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Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of inhibiting miR-767-5p on migration, invasion and epithelial-mesenchymal transition（EMT）of breast cancer cells. Methods Breast cancer cells were cultured in vitro, and miR-767-5p inhibitor and inhibitor NC were transfected into breast cancer cells. The cells were divided into three groups： Control group, miR-767-5p inhibitor group and inhibitor-NC group. The effects of miR-767-5p inhibitor on the proliferation, invasion and migration of breast cancer cells were detected by CCK-8 assay, Transwell Migration assay and scratch test. Western blot was used to detect the expression levels of migration related proteins MMP-2 and MMP-9. The dual luciferase reporter gene experiment verifies the targeted binding effect of miR-767- 5p and IGF1. RT-qPCR and Western blot experiments were used to detect the expression levels of IGF1 mRNA and protein. Western blot was used to detect the expression level of EMT related proteins. Results CCK-8 assay showed that compared with the control group and inhibitor-NC group, the miR-767-5p inhibitor group significantly inhibited the proliferation of MCF-7 cells（P < 0.05）. Transwell assay showed that the number of invasive cells of breast cancer cells in miR-767-5p inhibitor group was significantly lower than that in control group and inhibitor NC group （P < 0.05）. Scratch test showed that compared with the control group and inhibitor NC group, the migra⁃ tion rate of breast cancer cells in miR-767-5p inhibitor group decreased significantly （P < 0.05）. Luciferase re⁃ porter gene assay showed that miR-767-5p targeted IGF1 binding. Western blot showed that compared with the con⁃trol group and inhibitor NC group, the expression level of E-cadherin protein in the miR-767-5p inhibitor group was significantly increased （P < 0.05）, while the expression levels of N-cadherin, MMP-2, and MMP-9 protein were significantly reduced （P < 0.05）. Compared with the control group and inhibitor-NC group, the mRNA and protein expression levels of IGF1 in the miR-767-5p inhibitor group were significantly reduced （P < 0.05）. Conclu⁃ sion Suppressing the expression of miR-767-5p may inhibit the proliferation, invasion, migration and EMT of breast cancer cells by down-regulating IGF1. [ABSTRACT FROM AUTHOR]

Copyright of Engineering Management & Technology Discussion is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Science Research & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Cancer Biotherapy is the property of Editorial Office of Chinese Journal of Cancer Biotherapy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to test the energy saving and emission reduction effect of carbon emission trading policy pilot in China, this paper takes 287 prefecture-level cities as research samples from 2007 to 2018, measures the urban energy-environment efficiency from two dimensions, which are energy-environmental performance index and unified energy-environmental performance index, and uses the quasi-natural experiment method of difference-in-difference to examine the effect of carbon emission trading policy on energy environment efficiency and examines its influence mechanism. The results show that the carbon emission trading policy pilot can effectively promote the improvement of urban energy and environmental efficiency and promote urban energy conservation and emission reduction. Further research shows that the effect of carbon emission trading policy pilot is influenced by urban industrial structure, green innovation intensity and factor market development. In addition, carbon emission trading policy has a more significant role in promoting energy-environment efficiency of large-scale cities and old industrial base cities. Therefore, the further promotion process of carbon emission trading policy in China should focus on industrial structure optimization, green innovation incentive and factor market marketization, and focus on large cities, old industrial cities, so as to achieve the improvement of China’s overall energy environment efficiency. [ABSTRACT FROM AUTHOR]

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Southwest China Journal of Agricultural Sciences is the property of Editorial Department of Southwest China Journal of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The mechanical environment of cartilage with osteoarthritis at all levels has a certain influence on the development of osteoarthritis. Computer simulation provides a method to quantify the mechanical environment of knee joint cartilage, which makes it possible to study the mechanical behavior of osteoarthritis cartilage by finite element method. OBJECTIVE: To study the stress distribution of cartilage and the change rule of fluid velocity in cartilage of healthy adults and cartilage with osteoarthritis at all levels through numerical simulation so as to explore the mechanical behaviors of cartilage with osteoarthritis at gait cycle. METHODS: The knee joint data of healthy adults were obtained by CT and MRI scanning, and the three-dimensional finite element model of the whole knee joint was established by Abaqus software. The software HyperMesh was used to divide the mesh of the total knee joint, and the binding relationship and interaction between internal components of the knee was set. By changing the material properties of cartilage and adjusting the time length of each phase and the angle between femur and tibial plateau, the cartilage load and boundary conditions of healthy adults and osteoarthritis at all levels could be set in the model. RESULTS AND CONCLUSION: (1) The simulation results showed that the mean Mises stress and the change curves of fluid velocity in the femur cartilage and tibia cartilage increased firstly and then decreased in the gait cycle. (2) Compared with healthy adults, the Mises stress of cartilage in patients with osteoarthritis at all levels continually decreased with duration of disease. The flow velocity of fluid in cartilage firstly increased and then decreased when it developed to osteoarthritis grade 3, and the change range of Mises stress and fluid flow velocity of cartilage with osteoarthritis at all levels decreased. (3) Therefore, with the continuous development of osteoarthritis, the fluid flow velocity increased, the Mises stress decreased and the range of joint surface stress changes decreased in a gait cycle, which lead to the weakening of joint bearing and cushioning capacity. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agriculturae Zhejiangensis is the property of Acta Agriculturae Zhejiangensis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shenyang Agricultural University is the property of Journal of Shenyang Agricultural University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

MicroRNAs ( miRNAs) ait involved in ihe pathological and physiological process of life activities, and some of them exist stably and abundantly in serum, plasma, and other body fluids. Previous studies have indicated that there are significant differences in the expression patterns of circulating miRNAs between patients with viral hepatitis, liver fibrosis, liver cirrhosis, hepatocellular carcinoma, drug -induced hepatitis, and other hepatobiliary diseases at different disease stages. Among these circulating miRNAs. some can act as novel noninvasive biomarkers for the early diagnosis, disease progression, and prognostic evaluation of related diseases. The latest research advances in circulating miRNAs for the diagnosis of hepatobiliary diseases are reviewed. [ABSTRACT FROM AUTHOR]