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Some of the effects of climate change may be related to a change in patterns of rainfall intensity or scarcity. Therefore, humanity is facing environmental challenges due to an increase in the occurrence and intensity of droughts. The forecast of droughts can be of great help when trying to reduce the adverse effects that the scarcity of water brings, particularly in agriculture. When evaluating the conditions of water scarcity, as well as in the identification and characterization of droughts, the use of predictive models of drought indices could be a very useful tool. In this research, the utility of Artificial Neural Networks with exogenous inputs was tested, with the aim of predicting the monthly Standardized Precipitation Index in 4 regions (Semi-desert, Highlands, Canyons and Mountains) of north-central México using predictor data from 1979 to 2014. The best model was found using the scaled conjugate gradient backpropagation algorithm as the optimization method and was set to the following architecture: 6-25-1 network. The correlation coefficient of predicted and observed Standardized Precipitation Index values for the test dataset was between 0.84 and 0.95. As a result, the Artificial Neural Network models performed successfully in predicting Standardized Precipitation Index at the four analyzed regions. The developed and tested Artificial Neural Network models in this research suggest remarkable prediction abilities of the monthly Standardized Precipitation Index in the study region. [ABSTRACT FROM AUTHOR]