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5,713 results on '"A Khaw"'

4. Global 30-day morbidity and mortality of surgery for perforated peptic ulcer: GRACE study

Author

Abouelazayem, Mohamed, Jain, Rajesh, Wilson, Michael S. J., Martinino, Alessandro, Balasubaramaniam, Vignesh, Biffl, Walter, Coccolini, Federico, Riera, Manel, Wadhawan, Himanshu, Wazir, Ishaan, Abderaouf, Bettahar, Abramov, Daniil, Abu Jayyab, Mustafa A., Al-Shami, Khayry, Alfarwan, Ahmad, Alhajami, Faris M., Alkaseek, Akram, Alozairi, Ous, Ammar, Ahmed Siddique, Atar, Burak, Baatarjav, Gan-Erdene, Bains, Lovenish, Bakri, Ashraf, Bayramov, Nuru, Bhojwani, Rajesh, Brachini, Gioia, Calini, Giacomo, Campanelli, Michela, Cheng, Shi Yu, Choudhary, Charan Singh, Chowdhury, Sharfuddin, Colak, Elif, Das, Jayanta Kumar, Dawani, Surrendar, Dönmez, Turgut, Elzayat, Ibrahim, Erdene, Sarnai, Faizi, Tashaba Qaiser, Frountzas, Maximos, Gafsi, Besma, Gentileschi, Paolo, Guler, Mert, Gupta, Gaurav, Harkati, Nour Elhouda, Harris, Matthew, Hasan, Doaa M., Irowa, Omorodion Omoruyi, Jafferi, Salman, Jain, Sumita Agarwal, Jun Han, Lai, Kandiboyina, Satyanarayana Murthy, Karabulut, Mehmetu, Khamees, Almu’atasim, Khan, Shahzeb, Khan, Madiha Masood, Khaw, Cheng Jing, Kisielewski, Michal, Klib, Mohamad, Košir, Jurij A., Krawczyk, Wiktor Jan, Lisi, Giorgio, Makama, Jerry Godfrey, Maqbool, Baila, Marques, Cláudia Neves, Meric, Serhat, Mietła, Mateusz Przemysław, Ads, Alaa Mohamed, Muhumuza, Joshua, Mulita, Francesk, Mustafayeva, Matanat, Omar, Mohammed A., Omarov, Taryel, Pathak, Akshant Anil, Paul, Ratnadeep, Pavone, Giovanna, Podda, Mauro, Raja Ram, Novinth Kumar, Rauf, Fatima, Rauf, Sidra, Safy, Ahmed Mohamed, Sandag, Erdene, Şanlı, Ahmet Necati, Siddiqui, Adeela Z., Sotiropoulou, Maria, Talib, Vikash, Tatar, Cihad, Thota, Anuroop, Tokocin, Merve, Tolat, Aditya, Uchikov, Petar Angelov, Valenzuela, José I., Venkatappa, Sunil Kumar, Verras, Georgios-Ioannis, Vlahović, Ivan, Zreeg, Dafer Abdulhakim S., Cardoso, Victor Roth, Gkoutos, Georgios V., Singhal, Rishi, and Mahawar, Kamal

Published
2024
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8. Cluster effect for SNP–SNP interaction pairs for predicting complex traits

Author

Lin, Hui-Yi, Mazumder, Harun, Sarkar, Indrani, Huang, Po-Yu, Eeles, Rosalind A., Kote-Jarai, Zsofia, Muir, Kenneth R., Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Neal, David E., Nielsen, Sune F., Nordestgaard, Børge G., Grönberg, Henrik, Wiklund, Fredrik, MacInnis, Robert J., Haiman, Christopher A., Travis, Ruth C., Stanford, Janet L., Kibel, Adam S., Cybulski, Cezary, Khaw, Kay-Tee, Maier, Christiane, Thibodeau, Stephen N., Teixeira, Manuel R., Cannon-Albright, Lisa, Brenner, Hermann, Kaneva, Radka, Pandha, Hardev, and Park, Jong Y.

Published
2024
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11. How information technology influences organizational communication: the mediating role of organizational structure

Author

XinYing Chew, Raed Alharbi, Khai Wah Khaw, and Alhamzah Alnoor

Subjects
Information technology, Mediating role, Organizational communication, Organizational structure, Commerce, HF1-6182, Finance, HG1-9999
Abstract

Purpose – The study is interested in knowing “the role of the organizational structure as a mediating variable of the relationship between the information technology and organizational communication”. Design/methodology/approach – The study was conducted in several service companies, and the study adopted the questionnaire as a basic tool for the data collection on the practical side, as 267 opinions were surveyed, in addition to conducting personal interviews, and the normal distribution of data was tested, analyzing, describing and diagnosing study variables, testing correlations and determining direct effects. Findings – Findings show that there is no direct and significant statistical impact of information technology on organizational communications. Whereas there was a positive, direct and statistically significant impact of information technology on the organizational structure. There was also a positive, direct and statistically significant effect of the organizational structure on organizational communication. Research limitations/implications – This paper is restricted to the role of the organizational structure as a mediating variable of the relationship between the influence of information technology on organizational communication. Practical implications – As part of the practical implication, the paper suggests the need to increase support and attention to the importance of information technology in service organizations in order to increase coordination and organizational communication and achieve a high ability to explore and exploit ideas. Originality/value – Apart from the fact that several companies were engaged, the organizational structures of these companies were engaged too to examine the impacts of Information technology (ICT) on organizational communication.

Published
2024
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13. Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Author

Keaton, Jacob M., Kamali, Zoha, Xie, Tian, Vaez, Ahmad, Williams, Ariel, Goleva, Slavina B., Ani, Alireza, Evangelou, Evangelos, Hellwege, Jacklyn N., Yengo, Loic, Young, William J., Traylor, Matthew, Giri, Ayush, Zheng, Zhili, Zeng, Jian, Chasman, Daniel I., Morris, Andrew P., Caulfield, Mark J., Hwang, Shih-Jen, Kooner, Jaspal S., Conen, David, Attia, John R., Morrison, Alanna C., Loos, Ruth J. F., Kristiansson, Kati, Schmidt, Reinhold, Hicks, Andrew A., Pramstaller, Peter P., Nelson, Christopher P., Samani, Nilesh J., Risch, Lorenz, Gyllensten, Ulf, Melander, Olle, Riese, Harriette, Wilson, James F., Campbell, Harry, Rich, Stephen S., Psaty, Bruce M., Lu, Yingchang, Rotter, Jerome I., Guo, Xiuqing, Rice, Kenneth M., Vollenweider, Peter, Sundström, Johan, Langenberg, Claudia, Tobin, Martin D., Giedraitis, Vilmantas, Luan, Jian’an, Tuomilehto, Jaakko, Kutalik, Zoltan, Ripatti, Samuli, Salomaa, Veikko, Girotto, Giorgia, Trompet, Stella, Jukema, J. Wouter, van der Harst, Pim, Ridker, Paul M., Giulianini, Franco, Vitart, Veronique, Goel, Anuj, Watkins, Hugh, Harris, Sarah E., Deary, Ian J., van der Most, Peter J., Oldehinkel, Albertine J., Keavney, Bernard D., Hayward, Caroline, Campbell, Archie, Boehnke, Michael, Scott, Laura J., Boutin, Thibaud, Mamasoula, Chrysovalanto, Järvelin, Marjo-Riitta, Peters, Annette, Gieger, Christian, Lakatta, Edward G., Cucca, Francesco, Hui, Jennie, Knekt, Paul, Enroth, Stefan, De Borst, Martin H., Polašek, Ozren, Concas, Maria Pina, Catamo, Eulalia, Cocca, Massimiliano, Li-Gao, Ruifang, Hofer, Edith, Schmidt, Helena, Spedicati, Beatrice, Waldenberger, Melanie, Strachan, David P., Laan, Maris, Teumer, Alexander, Dörr, Marcus, Gudnason, Vilmundur, Cook, James P., Ruggiero, Daniela, Kolcic, Ivana, Boerwinkle, Eric, Traglia, Michela, Lehtimäki, Terho, Raitakari, Olli T., Johnson, Andrew D., Newton-Cheh, Christopher, Brown, Morris J., Dominiczak, Anna F., Sever, Peter J., Poulter, Neil, Chambers, John C., Elosua, Roberto, Siscovick, David, Esko, Tõnu, Metspalu, Andres, Strawbridge, Rona J., Laakso, Markku, Hamsten, Anders, Hottenga, Jouke-Jan, de Geus, Eco, Morris, Andrew D., Palmer, Colin N. A., Nolte, Ilja M., Milaneschi, Yuri, Marten, Jonathan, Wright, Alan, Zeggini, Eleftheria, Howson, Joanna M. M., O’Donnell, Christopher J., Spector, Tim, Nalls, Mike A., Simonsick, Eleanor M., Liu, Yongmei, van Duijn, Cornelia M., Butterworth, Adam S., Danesh, John N., Menni, Cristina, Wareham, Nicholas J., Khaw, Kay-Tee, Sun, Yan V., Wilson, Peter W. F., Cho, Kelly, Visscher, Peter M., Denny, Joshua C., Levy, Daniel, Edwards, Todd L., Munroe, Patricia B., Snieder, Harold, and Warren, Helen R.

Published
2024
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14. From bench to babies – drug development for male subfertility

Author

Shen Chuen Khaw and Sarah Martins da Silva

Subjects
male infertility, sperm, drug development, drug discovery, high throughput phenotypic screening, Reproduction, QH471-489, Gynecology and obstetrics, RG1-991
Abstract

Infertility is estimated to affect more than 50 million couples around the world, with the male factor accounting for half of these cases, yet there is a notable absence of effective treatment options for men, other than in-vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). This review considers unlicensed and empirical treatments used for male subfertility, including hormonal therapy, phosphodiesterase inhibitors, and antioxidants. Compounds generally demonstrate variable improvements in sperm function, but benefits for fertility are less clear. There is a pressing need for effective treatment options for subfertile men; however, our knowledge of sperm function is limited, restricting the identification of precise treatment targets. The traditional drug discovery pathway is also notorious for its extensive resource and time requirements, often extending over decades and demanding significant financial investment. Unfortunately, a substantial number of potential therapies fail before reaching the marketplace. Furthermore, reliance on mammalian models is not possible in the drug development process for male subfertility, due to significant variability between animals and man. We review recent breakthroughs and highlight novel methods aimed at improving the effectiveness and efficiency of drug discovery for male subfertility. High-throughput screening, combinatorial chemistry, and the repurposing of established medications have great potential. These strategies offer the promise of accelerating the pace of drug development, curbing the extensive demand for resources, and, in the case of drug repurposing, diminishing the demand for comprehensive pharmacokinetic and pharmacodynamic studies. As these innovative approaches are adopted, the feasibility of addressing male subfertility through scientific advancements appears to be increasingly attainable. Lay summary Globally, millions of men suffer from infertility, but with very few exceptions, there is no effective treatment or cure other than complex fertility treatments such as in vitro fertilisation. This review article considers various approaches to treat men, or sperm, which have been largely unsuccessful to date. A significant issue is that we lack a detailed understanding of how sperm work and why treatments do not work. Another issue is that drug discovery is slow and costly because many potential treatments fail early on. However, we discuss recent technical and technological advancements that offer hope, such as high-throughput and phenotypic screening, which allow for the rapid testing of thousands of chemicals to observe their effects on sperm, and combinatorial chemistry, which involves generating large numbers of compounds to find those with beneficial properties. Finding relevant new uses for prescription drugs could also significantly speed up the drug discovery process and result in much-needed new treatments for male infertility.

Published
2024
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15. CRATSM: An Effective Hybridization of Deep Neural Models for Customer Retention Prediction in the Telecom Industry

Author

Johnson Olanrewaju Victor, XinYing Chew, Khai Wah Khaw, and Zhi Lin Chong

Subjects
optimization, residual network, attention mechanism, tree-structured network, cost-sensitive, Mechanics of engineering. Applied mechanics, TA349-359, Technology
Abstract

In the dynamic field of Customer Retention Prediction (CRP), strategic marketing and promotion efforts targeting specific customers are crucial. Understanding customer behavior and identifying churn indicators are vital for devising effective retention strategies. However, identifying customers likely to terminate services presents a challenge, leading to data imbalance issues. Existing CRP studies using Machine Learning (ML) techniques and data imbalance methods face problems such as overfitting and computational complexity. Similarly, recent CRP studies employing Deep Learning (DL) approaches rely on data sampling techniques, which can result in overfitting and a lack of cost sensitivity. Additionally, DL approaches struggle with slow convergence and get stuck in local minima. This paper introduces an effective hybrid of Deep Learning (DL) classifiers focusing on cost-metric integration to address data imbalance issues and period-shift Cosine Annealing Learning Rate (ps-CALR) to accelerate model training, ultimately enhancing performance. Three Telecom datasets, namely IBM, Iranian, and Orange, were used to assess the model performance. Empirical findings show that the hybrid DL classifiers significantly improved CRP over conventional ML. This paper contributes methodological advancements and practical insights for effective customer retention in the telecom industry.

Published
2024
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16. Substituted Bi3.5Mg1.8Nb2.7O13.8 pyrochlores with transition metals (Zn, Ni and Cd): Doping mechanism, structure and electrical properties

Author

Tan Phei Yi, Tan Kar Ban, Khaw Chwin Chieh, Ananda Murthy H.C., Balachandran Ruthramurthy, Chen Soo Kien, Lee Jew Oon, Chan Kah Yoong, and Lu Ming

Subjects
bi/mg niobate, solid state synthesis, dielectric properties, impedance spectroscopy, capacitors, Clay industries. Ceramics. Glass, TP785-869
Abstract

The influence of transition metals (Zn, Cd and Ni) on bismuth magnesium niobate (Bi3.5Mg1.8Nb2.7O13.8, BMN) pyrochlores was investigated. Considering the difference in their ionic radii, Cd was postulated to substitute Mg at the eight-fold coordinated A-site whereas Zn and Ni were to replace Mg at the six-fold coordinated B-sites of the host structure. Solubility limits in these substitutional pyrochlore solid solutions were determined to be 0.4, 0.1 and 0.3 for Zn, Ni and Cd, respectively. Upon introducing these divalent cation dopants, notable changes in the lattice parameters and grain sizes were observed with increasing dopant concentration. The high dielectric constants, ε′ of Zn, Cd and Ni doped BMN pyrochlores were discernible with their bulk values of 195-216, 173-195 and 153-195, respectively. The highest ε′ of 216 was recorded for the composition with Zn = 0.1 in contrast to the lowest value of 153 found in the composition with Ni = 0.1. Meanwhile, these highly insulating divalent cation doped BMN pyrochlores also exhibit low dielectric losses, tan _ whose values are in the order of 10−3. The excellent dielectric properties allow these novel pyrochlore phases to be potentially applied for the energy storage applications.

Published
2024
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17. Design of hadronic calorimeter for DarkSHINE experiment

Author

Wang, Zhen, Yuan, Rui, Liu, Han-Qing, Chen, Jing, Chen, Xiang, Khaw, Kim Siang, Li, Liang, Li, Shu, Liu, Kun, Liu, Qi-Bin, Song, Si-Yuan, Sun, Tong, Wang, Xiao-Long, Wang, Yu-Feng, Yang, Hai-Jun, Zhang, Jun-Hua, Zhang, Yu-Lei, Zhao, Zhi-Yu, Zhu, Chun-Xiang, Zhu, Xu-Liang, and Zhu, Yi-Fan

Published
2024
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18. Factors affecting the implementation and sustainability of an Australian community-based doula service: A qualitative study

Author

Sarah Min-Lee Khaw, Caroline S.E. Homer, Red Dearnley, Kerryn O'Rourke, and Meghan A. Bohren

Subjects
Doulas, Community-based doulas, Health equity, Maternity care, Qualitative research, Public aspects of medicine, RA1-1270
Abstract

Background: Community-based doula support for women and gender-diverse birthing people has a range of benefits in improving maternal outcomes and experiences. However, there is limited research on how doula services operate in Australia. Birth for Humankind is an Australian community-based volunteer doula service, which provides free doula support for women and gender diverse birthing people experiencing social discrimination and financial disadvantage. The aim of this study was to understand facilitators and barriers to implementation and sustainability of a community-based doula service delivered to clients concurrently receiving care at a major maternity hospital in Melbourne, Australia. Methods: We conducted a qualitative study consisting of 30 in-depth interviews with doulas and managers of the community-based doula service Birth for Humankind, and midwives, doctors and social workers from a maternity hospital. Data were inductively thematically analysed, and themes were then deductively categorised using the Capability, Opportunity, and Motivation (COM-B) model and Theoretical Domains Framework (TDF) to understand behavioural influences and facilitators and barriers to implementing and sustaining the doula service within a hospital setting. Results: Facilitators to implementation of the doula service included: collaborative relationships; having sound knowledge of referral processes; and being a valued professional doula service with dedicated volunteers. Barriers to implementation included: limited knowledge of the doula service from hospital staff; difficulty in retaining volunteer doulas; being a small non-profit doula service; and limited capacity of hospitals to financially support the doula service. Advocacy for renumerating doulas may be one means to strengthen and sustain existing doula-provider service relationships. Conclusion: Consideration of establishing strategic partnerships between the doula service and hospitals may create financially-sustainable pathways to enable provision of high-quality, community-based doula support for women and gender diverse birthing people to continue.

Published
2024
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19. Influence of coal bottom ash aggregate grading on properties of GGBS binary blended cement mortar

Author

Ban Chee Cheah, Kevin Khaw Le Ping, Jia Jia Liew, Rafat Siddique, and Weerachart Tangchirapat

Subjects
Coal bottom ash, Aggregate grading, Binary blended cement, Mechanical properties, Durability, Fluid transport, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

The effect of different coal bottom ash (CBA) gradings on ground granulated blast furnace slag (GGBS) binary blended cement mortar is not well-documented in current literature. Therefore, previous studies have reported inconsistent and contradictory effects of using various CBA gradings as a fine aggregate replacement in mortar and concrete. Hence, the present work aimed to establish the influence of different coal bottom ash (CBA) gradings, which is crucial for reducing coal power plant waste by utilising larger fractions of CBA in mortar and concrete without compromising its hardened properties. Specifically, this study investigated the optimal grading of coal bottom ash (CBA) for natural sand replacement in ground granulated blast furnace slag (GGBS) binary blended cement mortar. The research examines three CBA gradings: passing 10 mm sieve (R-CBA), passing 4.75 mm sieve (S-CBA), and grading according to BS EN12620 (Gr-CBA) at 20 %, 40 %, and 60 % sand replacement levels for comparison. Resultant mortar specimens were tested at 7, 28, and 91 days for mechanical strength, fluid transport, and drying shrinkage. Results show that all CBA gradings performed better than the control mix (with river sand only). The Gr-CBA mix outperformed the S-CBA mix by up to 29 % in strength due to highly consistent grading. R-CBA mix exhibited optimal performance compared to the other two CBA mix up to 30 % in strength. The coarser grading of the R-CBA mix enhances the interfacial transition zone and aggregate-binder bond and, hence, exhibited a better performance. This study highlights the potential use of R-CBA grading to increase the CBA reuse rate in mortar or concrete while maintaining desirable performance.

Published
2024
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20. Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series

Author

Nai‐Chien Huan, Khai Lip Ng, Larry Ellee Nyanti, Jing Yi Khaw, Jiun Hang Lee, Nur Husna Mohd Aminudin, Dahziela Yunus, Nusaibah Azman, Maryam Ahmad Sharifuddin, Hema Yamini Ramarmuty, and Kunji Kannan Sivaraman Kannan

Subjects
lymphoma, malignant effusion, medical thoracoscopy, pleural effusion, Diseases of the respiratory system, RC705-779
Abstract

Abstract A third of patients with non‐Hodgkin's lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma‐related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the other hand, primary pleural lymphomas (PPLs) exhibit exclusive or dominant involvement of serous cavities, without detectable solid tumour masses. PPL is an uncommon disease and is of two types: primary effusion lymphoma (PEL) and diffuse large B‐cell lymphoma associated with chronic inflammation (DLBCL‐CI). PPLs not related to PELs and DLBCL‐CIs are exceedingly rare. Herein, we describe four patients with biopsy proven B‐cell NHL. One had no extra‐pleural involvement at the time of diagnosis, indicating PPL. In all cases, histopathological examination of pleural biopsies obtained via medical thoracoscopy (MT) were crucial in clinching the final diagnosis. Clinicians are alerted to the potential relationship between exudative effusion and NHL as well as the role of MT in the diagnosis of B‐cell NHL.

Published
2024
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21. Dengue Cardiomyopathy Treatment Strategy Optimisation by Integrating Point-of-Care Ultrasound with VExUS

Author

Wei Ven Chin and Mae Jane Khaw

Subjects
Case report, Dengue fever, Dengue cardiomyopathy, Point-of-care ultrasound, POCUS, Bedside ultrasound, Internal medicine, RC31-1245, Medical technology, R855-855.5
Abstract

Dengue fever is an arthropod-borne viral disease that is widespread throughout the world. Herein, we report a case of dengue cardiomyopathy that was detected and treated to best effect using point-of-care ultrasound (POCUS) and the VExUS score. A 75-year-old lady with no known comorbidities presented with a 10-day history of fever, vomiting, loose stool, and poor appetite. Upon arrival, she was febrile and hypotensive. Bedside POCUS showed poor left ventricular systolic function, inferior vena cava measuring 2.27cm and VExUS grading of 2 to 3. Dengue serology IgM and IgG were positive and NT-proBNP raised at 12500pg/ml. Instead of fluid resuscitation, diuretic and inotropes were initiated along the line of cardiogenic shock secondary to dengue cardiomyopathy. Serial normal cardiac enzymes and electrocardiogram excluded acute coronary syndrome. She was discharged well, and repeated echocardiography one-month post discharge showed normal left ventricular systolic function with no clinical signs or symptoms of heart failure.

Published
2024
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22. Correction to: Consumption of soft drinks and juices and risk of liver and biliary tract cancers in a European cohort

Author

Stepien, Magdalena, Duarte-Salles, Talita, Fedirko, Veronika, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Klinaki, Eleni, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Parr, Christine L., Quirós, José Ramón, Buckland, Genevieve, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, Maria-Dolores, Ardanaz, Eva, Sonestedt, Emily, Ericson, Ulrika, Wennberg, Maria, Nilsson, Lena Maria, Khaw, Kay-Tee, Wareham, Nick, Bradbury, Kathryn E., Ward, Heather A., Romieu, Isabelle, and Jenab, Mazda

Published
2024
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28. Ab-Externo MicroShunt versus Trabeculectomy in Primary Open-Angle Glaucoma: Two-Year Results from a Randomized, Multicenter Study

Author

Vold, Steven, McFarland, Michael, Stiles, Michael, Stechschulte, Ann, Strom, Amanda, Reynolds, Adam, Noecker, Robert, Thimons, Joseph, Khaimi, Mahmoud, Allen, Evan, Sarkisian, Steve, Barnebey, Howard, Golez, Ernesto, Feldman, Robert, Bell, Nicholas, Blieden, Lauren, Cantor, Louis, WuDunn, Darrell, Catoira-Boyle, Yara, Chen, Huiyi, Evans, Joshua, Martin, Elizabeth, Sozeri, Yasemin, Srivastava, Vinita, Wise, Ryan, Schwartz, Kenneth, Grover, Davinder, Butler, Michelle, Emanuel, Matthew, Fellman, Ronald, Godfrey, David, Smith, Oluwatosin, Kornmann, Helen, Khatana, Anup, Hagee, Daniel, Kuhlman, Brian, Zink, Jeffrey, Moster, Marlene, Dale, Elizabeth, Pro, Michael, Baker, Douglas, Chambers, Megan, Lehmann, David, Caprioli, Joseph, Francis, Brian, Giaconi, JoAnn, Law, Simon, Nouri-Mahdavi, Kouros, Coleman, Anne, Flynn, William, Rashid, Edward, Reilly, Charles, Rice, Robert, Sidoti, Paul, Panarelli, Joseph, Garg, Reena, Tania Tai, Tak Yee, Vinod, Kate, Harizman, Noga, Ritch, Robert, Reiss, George, Dewan, Vinay, Patel, Shamil, Sorenson, Christina, Larsen, Christine, Samuelson, Thomas, Hansen, Mark, Barth, Tara, Blakstad, Alyson, Buboltz, Mark, Fahmy, Ahmad, Fahmy, Mona, Montealegre, Kate, Mizener, Martin, Whitted, Peter, Lim, Michele, Brandt, James, Baik, Annie, Jiang, Angela, Brown, Steve V.L., Breunig, Adam C., Gorla, Madhu S.R., Riss, Isabelle, Feijoo, Garcia, Mendez Hernandez, Carmen, Martinez de la Casa, Jose, Dupré Pelaez, Mauro, Fernandez Vidal, Ana, García Sáenz, Sofia, Morales Fernandez, Laura, Sáenz Francés, Federico, Santos Bueso, Enrique, Perucho Gonzalez, Lucia, Beckers, Henny J.M., Kujovic, Stefani, Nardi, Marco, Maglionico, Maria N., Nasini, Francesco, Passani, Andrea, Strouthidis, Nick, Barton, Keith, Clarke, Jonathan, Gazzard, Gus, Jayaram, Hari, Khaw, Peng, Papadopoulos, Maria, Puertas, Renata, Toth, Marta, Lunt, David, Triolo, Giacinto, Kam, Ronald, Levine, Jason, Flowers, Brian, Nair, Unni, Simmons, Steven, Pokabla, Michael, Panarelli, Joseph F., Moster, Marlene R., Garcia-Feijoo, Julian, Flowers, Brian E., Baker, N. Douglas, Barnebey, Howard S., Grover, Davinder S., Khatana, Anup K., Lee, Bonny, Nguyen, Tuan, Stiles, Michael C., Sadruddin, Omar, and Khaw, Peng T.

Published
2024
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29. Evasive attacks against autoencoder-based cyberattack detection systems in power systems

Author

Yew Meng Khaw, Amir Abiri Jahromi, Mohammadreza F.M. Arani, and Deepa Kundur

Subjects
Cybersecurity, Adversarial attacks, Anomaly detection, Iterative-based methods, Substation automation, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Computer software, QA76.75-76.765
Abstract

The digital transformation process of power systems towards smart grids is resulting in improved reliability, efficiency and situational awareness at the expense of increased cybersecurity vulnerabilities. Given the availability of large volumes of smart grid data, machine learning-based methods are considered an effective way to improve cybersecurity posture. Despite the unquestionable merits of machine learning approaches for cybersecurity enhancement, they represent a component of the cyberattack surface that is vulnerable, in particular, to adversarial attacks. In this paper, we examine the robustness of autoencoder-based cyberattack detection systems in smart grids to adversarial attacks. A novel iterative-based method is first proposed to craft adversarial attack samples. Then, it is demonstrated that an attacker with white-box access to the autoencoder-based cyberattack detection systems can successfully craft evasive samples using the proposed method. The results indicate that naive initial adversarial seeds cannot be employed to craft successful adversarial attacks shedding insight on the complexity of designing adversarial attacks against autoencoder-based cyberattack detection systems in smart grids.

Published
2024
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34. Based on the perception of ethics in social commerce platforms: Adopting SEM and MCDM approaches for benchmarking customers in rural communities

Author

Sadaa, Abdullah Mohammed, Ganesan, Yuvaraj, Khaw, Khai Wah, Alnoor, Alhamzah, Abbas, Sammar, Chew, XinYing, and Bayram, Gül Erkol

Subjects
Electronic commerce, Electronic commerce -- Social aspects -- Models, Structural equation modeling -- Usage, Multiple criteria decision making -- Usage, Sparsely populated areas -- Social aspects -- Ethical aspects, Social media -- Usage -- Economic aspects
Abstract

The study aimed to determine customers' perceptions of the ethics of social commerce platforms by investigating the role of the impact of information quality, information credibility, website quality, innovativeness, altruism, sense of belongingness, self-enhancement, social support, and valuation of electronic word of mouth (eWOM) on the perception of ethics of social commerce platforms. In addition, the strength of the relationship between these factors and the perception of ethics of social commerce platforms was determined by the mediating role of the perceived risk of ethical violations. To this end, this study complements academic literature by integrating structural equation modeling (SEM) and multi criteria decision making (MCDM) techniques. In order to complete the strategic decisive solution, this study uses a survey to collect data from customers of rural communities in Malaysia and Turkey. The results demonstrate that perceived risk of ethical violations has a partial mediating role in the relationship between dependent variables and the perception of ethics of social commerce platforms for Malaysia and Turkey. Benchmarking and ranking customers from best to worst based on the perception of ethics of social commerce would identify customers with a high perception of the ethics of social commerce platforms and motivate them as opinion leaders of such platforms. Contrarily, social commerce platforms can treat worst-ranked customers with caution and strive to turn a negative perception into positive ethics. Besides, the cross-cluster study at the level of Asia and Europe would contribute to the literature to identify insights into the differences and similarities between the Asian and European contexts based on multiple and diverse cultures regarding social commerce ethics of rural communities., Author(s): Abdullah Mohammed Sadaa [sup.1] , Yuvaraj Ganesan [sup.2] , Khai Wah Khaw [sup.3] , Alhamzah Alnoor [sup.3] [sup.4] , Sammar Abbas [sup.5] , XinYing Chew [sup.6] , Gül Erkol [...]

Published
2023
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37. Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Author

Wang, Anqi, Shen, Jiayi, Rodriguez, Alex A., Saunders, Edward J., Chen, Fei, Janivara, Rohini, Darst, Burcu F., Sheng, Xin, Xu, Yili, Chou, Alisha J., Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Plym, Anna, Sahimi, Ali, Hoffman, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Laisk, Triin, Figuerêdo, Jéssica, Muir, Kenneth, Ito, Shuji, Liu, Xiaoxi, Uchio, Yuji, Kubo, Michiaki, Kamatani, Yoichiro, Lophatananon, Artitaya, Wan, Peggy, Andrews, Caroline, Lori, Adriana, Choudhury, Parichoy P., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Rentsch, Christopher T., Cho, Kelly, Mcmahon, Benjamin H., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Borge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Andreas, Stroomberg, Hein V., Batra, Jyotsna, Chambers, Suzanne, Horvath, Lisa, Clements, Judith A., Tilly, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordstrom, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie, Cook, Michael B., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Koutros, Stella, Beane Freeman, Laura E., Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Butler, Ebonee N., Mohler, James L., Taylor, Jack A., Kogevinas, Manolis, Dierssen-Sotos, Trinidad, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Pilie, Patrick, Yu, Yao, Bohlender, Ryan J., Gu, Jian, Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Brenner, Hermann, Chen, Xuechen, Holleczek, Bernd, Schöttker, Ben, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine M., Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Abraham, Aswin, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer, Petrovics, Gyorgy, Casey, Graham, Wang, Ying, Tettey, Yao, Lachance, Joseph, Tang, Wei, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Yamoah, Kosj, Govindasami, Koveela, Chokkalingam, Anand P., Keaton, Jacob M., Hellwege, Jacklyn N., Clark, Peter E., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Ogunbiyi, Olufemi, Shittu, Olayiwola, Amodu, Olukemi, Adebiyi, Akindele O., Aisuodionoe-Shadrach, Oseremen I., Ajibola, Hafees O., Jamda, Mustapha A., Oluwole, Olabode P., Nwegbu, Maxwell, Adusei, Ben, Mante, Sunny, Darkwa-Abrahams, Afua, Diop, Halimatou, Gundell, Susan M., Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Kachuri, Linda, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Preuss, Michael H., Loos, Ruth J. F., Zawistowski, Matthew, Zöllner, Sebastian, Lu, Zeyun, Van Den Eeden, Stephen K., Easton, Douglas F., Ambs, Stefan, Edwards, Todd L., Mägi, Reedik, Rebbeck, Timothy R., Fritsche, Lars, Chanock, Stephen J., Berndt, Sonja I., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Gaziano, J. Michael, Justice, Amy C., Mancuso, Nick, Terao, Chikashi, Eeles, Rosalind A., Kote-Jarai, Zsofia, Madduri, Ravi K., Conti, David V., and Haiman, Christopher A.

Published
2023
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38. Rectus Femoris Muscle Segmentation on Ultrasound Images of Older Adults Using Automatic Segment Anything Model, nnU-Net and U-Net—A Prospective Study of Hong Kong Community Cohort

Author

Dawei Zhang, Hongyu Kang, Yu Sun, Justina Yat Wa Liu, Ka-Shing Lee, Zhen Song, Jien Vei Khaw, Jackie Yeung, Tao Peng, Sai-kit Lam, and Yongping Zheng

Subjects
deep learning, medical segment anything model, rectus femoris muscle, Sarcopenia Ultrasound, U-Net, Technology, Biology (General), QH301-705.5
Abstract

Sarcopenia is characterized by a degeneration of muscle mass and strength that incurs impaired mobility, posing grievous impacts on the quality of life and well-being of older adults worldwide. In 2018, a new international consensus was formulated to incorporate ultrasound imaging of the rectus femoris (RF) muscle for early sarcopenia assessment. Nonetheless, current clinical RF muscle identification and delineation procedures are manual, subjective, inaccurate, and challenging. Thus, developing an effective AI-empowered RF segmentation model to streamline downstream sarcopenia assessment is highly desirable. Yet, this area of research readily goes unnoticed compared to other disciplines, and relevant research is desperately wanted, especially in comparison among traditional, classic, and cutting-edge segmentation networks. This study evaluated an emerging Automatic Segment Anything Model (AutoSAM) compared to the U-Net and nnU-Net models for RF segmentation on ultrasound images. We prospectively analyzed ultrasound images of 257 older adults (aged > 65) in a community setting from Hong Kong’s District Elderly Community Centers. Three models were developed on a training set (n = 219) and independently evaluated on a testing set (n = 38) in aspects of DICE, Intersection-over-Union, Hausdorff Distance (HD), accuracy, precision, recall, as well as stability. The results indicated that the AutoSAM achieved the best segmentation agreement in all the evaluating metrics, consistently outperforming the U-Net and nnU-Net models. The results offered an effective state-of-the-art RF muscle segmentation tool for sarcopenia assessment in the future.

Published
2024
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39. Critical appraisal of clinical practice guidelines for otitis media in Asian and Western countries with consideration of updates: A narrative review

Author

Nabeel Ibraheem Jaafar Albazah, Hui Min Loh, Jin Yun Lee, Woon Khong Chen, Elena Ying Jie Khaw, Ping Kiat Ngu, and Sherreen Yehia Zakaria Elhariri

Subjects
otitis media with effusion, guidelines, management, children, Medicine
Abstract

Introduction: Acute otitis media is a common disease in children under the age of 5 years due to their primitive ear anatomy. One of its consequences is otitis media with effusion (OME), which is a condition wherein serous secretion accumulates in the middle ear due to Eustachian tube dysfunction. OME results in conductive hearing loss, impacting children’s learning and development. This review aimed to identify discrepancies in clinical practice guidelines (CPGs) for managing OME in children across Asian and Western countries, focusing on updates to these guidelines. Methods: A comparative review involving critical appraisal using the Appraisal of Guidelines for Research and Evaluation II tool was conducted. CPGs for managing ear effusion in children in Western and Asian countries published in the PubMed, Cochrane Library, Scopus and Science Direct databases were reviewed. Four CPGs from Western countries (Scotland, England, the United States of America and France) and three CPGs from Asian countries (Japan, Korea and Malaysia) were selected. Results: There was a mild discrepancy regarding conducting surgery after 3 months, particularly myringotomy and adenoidectomy with or without grommets, between the Scottish CPG and other CPGs. Conclusion: Asian CPGs for the management of OME share many similarities with Western CPGs. However, Asian CPGs tend to be stronger in most domains and levels of evidence. Japanese and American CPGs are up to date as of 2022 and 2016, respectively, while other CPGs are outdated for about 10 years.

Published
2024
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42. The Association of Urinary Sodium Excretion with Glaucoma and Related Traits in a Large United Kingdom Population

Author

Aschard, Hugues, Chia, Mark, Chua, Sharon, Do, Ron, Foster, Paul, Kang, Jae, Kastner, Alan, Khawaja, Anthony, Kim, Jihye, Lentjes, Marleen, Luben, Robert, Madjedi, Kian, Montesano, Giovanni, Pasquale, Louis, Stuart, Kelsey, Warwick, Alasdair, Wiggs, Janey, Allen, Naomi, Aslam, Tariq, Atan, Denize, Barman, Sarah, Barrett, Jenny, Bishop, Paul, Black, Graeme, Braithwaite, Tasanee, Carare, Roxana, Chakravarthy, Usha, Chan, Michelle, Day, Alexander, Desai, Parul, Dhillon, Bal, Dick, Andrew, Doney, Alexander, Egan, Cathy, Ennis, Sarah, Fruttiger, Marcus, Garway-Heath, David (Ted), Gibson, Jane, Guggenheim, Jeremy, Hammond, Chris, Hardcastle, Alison, Harding, Simon, Hogg, Ruth, Hysi, Pirro, Keane, Pearse, Khaw, Peng Tee, Lascaratos, Gerassimos, Littlejohns, Thomas, Lotery, Andrew, Luthert, Phil, MacGillivray, Tom, Mackie, Sarah, McGuinness, Bernadette, McKay, Gareth, McKibbin, Martin, Moore, Tony, Morgan, James, O'Sullivan, Eoin, Oram, Richard, Owen, Chris, Patel, Praveen, Paterson, Euan, Peto, Tunde, Petzold, Axel, Pontikos, Nikolas, Rahi, Jugnoo, Rudnicka, Alicja, Sattar, Naveed, Self, Jay, Sergouniotis, Panagiotis, Sivaprasad, Sobha, Steel, David, Stratton, Irene, Strouthidis, Nicholas, Sudlow, Cathie, Sun, Zihan, Tapp, Robyn, Thomas, Dhanes, Trucco, Emanuele, Tufail, Adnan, Viswanathan, Ananth, Vitart, Veronique, Weedon, Mike, Williams, Katie, Williams, Cathy, Woodside, Jayne, Yates, Max, Yip, Jennifer, Zheng, Yalin, Aung, Tin, Burdon, Kathryn, Chen, Li, Cheng, Ching-Yu, Craig, Jamie, Cree, Angela, de Vries, Victor, Driessen, Sjoerd, Fingert, John, Gharahkhani, Puya, Hammond, Christopher, Hayward, Caroline, Hewitt, Alex, Jansonius, Nomdo, Jonansson, Fridbert, Jonas, Jost, Kass, Michael, Khor, Chiea, Klaver, Caroline, Koh, Jacyline, MacGregor, Stuart, Mackey, David, Mitchell, Paul, Pang, Calvin, Pasutto, Francesca, Pfeiffer, Norbert, Polašek, Ozren, Ramdas, Wishal, Schuster, Alexander, Segrè, Ayellet, Stefansson, Einer, Stefánsson, Kári, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, van Duijn, Cornelia, Vergroesen, Joëlle, Vithana, Eranga, Wilson, James, Wojciechowski, Robert, Wong, Tien, Young, Terri, Stuart, Kelsey V., Biradar, Mahantesh I., Luben, Robert N., Dhaun, Neeraj, Wagner, Siegfried K., Warwick, Alasdair N., Madjedi, Kian M., Pasquale, Louis R., Wiggs, Janey L., Kang, Jae H., Lentjes, Marleen A.H., Foster, Paul J., and Khawaja, Anthony P.

Published
2024
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43. Clinical research in endometrial cancer: consensus recommendations from the Gynecologic Cancer InterGroup

Author

Barretina-Ginesta, Pilar, Bennett, Katherine, Berek, Jonathan, Berger, Regina, Bjørge, Line, Boere, Ingrid, Brennan, Donal, Bruchim, Ilan, Chang, Ting-Chang, Chavez Blanco, Adriana, Chen, Xiaojun, Colombo, Nicoletta, Crosbie, Emma, Denys, Hannelore, Duska, Linda, Fruehauf, Filip, Gomez Garcia, Eva Maria, van Gorp, Toon, Grimm, Christoph, Guitmann, Gustavo, Han, Kathy, Hanker, Lars, Harano, Kenichi, Hasegawa, Kosei, Herrington, C Simon, Ip, Philip, Joly, Florence, Khaw, Pearly, Kohn, Elise, Kristeleit, Rebecca, Kroep, Judith, Leary, Alexandra, Lee, Jung-Yun, Lheureux, Stephanie, Liu, Jihong, Mackay, Helen, Mahner, Sven, Mariani, Andrea, McAlpine, Jessica, Mikami, Yoshiki, Mirza, Mansoor Raza, Mukhopadhyay, Asima, Nagao, Shoji, Ng, Joseph, Nogueira-Rodrigues, Angelica, Novák, Zoltán, O'Donnell, Jennifer, Osborne, Sherill, Perez-Fidalgo, J. Alejandro, Romeo Marin, Margarita, Roy Chowdhury, Rahul, Sadozye, Azmat, Safra, Tamar, Scott, Claire, Sehouli, Jalid, Slomovitz, Brian, Tan, David, Taylor, Alexandra, Valabrega, Giorgio, Veneziani, Ana, Verhoeven, Karen, Vetter, Marcus, Wampfler, Julian, Westin, Shannon, Wimberger, Pauline, Zola, Paolo, Creutzberg, Carien L, Kim, Jae-Weon, Eminowicz, Gemma, Allanson, Emma, Eberst, Lauriane, Kim, Se Ik, Nout, Remi A, Park, Jeong-Yeol, Lorusso, Domenica, Mileshkin, Linda, Ottevanger, Petronella B, Brand, Alison, Mezzanzanica, Delia, Oza, Amit, Gebski, Val, Pothuri, Bhavana, Batley, Tania, Gordon, Carol, Mitra, Tina, White, Helen, Howitt, Brooke, Matias-Guiu, Xavier, Ray-Coquard, Isabelle, Gaffney, David, Small, William, Jr, Miller, Austin, Concin, Nicole, Powell, Matthew A, Stuart, Gavin, and Bookman, Michael A

Published
2024
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45. Tepotinib plus osimertinib in patients with EGFR-mutated non-small-cell lung cancer with MET amplification following progression on first-line osimertinib (INSIGHT 2): a multicentre, open-label, phase 2 trial

Author

Wu, Yi-Long, Guarneri, Valentina, Voon, Pei Jye, Lim, Boon Khaw, Yang, Jin-Ji, Wislez, Marie, Huang, Cheng, Liam, Chong Kin, Mazieres, Julien, Tho, Lye Mun, Hayashi, Hidetoshi, Nhung, Nguyen Viet, Chia, Puey Ling, de Marinis, Filippo, Raskin, Jo, Zhou, Qinghua, Finocchiaro, Giovanna, Le, Anh Tuan, Wang, Jialei, Dooms, Christophe, Kato, Terufumi, Nadal, Ernest, Hin, How Soon, Smit, Egbert F, Wermke, Martin, Tan, Daniel, Morise, Masahiro, O'Brate, Aurora, Adrian, Svenja, Pfeiffer, Boris M, Stroh, Christopher, Juraeva, Dilafruz, Strotmann, Rainer, Goteti, Kosalaram, Berghoff, Karin, Ellers-Lenz, Barbara, Karachaliou, Niki, Le, Xiuning, and Kim, Tae Min

Published
2024
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