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Dyadic interviews, in which two participants are interviewed together, are becoming more popular in qualitative research, but are much less discussed in the methodological literature than individual and group forms. In this article, we consider the nature and value of dyadic interviews, recognizing them as active, relational encounters, shaped by what all parties bring to them, and infused with issues of power. Drawing on our research on altruistic motivation which involved 47 dyadic interviews conducted with 94 individuals and post-interview feedback from participants, we demonstrate the strengths and point out some of the potential pitfalls associated with the dyadic format, focusing on the practical and ethical issues in defining and recruiting dyads and the practice of conducting such interviews. We provide recommendations for researchers interested in using this method, and suggest research priorities for the further development of dyadic interviewing. [ABSTRACT FROM AUTHOR]

Objective: We assessed longitudinal patterns of maternal C-peptide concentration to examine the hypothesis of β-cell regeneration in pregnancy with type 1 diabetes.Research Design and Methods: C-peptide was measured on maternal serum samples from 127 participants (12, 24, and 34 weeks) and cord blood during the Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT). C-peptide was measured using a highly sensitive direct and solid-phase competitive electrochemiluminescent immunoassay.Results: Three discrete patterns of maternal C-peptide trajectory were identified: pattern 1, undetectable throughout pregnancy, n = 74 (58%; maternal C-peptide <3 pmol/L); pattern 2, detectable at baseline, n = 22 (17%; maternal C-peptide 7-272 pmol/L at baseline); and pattern 3, undetectable maternal C-peptide at 12 and 24 weeks, which first became detectable at 34 weeks, n = 31 (24%; maternal C-peptide 4-26 pmol/L at 34 weeks). Baseline characteristics and third trimester glucose profiles of women with pattern 1 and pattern 3 C-peptide trajectories were similar, but women in pattern 3 had suboptimal glycemia (50% time above range) at 24 weeks' gestation. Offspring of women with pattern 3 C-peptide trajectories had elevated cord blood C-peptide (geometric mean 1,319 vs. 718 pmol/L; P = 0.007), increased rates of large for gestational age (90% vs. 60%; P = 0.002), neonatal hypoglycemia (42% vs. 14%; P = 0.001), and neonatal intensive care admission (45% vs. 23%; P = 0.023) compared with pattern 1 offspring.Conclusions: First maternal C-peptide appearance at 34 weeks was associated with midtrimester hyperglycemia, elevated cord blood C-peptide, and high rates of neonatal complications. This suggests transfer of C-peptide from fetal to maternal serum and is inconsistent with pregnancy-related β-cell regeneration. [ABSTRACT FROM AUTHOR]