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1. A machine learning-based methodology for pulse classification in dual-phase xenon time projection chambers

Author

P. Brás, F. Neves, A. Lindote, A. Cottle, R. Cabrita, E. Lopez Asamar, G. Pereira, C. Silva, V. Solovov, and M. I. Lopes

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract Machine learning techniques are now well established in experimental particle physics, allowing detector data to be analyzed in new and unique ways. The identification of signals in particle observatories is an essential data processing task that can potentially be improved using such methods. This paper aims at exploring the benefits that a dedicated machine learning approach might provide to the classification of signals in dual-phase noble gas time projection chambers. A full methodology is presented, from exploratory data analysis using Gaussian mixture models and feature importance ranking to the construction of dedicated predictive models based on standard implementations of neural networks and random forests, validated using unlabeled simulated data from the LZ experiment as a proxy to real data. The global classification accuracy of the predictive models developed in this work is estimated to be >99.0%, which is an improvement over conventional algorithms tested with similar data. The results from the clustering analysis were also used to identify anomalies in the data caused by miscalculated signal properties, showing that this methodology can also be used for data monitoring.

Published
2022
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2. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author

D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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3. The data acquisition system of the LZ dark matter detector: FADR

Author

Aalbers, J, Akerib, DS, Al Musalhi, AK, Alder, F, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Baker, A, Balashov, S, Bang, J, Barillier, EE, Bargemann, JW, Beattie, K, Benson, T, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Bishop, E, Blockinger, GM, Boxer, B, Brew, CAJ, Brás, P, Buckley, JH, Burdin, S, Buuck, M, Carmona-Benitez, MC, Carter, M, Chawla, A, Chen, H, Cherwinka, JJ, Chin, YT, Chott, NI, Converse, MV, Cottle, A, Cox, G, Curran, D, Dahl, CE, David, A, Delgaudio, J, Dey, S, de Viveiros, L, Di Felice, L, Dimino, T, Ding, C, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fearon, NM, Fieldhouse, N, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, TMA, Gaitskell, RJ, Geffre, A, Gelfand, R, Genovesi, J, Ghag, C, Gibbons, R, Gokhale, S, Green, J, van der Grinten, MGD, Haiston, JJ, Hall, CR, Han, S, Hartigan-O’Connor, E, Haselschwardt, SJ, Hernandez, MA, Hertel, SA, Heuermann, G, Homenides, GJ, Horn, M, Huang, DQ, Hunt, D, Jacquet, E, James, RS, Johnson, J, Kaboth, AC, Kamaha, AC, Kannichankandy, M, Khaitan, D, Khazov, A, Khurana, I, Kim, J, Kim, YD, Kingston, J, Kirk, R, Kodroff, D, Korley, L, Korolkova, EV, Koyuncu, M, Kraus, H, Kravitz, S, and Kreczko, L

Subjects
Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Networking and Information Technology R&D (NITRD), Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Other Physical Sciences, Nuclear & Particles Physics, Nuclear and plasma physics
Abstract

The Data Acquisition System (DAQ) for the LUX-ZEPLIN (LZ) dark matter detector is described. The signals from 745 PMTs, distributed across three subsystems, are sampled with 100-MHz 32-channel digitizers (DDC-32s). A basic waveform analysis is carried out on the on-board Field Programmable Gate Arrays (FPGAs) to extract information about the observed scintillation and electroluminescence signals. This information is used to determine if the digitized waveforms should be preserved for offline analysis. The system is designed around the Kintex-7 FPGA. In addition to digitizing the PMT signals and providing basic event selection in real time, the flexibility provided by the use of FPGAs allows us to monitor the performance of the detector and the DAQ in parallel to normal data acquisition. The hardware and software/firmware of this FPGA-based Architecture for Data acquisition and Realtime monitoring (FADR) are discussed and performance measurements are described.

Published
2024

4. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author

D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $${1.4 \times 10^{-48}}\, {\hbox {cm}}^{2}$$ 1.4 × 10 - 48 cm 2 for a WIMP mass of $${40}\, \hbox {GeV}/{\hbox {c}}^{2}$$ 40 GeV / c 2 and a $${1000}\, \hbox {days}$$ 1000 days exposure. LZ achieves this sensitivity through a combination of a large $${5.6}\, \hbox {t}$$ 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented.

Published
2020
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5. The design, implementation, and performance of the LZ calibration systems

Author

Aalbers, J, Akerib, DS, Al Musalhi, AK, Alder, F, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Baker, A, Balashov, S, Bang, J, Barillier, EE, Bargemann, JW, Beattie, K, Benson, T, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Bishop, E, Blockinger, GM, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Buuck, M, Carmona-Benitez, MC, Carter, M, Chawla, A, Chen, H, Cherwinka, JJ, Chin, YT, Chott, NI, Converse, MV, Cottle, A, Cox, G, Curran, D, Dahl, CE, David, A, Delgaudio, J, Dey, S, de Viveiros, L, Di Felice, L, Ding, C, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fearon, NM, Fieldhouse, N, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, TMA, Gaitskell, RJ, Geffre, A, Genovesi, J, Ghag, C, Gibbons, R, Gokhale, S, Green, J, van der Grinten, MGD, Haiston, JJ, Hall, CR, Han, S, Hartigan-O'Connor, E, Haselschwardt, SJ, Hernandez, MA, Hertel, SA, Heuermann, G, Homenides, GJ, Horn, M, Huang, DQ, Hunt, D, Jacquet, E, James, RS, Johnson, J, Kaboth, AC, Kamaha, AC, Kannichankandy, M, Khaitan, D, Khazov, A, Khurana, I, Kim, J, Kim, YD, Kingston, J, Kirk, R, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Kudryavtsev, VA, Leonard, DS, Lesko, KT, and Levy, C

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract

LUX-ZEPLIN (LZ) is a tonne-scale experiment searching for direct dark matter interactions and other rare events. It is located at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. The core of the LZ detector is a dual-phase xenon time projection chamber (TPC), designed with the primary goal of detecting Weakly Interacting Massive Particles (WIMPs) via their induced low energy nuclear recoils. Surrounding the TPC, two veto detectors immersed in an ultra-pure water tank enable reducing background events to enhance the discovery potential. Intricate calibration systems are purposely designed to precisely understand the responses of these three detector volumes to various types of particle interactions and to demonstrate LZ’s ability to discriminate between signals and backgrounds. In this paper, we present a comprehensive discussion of the key features, requirements, and performance of the LZ calibration systems, which play a crucial role in enabling LZ’s WIMP-search and its broad science program. The thorough description of these calibration systems, with an emphasis on their novel aspects, is valuable for future calibration efforts in direct dark matter and other rare-event search experiments.

Published
2024

6. New constraints on ultraheavy dark matter from the LZ experiment

Author

Aalbers, J, Akerib, DS, Al Musalhi, AK, Alder, F, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Baker, A, Balashov, S, Bang, J, Barillier, EE, Bargemann, JW, Baxter, A, Beattie, K, Benson, T, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Bishop, EJ, Blockinger, GM, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Buuck, M, Carmona-Benitez, MC, Carter, M, Chawla, A, Chen, H, Cherwinka, JJ, Chin, YT, Chott, NI, Converse, MV, Cottle, A, Cox, G, Curran, D, Dahl, CE, David, A, Delgaudio, J, Dey, S, de Viveiros, L, Di Felice, L, Ding, C, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fearon, NM, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, TMA, Gaitskell, RJ, Geffre, A, Genovesi, J, Ghag, C, Gibbons, R, Gokhale, S, Green, J, van der Grinten, MGD, Haiston, JH, Hall, CR, Han, S, Hartigan-O’Connor, E, Haselschwardt, SJ, Hernandez, MA, Hertel, SA, Heuermann, G, Homenides, GJ, Horn, M, Huang, DQ, Hunt, D, Ignarra, CM, Jacquet, E, James, RS, Johnson, J, Kaboth, AC, Kamaha, AC, Kannichankandy, M, Khaitan, D, Khazov, A, Khurana, I, Kim, J, Kingston, J, Kirk, R, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Krikler, B, Kudryavtsev, VA, Lee, J, and Leonard, DS

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences
Abstract

Searches for dark matter with liquid xenon time projection chamber experiments have traditionally focused on the region of the parameter space that is characteristic of weakly interacting massive particles, ranging from a few GeV/c2 to a few TeV/c2. Models of dark matter with a mass much heavier than this are well motivated by early production mechanisms different from the standard thermal freeze-out, but they have generally been less explored experimentally. In this work, we present a reanalysis of the first science run of the LZ experiment, with an exposure of 0.9 tonne×yr, to search for ultraheavy particle dark matter. The signal topology consists of multiple energy deposits in the active region of the detector forming a straight line, from which the velocity of the incoming particle can be reconstructed on an event-by-event basis. Zero events with this topology were observed after applying the data selection calibrated on a simulated sample of signal-like events. New experimental constraints are derived, which rule out previously unexplored regions of the dark matter parameter space of spin-independent interactions beyond a mass of 1017 GeV/c2.

Published
2024

9. First constraints on WIMP-nucleon effective field theory couplings in an extended energy region from LUX-ZEPLIN

Author

Aalbers, J, Akerib, DS, Al Musalhi, AK, Alder, F, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Baker, A, Balashov, S, Bang, J, Bargemann, JW, Baxter, A, Beattie, K, Benson, T, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Bishop, E, Blockinger, GM, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Buuck, M, Carmona-Benitez, MC, Carter, M, Chawla, A, Chen, H, Cherwinka, JJ, Chott, NI, Converse, MV, Cottle, A, Cox, G, Curran, D, Dahl, CE, David, A, Delgaudio, J, Dey, S, de Viveiros, L, Ding, C, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fearon, NM, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, TMA, Gaitskell, RJ, Geffre, A, Genovesi, J, Ghag, C, Gibbons, R, Gokhale, S, Green, J, van der Grinten, MGD, Hall, CR, Han, S, Hartigan-O’Connor, E, Haselschwardt, SJ, Hernandez, MA, Hertel, SA, Heuermann, G, Homenides, GJ, Horn, M, Huang, DQ, Hunt, D, Ignarra, CM, Jacquet, E, James, RS, Johnson, J, Kaboth, AC, Kamaha, AC, Khaitan, D, Khazov, A, Khurana, I, Kim, J, Kingston, J, Kirk, R, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Krikler, B, Kudryavtsev, VA, Lee, J, Leonard, DS, Lesko, KT, Levy, C, Lin, J, Lindote, A, and Linehan, R

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Affordable and Clean Energy
Abstract

Following the first science results of the LUX-ZEPLIN (LZ) experiment, a dual-phase xenon time projection chamber operating from the Sanford Underground Research Facility in Lead, South Dakota, USA, we report the initial limits on a model-independent nonrelativistic effective field theory describing the complete set of possible interactions of a weakly interacting massive particle (WIMP) with a nucleon. These results utilize the same 5.5 t fiducial mass and 60 live days of exposure collected for the LZ spin-independent and spin-dependent analyses while extending the upper limit of the energy region of interest by a factor of 7.5 to 270 keV. No significant excess in this high energy region is observed. Using a profile-likelihood ratio analysis, we report 90% confidence level exclusion limits on the coupling of each individual nonrelativistic WIMP-nucleon operator for both elastic and inelastic interactions in the isoscalar and isovector bases.

Published
2024

11. Single-neutron adding on 34S

Author

Kuchera, A. N., Hoffman, C. R., Ryan, G., D’Amato, I. B., Guarinello, O. M., Kielb, P. S., Aggarwal, R., Ajayi, S., Conley, A. L., Conroy, I., Cottle, P. D., Esparza, J. C., Genty, S., Hanselman, K., Heinze, M., Houlihan, D., Kelly, B., Khawaja, M. I., Lopez-Saavedra, E., McCann, G. W., Morelock, A. B., Riley, L. A., Sandrik, A., Sitaraman, V., Spieker, M., Temanson, E., Wibisono, C., and Wiedenhöver, I.

Published
2024
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12. Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain

Author

Benjamin Guy Trist, Courtney Jade Wright, Alejandra Rangel, Louise Cottle, Asheeta Prasad, Nanna Møller Jensen, Hjalte Gram, Nicolas Dzamko, Poul Henning Jensen, and Deniz Kirik

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Assays for quantifying aggregated and phosphorylated (S129) human α-synuclein protein are widely used to evaluate pathological burden in patients suffering from synucleinopathy disorders. Many of these assays, however, do not cross-react with mouse α-synuclein or exhibit poor sensitivity for this target, which is problematic considering the preponderance of mouse models at the forefront of pre-clinical α-synuclein research. In this project, we addressed this unmet need by reformulating two existing AlphaLISA® SureFire® Ultra™ total and pS129 α-synuclein assay kits to yield robust and ultrasensitive (LLoQ ≤ 0.5 pg/mL) quantification of mouse and human wild-type and pS129 α-synuclein protein. We then employed these assays, together with the BioLegend α-synuclein aggregate ELISA, to assess α-synuclein S129 phosphorylation and aggregation in different mouse brain tissue preparations. Overall, we highlight the compatibility of these new immunoassays with rodent models and demonstrate their potential to advance knowledge surrounding α-synuclein phosphorylation and aggregation in synucleinopathies.

Published
2024
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13. Integrating mental health and psychosocial support into economic inclusion programming for displaced families in Ecuador

Author

Arianna Moyano, Daniela Vergara, Amaleah Mirti, Annie G. Bonz, Adriana Monar, Efrén Astudillo, Sara Vaca, Karen Cordova, Andrea Armijos, Adrian Barroso, Cesar Cherrez, Jennie Cottle, Aimée DuBois, Isabella Fernandez Capriles, Jean Pierre Grandes, Matias Irarrazaval, Belen Jaramillo, Jeremy C. Kane, Carmen Martinez-Viciana, Franco Mascayano, Yescárleth Rodríguez, Matthew Schojan, Kathleen Sikkema, Ezra Susser, Peter Ventevogel, Mike Wessells, Aaron Zambrano López, Kathryn L. Lovero, and M. Claire Greene

Subjects
Mental health and psychosocial support, Poverty alleviation, Economic inclusion, Forcibly displaced persons, Special situations and conditions, RC952-1245, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Poverty is a key social determinant of mental health among forcibly displaced persons. This study aimed to design and pilot test a strategy to integrate existing mental health and economic inclusion interventions for displaced families in Ecuador. Methods We conducted a series of qualitative interviews (n = 30), focus groups (n = 6), and workshops (n = 3) to develop a set of strategies for integrating cross-cutting and focused mental health and psychosocial support (MHPSS) strategies into an existing economic inclusion program for displaced families in Quito. We non-randomly assigned two field offices in Quito to (1) integrate cross-cutting strategies focused on improving economic outcomes or (2) integrate both those cross-cutting strategies plus focused MHPSS strategies into an economic inclusion program. We measured site-level implementation outcomes (adoption, appropriateness, acceptability, feasibility, fidelity, reach, retention, usability) and participant-level psychosocial (wellbeing, depressive symptoms, anxiety symptoms, functioning) and economic inclusion outcomes (financial resources, diet diversity, social capital/networks, self-reliance) over six months. We conducted a mixed-methods analysis to explore the acceptability and feasibility of the integration strategies and the ability to evaluate their effects in a future cluster randomized trial. Results We developed a toolkit that included 10 strategies for integrating MHPSS into economic inclusion interventions. Fifty displaced persons participating in an existing economic inclusion program (25 per study condition) were enrolled and 88% remained in the study through the six-month follow-up. Participants and implementers reported that the integration strategy was appropriate, acceptable, feasible, and usable. Implementers, including people without prior experience in delivering mental health services, were able to deliver the intervention with high fidelity. Integration of focused MHPSS intervention components into an economic inclusion program appeared to improve MHPSS outcomes, the strength of social capital and networks, and engagement in economic and other programs. Conclusions This study provides preliminary evidence of the acceptability and feasibility of integrating MHPSS into economic inclusion programs for displaced people. We found evidence supporting evaluation methods that can be employed in a future study to definitively test the added value of integrated approaches to mental health and economic wellbeing for displaced persons.

Published
2024
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14. Search for new physics in low-energy electron recoils from the first LZ exposure

Author

Aalbers, J, Akerib, DS, Al Musalhi, AK, Alder, F, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Baker, A, Balashov, S, Bang, J, Bargemann, JW, Baxter, A, Beattie, K, Beltrame, P, Benson, T, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Blockinger, GM, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Buuck, M, Carmona-Benitez, MC, Chan, C, Chawla, A, Chen, H, Cherwinka, JJ, Chott, NI, Converse, MV, Cottle, A, Cox, G, Curran, D, Dahl, CE, David, A, Delgaudio, J, Dey, S, de Viveiros, L, Ding, C, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fearon, NM, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, TMA, Gaitskell, RJ, Geffre, A, Genovesi, J, Ghag, C, Gibbons, R, Gokhale, S, Green, J, van der Grinten, MGD, Hall, CR, Han, S, Hartigan-O’Connor, E, Haselschwardt, SJ, Huang, DQ, Hertel, SA, Heuermann, G, Horn, M, Hunt, D, Ignarra, CM, Jahangir, O, James, RS, Johnson, J, Kaboth, AC, Kamaha, AC, Khaitan, D, Khazov, A, Khurana, I, Kim, J, Kingston, J, Kirk, R, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Krikler, B, Kudryavtsev, VA, Leason, EA, Lee, J, Leonard, DS, Lesko, KT, Levy, C, Lin, J, Lindote, A, Linehan, R, and Lippincott, WH

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences
Abstract

The LUX-ZEPLIN (LZ) experiment is a dark matter detector centered on a dual-phase xenon time projection chamber. We report searches for new physics appearing through few-keV-scale electron recoils, using the experiment's first exposure of 60 live days and a fiducial mass of 5.5 t. The data are found to be consistent with a background-only hypothesis, and limits are set on models for new physics including solar axion electron coupling, solar neutrino magnetic moment and millicharge, and electron couplings to galactic axionlike particles and hidden photons. Similar limits are set on weakly interacting massive particle (WIMP) dark matter producing signals through ionized atomic states from the Migdal effect.

Published
2023

15. Integrating mental health and psychosocial support into economic inclusion programming for displaced families in Ecuador

Author

Moyano, Arianna, Vergara, Daniela, Mirti, Amaleah, Bonz, Annie G., Monar, Adriana, Astudillo, Efrén, Vaca, Sara, Cordova, Karen, Armijos, Andrea, Barroso, Adrian, Cherrez, Cesar, Cottle, Jennie, DuBois, Aimée, Capriles, Isabella Fernandez, Grandes, Jean Pierre, Irarrazaval, Matias, Jaramillo, Belen, Kane, Jeremy C., Martinez-Viciana, Carmen, Mascayano, Franco, Rodríguez, Yescárleth, Schojan, Matthew, Sikkema, Kathleen, Susser, Ezra, Ventevogel, Peter, Wessells, Mike, Zambrano López, Aaron, Lovero, Kathryn L., and Greene, M. Claire

Published
2024
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20. First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment

Author

Aalbers, J, Akerib, DS, Akerlof, CW, Al Musalhi, AK, Alder, F, Alqahtani, A, Alsum, SK, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Azadi, S, Bailey, AJ, Baker, A, Balajthy, J, Balashov, S, Bang, J, Bargemann, JW, Barry, MJ, Barthel, J, Bauer, D, Baxter, A, Beattie, K, Belle, J, Beltrame, P, Bensinger, J, Benson, T, Bernard, EP, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Birrittella, B, Blockinger, GM, Boast, KE, Boxer, B, Bramante, R, Brew, CAJ, Brás, P, Buckley, JH, Bugaev, VV, Burdin, S, Busenitz, JK, Buuck, M, Cabrita, R, Carels, C, Carlsmith, DL, Carlson, B, Carmona-Benitez, MC, Cascella, M, Chan, C, Chawla, A, Chen, H, Cherwinka, JJ, Chott, NI, Cole, A, Coleman, J, Converse, MV, Cottle, A, Cox, G, Craddock, WW, Creaner, O, Curran, D, Currie, A, Cutter, JE, Dahl, CE, David, A, Davis, J, Davison, TJR, Delgaudio, J, Dey, S, de Viveiros, L, Dobi, A, Dobson, JEY, Druszkiewicz, E, Dushkin, A, Edberg, TK, Edwards, WR, Elnimr, MM, Emmet, WT, Eriksen, SR, Faham, CH, Fan, A, Fayer, S, Fearon, NM, Fiorucci, S, Flaecher, H, Ford, P, Francis, VB, Fraser, ED, Fruth, T, Gaitskell, RJ, Gantos, NJ, Garcia, D, Geffre, A, Gehman, VM, and Genovesi, J

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, LUX-ZEPLIN Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract

The LUX-ZEPLIN experiment is a dark matter detector centered on a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility in Lead, South Dakota, USA. This Letter reports results from LUX-ZEPLIN's first search for weakly interacting massive particles (WIMPs) with an exposure of 60 live days using a fiducial mass of 5.5 t. A profile-likelihood ratio analysis shows the data to be consistent with a background-only hypothesis, setting new limits on spin-independent WIMP-nucleon, spin-dependent WIMP-neutron, and spin-dependent WIMP-proton cross sections for WIMP masses above 9  GeV/c^{2}. The most stringent limit is set for spin-independent scattering at 36  GeV/c^{2}, rejecting cross sections above 9.2×10^{-48}  cm at the 90% confidence level.

Published
2023

21. Background determination for the LUX-ZEPLIN dark matter experiment

Author

Aalbers, J, Akerib, DS, Al Musalhi, AK, Alder, F, Alsum, SK, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Baker, A, Bang, J, Bargemann, JW, Baxter, A, Beattie, K, Beltrame, P, Bernard, EP, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Blockinger, GM, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Buuck, M, Cabrita, R, Carmona-Benitez, MC, Chan, C, Chawla, A, Chen, H, Chiang, APS, Chott, NI, Converse, MV, Cottle, A, Cox, G, Creaner, O, Dahl, CE, David, A, Dey, S, de Viveiros, L, Ding, C, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fearon, NM, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, T, Gaitskell, RJ, Genovesi, J, Ghag, C, Gibbons, R, Gilchriese, MGD, Gokhale, S, Green, J, van der Grinten, MGD, Gwilliam, CB, Hall, CR, Han, S, Hartigan-O’Connor, E, Haselschwardt, SJ, Hertel, SA, Heuermann, G, Horn, M, Huang, DQ, Hunt, D, Ignarra, CM, Jacobsen, RG, Jahangir, O, James, RS, Johnson, J, Kaboth, AC, Kamaha, AC, Khaitan, D, Khurana, I, Kirk, R, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Krikler, B, Kudryavtsev, VA, Leason, EA, Lee, J, Leonard, DS, Lesko, KT, Levy, C, Lin, J, Lindote, A, Linehan, R, Lippincott, WH, and Liu, X

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences
Abstract

The LUX-ZEPLIN experiment recently reported limits on WIMP-nucleus interactions from its initial science run, down to 9.2×10-48 cm2 for the spin-independent interaction of a 36 GeV/c2 WIMP at 90% confidence level. In this paper, we present a comprehensive analysis of the backgrounds important for this result and for other upcoming physics analyses, including neutrinoless double-beta decay searches and effective field theory interpretations of LUX-ZEPLIN data. We confirm that the in-situ determinations of bulk and fixed radioactive backgrounds are consistent with expectations from the ex-situ assays. The observed background rate after WIMP search criteria were applied was (6.3±0.5)×10-5 events/keVee/kg/day in the low-energy region, approximately 60 times lower than the equivalent rate reported by the LUX experiment.

Published
2023

23. The data acquisition system of the LZ dark matter detector: FADR

Author

Aalbers, J., Akerib, D.S., Al Musalhi, A.K., Alder, F., Amarasinghe, C.S., Ames, A., Anderson, T.J., Angelides, N., Araújo, H.M., Armstrong, J.E., Arthurs, M., Baker, A., Balashov, S., Bang, J., Barillier, E.E., Bargemann, J.W., Beattie, K., Benson, T., Bhatti, A., Biekert, A., Biesiadzinski, T.P., Birch, H.J., Bishop, E., Blockinger, G.M., Boxer, B., Brew, C.A.J., Brás, P., Buckley, J.H., Burdin, S., Buuck, M., Carmona-Benitez, M.C., Carter, M., Chawla, A., Chen, H., Cherwinka, J.J., Chin, Y.T., Chott, N.I., Converse, M.V., Cottle, A., Cox, G., Curran, D., Dahl, C.E., David, A., Delgaudio, J., Dey, S., de Viveiros, L., Di Felice, L., Dimino, T., Ding, C., Dobson, J.E.Y., Druszkiewicz, E., Eriksen, S.R., Fan, A., Fearon, N.M., Fieldhouse, N., Fiorucci, S., Flaecher, H., Fraser, E.D., Fruth, T.M.A., Gaitskell, R.J., Geffre, A., Gelfand, R., Genovesi, J., Ghag, C., Gibbons, R., Gokhale, S., Green, J., van der Grinten, M.G.D., Haiston, J.J., Hall, C.R., Han, S., Hartigan-O’Connor, E., Haselschwardt, S.J., Hernandez, M.A., Hertel, S.A., Heuermann, G., Homenides, G.J., Horn, M., Huang, D.Q., Hunt, D., Jacquet, E., James, R.S., Johnson, J., Kaboth, A.C., Kamaha, A.C., Kannichankandy, M., Khaitan, D., Khazov, A., Khurana, I., Kim, J., Kim, Y.D., Kingston, J., Kirk, R., Kodroff, D., Korley, L., Korolkova, E.V., Koyuncu, M., Kraus, H., Kravitz, S., Kreczko, L., Kudryavtsev, V.A., Leonard, D.S., Lesko, K.T., Levy, C., Lin, J., Lindote, A., Linehan, R., Lippincott, W.H., Loniewski, C., Lopes, M.I., Lorenzon, W., Lu, C., Luitz, S., Majewski, P.A., Manalaysay, A., Mannino, R.L., Maupin, C., McCarthy, M.E., McDowell, G., McKinsey, D.N., McLaughlin, J., Mclaughlin, J.B., McMonigle, R., Miller, E.H., Mizrachi, E., Monte, A., Monzani, M.E., Moongweluwan, M., Mendoza, J.D. Morales, Morrison, E., Mount, B.J., Murdy, M., Murphy, A.St.J., Naylor, A., Nelson, H.N., Neves, F., Nguyen, A., Nikoleyczik, J.A., Oh, H., Olcina, I., Olevitch, M.A., Oliver-Mallory, K.C., Orpwood, J., Palladino, K.J., Palmer, J., Pannifer, N.J., Parveen, N., Patton, S.J., Penning, B., Pereira, G., Perry, E., Pershing, T., Piepke, A., Qie, Y., Reichenbacher, J., Rhyne, C.A., Riffard, Q., Rischbieter, G.R.C., Riyat, H.S., Rosero, R., Rushton, T., Rynders, D., Santone, D., Sarkis, R., Sazzad, A.B.M.R., Schnee, R.W., Shaw, S., Shutt, T., Silk, J.J., Silva, C., Sinev, G., Siniscalco, J., Skulski, W., Smith, R., Solovov, V.N., Sorensen, P., Soria, J., Stancu, I., Stevens, A., Stifter, K., Suerfu, B., Sumner, T.J., Szydagis, M., Taylor, W.C., Tiedt, D.R., Timalsina, M., Tong, Z., Tovey, D.R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D.R., Vacheret, A., Vaitkus, A.C., Vaitkus, J., Valentino, O., Velan, V., Wang, A., Wang, J.J., Wang, Y., Watson, J.R., Webb, R.C., Weeldreyer, L., Whitis, T.J., Williams, M., Wisniewski, W.J., Wolfs, F.L.H., Wolfs, J.D., Woodford, S., Woodward, D., Wright, C.J., Xia, Q., Xiang, X., Xu, J., Yeh, M., and Yin, J.

Published
2024
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27. Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice

Author

Ming Shen Tham, Denny L. Cottle, Allara K. Zylberberg, Kieran M. Short, Lynelle K. Jones, Perkin Chan, Sarah E. Conduit, Jennifer M. Dyson, Christina A. Mitchell, and Ian M. Smyth

Subjects
Science
Abstract

Abstract Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA’s role in regulating renal cyst development we conditionally deleted the gene in mouse models of Autosomal Dominant PKD (ADPKD) and Joubert Syndrome, caused by Polycystin 1 (Pkd1) and Inositol polyphosphate-5-phosphatase E (Inpp5e) mutations respectively. We show that while Aurka is dispensable for collecting duct development and homeostasis, its deletion prevents cyst formation in both disease models. Cross-comparison of transcriptional changes implicated AKT signaling in cyst prevention and we show that (i) AURKA and AKT physically interact, (ii) AURKA regulates AKT activity in a kinase-independent manner and (iii) inhibition of AKT can reduce disease severity. AKT activation also regulates Aurka expression, creating a feed-forward loop driving renal cystogenesis. We find that the AURKA kinase inhibitor Alisertib stabilises the AURKA protein, agonizing its cystogenic functions. These studies identify AURKA as a master regulator of renal cyst development in different types of PKD, functioning in-part via AKT.

Published
2024
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29. Heat stress vulnerability and critical environmental limits for older adults

Author

S. Tony Wolf, Rachel M. Cottle, Kat G. Fisher, Daniel J. Vecellio, and W. Larry Kenney

Subjects
Geology, QE1-996.5, Environmental sciences, GE1-350
Abstract

Abstract The present study examined heat stress vulnerability of apparently healthy older vs. young adults and characterized critical environmental limits for older adults in an indoor setting at rest (Rest) and during minimal activity associated with activities of daily living. Critical environmental limits are combinations of ambient temperature and humidity above which heat balance cannot be maintained (i.e., becomes uncompensable) for a given metabolic heat production. Here we exposed fifty-one young (23 ± 4 yrs) and 49 older (71 ± 6 yrs) adults to progressive heat stress across a wide range of environments in an environmental chamber during Minimal Activity (young and older subjects) and Rest (older adults only). Heat compensability curves were shifted leftward for older adults indicating age-dependent heat vulnerablity (p

Published
2023
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31. The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening

Author

Patrick, Ralph, Naval-Sanchez, Marina, Deshpande, Nikita, Huang, Yifei, Zhang, Jingyu, Chen, Xiaoli, Yang, Ying, Tiwari, Kanupriya, Esmaeili, Mohammadhossein, Tran, Minh, Mohamed, Amin R., Wang, Binxu, Xia, Di, Ma, Jun, Bayliss, Jacqueline, Wong, Kahlia, Hun, Michael L., Sun, Xuan, Cao, Benjamin, Cottle, Denny L., Catterall, Tara, Barzilai-Tutsch, Hila, Troskie, Robin-Lee, Chen, Zhian, Wise, Andrea F., Saini, Sheetal, Soe, Ye Mon, Kumari, Snehlata, Sweet, Matthew J., Thomas, Helen E., Smyth, Ian M., Fletcher, Anne L., Knoblich, Konstantin, Watt, Matthew J., Alhomrani, Majid, Alsanie, Walaa, Quinn, Kylie M., Merson, Tobias D., Chidgey, Ann P., Ricardo, Sharon D., Yu, Di, Jardé, Thierry, Cheetham, Seth W., Marcelle, Christophe, Nilsson, Susan K., Nguyen, Quan, White, Melanie D., and Nefzger, Christian M.

Published
2024
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34. Ex vivo gene editing and cell therapy for hereditary tyrosinemia type 1

Author

Ilayda Ates, Callie Stuart, Tanner Rathbone, Mercedes Barzi, Gordon He, Angela M. Major, Vijay Shankar, Rachel A. Lyman, Sidney S. Angner, Trudy F.C. Mackay, Shanthi Srinivasan, Alton Brad Farris, Karl-Dimiter Bissig, and Renee N. Cottle

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background:. We previously demonstrated the successful use of in vivo CRISPR gene editing to delete 4-hydroxyphenylpyruvate dioxygenase (HPD) to rescue mice deficient in fumarylacetoacetate hydrolase (FAH), a disorder known as hereditary tyrosinemia type 1 (HT1). The aim of this study was to develop an ex vivo gene-editing protocol and apply it as a cell therapy for HT1. Methods:. We isolated hepatocytes from wild-type (C57BL/6J) and Fah −/− mice and then used an optimized electroporation protocol to deliver Hpd-targeting CRISPR-Cas9 ribonucleoproteins into hepatocytes. Next, hepatocytes were transiently incubated in cytokine recovery media formulated to block apoptosis, followed by splenic injection into recipient Fah −/− mice. Results:. We observed robust engraftment and expansion of transplanted gene-edited hepatocytes from wild-type donors in the livers of recipient mice when transient incubation with our cytokine recovery media was used after electroporation and negligible engraftment without the media (mean: 46.8% and 0.83%, respectively; p=0.0025). Thus, the cytokine recovery medium was critical to our electroporation protocol. When hepatocytes from Fah −/− mice were used as donors for transplantation, we observed 35% and 28% engraftment for Hpd-Cas9 ribonucleoproteins and Cas9 mRNA, respectively. Tyrosine, phenylalanine, and biochemical markers of liver injury normalized in both Hpd-targeting Cas9 ribonucleoprotein and mRNA groups independent of induced inhibition of Hpd through nitisinone, indicating correction of disease indicators in Fah −/− mice. Conclusions:. The successful liver cell therapy for HT1 validates our protocol and, despite the known growth advantage of HT1, showcases ex vivo gene editing using electroporation in combination with liver cell therapy to cure a disease model. These advancements underscore the potential impacts of electroporation combined with transplantation as a cell therapy.

Published
2024
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35. WIDER PALEOGEOGRAPHICAL DISTRIBUTION OF BOTHREMYDID TURTLES IN NORTHERN SOUTH AMERICA DURING THE PALEOCENE–EOCENE

Author

Edwin-Alberto Cadena, Byron Benítez, Francisco Emmanuel Apen, James Leahey Crowley, John Cottle, and Carlos Jaramillo

Subjects
Testudines, Colombia, Paleobiogeography, Bothremydidae, Arcillolitas de Socha Formation, Fossil man. Human paleontology, GN282-286.7, Paleontology, QE701-760
Abstract

Bothremydidae was one of the most diverse and widespread group of side-necked turtles (pleurodirans) during the Cretaceous and part of the Paleogene. In South America, the Paleogene record of bothremydids is restricted to Puentemys mushaisaensis from the middle–late Paleocene Cerrejón Formation of Colombia, Inaechelys pernambucensis from the Paleocene of Brazil, and Motelomama olssoni from the early Eocene of Perú. Here, we describe two shells of P. mushaisaensis and several other isolated bones conferred to this taxon from the upper Paleocene and lower Eocene Arcillolitas de Socha Formation found in the Socha Region, Boyacá Department of Colombia. U-Pb dating of detrital zircon from two levels from this formation indicates maximum depositional ages of 56.83±0.04 Ma and 57.2±0.5 Ma for the areniscas guía interval of the formation. The new occurrence of P. mushaisaensis in the Socha region, at least 500 km south from Cerrejón, indicates a wider biogeographical distribution of northern South America Paleocene herpetofauna, possibly helped by low topography and ecosystems connectivity via a faunistic corridor.

Published
2024
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36. Cosmogenic production of Ar37 in the context of the LUX-ZEPLIN experiment

Author

Aalbers, J, Akerib, DS, Al Musalhi, AK, Alder, F, Alsum, SK, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Bai, X, Baker, A, Balajthy, J, Balashov, S, Bang, J, Bargemann, JW, Bauer, D, Baxter, A, Beattie, K, Bernard, EP, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Blockinger, GM, Bodnia, E, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Busenitz, JK, Buuck, M, Cabrita, R, Carmona-Benitez, MC, Cascella, M, Chan, C, Chawla, A, Chen, H, Chott, NI, Cole, A, Converse, MV, Cottle, A, Cox, G, Creaner, O, Cutter, JE, Dahl, CE, David, A, de Viveiros, L, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fayer, S, Fearon, NM, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, T, Gaitskell, RJ, Genovesi, J, Ghag, C, Gibson, E, Gilchriese, MGD, Gokhale, S, van der Grinten, MGD, Gwilliam, CB, Hall, CR, Haselschwardt, SJ, Hertel, SA, Horn, M, Huang, DQ, Hunt, D, Ignarra, CM, Jahangir, O, James, RS, Ji, W, Johnson, J, Kaboth, AC, Kamaha, AC, Kamdin, K, Khaitan, D, Khazov, A, Khurana, I, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Kudryavtsev, VA, Leason, EA, Leonard, DS, Lesko, KT, Levy, C, Lee, J, Lin, J, Lindote, A, and Linehan, R

Subjects
Nuclear and Plasma Physics, Physical Sciences
Abstract

We estimate the amount of Ar37 produced in natural xenon via cosmic-ray-induced spallation, an inevitable consequence of the transportation and storage of xenon on the Earth's surface. We then calculate the resulting Ar37 concentration in a 10-tonne payload (similar to that of the LUX-ZEPLIN experiment) assuming a representative schedule of xenon purification, storage, and delivery to the underground facility. Using the spallation model by Silberberg and Tsao, the sea-level production rate of Ar37 in natural xenon is estimated to be 0.024 atoms/kg/day. Assuming the xenon is successively purified to remove radioactive contaminants in 1-tonne batches at a rate of 1 tonne/month, the average Ar37 activity after 10 tons are purified and transported underground is 0.058-0.090 μBq/kg, depending on the degree of argon removal during above-ground purification. Such cosmogenic Ar37 will appear as a noticeable background in the early science data, while decaying with a 35-day half-life. This newly noticed production mechanism of Ar37 should be considered when planning for future liquid-xenon-based experiments.

Published
2022

37. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author

Akerib, DS, Akerlof, CW, Akimov, D Yu, Alquahtani, A, Alsum, SK, Anderson, TJ, Angelides, N, Araújo, HM, Arbuckle, A, Armstrong, JE, Arthurs, M, Auyeung, H, Aviles, S, Bai, X, Bailey, AJ, Balajthy, J, Balashov, S, Bang, J, Barry, MJ, Bauer, D, Bauer, P, Baxter, A, Belle, J, Beltrame, P, Bensinger, J, Benson, T, Bernard, EP, Bernstein, A, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Birrittella, B, Boast, KE, Bolozdynya, AI, Boulton, EM, Boxer, B, Bramante, R, Branson, S, Brás, P, Breidenbach, M, Brew, CAJ, Buckley, JH, Bugaev, VV, Bunker, R, Burdin, S, Busenitz, JK, Cabrita, R, Campbell, JS, Carels, C, Carlsmith, DL, Carlson, B, Carmona-Benitez, MC, Cascella, M, Chan, C, Cherwinka, JJ, Chiller, AA, Chiller, C, Chott, NI, Cole, A, Coleman, J, Colling, D, Conley, RA, Cottle, A, Coughlen, R, Cox, G, Craddock, WW, Curran, D, Currie, A, Cutter, JE, da Cunha, JP, Dahl, CE, Dardin, S, Dasu, S, Davis, J, Davison, TJR, de Viveiros, L, Decheine, N, Dobi, A, Dobson, JEY, Druszkiewicz, E, Dushkin, A, Edberg, TK, Edwards, WR, Edwards, BN, Edwards, J, Elnimr, MM, Emmet, WT, Eriksen, SR, Faham, CH, Fan, A, Fayer, S, Fiorucci, S, Flaecher, H, Florang, IM Fogarty, Ford, P, Francis, VB, Fraser, ED, Froborg, F, and Fruth, T

Subjects
Particle and High Energy Physics, Astronomical Sciences, Atomic, Molecular and Optical Physics, Physical Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

The reference to the article is Manuscript ID EPJC-20-06-042 from the internal review perspective. The reference to the article as published, is: (Table presented.).

Published
2022

43. Ultra-depleted hydrogen isotopes in hydrated glass record Late Cretaceous glaciation in Antarctica

Author

Nelson, Demian A, Cottle, John M, Bindeman, Ilya N, and Camacho, Alfredo

Subjects
Earth Sciences, Physical Geography and Environmental Geoscience, Geochemistry, Geology
Abstract

The Early Jurassic Butcher Ridge Igneous Complex (BRIC) in the Transantarctic Mountains contains abundant and variably hydrated silicic glass which has the potential to preserve a rich paleoclimate record. Here we present Fourier Transform Infrared Spectroscopic data that indicates BRIC glasses contain up to ~8 wt.% molecular water (H2Om), and low (

Published
2022

44. Projected sensitivity of the LUX-ZEPLIN experiment to the two-neutrino and neutrinoless double β decays of Xe134

Author

Akerib, DS, Al Musalhi, AK, Alsum, SK, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Bai, X, Balajthy, J, Balashov, S, Bang, J, Bargemann, JW, Bauer, D, Baxter, A, Beltrame, P, Bernard, EP, Bernstein, A, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Blockinger, GM, Bodnia, E, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Busenitz, JK, Buuck, M, Cabrita, R, Carmona-Benitez, MC, Cascella, M, Chan, C, Chott, NI, Cole, A, Converse, MV, Cottle, A, Cox, G, Creaner, O, Cutter, JE, Dahl, CE, de Viveiros, L, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fayer, S, Fearon, NM, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, T, Gaitskell, RJ, Genovesi, J, Ghag, C, Gibson, E, Gokhale, S, van der Grinten, MGD, Gwilliam, CB, Hall, CR, Haselschwardt, SJ, Hertel, SA, Horn, M, Huang, DQ, gnarra, MCI, Jahangir, O, James, RS, Ji, W, Johnson, J, Kaboth, AC, Kamaha, AC, Kamdin, K, Kazkaz, K, Khaitan, D, Khazov, A, Khurana, I, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Krikler, B, Kudryavtsev, VA, Leason, EA, Lee, J, Leonard, DS, Lesko, KT, Levy, C, Liao, J, Lin, J, Lindote, A, Linehan, R, Lippincott, WH, Liu, X, Lopes, MI, and Asamar, E López

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Nuclear and plasma physics
Abstract

The projected sensitivity of the LUX-ZEPLIN (LZ) experiment to two-neutrino and neutrinoless double β decay of Xe134 is presented. LZ is a 10-tonne xenon time-projection chamber optimized for the detection of dark matter particles and is expected to start operating in 2021 at Sanford Underground Research Facility, USA. Its large mass of natural xenon provides an exceptional opportunity to search for the double β decay of Xe134, for which xenon detectors enriched in Xe136 are less effective. For the two-neutrino decay mode, LZ is predicted to exclude values of the half-life up to 1.7×1024 years at 90% confidence level (CL) and has a three-sigma observation potential of 8.7×1023 years, approaching the predictions of nuclear models. For the neutrinoless decay mode LZ, is projected to exclude values of the half-life up to 7.3×1024 years at 90% CL.

Published
2021

45. Dynamic Optimization with Timing Risk

Author

Erin Cottle Hunt and Frank N. Caliendo

Subjects
dynamic modeling, optimization techniques, timing risk, Mathematics, QA1-939
Abstract

Timing risk refers to a situation in which the timing of an economically important event is unknown (risky) from the perspective of an economic decision maker. While this special class of dynamic stochastic control problems has many applications in economics, the methods used to solve them are not easily accessible within a single, comprehensive survey. We provide a survey of dynamic optimization methods under comprehensive assumptions about the nature of timing risk. We also relax the assumption of full information and summarize optimization with limited information, ambiguity, imperfect hedging, and dynamic inconsistency. Our goal is to provide a concise user guide for specialists and nonspecialists alike.

Published
2024
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46. Projected sensitivities of the LUX-ZEPLIN experiment to new physics via low-energy electron recoils

Author

Akerib, DS, Al Musalhi, AK, Alsum, SK, Amarasinghe, CS, Ames, A, Anderson, TJ, Angelides, N, Araújo, HM, Armstrong, JE, Arthurs, M, Bai, X, Balajthy, J, Balashov, S, Bang, J, Bargemann, JW, Bauer, D, Baxter, A, Beltrame, P, Bernard, EP, Bernstein, A, Bhatti, A, Biekert, A, Biesiadzinski, TP, Birch, HJ, Blockinger, GM, Bodnia, E, Boxer, B, Brew, CAJ, Brás, P, Burdin, S, Busenitz, JK, Buuck, M, Cabrita, R, Carmona-Benitez, MC, Cascella, M, Chan, C, Chott, NI, Cole, A, Converse, MV, Cottle, A, Cox, G, Creaner, O, Cutter, JE, Dahl, CE, de Viveiros, L, Dobson, JEY, Druszkiewicz, E, Eriksen, SR, Fan, A, Fayer, S, Fearon, NM, Fiorucci, S, Flaecher, H, Fraser, ED, Fruth, T, Gaitskell, RJ, Genovesi, J, Ghag, C, Gibson, E, Gokhale, S, van der Grinten, MGD, Gwilliam, CB, Hall, CR, Hardy, CA, Haselschwardt, SJ, Hertel, SA, Horn, M, Huang, DQ, Ignarra, CM, Jahangir, O, James, RS, Ji, W, Johnson, J, Kaboth, AC, Kamaha, AC, Kamdin, K, Kazkaz, K, Khaitan, D, Khazov, A, Khurana, I, Kodroff, D, Korley, L, Korolkova, EV, Kraus, H, Kravitz, S, Kreczko, L, Krikler, B, Kudryavtsev, VA, Leason, EA, Lee, J, Leonard, DS, Lesko, KT, Levy, C, Li, J, Liao, J, Lindote, A, Linehan, R, Lippincott, WH, Liu, X, and Lopes, MI

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences
Abstract

LUX-ZEPLIN is a dark matter detector expected to obtain world-leading sensitivity to weakly-interacting massive particles interacting via nuclear recoils with a ∼7-tonne xenon target mass. This paper presents sensitivity projections to several low-energy signals of the complementary electron recoil signal type: 1) an effective neutrino magnetic moment, and 2) an effective neutrino millicharge, both for pp-chain solar neutrinos, 3) an axion flux generated by the Sun, 4) axionlike particles forming the Galactic dark matter, 5) hidden photons, 6) mirror dark matter, and 7) leptophilic dark matter. World-leading sensitivities are expected in each case, a result of the large 5.6 t 1000 d exposure and low expected rate of electron-recoil backgrounds in the

Published
2021

50. The CeBrA demonstrator for particle-[formula omitted] coincidence experiments at the FSU Super-Enge Split-Pole Spectrograph

Author

Conley, A.L., Kelly, B., Spieker, M., Aggarwal, R., Ajayi, S., Baby, L.T., Baker, S., Benetti, C., Conroy, I., Cottle, P.D., D’Amato, I.B., DeRosa, P., Esparza, J., Genty, S., Hanselman, K., Hay, I., Heinze, M., Houlihan, D., Khawaja, M.I., Kielb, P.S., Kuchera, A.N., McCann, G.W., Morelock, A.B., Lopez-Saavedra, E., Renom, R., Riley, L.A., Ryan, G., Sandrik, A., Sitaraman, V., Temanson, E., Wheeler, M., Wibisono, C., and Wiedenhöver, I.

Published
2024
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