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35,895 results on '"A, Rizzo"'

1. Structure and diversity patterns of coralligenous cliffs across three ecoregions in the Central-Western Mediterranean Sea

Author

Casoli, Edoardo, Moro, Stefano, Falasca, Matteo, Montefalcone, Monica, Rizzo, Lucia, Teixidó, Núria, Piazzi, Luigi, Longo, Caterina, Mercurio, Maria, Gennaro, Paola, Cecchi, Enrico, Penna, Marina, Gambi, Maria Cristina, Mirasole, Alice, Ballesteros, Enric, Andrello, Marco, Ventura, Daniele, Mancini, Gianluca, Belluscio, Andrea, Fraschetti, Simonetta, Ardizzone, Giandomenico, and Jona-Lasinio, Giovanna

Published
2024

3. Unpacking Vaping in Schools: Voices from the School Community

Author

Catriona Lockett, Smita Shah, Kym Rizzo Liu, Susan Towns, Rebecca Smith, and Julie Mooney-Somers

Abstract

Objectives: In early 2021, Western Sydney school principals expressed heightened concern about rising e-cigarette usage among high school students. This prompted us to assess knowledge, attitudes and perceptions surrounding adolescent vaping in students, school staff and parents, and their preferred strategies to effectively communicate prevention messages. Design: Exploratory qualitative study. Setting: Participants included students (aged 12-16 years), school staff and parents from government high schools in Greater Western Sydney, Australia. Methods: We held research workshops with 162 students, 133 school staff and 29 parents across seven schools. We used interactive activities which included individual written responses, small-group brainstorming and open group discussions. Data analysis was undertaken by two researchers using Framework Analysis. Results: Findings demonstrated differing perceptions among students, staff and parents regarding reasons why adolescents vape. Although common motives emerged, such as the perception that vaping differs from smoking, social normalisation, peer pressure and mental health considerations, there were important differences in emphasis. Students were concerned about dependency and vaping to cope, staff were concerned about the impact of vaping on students' learning and behaviour, and parents were concerned about being ill-equipped to support their children. Strategies to tackle vaping also differed, with an emphasis on education and engagement over surveillance and consequences. Conclusion: Adolescent vaping is a pressing concern within Australian school communities, necessitating a comprehensive, holistic approach supported by strong partnerships between the health and education sectors. Addressing this issue effectively demands heightened education and engagement among students, staff and parents.

Published
2024
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4. Cumulative incidence estimates for solid tumors after HCT in the CIBMTR and California Cancer Registry

Author

Schonfeld, Sara J, Valcarcel, Bryan, Meyer, Christa L, Shaw, Bronwen E, Phelan, Rachel, Rizzo, J Douglas, Brunson, Ann, Cooley, Julianne JP, Abrahão, Renata, Wun, Ted, Gadalla, Shahinaz M, Engels, Eric, Albert, Paul S, Yusuf, Rafeek, Spellman, Stephen R, Curtis, Rochelle E, Auletta, Jeffery J, Muffly, Lori, Keegan, Theresa HM, and Morton, Lindsay M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, HIV/AIDS, Sexually Transmitted Infections, Hematology, Cancer, Minority Health, Transplantation, Clinical Research, Infectious Diseases, Humans, Registries, Hematopoietic Stem Cell Transplantation, California, Incidence, Female, Male, Middle Aged, Neoplasms, Adult, Aged, Adolescent, Young Adult, Child, Cardiovascular medicine and haematology
Abstract

AbstractCompared with the general population, hematopoietic cell transplantation (HCT) survivors are at elevated risk for developing solid subsequent neoplasms (SNs). The Center for International Blood and Marrow Transplant Research (CIBMTR) is a key resource for quantifying solid SN incidence following HCT, but the completeness of SN ascertainment is uncertain. Within a cohort of 18 450 CIBMTR patients linked to the California Cancer Registry (CCR), we evaluated the completeness of solid SN data reported to the CIBMTR from 1991 to 2018 to understand the implications of using CIBMTR data alone or combined with CCR data to quantify the burden of solid SNs after HCT. We estimated the cumulative incidence of developing a solid SN, accounting for the competing risk of death. Within the cohort, solid SNs were reported among 724 patients; 15.6% of these patients had an SN reported by CIBMTR only, 36.9% by CCR only, and 47.5% by both. The corresponding cumulative incidence of developing a solid SN at 10 years following a first HCT was 4.0% (95% confidence interval [CI], 3.5-4.4) according to CIBMTR data only, 5.3% (95% CI, 4.9-5.9) according to CCR data only, and 6.3% (95% CI, 5.7-6.8) according to both sources combined. The patterns were similar for allogeneic and autologous HCT recipients. Linking detailed HCT information from CIBMTR with comprehensive SN data from cancer registries provides an opportunity to optimize SN ascertainment for informing follow-up care practices and evaluating risk factors in the growing population of HCT survivors.

Published
2024

5. How rainfall events modify trace gas mixing ratios in central Amazonia

Author

Machado, Luiz AT, Kesselmeier, Jürgen, Botía, Santiago, van Asperen, Hella, Andreae, Meinrat O, de Araújo, Alessandro C, Artaxo, Paulo, Edtbauer, Achim, Ferreira, Rosaria R, Franco, Marco A, Harder, Hartwig, Jones, Sam P, Dias-Júnior, Cléo Q, Haytzmann, Guido G, Quesada, Carlos A, Komiya, Shujiro, Lavric, Jost, Lelieveld, Jos, Levin, Ingeborg, Nölscher, Anke, Pfannerstill, Eva, Pöhlker, Mira L, Pöschl, Ulrich, Ringsdorf, Akima, Rizzo, Luciana, Yáñez-Serrano, Ana M, Trumbore, Susan, Valenti, Wanda ID, de Arellano, Jordi Vila-Guerau, Walter, David, Williams, Jonathan, Wolff, Stefan, and Pöhlker, Christopher

Subjects
Earth Sciences, Atmospheric Sciences, Astronomical and Space Sciences, Meteorology & Atmospheric Sciences, Atmospheric sciences, Climate change science
Abstract

This study investigates the rain-initiated mixing and variability in the mixing ratio of selected trace gases in the atmosphere over the central Amazon rain forest. It builds on comprehensive data from the Amazon Tall Tower Observatory (ATTO), spanning from 2013 to 2020 and comprising the greenhouse gases (GHGs) carbon dioxide (CO2) and methane (CH4); the reactive trace gases carbon monoxide (CO), ozone (O3), nitric oxide (NO), and nitrogen dioxide (NO2); and selected volatile organic compounds (VOCs). Based on more than 1000 analyzed rainfall events, the study resolves the trace gas mixing ratio patterns before, during, and after the rain events, along with vertical mixing ratio gradients across the forest canopy. The assessment of the rainfall events was conducted independently for daytime and nighttime periods, which allows us to elucidate the influence of solar radiation. The mixing ratios of CO2, CO, and CH4 clearly declined during rainfall, which can be attributed to the downdraft-related entrainment of pristine air from higher altitudes into the boundary layer, a reduction of the photosynthetic activity under increased cloud cover, and changes in the surface fluxes. Notably, CO showed a faster reduction than CO2, and the vertical gradient of CO2 and CO is steeper than for CH4. Conversely, the O3 mixing ratio increased across all measurement heights in the course of the rain-related downdrafts. Following the O3 enhancement by up to a factor of 2, NO, NO2, and isoprene mixing ratios decreased. The temporal and vertical variability of the trace gases is intricately linked to the diverse sink and source processes, surface fluxes, and free-troposphere transport. Within the canopy, several interactions unfold among soil, atmosphere, and plants, shaping the overall dynamics. Also, the mixing ratio of biogenic VOCs (BVOCs) clearly varied with rainfall, driven by factors such as light, temperature, physical transport, and soil processes. Our results disentangle the patterns in the trace gas mixing ratio in the course of sudden and vigorous atmospheric mixing during rainfall events. By selectively uncovering processes that are not clearly detectable under undisturbed conditions, our results contribute to a better understanding of the trace gas life cycle and its interplay with meteorology, cloud dynamics, and rainfall in the Amazon.

Published
2024

7. Utilising Narrative Medicine to Identify Key Factors Affecting Quality of Life in Dry Eye Disease: An Italian Multicentre Study

Author

Aragona, Pasquale, Barabino, Stefano, Akbas, Ertugrul, Ryan, Robert, Landini, Linda, Marini, Maria G., Fiorencis, Alessandra, Cappuccio, Antonietta, Leonardi, Andrea, Vercesi, Antonio, Frisina, Rino, Bandello, Francesco, Berchicci, Luigi, Aragona, Emanuela, Semeraro, Francesco, Romano, Vito, Di Carlo, Igor, Reibaldi, Michele, Ghilardi, Andrea, De Cillà, Stefano, Marchini, Giorgio, Tognetto, Daniele, Fontana, Luigi, Versura, Piera, D’Eliseo, Domenico, Mularoni, Alessandro, Cagini, Carlo, Mencucci, Rita, Coassin, Marco, Di Zazzo, Antonio, Rizzo, Stanislao, Fasciani, Romina, Gualdi, Luca, Cusumano, Andrea, Spadea, Leopoldo, Cantera, Emily, Scorcia, Vincenzo, Giannaccare, Giuseppe, Rosa, Pasquale, Troisi, Salvatore, Provenzano, Antonio, Simonelli, Francesca, Marullo, Michele, Ciracì, Lorenza, Costagliola, Ciro, Primavera, Vito, Gagliano, Caterina, Pinna, Antonio, Giovanni, Alessio, Boscia, Francesco, Gelso, Aldo, Mastropasqua, Leonardo, Bonfiglio, Enza, Rolando, Maurizio, and Bonini, Stefano

Published
2024
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8. Biliary drainage in patients with malignant distal biliary obstruction: results of an Italian consensus conference

Author

Marzioni, Marco, Crinò, Stefano Francesco, Lisotti, Andrea, Fuccio, Lorenzo, Vanella, Giuseppe, Amato, Arnaldo, Bertani, Helga, Binda, Cecilia, Coluccio, Chiara, Forti, Edoardo, Fugazza, Alessandro, Ligresti, Dario, Maida, Marcello, Marchegiani, Giovanni, Mauro, Aurelio, Mirante, Vincenzo Giorgio, Ricci, Claudio, Rizzo, Giacomo Emanuele Maria, Scimeca, Daniela, Spadaccini, Marco, Arvanitakis, Marianna, Anderloni, Andrea, Fabbri, Carlo, Tarantino, Ilaria, and Arcidiacono, Paolo Giorgio

Published
2024
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11. Thrombectomy in ischemic stroke patients with tandem occlusion in the posterior versus anterior circulation

Author

Cappellari, Manuel, Pracucci, Giovanni, Saia, Valentina, Mandruzzato, Nicolò, Valletta, Francesco, Sallustio, Fabrizio, Casetta, Ilaria, Fainardi, Enrico, Da Ros, Valerio, Diomedi, Marina, Capasso, Francesco, Nencini, Patrizia, Vallone, Stefano, Bigliardi, Guido, Tessitore, Agostino, La Spina, Paolino, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Ruggiero, Maria, Longoni, Marco, Castellan, Lucio, Malfatto, Laura, Saletti, Andrea, De Vito, Alessandro, Menozzi, Roberto, Scoditti, Umberto, Simonetti, Luigi, Zini, Andrea, Lafe, Elvis, Cavallini, Anna, Lazzarotti, Guido Andrea, Giannini, Nicola, Boghi, Andrea, Naldi, Andrea, Romano, Daniele, Napoletano, Rosa, Comai, Alessio, Franchini, Enrica, Cavasin, Nicola, Critelli, Adriana, Giorgianni, Andrea, Cariddi, Lucia Princiotta, Semeraro, Vittorio, Boero, Giovanni, Zimatore, Domenico Sergio, Petruzzellis, Marco, Biraschi, Francesco, Nicolini, Ettore, Pedicelli, Alessandro, Frisullo, Giovanni, Calzoni, Andrea, Tassinari, Tiziana, Gallesio, Ivan, Sepe, Federica, Filauri, Pietro, Sacco, Simona, Lozupone, Emilio, Rizzo, Annalisa, Besana, Michele, Giossi, Alessia, Pavia, Marco, Invernizzi, Paolo, Amistà, Pietro, Russo, Monia, Florio, Francesco, Inchingolo, Vincenzo, Filizzolo, Marco, Mannino, Marina, Mangiafico, Salvatore, and Toni, Danilo

Published
2024
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13. Validation of the Quality Analysis of Medical Artificial Intelligence (QAMAI) tool: a new tool to assess the quality of health information provided by AI platforms

Author

Vaira, Luigi Angelo, Lechien, Jerome R., Abbate, Vincenzo, Allevi, Fabiana, Audino, Giovanni, Beltramini, Giada Anna, Bergonzani, Michela, Boscolo-Rizzo, Paolo, Califano, Gianluigi, Cammaroto, Giovanni, Chiesa-Estomba, Carlos M., Committeri, Umberto, Crimi, Salvatore, Curran, Nicholas R., di Bello, Francesco, di Stadio, Arianna, Frosolini, Andrea, Gabriele, Guido, Gengler, Isabelle M., Lonardi, Fabio, Maglitto, Fabio, Mayo-Yáñez, Miguel, Petrocelli, Marzia, Pucci, Resi, Saibene, Alberto Maria, Saponaro, Gianmarco, Tel, Alessandro, Trabalzini, Franco, Trecca, Eleonora M. C., Vellone, Valentino, Salzano, Giovanni, and De Riu, Giacomo

Published
2024
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18. An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress

Author

Sorge, Matteo, Savoré, Giulia, Gallo, Andrea, Acquarone, Davide, Sbroggiò, Mauro, Velasco, Silvia, Zamporlini, Federica, Femminò, Saveria, Moiso, Enrico, Morciano, Giampaolo, Balmas, Elisa, Raimondi, Andrea, Nattenberg, Gabrielle, Stefania, Rachele, Tacchetti, Carlo, Rizzo, Angela Maria, Corsetto, Paola, Ghigo, Alessandra, Turco, Emilia, Altruda, Fiorella, Silengo, Lorenzo, Pinton, Paolo, Raffaelli, Nadia, Sniadecki, Nathan J, Penna, Claudia, Pagliaro, Pasquale, Hirsch, Emilio, Riganti, Chiara, Tarone, Guido, Bertero, Alessandro, and Brancaccio, Mara

Published
2024
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19. Radioligand therapy in the therapeutic strategy for patients with gastro-entero-pancreatic neuroendocrine tumors: a consensus statement from the Italian Association for Neuroendocrine Tumors (Itanet), Italian Association of Nuclear Medicine (AIMN), Italian Society of Endocrinology (SIE), Italian Association of Medical Oncology (AIOM).

Author

Panzuto, Francesco, Albertelli, Manuela, De Rimini, Maria Luisa, Rizzo, Francesca Maria, Grana, Chiara Maria, Cives, Mauro, Faggiano, Antongiulio, Versari, Annibale, Tafuto, Salvatore, Fazio, Nicola, Colao, Annamaria, Scalorbi, Federica, Ferone, Diego, Cinieri, Saverio, and Maccauro, Marco

Published
2024
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22. Enfortumab Vedotin Following Platinum Chemotherapy and Avelumab Maintenance in Patients with Metastatic Urothelial Carcinoma: A Retrospective Data from the ARON-2EV Study

Author

Fiala, Ondřej, Massari, Francesco, Basso, Umberto, Giannatempo, Patrizia, Grande, Enrique, Buti, Sebastiano, Myint, Zin W., De Giorgi, Ugo, Pichler, Renate, Grillone, Francesco, Ürün, Yüksel, Calabrò, Fabio, Bourlon, Maria T., Galli, Luca, Kanesvaran, Ravindran, Roviello, Giandomenico, Kucharz, Jakub, Rizzo, Mimma, Park, Se Hoon, Cerbone, Linda, Seront, Emmanuel, Messina, Carlo, Molina-Cerrillo, Javier, Santini, Daniele, Yano, Akihiro, Incorvaia, Lorena, Catalano, Martina, Pinto, Alvaro, Formisano, Luigi, Soares, Andrey, Facchini, Gaetano, Fornarini, Giuseppe, Poprach, Alexandr, Rebuzzi, Sara Elena, Nasso, Cecilia, Spinelli, Gian Paolo, Angel, Martin, Stellato, Marco, Tural, Deniz, Aurilio, Gaetano, Epstein, Ilana, Carrozza, Francesco, Monteiro, Fernando Sabino Marques, Benedetti, Giovanni, Büchler, Tomáš, Ortega, Cinzia, Zakopoulou, Roubini, Battelli, Nicola, Porta, Camillo, Bellmunt, Joaquin, Gupta, Shilpa, and Santoni, Matteo

Published
2024
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29. Pembrolizumab in patients with advanced upper tract urothelial carcinoma: a real-world study from ARON-2 project

Author

Rizzo, Alessandro, Buti, Sebastiano, Giannatempo, Patrizia, Salah, Samer, Molina-Cerrillo, Javier, Massari, Francesco, Kopp, Ray Manneh, Fiala, Ondřej, Galli, Luca, Myint, Zin W., Tural, Deniz, Soares, Andrey, Pichler, Renate, Mennitto, Alessia, Abahssain, Halima, Calabrò, Fabio, Monteiro, Fernando Sabino M., Albano, Anna, Mollica, Veronica, Giudice, Giulia Claire, Takeshita, Hideki, and Santoni, Matteo

Published
2024
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35. Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Author

Zumerle, Sara, Sarill, Miles, Saponaro, Miriam, Colucci, Manuel, Contu, Liliana, Lazzarini, Edoardo, Sartori, Roberta, Pezzini, Camilla, Rinaldi, Anna, Scanu, Anna, Sgrignani, Jacopo, Locatelli, Patrizia, Sabbadin, Marianna, Valdata, Aurora, Brina, Daniela, Giacomini, Isabella, Rizzo, Beatrice, Pierantoni, Alessandra, Sharifi, Saman, Bressan, Silvia, Altomare, Claudia, Goshovska, Yulia, Giraudo, Chiara, Luisetto, Roberto, Iaccarino, Luca, Torcasio, Cristina, Mosole, Simone, Pasquini, Emiliano, Rinaldi, Andrea, Pellegrini, Laura, Peron, Gregorio, Fassan, Matteo, Masiero, Stefano, Giori, Andrea Maria, Dall’Acqua, Stefano, Auwerx, Johan, Cippà, Pietro, Cavalli, Andrea, Bolis, Marco, Sandri, Marco, Barile, Lucio, Montopoli, Monica, and Alimonti, Andrea

Published
2024
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40. Modern Management of Cardiometabolic Continuum: From Overweight/Obesity to Prediabetes/Type 2 Diabetes Mellitus. Recommendations from the Eastern and Southern Europe Diabetes and Obesity Expert Group

Author

Janez, Andrej, Muzurovic, Emir, Bogdanski, Pawel, Czupryniak, Leszek, Fabryova, Lubomira, Fras, Zlatko, Guja, Cristian, Haluzik, Martin, Kempler, Peter, Lalic, Nebojsa, Mullerova, Dana, Stoian, Anca Pantea, Papanas, Nikolaos, Rahelic, Dario, Silva-Nunes, José, Tankova, Tsvetalina, Yumuk, Volkan, and Rizzo, Manfredi

Published
2024
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43. Oromandibular dystonia: from onset to spread a multicenter italian study

Author

Trinchillo, Assunta, Esposito, Marcello, Terranova, Carmen, Rizzo, Vincenzo, Fabbrini, Giovanni, Ferrazzano, Gina, Belvisi, Daniele, Erro, Roberto, Barone, Paolo, Bono, Francesco, Di Biasio, Francesca, Bentivoglio, Anna Rita, Lettieri, Christian, Altavista, Maria Concetta, Scaglione, Cesa Lorella Maria, Albanese, Alberto, Mascia, Marcello Mario, Muroni, Antonella, Pisani, Antonio, Berardelli, Alfredo, and Defazio, Giovanni

Published
2024
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44. Pembrolizumab in Patients with Advanced Urothelial Carcinoma with ECOG Performance Status 2: A Real-World Study from the ARON-2 Project

Author

Rizzo, Alessandro, Monteiro, Fernando Sabino Marques, Ürün, Yüksel, Massari, Francesco, Park, Se Hoon, Bourlon, Maria T., Poprach, Alexandr, Rizzo, Mimma, Takeshita, Hideki, Giannatempo, Patrizia, Soares, Andrey, Roviello, Giandomenico, Molina-Cerrillo, Javier, Carrozza, Francesco, Abahssain, Halima, Messina, Carlo, Kopp, Ray Manneh, Pichler, Renate, Formisano, Luigi, Tural, Deniz, Atzori, Francesco, Calabrò, Fabio, Kanesvaran, Ravindran, Buti, Sebastiano, and Santoni, Matteo

Published
2024
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45. Chorioretinal biomarkers in hypothalamic amenorrhea

Author

Savastano, Maria Cristina, Fossataro, Claudia, Carlà, Matteo Mario, Cestrone, Valentina, Biagini, Ilaria, Sammarco, Leonardo, Giannuzzi, Federico, Fasciani, Romina, Apa, Rosanna, Lanzone, Antonio, Diterlizzi, Alice, Policriti, Martina, Di Stasio, Enrico, Killian, Raphael, Rizzo, Clara, and Rizzo, Stanislao

Published
2024
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46. Virtual Learning Decreases the Carbon Footprint of Medical Education.

Author

Sharma, Divya, Rizzo, Julianne, Nong, Yvonne, Murase, Lilia, Fong, Sydney, Lo, Kenny, Rosenbach, Misha, Murase, Jenny, and Sivamani, Raja

Subjects
Carbon dioxide emissions, Conference, Emissions, Greenhouse gas, In-person conferences, Travel, Virtual learning
Abstract

INTRODUCTION: The environmental impact of holding in-person academic conferences and continuing medical education (CME) programs can be significant. In-person conferences provide a unique social and professional platform to engage in networking and foster professional development; however, there is an opportunity for hybrid and virtual platforms to provide CME for broader audiences looking to improve their clinical skills and strengthen their knowledge base. This study seeks to describe the reduction in carbon emissions associated with a webinar hosted by an online dermatology-focused medical education platform. METHODS: This cross-sectional study used the location of deidentified virtual attendees of a webinar to predict the carbon emissions produced if attendees had instead traveled to the location of the most recent Integrative Dermatology Symposium (Sacramento, CA). Following collection of each virtual attendees location, the mode of transportation was predicted on the basis of each participants distance to the conference. RESULTS: The estimated carbon emissions were calculated for 576 participants. The total estimated, unadjusted carbon emissions for both attendees predicted to fly or drive was 370,100 kg CO2. The emissions produced per participant from those expected to fly to an in-person CME after adjusting for all additional passengers on every flight were 4.5 kg CO2. The emissions produced per participant from those expected to drive were 42.7 kg CO2. CONCLUSION: The use of a virtual CME webinar led to a significant reduction in travel-related carbon dioxide emissions when compared to running the same program in-person event. When accounting for all passengers traveling via plane on any flight, driving to an event produced more emissions per participant than flying.

Published
2024

47. Academic Verb Knowledge of DHH College Students and Their Hearing Peers

Author

Gerald P. Berent, Ronald R. Kelly, Susan P. Rizzo, Zhong Chen, Tanya Schueler-Choukairi, Kimberly Persky, Kathryn L. Schmitz, and Stanley Van Horn

Abstract

This study addressed the critical gap in research on the academic English vocabulary knowledge of deaf and hard-of-hearing (DHH) students at the college level, with a specific focus on academic English verbs. An English vocabulary test was developed to assess knowledge of academic verbs at three distinct corpus-defined lexical frequency ranges. The test was administered to the DHH students along with two comparison groups of college peers--students of English as an Additional Language (EAL) and hearing native-English-speaking students. Results revealed near-ceiling performance by hearing native speakers but significant vocabulary challenges in the DHH and EAL learner groups, who exhibited parallel lexical knowledge. Learner group performance increased as verb frequency range increased and as overall English proficiency level increased. The findings demonstrate that lexical frequency effects guide English verb acquisition in the targeted populations.

Published
2024
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48. Efficacy and safety of treat-and-extend intravitreal brolucizumab in naive and switched patients with macular neovascularization: one-year follow-up study

Author

Francesco Faraldi, Carlo Alessandro Lavia, Marco Nassisi, Raphael Kilian, Clara Rizzo, Maria Cristina Savastano, Stanislao Rizzo, Fabrizio Giansanti, and Daniela Bacherini

Subjects
Intravitreal Brolucizumab, Macular neovascularization, Treat and extend, Naïve patients, Switched patients, Intravitreal injection interval, Ophthalmology, RE1-994
Abstract

Abstract Background to analyze, at one year, the efficacy and safety of treat-and-extend (T&E) intravitreal (IV) Brolucizumab in patients affected by macular neovascularization (MNV). Both naïve and previously treated (i.e., switched) patients were included, and the data from the two groups were compared. Methods anatomical (i.e., central subfoveal thickness, CST; presence of fluid), functional (i.e., best corrected visual acuity, BCVA) and treatment-related (i.e., number of IV injections within the study period; number of patients reaching a 12-weeks interval between treatments) data from 41 eyes of 41 subjects (20 naïve and 21 switched) were analyzed. Patients were treated with 3 monthly IV injections followed by a T&E regimen based on a disease activity assessment performed at each scheduled IV treatment. Results significant CST reduction (from 412.1 ± 115.8 to 273.2 ± 61.6; p

Published
2024
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