1. 肿瘤病灶体积与子宫体积比值和组织中Ki-67、p16 蛋白表达与子宫内膜癌病理特征及复发的关联.
- Author
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陈丽萍, 罗菊玉, 彭章艳, 吴秀兰, 杨宇宏, 石连炎, 李笑云, and 王灵
- Abstract
Objective To investigate the correlation between the ratio of lesion volume to uterine volume (T/U), the expression levels of Ki-67 and p16 proteins in lesion tissue, and the recurrence risk of endometrial cancer. Methods A total of 150 patients diagnosed with endometrial carcinoma through pathological examination at Qiandongnan Prefecture People's Hospital were enrolled for follow-up observation. Among them, 28 patients experienced recurrence after a 2-year follow-up period, while 122 patients remained recurrence-free. The expression differences of Ki-67 protein and p16 protein in T/U and lesion tissues during surgery were compared between the two groups. Furthermore, these indexes were analyzed based on different pathological features, and the variation in relapse-free survival time was assessed among patients with distinct T/U status as well as Ki-67 and p16 protein expressions. Results The T/U value and the positive expression rate of Ki-67 protein were significantly higher in the relapsed group compared to the non-relapsed group, while the positive expression rate of p16 protein was significantly lower in the relapsed group (P < 0.05). Additionally, patients with T/U ≥ 0.18 had a significantly higher proportion of stage Ⅲ patients and patients with low histological differentiation compared to those with T/U < 0.18(P < 0.05). Furthermore, patients with positive expression of Ki-67 protein exhibited a significantly higher proportion of stage Ⅲ patients, patients with low histological differentiation, and lymph node metastasis compared to those with negative expression of Ki-67 protein (P < 0.05). The proportion of stage Ⅲ patients exhibiting positive p16 protein expression, low histological differentiation, and lymph node metastasis was significantly lower compared to those with negative p16 protein expression (P < 0.05). Patients with endometrial cancer having a T/U ≥ 0.18 experienced shorter recurrence-free survival time 2 years post-surgery in comparison to patients with T/U < 0.18(χ² = 6.962, P = 0.008). Patients displaying positive Ki-67 expression had a shorter recurrence-free survival time 2 years after surgery than those with negative Ki-67 expression (χ² = 4.815, P = 0.028). The recurrence-free survival time 2 years after surgery for patients expressing p16 protein positively was longer than that for patients expressing it negatively (χ² = 4.279, P = 0.039). The presence of FIGO stage Ⅲ, lymph node metastasis, depth of myographic invasion ≥1/2, T/U value ≥ 0.18, and positive expression of Ki-67 protein were identified as significant risk factors for postoperative recurrence in endometrial cancer (P < 0.05). Conversely, the positive expression of p16 protein was found to be a protective factor against recurrence in endometrial carcinoma following surgery (P < 0.05). Conclusion The expression of T/U, Ki-67 protein, and p16 protein in endometrial cancer patients is associated with tumor progression and may augment the risk of postoperative recurrence. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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