Search

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Rubber Industry is the property of Editorial Office of China Rubber Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To analyze the expression characteristics of plasma miR-106 b and miR-146 a, and to analyze the correlation between miR-106 b and miR-146 a and electroencephalogram parameters, helper T cell 17(Th17) and apoptosis molecules, as well as their diagnostic value in epilepsy. Methods: A total of 75 children with epilepsy admitted to our hospital from January 2018 to October 2020 were selected as the epilepsy group. The expression of plasma miR-106 b and miR-146 a of the subjects were detected, the proportion of Th17 cells in peripheral blood, the levels of serum B-cell lymphoma/leukemia-1(Bcl-1), BCL2-Associated X protein(Bax), Survivin, cysteine asparaginase(Caspase-3) and electroencephalogram parameters α, β, δ, θ wave power were measured. The correlation between miR-106 b, miR-146 a and the proportion of Th17 cells, Bcl-1, Bax, Survivin, Caspase-3, α, β, δ, θ wave power were analyzed. The value of miR-106 b and miR-146 a in the diagnosis of epilepsy was analyzed by receiver operating characteristic (ROC) curve. Results: The expressions of plasma miR-106 b and miR-146 a, the proportion of Th17 cells, the levels of serum Bax and Caspase-3 in epilepsy group were higher than those in control group(P<0.05), and the α wave power, θ wave power, the levels of Bcl-1 and Survivin were lower than those in control group(P<0.05). The expression of miR-106 b and miR-146 a were positively correlated with the proportion of Th17 cells, Bax and Caspase-3(P<0.05), and negatively correlated with α wave power, θ wave power, Bcl-1 and Survivin(P<0.05). The area under curve(AUC) of combined miR-106 b and miR-146 a in the diagnosis of epilepsy was 0.975, which was higher than that of 0.884 and 0.835 of miR-106 b and miR-146 a alone. Conclusion: The expression of plasma miR-146 a and miR-106 b of children with epilepsy is increased, and the high expression of miR-146 a and miR-106 b are related to abnormal electroencephalogram, Th17 cell dysfunction and nerve cell apoptosis, miR-146 a and miR-106 b are expected to be new biomarkers for the diagnosis of epilepsy. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)