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目的 探讨急性缺血性卒中（acute ischemic stroke，AIS）不良出院结局的影响因素，以及感染对出院结局的影响。 方法 回顾性连续纳入2019年6月—2022年6月在首都医科大学附属北京天坛医院神经内科住院治疗的AIS患者，根据出院结局分为结局良好组（mRS评分＜3分）和结局不良组（mRS评分≥3分或住院期间死亡），比较两组患者的临床特点和卒中后感染（肺部感染、尿路感染及中枢神经系统感染）等指标的差异。进一步采用多因素logistic回归分析AIS患者不良出院结局的影响因素。 结果 共纳入AIS患者1024例，平均年龄（60.3±12.4）岁，其中男性788例（77.0%），出院结局良好组761例（74.3%），结局不良组263例（25.7%）。85例患者出现卒中后感染，总体感染发生率为8.3%，其中69例（6.7%）为肺部感染，16例（1.6%）为尿路感染，3例（0.3%）为中枢神经系统感染。多因素分析结果显示，卒中后出现肺部感染（OR 2.522，95%CI 1.318～4.828，P=0.005）、合并糖尿病（OR 1.486，95%CI 1.048～2.106，P=0.026）、入院NIHSS评分升高（OR 1.286，95%CI 1.233～1.342，P＜0.001）和血白细胞计数升高（OR 1.094，95%CI 1.014～1.180，P=0.020）为AIS患者不良出院结局的危险因素。 结论 肺部感染可显著增加AIS患者出院结局不良的风险。 Abstract: Objective To explore the risk factors of adverse discharge outcomes in patients with acute ischemic stroke (AIS), and the effects of post-stroke infection on discharge outcomes. Methods AIS patients who were hospitalized in the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University from June 2019 to June 2022 were retrospectively included in this study. The patients were divided into good outcome group (mRS score

目的 探讨急性卒中患者住院期间感染的临床特征及危险因素，为制订感染预防策略提供思路。 方法 连续纳入2019年6月-2021年6月首都医科大学附属北京天坛医院神经内科收治的缺血性卒中（ischemic stroke，IS）、脑出血（intracerebral hemorrhage，ICH）及蛛网膜下腔出血（subarachnoid hemorrhage，SAH）患者，对其临床资料进行回顾性分析。根据患者住院期间是否发生感染分为感染组和非感染组，比较2组的临床特征、感染部位及时间分布，采用单因素及多因素logistic回归分析感染的危险因素。 结果 共纳入2884例急性卒中患者，男性2138例（74.1%），IS 2049例，ICH 531例，SAH 304例。426例患者住院期间出现感染，发生率为14.8%，感染发生的中位时间为卒中后4（1～7）d。IS、ICH及SAH患者的感染率分别为10.8%、21.3%和29.9%，呈逐渐升高趋势。肺脏为急性卒中后感染率最高且最早出现的感染部位。多因素分析显示，年龄增长（OR 1.038，95%CI 1.026～1.050，P＜0.001）、合并心力衰竭（OR 2.339，95%CI 1.197～4.572，P=0.013）、慢性阻塞性肺疾病（OR 3.297，95%CI 1.676～6.486，P=0.001）、卒中类型为脑出血（OR 2.162，95%CI 1.548～3.021，P＜0.001）或蛛网膜下腔出血（OR 8.271，95%CI 5.591～12.236，P＜0.001）、入院NIHSS升高（OR 1.162，95%CI 1.132～1.193，P＜0.001）及住院时间延长（OR 1.138，95%CI 1.109～1.168，P＜0.001）为急性卒中患者住院期间发生感染的独立危险因素。 结论 感染是急性卒中患者常见的并发症之一，其中肺部感染发生率高且发病时间早。年龄升高、合并心力衰竭或慢性阻塞性肺疾病、神经功能损伤较重的患者感染发生率升高，与IS相比，ICH和SAH患者的感染发生率升高。 Abstract: Objective To investigate the clinical characteristics and risk factors of infection in patients with acute stroke during hospitalization, and to provide clinical guidance for the infection prevention strategies. Methods The patients with either ischemic stroke (IS), intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH) who were admitted to Beijing Tiantan Hospital from June 2019 to June 2021 were included in this retrospective study. According to having post-stroke infection or not during hospitalization, patients were divided into infection group and non-infection group. The clinical characteristics, infection sites and time distribution were compared between two groups. Univariate and multivariate logistic regression analysis were used to determine the risk factors for post-stroke infection. Results A total of 2884 patients with acute stroke were enrolled, including 2138 (74.1%) males, 2049 patients with IS, 531 patients with ICH, and 304 patients with SAH. 426 (14.8%) patients developed infection during hospitalization, with a median infection time of 4 (1-7) days after stroke. The infection rates were 10.8%, 21.3% and 29.9% in patients with IS, ICH and SAH, respectively, showing a significant increasing trend. Lung was the highest and earliest infection site in patients with acute stroke. Multivariate analysis showed that increasing age (OR 1.038, 95%CI 1.026-1.050, P

Copyright of Coal Geology & Exploration is the property of Xian Research Institute of China Coal Research Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper explores the reform directions and practical measures implemented by the Chemistry Experiment Teaching Demonstration Center at Shanxi University within the framework of first-class major construction. The center focuses on the coordinated development of students’ “knowledge, abilities, and qualities”, adhering to the “Three-Holistic-Education”, and with the characteristic development direction of “leveraging chemistry strengths and serving Shanxi's coal-based industry”, has taken innovative experiments, virtual simulation experiments, and curriculum group construction as the main approaches, implementing a series of reform measures and achieving remarkable results. [ABSTRACT FROM AUTHOR]

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In this paper, we investigate the space-time pointwise behaviors of global solutions to the pressureless Euler-Navier-Stokes system in three dimensions, which characterizes the motion of a twophase fluid. First, we construct the Green's function for the linearized system, which consists of the Huygens wave, the diffusion wave, the Riesz wave, and the singular part containing the stationary delta wave arising from the pressureless structure. Then, under the assumptions on the initial data with appropriate spatial decay rates, we obtain the space-time pointwise estimates of global solutions to the Cauchy problem for the linearized system. [ABSTRACT FROM AUTHOR]

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The abnormal concentration of adenosine 5-triphosphate (ATP) in cancer cells is closely related to the process of tumorigenesis and development. Therefore, rapid and accurate detection of ATP level in and out of cells is of great significance. Graphene oxide (GO) is widely used owing to its advantages of low toxicity, large specific surface area, easy functionalization, efficient and stable loading of DNA nanoprobes into cells. However, ssDNA bound to GO by physical adsorption is easily displaced by biomolecules in complex biological environment, leading to false positive signals. Based on this, a novel GO-DNA nanoprobe is proposed and applied to the detection of ATP and targeted delivery of the anticancer drug doxorubicin hydrochloride (DOX). Double stranded DNA (dsDNA) is formed by hybridization of aptamer of ATP with complementary strand, and then DOX is loaded by G-C base pair to form dsDNA-DOX. dsDNA-DOX is adsorbed on GO surface through polyA sequence extended by complementary strand to construct GO-dsDNADOX nanoprobes, which could greatly reduce false positive signal caused by the physical adsorption of biomolecules in complex environment. The specific binding of ATP to aptamer can lead to the release of DOX, and quantitative analysis of ATP is achieved according to its fluorescence “off-on”. DOX fluorescence intensity shows a good linear relationship with the ATP content within the range of 0. 08~8. 0 mmol/L, and the linear equation is IF=3. 0897c+129. 08. The detection limit (3σ/k) is 0. 059 mmol/L, and the method has good selectivity and anti-interference ability. Cytotoxicity and fluorescence imaging results show that the DOXloaded nanoprobes have significant drug release in MCF-7 cells and significantly induce apoptosis. This study establishes a label-free, simple and rapid method for ATP content detection and realizes targeted drug delivery by the high content of ATP in cancer cells, which reduces the toxic and side effects on normal cells and provides a new idea for cancer treatment. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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To investigate the soil hydraulic characteristics across a wide range of suctions (0-10 MPa) of Benggang soil, the soil water holding capacities of different soil layers in Benggang was determined using the pressure film meter and the filter paper methods. Traditional and modified Van Genuchten-Mualem (VG) models were used to fit the soil moisture characteristics curves. The results showed that the water-holding curves determined by the pressure film meter and filter paper methods intersected and tended to overlap. This observation suggested combining the two measurement methods to obtain soil moisture characteristic curves over a wide suction range. Further, within the wide suction range, the water-holding capacity of the sandy soil layer was higher than that of the red and detritus soil layers in the low suction stage (h<0.1 MPa). However, in the high suction stage (h>0.1 MPa), the red soil layer had the highest water-holding capacity. Both the traditional and modified VG models were able to fit the soil moisture characteristics of each soil layer of the Benggang wall with a root mean square error of less than 0.021 5. The Nash efficiency and correlation coefficients were greater than 0.926 6 and 0.899 1, respectively. Noticeably, the modified VG model was more suitable for describing the soil moisture characteristic curves of the Benggang wall across a wide suction range. The residual values of the soil moisture characteristic curves for the red, sandy, and detritus layers were 378 kPa (corresponding to a water content of 18.82%), 173 kPa (corresponding to a water content of 18.95%), and 92 kPa (corresponding to a water content of 18.41%), respectively. Finally, the form of the segmental function (with the residual value as the inflection point) was more suitable for describing the unsaturated hydraulic conductivity over a wide suction range of Benggang soils than the conventional VG model. [ABSTRACT FROM AUTHOR]

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In this paper, selenated konjac glucomannan (SeKGM) and sulfhydrated sodium al- ginated (TSA) were prepared, following crosslinking using calcium lactate (CL) and obtaining SeKGM-TSA/Ca2+ microgel. Then SeKGM-TSA/Ca2+ @Q was fabricated after querce-tin (Q) loading. Fourier transform infrared spectroscopy (FT-IR) was selected to confirm the chemical structure of microgel, and the morphology of microgel was observed by TEM. The SeKGM-TSA/Ca2+ @Q microgel possessed an uniform spherical morphology with a particle size of 88.8±13. 56 nm. Moreover, OH scavenging rate, mucoadhesion behavior andin vitro Q release behavior of microgel were investigated. the results showed that the · OH scavenging rate of SeKGM-TSA/Ca2+ @Q was 50. 2% +1. 12% and the adhesion to mucin was up to 141.0±0. 46 mg. This work proposed a meaningful strategy for intestinal targeted delivery of Q by using microgel with acidproof. intestinal adhesive properties and ROS scavenging effect. [ABSTRACT FROM AUTHOR]

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In the traditional “acetone iodination” experiment, there are problems such as corrosion, irritation caused by HCl volatilization, and inconsistent temperature or time between the spectrophotometric test and the actual reaction process. These problems are inevitably encountered and have not been effectively addressed. With a focus on these problems, the improved experiment presented a colorimetric analysis system based on a smartphone and new glass reactor; the test method was also proposed. The improved experiment avoids instrument corrosion, human body stimulation caused by HCl, improves the accuracy of the experimental data, and is helpful for students to gain theoretical and experimental expertise on the Lambert-Beer law and its offset phenomenon. In addition, since a spectrophotometer is not required, the improved experiment is easier to popularize and more interesting. It also provides a new strategy for online experimental teaching under difficult conditions such as the epidemic. [ABSTRACT FROM AUTHOR]

Copyright of Basic & Clinical Medicine is the property of Editorial Office of Basic & Clinical Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective·To explore the effect of continuous positive urine ketone body in pregnant women with gestational diabetes mellitus (GDM) on the maternal and infant outcomes. Methods·A total of 168 GDM pregnant women who attended the Nutrition Clinic of the International Peace Maternal & Child Health Hospital, Shanghai Jiao Tong University School of Medicine from January 2021 to January 2022 and gave birth in the hospital were selected as the study subjects. According to the difference of urine ketone body test results in prenatal examination, they were divided into ketone body-positive group (56 cases, the pregnant women had ketone body test positive for three times or more after the diagnosis of GDM) and ketone body-negative group (112 cases, the ketone body test was continuously negative after the diagnosis of GDM). The general information included clinical data and laboratory indicators of pregnant women and clinical outcomes of pregnant women and their newborns were collected and compared. Results·There were no statistically significant differences in clinical data and laboratory indicators of pregnant women between the two groups, among which the body mass index before pregnancy, weight change before diagnosis of GDM, family history of diabetes mellitus, history of GDM, total cholesterol and triacylglycerol levels in the early pregnancy, fasting blood glucose and insulin levels in the middle pregnancy had no significant correlation with the production of urine ketone body. The results of clinical outcome indicators of pregnant women showed that there were statistically significant differences in weight change (P= 0.000; RR=6.000, 95% CI 1.251 ‒ 28.777) and rate of weight gain (P=0.000; RR=1.829, 95% CI 1.132 ‒ 2.953) after diagnosis of GDM between the two groups. The results of neonatal clinical outcome indicators showed that there was statistically significant difference in the neonatal hospitalization rate (P=0.023; RR=2.167, 95% CI 1.059 ‒ 4.434) between the two groups; among them, there were 4 adverse events in the ketone body positive group and no such adverse events in the ketone body negative group. Conclusion·The continuous positive urine ketone body of pregnant women with GDM may increase the risk of insufficient weight gain in pregnant women and neonatal hospitalization. It is recommended to timely detect and intervene in clinical practice. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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The Ag@AgCl/Bi4Ti3O12photocatalyst was used to treat the methylene blue solution under visible light. The effects of the photocatalyst dosage, the pH value of the wastewater and the photodeposition time on the degradation effect were investigated. The photocatalytic reaction kinetic analysis was performed. The results show that when the photocatalyst dosage is 180 mg, the pH value is 10,and the photodeposition time is 30 min, the degradation effect of 200 mL of 10 mg/L MB solution for 60 min with a 300 W xenon lamp. The photocatalytic decolorization rate reaches 98.96%,the first-order reaction kinetics of the Ag@AgCl/Bi4Ti3O12 catalytic degradation of MB solution under visible light has a good fit value, the surface reaction rate k reaches 0.074 11 min-1,and the half-life t1/2 is 9.35 min, which further proves that Ag@AgCl/Bi4Ti3O12 has better catalytic performance. [ABSTRACT FROM AUTHOR]

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