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Objective: To investigate the association between the interleukin 23 Receptor (IL23R) rs6682925 variant with coronary artery disease (CAD) in Northern Han population of China. Methods: The study was conducted in 568 coronary artery disease patients and 529 control subjects in a case-control study. We used the gene directing sequencing technology to detect the IL23R rs6682925 and rs1884444 variant. Results: We found that the IL23R rs6682925 and rs1884444 variant frequency conformed well to the Hardy-Weinberg equilibrium in both case and control subject. IL23R rs6682925 (CC, TC and TT) genotype frequency was 22.9 %, 39.6 % and 37.5 % in CAD group and 41.7 %, 47.2 % and 11.1 % in control group. IL23 R rs6682925 C allele was a genetic risk factor for coronary artery disease in Northern Han population of China (P<0.05). There were no significant differences in the genotype and allele distribution of IL23R rs1884444 variant between CAD and control subjects (P>0.05). Logistic regression analysis with adjustments for the other risk factors showed that the C allele carriers of IL23R rs6682925 variant significantly increased the risk of coronary artery disease compared with the non-carriers (P<0.05). Conclusions: IL23R rs6682925 variant may be considered a genetic risk factor for CAD in Northern Han population of China. [ABSTRACT FROM AUTHOR]