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Many geospatial analyses require flexible aggregation of adjacent units to meet a minimum target area or attribute value. This is usually accomplished using several non-automated and complex GIS tasks. We developed an integrated user-friendly approach and algorithm implemented in the 'GHS-SmartDissolve' tool, which addresses minimum mapping unit or attribute value requirements, layers resolution mismatch, spatial uncertainty or modifiable areal unit problem in GIScience. This method automatically dissolves adjacent features updating fields' values to reach a minimum target area or attribute value, using a flexible settings framework to meet user requirements. Also provided as a toolbox for ArcGIS (Esri), the approach is demonstrated by (i) estimating the mean particulate matter concentrations for all municipalities in Italy in 2011 by combining a coarse grid of global PM2.5 concentrations with fine administrative units; (ii) estimating boundaries of Metropolitan areas in Portugal as aggregation of municipalities, by matching their total population. [ABSTRACT FROM AUTHOR]