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The Yemaquan skarn deposit in the northwestern part of the Qimantagh is located in the eastern Kunlun orogenic belt. The deposit is hosted in carbonate rocks, siltstones, and sandstones of the Cambrian–Ordovician Tanjianshan Group and Late Carboniferous Di'aosu Formation. These rocks are intruded by Triassic calc-alkaline granitoid that extended NW–SE. Three stages of mineralization have been identified, i.e., pre-ore stage, syn-ore stage, and post-ore stage. The prograde skarn stage, which corresponds to the pre-ore stage, is dominated by clinopyroxene and garnet. Clinopyroxene is much more abundant than garnet in the deposit and consists of three types of clinopyroxene in the deposit. In terms of the end-members diopside (CaMgSi 2 O 6 ), hedenbergite (CaFeSi 2 O 6 ), and johannsenite (CaMnSi 2 O 6 ), namely, type I (with an average composition of Di 92 Hd 7 Joh 1 ), type II (with an average of composition of Di 62 Hd 36 Joh 2 ), and type III (with an average composition of Di 24 Hd 54 Joh 22 ) occurred from the proximal intrusions to the distal wall rocks. Type I, II, and III clinopyroxenes are associated with copper–iron, iron, and zinc–lead mineralization, respectively. Garnet mostly occurred in the middle of exoskarn zonations and is associated with type II clinopyroxene. The distribution of the garnet in the skarn zonation could be explained by the stability fields of clinopyroxene, which is strongly dependent on composition. Based on mineral assemblages, the formation of type II and type III, comparative to type I clinopyroxene, is in more reduced condition in the distal skarn. Moreover sulfur isotope carried out on sulfide minerals from both the prograde and retrograde stages show a variable and wide range of δ 34 S values (− 6.9 to 4.2‰ δ 34 S), suggesting that the skarn-forming fluid may have been affected by the reduced wall rocks. The low garnet/clinopyroxene ratios observed at the deposit might be caused by the clinopyroxene composition variations and reduced wall rocks. [ABSTRACT FROM AUTHOR]