme will include the determination of pulsar geometries, the location of the radio emission within the pulsar magnetosphere, the connection between the magnetosphere and the crust and core of the star, tighter constraints on the nature of the radio emission itself, as well as interstellar medium studies. First, results presented here include updated dispersion measures, 26 pulsars with Faraday rotation measures derived for the first time, and a description of interesting emission phenomena observed thus far. [ABSTRACT FROM AUTHOR]

Despite considerations of mass-loss from stellar evolution suggesting otherwise, the content of gas in globular clusters seems poor and hence its measurement very elusive. One way of constraining the presence of ionized gas in a globular cluster is through its dispersive effects on the radiation of the millisecond pulsars included in the cluster. This effect led Freire et al. to the first detection of any kind of gas in a globular cluster in the case of 47 Tucanae. By exploiting the results of 12 additional years of timing, as well as the observation of new millisecond pulsars in 47 Tucanae, we revisited this measurement: we first used the entire set of available timing parameters in order to measure the dynamical properties of the cluster and the three-dimensional position of the pulsars. Then we applied and tested various gas distribution models: assuming a constant gas density, we confirmed the detection of ionized gas with a number density of n  = 0.23 ± 0.05 cm−3, larger than the previous determination (at 2σ uncertainty). Models predicting a decreasing density or following the stellar distribution density are highly disfavoured. We are also able to investigate the presence of an intermediate mass black hole in the centre of the cluster, showing that is not required by the available data, with an upper limit for the mass at ∼4000 M⊙. [ABSTRACT FROM AUTHOR]

Summary: The mechanosensory lateral line system of fish is responsible for several functions such as balance, hearing, and orientation in water flow and is formed by neuromast receptor organs distributed on head, trunk and tail. Superficial and canal neuromasts can be distinguished for localization and morphological differences. Several information is present regarding the superficial neuromasts of zebrafish and other teleosts especially during larval and juvenile stages, while not as numerous data are so far available about the ultrastructural characteristics of the canal neuromasts in adult zebrafish. Therefore, the aim of this study was to investigate by transmission electron microscopy the ultrastructural aspects of cells present in the canal neuromasts. Besides the typical cellular aspects of the neuromast, different cellular types of hair cells were observed that could be identified as developing hair cells during the physiological turnover. The knowledge of the observed cellular types of the canal neuromasts and their origin could give a contribution to studies carried out on adult zebrafish used as model in neurological and non‐neurological damages, such as deafness and vestibular disorders. [ABSTRACT FROM AUTHOR]

The origin of the nuclear star cluster in the centre of our Galaxy is still unknown.One possibility is that it formed after the disruption of stellar clusters that spiralled into the Galactic Centre due to dynamical friction.We trace the formation of the nuclear star cluster around the central black hole, using state-of-the-art N-body simulations, and follow the dynamics of the neutron stars born in the clusters.We then estimate the number of millisecond pulsars (MSPs) that are released in the nuclear star cluster during its formation. The assembly and tidal dismemberment of globular clusters lead to a population ofMSPs distributed over a radius of about 20 pc, with a peak near 3 pc. No clustering is found on the subparsec scale. We simulate the detectability of this population with future radio telescopes like the MeerKAT radio telescope and SKA1, and find that about an order of 10 MSPs can be observed over this large volume, with a paucity of MSPs within the central parsec. This helps discriminating this scenario from the in situ formation model for the nuclear star cluster that would predict an overabundance of MSPs closer to the black hole. We then discuss the potential contribution of our MSP population to the gamma-ray excess at the Galactic Centre. [ABSTRACT FROM AUTHOR]

The linearly polarized component of a pulsar signal at different radio frequencies can help to constrain the parallel component of the magnetic field along the line of sight. In this work we measured the polarimetric properties of the pulsars in the globular cluster 47 Tucanae and we report the Rotation Measure (RM) for 13 of them. A gradient in the RM values of the pulsars across the cluster is detected suggesting the presence of significant variations in the magnetic field across the very small angular scales associated with the lines of sight to the pulsars in 47 Tucanae. Both magnetic fields located in the globular cluster or in the Galactic disk in the direction of the cluster are taken into consideration. However, more detailed modelling of the dynamics of the cluster and deeper observations with the MeerKAT and/or the SKA1 radio telescopes are necessary to discriminate among the models. [ABSTRACT FROM AUTHOR]

The oral cavity of vertebrates has a very important role in many functions strictly related to the food processing. Two species, sea bass Dicentrarchus labrax and seabream Sparus aurata, are mainly involved in the aquaculture industry in the mediterranean area; moreover, the white seabream Diplodus sargus sargus was recently chosen as the best candidate for the diversification of species of commercial interest. This investigation was carried out, using the standard procedures for light and scanning electron microscopy, to analyse the morphology of the tongue dorsal surface in order to show whether relationships are present between the tongue morphology and the nutritional choices of these species. In all the three investigated species, three different areas were observed on the dorsal lingual surface: an apex, a body and a root. In the sea bass D. labrax, numerous caninelike teeth, organized in pads, were present along the dorsal surface. The presence of numerous taste buds, scattered on the tongue, was shown. In the seabream S. aurata, the apical part of the tongue is inserted in a pouch with a characteristic medial ridge on the body surface. Numerous taste buds were scattered on the whole surface. In the white seabream D. sargus sargus, a pouch partially covering the apex was clearly observed. In the pouch, filiform-like and foliate-like papillae can be distinguished. The results show the important role of the fish tongue in the food ingestion process, demonstrating the interaction of food processing, taste and morphological characteristics. [ABSTRACT FROM AUTHOR]

Contents Orexin A and B, also known as hypocretin A and B, are hypothalamic neuropeptides arising from a precursor to the 130 amino acid, called pre-pro orexin. They are synthesized mainly in lateral and posterior hypothalamus and are involved in different functions such as regulation of food intake and energy balance. Orexins and orexin receptors were previously described also in different tissues and organs outside the brain. The aim of this study was to demonstrate by means of the immunofluorescence technique, the presence of orexin A in the ovary of cat and dog, to support the hypothesis of the role of this substance also at the level of the female genital system. The presence of orexin A in the ovary either in dog or in cat is in agreement with previous data on the presence and role of orexins in the female genital system of other species. [ABSTRACT FROM AUTHOR]