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Antibiotics are choice of drugs in patients with respiratory infections. Irrational use of antibiotics is an important public health issue faced on daily basis by the community and the individual. Keeping this in consideration, the current study investigates the prescription pattern of antibiotics in lower respiratory tract infection in general population.The objectives of the study include prescription pattern analysis of antibiotics for LRTIs in general population and to evaluate adherence to antibiotic treatment. This was a hospital based prospective observational study conducted between November 2021 to April 2022 in the department of general medicine and pediatrics. Compliance to various antibiotics was scrutinized by using MMAS 4 scale. Patient demographics, laboratory details, prescribed antibiotics, duration of hospital stay were gathered over a period of 6 months.A total of 200 patients were involved in the study, out of which 53% were males and 47% were females. A total of 2127 drugs were prescribed in 200 patients (10.6 drugs/prescription). Ceftriaxone was the most commonly used antibiotic followed by azithromycin and piperacillin/tazobactam. The most frequently diagnosed disease was Bronchopneumonia (41%) followed by A/E COPD (28%). Evaluation of medication adherence resulted in 58% high and 11% poor adherence. The number of antibiotics prescribed was found to be rational but prevalence of polypharmacy should be prevented. Medication adherence decreases as the frequency of antibiotic increases, so it is recommended to lower the frequency of drugs as possible to enhance the compliance.

Objective: The present study was designed to investigate the protective and potential effect of gallic acid against doxorubicin (DOX) induced cardiotoxicity. Materials and Methods: Adult Wistar albino rats of either sex weighing 150-200 g were used in this study. DOX administered intraperitoneally in six equal injections (each containing 2.5 mg/kg at 48 h intervals) to total cumulative doses of 15 mg/kg over a period of 2 weeks to induce cardiotoxicity. The estimation of cardiac and lipid biomarkers of both control and treated animals were observed. In vivo antioxidant parameters such as glutathione, superoxide dismutase, catalase, and malondialdehyde were also monitored. The remaining portion of the heart tissue used for histopathological studies. Results: The treatment with doxorubicin increased the levels (P > 0.01) of serum cardiac and lipid biomarker which were brought down by gallic acid treatment. It also exhibited electrocardiographic changes such as reduced R wave and ST segment elevation. Histopathological study revealed that gallic acid restored the myocardial cells towards normal. The restoration of the endogenous antioxidant system clearly depicts that gallic acid have produced its protective effect by scavenging the reactive oxygen species. Conclusion: The results of this study indicated that the cardioprotective effect of gallic acid might be attributed to its antioxidant property.