Search

Abstract Carbon dots (CDs) were paid more and more attention for detecting ferric ions (Fe3+) containing in the organism or environment. Thus, nitrogen and phosphorus co‐doping green CDs were synthesized using p‐Phenylenediamine as the carbon source and phosphoric acid as phosphorus source by the solvo‐thermal method. As‐prepared CDs were characterized by morphology, optical properties, and surface functional groups. The CDs can emit better green light peak at 511 nm excited by 380 nm UV light. Excitation independence property of N, P‐CDs was determined by measuring the photoluminescence (PL) spectra with different excitation wavelengths. The ions detection ability was investigated by analyzing the emission intensity of CDs in eight different kinds of ions solutions and different concentrations of Fe3+ ions solutions. The N, P‐CDs show high selectivity towards Fe3+ ions with a limit of detection (LOD) of 0.11 μM in the concentration region of 300 to 450 μM. The results illuminated that this kind of CDs can be a candidate material for Fe3+ ions detection.

The physical and mechanical properties of recycled coarse aggregate (RCA) are worse than those of natural coarse aggregate (NCA), and the overall performance of recycled concrete prepared from RCA is worse than that of natural aggregate concrete. Treatment of RCA by CO2-accelerated carbonation effectively improves the macroscopic properties of RCA. The degree of influence of raw material factors, i.e., the original concrete strength (OCS) and initial moisture content (IMC) of RCA, on the carbonation of RCAs is very complex. Herein, an accelerated carbonation experiment for RCA with different material factors as variables was carried out to explore the influence of the abovementioned factors on the physical properties of carbonated recycled coarse aggregate (CRCA). By analyzing the microstructure of the RCA with the best modification effect before and after carbonation, the carbonation modification mechanism of the RCA was revealed. The physical performance indexes, including the apparent density, water absorption and carbonation rate, of the dried RCA with an OCS of C40 and C50 were significantly improved. The research results can provide basic data and theoretical support for promoting the popularization and application of RCA and recycled concrete in practical engineering.

This study aims to explore the correlation between the activity trajectory of Crested Ibis and meteorological changes. The trajectory data of Crested Ibis were obtained using the HQBG3621L backpack-style tracker, and the spatiotemporal characteristics of the trajectory data were analyzed to obtain information on the activity range and habitat of Crested Ibis. The Scheirer–Ray–Hare test and Kruskal–Wallis test were used to investigate the impact of meteorological factors on the activity of Crested Ibis. The study found that meteorological factors have a certain influence on the habitat selection and activity patterns of Crested Ibis. Through this research, a better understanding of the interaction between Crested Ibis and the meteorological environment can be achieved, providing a scientific basis for the conservation and ecological management of Crested Ibis.

Objective: This study aimed to improve the tenderness and flavor content of Yanbian cattle beef. Methods: Rump beef of Yanbian cattle were dry-aged by using three different methods, i.e., Method A: RH（65±5）% aging for 10 days, RH（75±5）% aging for 10 days, and then RH （85±5）% aging for 20 days; Method B: RH（75±5）% aging for 20 days and then RH（85±5）% aging for 20 days; Method C: RH（85±5）% aging for 40 days. The quality changes caused by the different aging processes were then analyzed and compared. Results: The cooking loss of the beef processed by all the three methods increased significantly with the extension of aging time, but the beef loss (39.14%) in Group A was the highest. The TBARS and TVB-N values of group C were 1.387 and 14.833, respectively, significantly higher than those of the other two groups. The fat and protein contents of each group showed an increasing trend, while the shear force value decreased by 50%. No significant difference in the changes of cooking loss rate, color and pH value were found among the groups. The results showed that with dry-aging, the richness of taste attributes was elevated with higher freshness and aftertaste. The bitterness in group B was lower, and the relative content of aldehydes and ketones among volatile flavor compounds was higher. Conclusion: Method B was the best dry-aging process for Yanbian cattle rump beef.

ObjectiveTo explore the mediating role of depression in the relationship between family functioning and suicidal ideation (SI) in college students, and to explore whether acceptance (It is one of the core components of psychological flexibility) plays a moderating role in this mediating model.MethodsIn a cross-sectional study, questionnaires were distributed to college students during November and December 2022. The sample of Chinese college students (n = 592, 43.07% male, 56.93% female, mean age 19.40 years, SD = 1.24 years) completed the Family Adaptability and Cohesion Evaluation Scale (FACES III), the Center for Epidemiological Depression Scale (CES-D), the Positive and Negative Suicide Ideation Inventory (PANSI), and the Acceptance and Action Questionnaire-Second Edition (AAQ II). SPSS 25.0 for Windows and PROCESS 2.15 macros were used for data analysis.ResultsThere was a significant negative correlation between family functioning and SI, and depression played a mediating role in this relationship. Acceptance moderated the indirect effects of depression and SI in college students. In college students with a lower acceptance level (i.e., higher experiential avoidance level), depression had more influence on SI, while the influence of depression on SI was less in college students with a higher acceptance level (i.e., lower experiential avoidance level). Family functioning indirectly influenced SI through the moderation of acceptance.ConclusionMental health educators in colleges and universities should pay more attention to identifying and relieving depression in college students, thereby dealing with suicide risk more effectively. At the same time, college students should be discouraged from excessive use of experiential avoidance strategies, and instead taught to master effective emotional regulation strategies such as mindfulness, distress tolerance, and radical acceptance skills to improve their acceptance level and alleviate the influence of depression on SI.

Abstract Background and objective The Cortical Bone Trajectory (CBT) technique provides an alternative method for fixation in the lumbar spine in patients with osteoporosis. An accuracy CBT screw placement could improve mechanical stability and reduce complication rates. Purpose The purpose of this study is to explore the accuracy of cortical screw placement with the application of implanted spinous process clip (SPC) guide. Methods and materials Four lumbar specimens with T12-S1 were used to access the accuracy of the cortical screw. The SPC-guided planning screws were compared to the actual inserted screws by superimposing the vertebrae and screws preoperative and postoperative CT scans. According to preoperative planning, the SPC guide was adjusted to the appropriate posture to allow the K-wire drilling along the planned trajectory. Pre and postoperative 3D-CT reconstructions was used to evaluate the screw accuracy according to Gertzbein and Robbins classification. Intraclass correlation coefficients (ICCs) and Bland–Altman plots were used to examine SPC-guided agreements for CBT screw placement. Results A total of 48 screws were documented in the study. Clinically acceptable trajectory (grades A and B) was accessed in 100% of 48 screws in the planning screws group, and 93.8% of 48 screws in the inserted screws group (p = 0.242). The incidence of proximal facet joint violation (FJV) in the planning screws group (2.1%) was comparable to the inserted screws group (6.3%) (p = 0.617). The lateral angle and cranial angle of the planned screws (9.2 ± 1.8° and 22.8 ± 5.6°) were similar to inserted screws (9.1 ± 1.7° and 23.0 ± 5.1°, p = 0.662 and p = 0.760). Reliability evaluated by intraclass correlation coefficients and Bland–Altman showed good consistency in cranial angle and excellent results in lateral angle and distance of screw tip. Conclusions Compared with preoperative planning screws and the actually inserted screws, the SPC guide could achieve reliable execution for cortical screw placement.

Composites ‘salt in porous matrix’ has been considered as a promising candidate for thermal energy storage due to their large sorption capacity, energy density and high cyclic stability. In this study, novel salt composites were prepared by using different mesoporous silica with large pore size and pore volume as the porous matrices and MgSO4 via impregnation method. The results demonstrated that both MgSO4 loading level and textural properties of the porous matrices played a critical role in determining tha vapour pressure ofe water adsorption performance of salt composites. Tested at 30 °C and a vapour pressure of 25 mbar, salt composites prepared by using mesostructured cellular foam (MCF) with 3D-interconnected porous structure exhibited excellent water adsorption capacity of 50 wt% at MgSO4 loading level of 50 wt%, which was much higher than that of commercial PQ Silica. Further characterization showed that the 3D-interconnected porous structure and large pore size of MCF benefited the dispersion of salt and the reduced diffusion resistance of vapour flux inside the pores, which could effectively improve the water adsorption capacity and hydration/dehydration rate of salt composites. All the results indicated that the novel composites are expected to be a promising candidate for low temperature energy storage.

Summarizes Weissiella spp. including the isolation and identification, biological properties, acid tolerance, bacterial inhibition, extracellular polysaccharide production, probiotic properties, histological studies, and food and pharmaceutical applications, and provides suggestions for the development and utilization of Weissiella spp.

According to the United Nations trade policy review documents, notifications, comments, special trade concerns and official authoritative research reports, the Bangladesh agricultural food product quality and safety regulatory bodies, laws and regulations, standard system, and other aspects were reviewed. It was suggested that Chinese export enterprises take advantage of local agricultural food products to actively explore the import and export trade market between China and Bangladesh. Moreover, Chinese regulators should be followed Bangladesh agricultural food products regulatory system changes, to further strengthen the assistance of agricultural and food product safety system in Bangladesh. Functional advantages can better promote bilateral trade between the two countries.

With the enrichment of data sources,data can be obtained easily but with low quality,resulting that the MVs are ubi-quitous and hard to avoid.Consequently,MV imputation has become one of the classical problems in the field of data quality mana-gement.However,most existing MV imputation approaches are proposed for static data,which cannot handle dynamic data streams arriving at high-speed.Moreover,they do not consider data sparsity and heterogeneity simultaneously.Therefore,a novel MV imputation approach,real-time imputation based on individual models (RIIM) is proposed.In RIIM,the MVs are effectively filled by combining the basic ideas of neighbors-based imputation and regression-based imputation with consideration of sparsity and heterogeneity of data.For the dynamic and real time of data streams,the MV imputation model is updated incrementally.Moreover,an adaptive and periodic updating strategy for optimal neighbors search is proposed to solve the problem of high time cost and hard to determine the number of neighbors.Finally,the effectiveness of the proposed RIIM is evaluated based on extensive experiments over real-world datasets.

Existing knowledge graph completion models learn a single static feature representation for entities and relationships by integrating multi-source information.But they can't represent the subtle meaning and dynamic attributes of entities and relationships that appear in different contexts.That is,entities and relationships will show different attributes,because they have different roles and meanings when they are involved in different triples.To solve above problems,an adaptive attention network for knowledge graph completion is proposed,which uses adaptive attention to model the contribution of each task-specified feature dimension,and generates dynamic and variable embedding representations for target entities and relationships.Specifically,the proposed model defines the neighbor encoder and the path aggregator to process two structures in the entity neighborhood subgraph,adaptively learn the attention weights to capture the most logically related features of the task,and to give the entities and relationships with fine-grained semantics in line with the current task.Experimental results in link prediction task show that,the MeanRank of the proposed model on FB15K-237 dataset is 6.9% lower than PathCon,and Hits@1 is 2.3% higher than PathCon.For the sparse datasets NELL-995 and DDB14,its Hits@1 reaches 87.9% and 98% respectively.Therefore,it proves that the introduction of adaptive attention mechanism can effectively extract the dynamic attributes of entities and relationships to generate a more comprehensive embedding representation,and improves the accuracy of knowledge graph completion.

Objective(s): The involvement of tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors.Materials and sMethods: Using female Ttc9a knockout (Ttc9a-/-) mice, the role of TTC9A in anxiety was investigated in non-social and social environments through home-cage emergence and social interaction tests, respectively, whereas aggressive behaviors were examined under the female intruder test. Results: We observed significant social behavioral deficits with pronounced social and non-social anxiogenic phenotypes in female Ttc9a-/- mice. When tested for aggressive-like behaviors, we found a reduction in offense in Ttc9a-/- animals, suggesting that TTC9A deficiency impairs the offense responses in female mice. Conclusion: Future study investigating mechanisms underlying the social anxiety-like behavioral changes in Ttc9a-/- mice may promote the understanding of social and anxiety disorders.

This study investigates the relationship between three discourse synthesis skills (i.e., quotation, summarization, and connection) and students' overall integrated writing performance in Chinese, students' first language, and English, their second language. Hierarchical regression analyses revealed that 63.6% of the variance in students' overall Chinese integrated writing performance was accounted for by the three discourse synthesis skills, with connection and summarization contributed almost equally to the overall scores. In the English test, the three skills explained 47.9% of the variance. Cross-linguistic facilitation of the L1 discourse synthesis skills to the overall L2 integrated writing performance was observed, although the predictive strength of the three skills was comparatively low. Eye-tracking data together with subsequent stimulated-recall interviews illuminated the differences in students' approaches to discourse synthesis. Findings of the study support the decisive role of discourse synthesis abilities in both L1 and L2 integrated writing assessments. Implications for writing instruction are discussed.

Background: Given that visual impairment is bi-directionally associated with depression, we examined whether transcorneal electrical stimulation (TES), a non-invasive treatment for visual disorders, can ameliorate depressive symptoms. Objective: The putative antidepressant-like effects of TES and the underlying mechanisms were investigated in an S334ter-line-3 rat model of retinal degeneration and a rat model of chronic unpredictable stress (CUS). Methods: TES was administered daily for 1 week in S334ter-line-3 and CUS rats. The effects of TES on behavioral parameters, plasma corticosterone levels, and different aspects of neuroplasticity, including neurogenesis, synaptic plasticity, and apoptosis, were examined. Results: In S334ter-line-3 rats, TES induced anxiolytic and antidepressant-like behaviors in the cylinder, open field, home cage emergence, and forced swim tests. In the CUS rat model, TES induced hedonic-like behavior and decreased behavioral despair, which were accompanied by reduced plasma corticosterone levels and upregulated expression of neurogenesis-related genes. Treatment with the neurogenesis blocker temozolomide only inhibited the hedonic-like effect of TES, suggesting the antidepressant-like effects of TES were mediated through both neurogenesis-dependent and -independent mechanisms. Furthermore, TES was found to normalize the protein expression of synaptic markers and apoptotic Bcl-2-associated X protein in the hippocampus and amygdala in the CUS rat model. The improvements in neuroplasticity may involve protein kinase B (AKT) and protein kinase A (PKA) signaling pathways in the hippocampus and amygdala, respectively, as demonstrated by the altered pAKT/AKT and pPKA/PKA ratios. Conclusion: The overall findings suggest a possible neuroplasticity mechanism of the antidepressant-like effects of TES.

Abstract Study design Retrospective cohort study. Objective To compare the early radiographic adjacent segment degeneration (R-ASD) and regional lumbar sagittal alignment after midline lumbar interbody fusion (MIDLIF) with cortical bone trajectory (CBT) screw fixation (CBT-MIDLIF) and posterior lumbar interbody fusion (PLIF) with the traditional pedicle screw fixation (PS-PLIF) during long-term follow-up. Methods All patients who underwent CBT-MIDLIF or PS-PLIF were identified by a retrospective consecutive case review. Radiographic parameters in cephalad adjacent segment (L3/4), including intervertebral space height (ISH), foraminal height (FH), foraminal width (FW), range of motion were assessed. Lumbar lordosis (LL), sacral slope (SS), L4–L5 Cobb angle, Cobb angle of the intervertebral space at L4–L5, and height of the anterior and posterior edges of the intervertebral space at L4–L5, were measured and compared on preoperative, postoperative, and 3-year follow-up radiographic evaluation. Results Seventy-four patients underwent CBT-MIDLIF (CBT-MIDLIF group) and 114 patients underwent conventional PS-PLIF (PS-PLIF group). ISH, FH and FW were significantly smaller at 6-month follow-up than before operation with PS-PLIF (p 0.05). At the last follow-up, the changes in cephalad R-ASD parameters were more remarkable after PS-PLIF than after CBT-MIDLIF (p

Abstract Objective To compare the safety and accuracy of cortical bone trajectory screw placement between the robot-assisted and fluoroscopy-assisted approaches. Methods This retrospective study was conducted between November 2018 and June 2020, including 81 patients who underwent cortical bone trajectory (CBT) surgery for degenerative lumbar spine disease. CBT was performed by the same team of experienced surgeons. The patients were randomly divided into two groups—the fluoroscopy-assisted group (FA, 44 patients) and the robot-assisted group (RA, 37 patients). Robots for orthopedic surgery were used in the robot-assisted group, whereas conventional fluoroscopy-guided screw placement was used in the fluoroscopy-assisted group. The accuracy of screw placement and rate of superior facet joint violation were assessed using postoperative computed tomography (CT). The time of single screw placement, intraoperative blood loss, and radiation exposure to the surgical team were also recorded. The χ2 test and Student’s t-test were used to analyze the significance of the variables (P

Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer’s disease. Low-grade inflammation is common in obesity, but the mechanism between inflammation and cognitive impairment in obesity is unclear. Accumulative evidence shows that quinolinic acid (QA), a neuroinflammatory neurotoxin, is involved in the pathogenesis of neurodegenerative processes. We investigated the role of QA in obesity-induced cognitive impairment and the beneficial effect of butyrate in counteracting impairments of cognition, neural morphology, and signaling. We show that in human obesity, there was a negative relationship between serum QA levels and cognitive function and decreased cortical gray matter. Diet-induced obese mice had increased QA levels in the cortex associated with cognitive impairment. At single-cell resolution, we confirmed that QA impaired neurons, altered the dendritic spine’s intracellular signal, and reduced brain-derived neurotrophic factor (BDNF) levels. Using Caenorhabditis elegans models, QA induced dopaminergic and glutamatergic neuron lesions. Importantly, the gut microbiota metabolite butyrate was able to counteract those alterations, including cognitive impairment, neuronal spine loss, and BDNF reduction in both in vivo and in vitro studies. Finally, we show that butyrate prevented QA-induced BDNF reductions by epigenetic enhancement of H3K18ac at BDNF promoters. These findings suggest that increased QA is associated with cognitive decline in obesity and that butyrate alleviates neurodegeneration.

After proposing the carbon peaking and carbon neutrality target, China further proposed a series of specific carbon emission growth limit sub-targets. How to decarbonize the energy system to ensure the realization of the carbon growth limit sub-targets is a meaningful topic. At present, generation expansion planning of renewable energy in integrated energy systems has been well studied. However, few of the existing studies consider specific carbon emission growth targets. To address this research gap, a two-stage robust generation expansion planning framework for regional integrated energy systems with carbon growth constraints is proposed in this paper, which takes into account multiple uncertainties. In this framework, the objective function is to minimize the total operation cost and wind turbine investment cost. The first stage is the decision-making level of the wind turbine capacity configuration scheme. The second stage is the optimal economic dispatching in the worst-case scenario, which is a bi-level problem of max-min form. Thus, the two-stage robust optimization framework constitutes a problem of min-max-min form, which is pretty hard to solve directly with a commercial solver. Therefore, a nested column-and-constraint generation algorithm is adopted and nested iterations are performed to solve the complex problem. Finally, case studies are carried out on a regional electric-gas integrated energy system. The MATLAB/YALMIP simulation platform with the Gurobi solver is used to verify the effectiveness and superiority of the proposed framework. Compared with other four cases, 5,000 Monte Carlo scheduling tests demonstrate that the proposed framework can ensure the system carbon emission to be controlled within a certain limit even in the worst scenario. Due to the consideration of multiple uncertainties, the proposed framework planning results are both robust and economical for investment. This study can provide theoretical support for the actual regional integrated energy system to achieve a certain carbon growth target.

Background: Allergen-specific immunotherapy (AIT) has been employed in the treatment of allergic diseases for many years. However, the effectiveness of AIT requires improvement. Substance P (SP) can interact with immune cells, modulate immune cell activity, and regulate immune reaction. The purpose of this study is to use SP as an immune regulator to enhance the therapeutic efficacy of AIT. Methods: An established mouse model of the airway allergy disorder (AAD) was employed with ovalbumin as a specific antigen. The AAD response was evaluated through established procedures. AAD mice were treated with AIT employing SP as an immune regulator. Dendritic cells were isolated from the airway tissues by magnetic cell sorting, and were analyzed by RNA sequencing (RNAseq). Results: We observed that after sensitization with ovalbumin, mice exhibited AAD-like symptoms, serum specific IgE, and Th2 polarization. The presence of SP in the course of sensitization prevented the development of AAD. Treating mice with SP by nasal instillations induced IL-10, but not TGF-β, in dendritic cells of the airway tissues. The most differentially expressed genes (DEG) in the dendritic cells were those related to the IL-10 expression, including Il10, Tac1r, and Mtor. The gene ontology analysis showed that these DEGs mainly mapped to the tachykinin-PI3K-AKT-mTOR pathway. The addition of SP substantially enhanced the therapeutic efficacy of AIT for AAD by inducing antigen specific type 1 regulatory T cells (Tr1 cells). Conclusion: Acting as an immune regulator, SP promotes the therapeutic efficacy for AAD by inducing antigen specific Tr1 cells in the airway tissues.

Integrated writing skills that emphasize integrated use of language skills and multiple source materials have attracted increasing attention in language education globally and locally in Hong Kong. This study examines teachers' conceptions of integrated writing skills and interviewed twenty-five Chinese language teachers. Three conceptions emerged from the data, representing writing as a composite of disconnected parts (Category1), a logical inquiry (Category 2), and a developmental process (Category 3). As the categories move up, the alignment between teachers' conceptions and the curriculum objectives increases accordingly, with the purpose of writing instruction ranging from fulfilling examination requirements, enhancing reasoning skills, to developing integrated use of language skills. The findings also reveal that although the development of integrated writing skills has been a critical component of the Chinese language curriculum since the first public examination in 2007, teachers' receptivity toward it still varied greatly. Insufficient professional training, the legitimacy of integrated writing as a curriculum component, and the fossilization of the public examination were the factors that accounted for the differing attitudes among the teachers. The discourse of integrated writing in the Hong Kong context has been centered around high-stakes testing. The unbalanced discourse resulted in an oversimplified view that conflated the teaching and learning of integrated writing with integrated writing assessment. The study contributes to the conversation between integrated writing curriculum, instruction, and assessment. Implications for teacher professional development are discussed.